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A machine learning approach for regional geochemical data:Platinum-group element geochemistry vs geodynamic settings of the North Atlantic Igneous Province

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Geoscience Frontiers 2021年第3期12卷 42-59页

作者： jordan J.Lindsay Hannah S.R.Hughes Christopher m.Yeomans Jens C.Ø.Andersen Iain mcDonald Camborne School of mines University of ExeterPenryn CampusPenrynCornwall TR109FEUnited Kingdom School of Earth and Ocean Sciences Main CollegeCardiff UniversityPark PlaceCardiff CF103ATUnited Kingdom

Whilst traditional approaches to geochemistry provide valuable insights into magmatic processes such as melting and element fractionation,by considering entire regional data sets on an objective basis using machine learning algorithms(mLAs),we can highlight new facets within the broader data structure and significantly enhance previous geochemical *** platinum-group element(PGE)budget of lavas in the North Atlantic Igneous Province(NAIP)has been shown to vary systematically according to age,geographic location and geodynamic *** the large multi-element geochemical data set available for the region,mLAs were employed to explore the magmatic controls on these shifting *** key advantage of using machine learning in analysis is its ability to cluster samples across multi-dimensional(i.e.,multi-element)*** NAIP data set is manipulated using Principal Component Analysis(PCA)and t-Distributed Stochastic Neighbour Embedding(t-SNE)techniques to increase separability in the data alongside clustering using the k-means *** new multi-element classification is compared to the original geographic classification to assess the performance of both *** workflow provides a means for creating an objective high-dimensional investigation on a geochemical data set and particularly enhances the identification of metallogenic anomalies across the *** techniques used highlight three distinct multi-element end-members which successfully capture the variability of the majority of elements included as input *** end-members are seen to fluctuate in prominence throughout the NAIP,which we propose reflects the changing geodynamic environment and melting ***,the variability of Pt and Pd are not reflected in mLA-based clustering trends,suggesting that they vary independently through controls not readily demonstrated by the NAIP major or trace element data structure(i.e.,other proxies for magmatic differe

关键词： Platinum-group elements machine learning Plume Geochemistry metallogenesis mantle

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Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第28期25卷 3704-3721页

作者： Clifford Akateh Sylvester m Black Lanla Conteh Eric D miller Anne Noonan Eric Elliott Timothy m Pawlik Allan Tsung jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Transplant Surgery Department of Surgery The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Gastroenterology Hepatology and Nutrition Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus OH 43210 United States Department of Radiation Oncology The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of medical Oncology Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Diagnostic Radiology Department of Radiology The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Surgical Oncology Department of Surgery The Ohio State University Wexner Medical Center Columbus OH 43210 United States

Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research.

关键词： Hepatocellular carcinoma Neoadjuvant therapy Adjuvant therapy Neoplasm recurrence Hepatectomy Liver cirrhosis

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A comparison of lower limb stiffness and mechanical muscle function in ACL-reconstructed,elite,and adolescent alpine ski racers/ski cross athletes

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Journal of Sport and Health Science 2018年第4期7卷 416-424页

作者： matthew J.jordan Per Aagaard Walter Herzog Canadian Sport Institute Calgary Calgary AB T2N IN4Canada Department of Sports Science and Clinical Biomechanics SDU Muscle Research ClusterUniversity of Southern DenmarkOdense DK-5230Denmark Human Performance Laboratory University of CalgaryCalgaryAB T2N IN4Canada Corresponding author.E-mail address： mjordan@ucalgary.ca

