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基于系统保护的配电网馈线故障处理技术

科学技术创新 2024年第12期 225-228页

作者：张爱辉浏阳新华电力有限公司湖南浏阳

本文探究了基于系统保护的馈线故障处理技术。相比于基于重合器的馈线故障处理,该技术具有故障识别精准、故障隔离及时、自动化程度高等特点,在保证配电网可靠运行和提供电能质量方面有良好效果。馈线系统保护采用主保护和后备保护相结... 详细信息

本文探究了基于系统保护的馈线故障处理技术。相比于基于重合器的馈线故障处理,该技术具有故障识别精准、故障隔离及时、自动化程度高等特点,在保证配电网可靠运行和提供电能质量方面有良好效果。馈线系统保护采用主保护和后备保护相结合的方式,确保在通信发生故障的情况下也能快速隔离故障。从实验结果看,系统保护装置可以在150 ms内完成故障处理,满足配电网安全、可靠运行的要求。

关键词：系统保护配电网馈线故障后备保护

Celastrol promotes apoptotic cell death in children neuroblastoma cells through caspases dependent