Purpose： The aim of this study was to compare mechanical muscle function in the eccentric/concentric phases of vertical bilateral jumping in anterior cruciate ligament-reconstructed （ACLR）, elite （ELITE）, and adolescent （ADOL） alpine ski racers and ski cross athletes. methods： Alpine ski racers/ski crossers （ACLR： n = 12, age = 26.7 ± 3.8 years; ELITE： n = 12, age = 23.9 ± 3.0 years; ADOL： n = 12, age = 17.8 ± 0.7 years; females： n = 6 per group, males： n = 6 per group） performed 5 maximal countermovement jumps （CmJs） and 5 squat jumps. The ground reaction forces for each limb were analyzed using dual force plate recording to obtain body center of mass （BCm） velocity, displacement, and power. The eccentric deceleration （ECC） and concentric phases were determined from BCm velocity. CmJ net concentric and ECC impulses were calculated （body mass normalized） along with the peak and mean BCm power and maximal vertical jump height. CmJ lower limb stiffness （LLS） was determined by the slope of the ground reaction forces vs. the BCm displacement curve over the ECC phase. Concentric and ECC asymmetry indices were calculated for each leg, and the left vs. right LLS was compared. Outcome measures （reported as mean ± SD） calculated as a 5-jump mean were normalized to body mass and compared using an analysis of variance. Results： No between-group differences were found for peak and mean power or jump heights. There were no group differences for LLS or net concentric phase impulse, but the net ECC impulse was lower in the ADOL group compared with ELITE skiers （ADOL： 1.33 ± 0.32 Ns/kg; ELITE： 1.59 ± 0.16 Ns/kg; p 〈 0.05）. Although no group differences were found for ECC asymmetry indices, a group × limb interaction was found for LLS （p 〈 0.01）, which was systematically higher in the right vs. the left limb of ADOL skiers （right： 54.1 ± 17.9 N/m/kg; left： 48.7 ± 15.7 N/m/kg;p 〈 0.01）. Conclusion： ADOL skiers demonstrated decreased ECC impulse and systematic right limb dominance in

关键词： Between-limb asymmetry Injury prevention Knee injuries muscle power Vertical jump

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microbial symphony orchestrated by mucosal IgA

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Cellular & molecular Immunology 2022年第4期19卷 456-457页

作者： Alejandra Reyes-Ruiz jordan D.Dimitrov Centre de Recherche des Cordeliers INSERMCNRSSorbonne UniversitéUniversitéde Paris75006ParisFrance

The ability of an organism to handle the beauty and cruelty of existence is largely due to a complex network of molecular and cellular interactions and processes named the immune *** components of this network are antibodies(Abs)that have key roles in immune defense and *** biological functions of Abs include neutralizing pathogens by blocking functionally important molecules and/or to eliciting lethal effector functions by bridging the recognition of pathogens with binding to different innate immune receptors.

关键词： bridging neutral network

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Efficient Communication in Wireless Sensor Networks Using Optimized Energy Efficient Engroove Leach Clustering Protocol

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Tsinghua Science and Technology 2024年第4期29卷 985-1001页

作者： N.meenakshi Sultan Ahmad A.V.Prabu J.Nageswara Rao Nashwan Adnan Othman Hikmat A.m.Abdeljaber R.Sekar Jabeen Nazeer SRm Institute of Science and Technology KattankulathurChennai 603203India Department of Computer Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharj 11942Saudi Arabia University Center for Research and Development(UCRD) Department of Computer Science and EngineeringChandigarh UniversityGharuanMohali 140413India Department of ECE Koneru Lakshmaiah Education FoundationVaddeswaramGuntur 522502India Department of Computer Science and Engineering Lakireddy Balireddy College of Engineering(A)NTR District 521230India Department of Computer Engineering College of EngineeringKnowledge UniversityErbil 44001Iraq Department of Computer Science Faculty of Information TechnologyApplied Science Private UniversityAmman 11937Jordan Department of Electronics and Communication Engineering(ECE) School of EngineeringPresidency UniversityBangalore 834001India

The Wireless Sensor Network(WSN)is a network that is constructed in regions that are inaccessible to human *** widespread deployment of wireless micro sensors will make it possible to conduct accurate environmental monitoring for a use in both civil and military *** make use of these data to monitor and keep track of the physical data of the surrounding environment in order to ensure the sustainability of the *** data have to be picked up by the sensor,and then sent to the sink node where they may be *** nodes of the WSNs are powered by batteries,therefore they eventually run out of *** energy restriction has an effect on the network life span and environmental *** objective of this study is to further improve the Engroove Leach(EL)protocol’s energy efficiency so that the network can operate for a very long time while consuming the least amount of *** lifespan of WSNs is being extended often using clustering and routing *** meta Inspired Hawks Fragment Optimization(mIHFO)system,which is based on passive clustering,is used in this study to do *** cluster head is chosen based on the nodes’residual energy,distance to neighbors,distance to base station,node degree,and node *** on distance,residual energy,and node degree,an algorithm known as Heuristic Wing Antfly Optimization(HWAFO)selects the optimum path between the cluster head and Base Station(BS).They examine the number of nodes that are active,their energy consumption,and the number of data packets that the BS *** overall experimentation is carried out under the mATLAB *** the analysis,it has been discovered that the suggested approach yields noticeably superior outcomes in terms of throughput,packet delivery and drop ratio,and average energy consumption.

关键词： wireless sensor networks energy efficient engroove leach protocol meta inspired Hawks fragment optimization heuristic wing antfly optimization

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Update on Liver Failure Following Hepatic Resection: Strategies for Prediction and Avoidance of Post-operative Liver Insufficiency

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Journal of Clinical and Translational Hepatology 2018年第1期6卷 97-104页

作者： Amir A. Rahnemai-Azar jordan m. Cloyd Sharon m. Weber mary Dillhoff Carl Schmidt Emily R. Winslow Timothy m. Pawlik Department of Surgery Division of Surgical OncologyUniversity of Wisconsin HospitalMadisonWIUSA Department of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical CenterColumbusOHUSA Department of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Liver resection is increasingly used for a variety of benign and malignant *** advances in preoperative selection,surgical technique and perioperative management,posthepatectomy liver failure(PHLF)is still a leading cause of morbidity and mortality following liver *** the devastating physiological consequences of PHLF and the lack of effective treatment options,identifying risk factors and preventative strategies for PHLF is *** the past,a major limitation to conducting high quality research on risk factors and prevention strategies for PHLF has been the absence of a standardized *** this article,we describe relevant definitions for PHLF,discuss risk factors and prediction models,and review advances in liver assessment tools and PHLF prevention strategies.

关键词： Complication Hepatectomy Liver failure Liver resection Prevention Risk models

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Fuzzy Difference Equations in Diagnoses of Glaucoma from Retinal Images Using Deep Learning

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Computer modeling in Engineering & Sciences 2024年第4期139卷 801-816页

作者： D.Dorathy Prema Kavitha L.Francis Raj Sandeep Kautish Abdulaziz S.Almazyad Karam m.Sallam Ali Wagdy mohamed Department of mathematics Voorhees CollegeVelloreTamil NaduIndia Chandigarh Group of Colleges JhanjeriMohaliPunjabIndia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Faculty of Science and Technology School of IT and SystemsUniversity of CanberraCanberraAustralia Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied Science Research Center Applied Science Private UniversityAmman11937Jordan

The intuitive fuzzy set has found important application in decision-making and machine *** enrich and utilize the intuitive fuzzy set,this study designed and developed a deep neural network-based glaucoma eye detection using fuzzy difference equations in the domain where the retinal images *** image detections are categorized as normal eye recognition,suspected glaucomatous eye recognition,and glaucomatous eye *** degrees associated with weighted values are calculated to determine the level of concentration between the fuzzy partition and the retinal *** proposed model was used to diagnose glaucoma using retinal images and involved utilizing the Convolutional Neural Network(CNN)and deep learning to identify the fuzzy weighted regularization between *** methodology was used to clarify the input images and make them adequate for the process of glaucoma *** objective of this study was to propose a novel approach to the early diagnosis of glaucoma using the Fuzzy Expert System(FES)and Fuzzy differential equation(FDE).The intensities of the different regions in the images and their respective peak levels were *** the peak regions were identified,the recurrence relationships among those peaks were then *** partitioning was done due to varying degrees of similar and dissimilar concentrations in the *** and dissimilar concentration levels and spatial frequency generated a threshold image from the combined fuzzy matrix and *** distinguished between a normal and abnormal eye condition,thus detecting patients with glaucomatous eyes.

关键词： Convolutional Neural Network(CNN) glaucomatous eyes fuzzy difference equation intuitive fuzzy sets image segmentation retinal images

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Long-term irritable bowel syndrome symptom control with reintroduction of selected FODmAPs

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World Journal of Gastroenterology 2017年第25期23卷 4632-4643页

作者： Ruth m Harvie Alexandra W Chisholm.jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz michael Schultz Department of medicine Dunedin School of MedicineUniversity of Otago Department of Human Nutrition University of Otago Departments of Surgery and microbiology&Immunology Western UniversityOntario Department of Preventative and Social medicine University of Otago

To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol (FODmAP) diet on irritable bowel syndrome (IBS) symptoms and quality of life (QoL). mETHODSParticipants with IBS (Rome III) were randomized to two groups. Group I commenced a low FODmAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODmAP diet while group I started re-challenging foods. All patients completed the IBS SSS (IBS symptom severity scoring system, 0-500 points increasing with severity), IBS QoL questionnaire (0-100 increasing with QoL), a FODmAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis. RESULTSFifty participants were enrolled into group I (n = 23) or group II (n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS (275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1) (P mo. The reduced IBS SSS was sustained at 6 mo in group I (160 ± 102) and replicated in group II (124 ± 76). Fiber intake decreased on the low FODmAP diet (33 ± 17 g/d to 21 ± 8 g/d) (P mAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODmAP diet. CONCLUSIONThis study demonstrated that a reduction in FODmAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODmAPs.

关键词： Irritable bowel syndrome FODmAP Short chain fermentable carbohydrates microbiota Diet microbiome

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Simultaneous removal of arsenic and antimony from mining wastewater

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Journal of Environmental Sciences 2020年第7期32卷 117-119页

作者： Jiaojiao Xie jordan R.m.Schofield Lejun Liao Hanyong Peng Jagdeesh S.Uppal Qi Zheng X.Chris Le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of Alberta10-102 Clinical Sciences BuildingEdmontonAlberta T6G 2G3Canada Department of Chemistry University of AlbertaEdmontonAlbertaCanada Key Laboratory of Optoelectronic Chemical materials and Devices Ministry of EducationInstitute of Environment and HealthJianghan UniversityWuhan 430056China Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of Alberta10-102 Clinical Sciences BuildingEdmontonAlberta T6G 2G3Canada Department of ChemistryUniversity of AlbertaEdmontonAlbertaCanada

Arsenic(As)and antimony(Sb)rank 1 st and 244 th,respectively,on the 2019 Substance Priority List of the Agency for Toxic Substances and Disease Registry(ATSDR,2019).ATSDR lists substances,in order of priority,that are"most commonly found at facilities on the National Priorities List(NPL)and which are determined to pose the most significant potential threat to human health due to their known or suspected toxicity and potential for human exposure at these NPL sites".

关键词： wastewater mining arsenic

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Evaluation of Cuban Bacillus thuringiensis(Berliner,1911)(Bacillales:Bacillacea)isolates with larvicidal activity against Aedes aegypti(Linnaeus,1762)(Diptera:Culicidae)

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Asian Pacific Journal of Tropical medicine 2022年第2期15卷 79-86页

作者： aileen Gonzalez Rizo Camilo E Castañet martinez Celeste Ramírez Cardentey Ariamys Companioni Ibañez Zulema menéndez Díaz Lianet monzote Fidalgo Hilda m HernandezÁlvarez Vector Control Department Institute of Tropical MedicinePedro KouríAutopistaNovia del Mediodía km 6½La Habana 11400Cuba Virology Department Institute of Tropical MedicinePedro KouríAutopista Novia del Mediodía km 6½La Habana 11400Cuba Parasitology Department Institute of Tropical MedicinePedro KouríAutopista Novia del Mediodía km 6½La Habana 11400Cuba

Objective:To evaluate 11 Cuban native Bacillus(B.)thuringiensis isolates in order to select one with the best larvicidal activity against Aedes(Ae.)aegypti and low ***:The cry and cyt genes of the isolates(A21,A51,L95,L910,m29,R84,R85,R87,R89,U81 and X48)were amplified by *** influence of organic matter and NaCl on the larvicidal activity was tested by *** was assayed on peritoneal macrophages of BALB/c ***:The cyt1(Aa,Ab,Ba),cyt2,cry4aA,cry4Ba,cry11(Aa,Ba,Bb)and cry10 genes were identified in all native Cuban *** larvicidal activity(LC_(90))of seven isolates was affected by the presence of organic matter in the water,while A21,A51,L910,R84,U81 and X48 had better LC_(50),LC_(90),LC_(95) than the 266/29-Ⅶ-98 control *** LC_(50) of two isolates was affected by the presence of NaCl and A21,A51,R85 isolate had better larvicidal activity than the 266/29-Ⅶ-98 control *** terms of toxicity against macrophages,the extracts of nine isolates were less cytotoxic than the control ***:Native isolate A21 had the main virulence factors against *** larvae,displayed a good larvicidal activity in presence of different factors related with *** breeding sites,and had low citotoxicity against *** results can contribute to the improvement of existing biological control strategies and the development of new biolarvicides.

关键词： mosquitoes Biological control agent Bacillus thuringiensis Bioassays Aedes aegypti cry and cyt genes

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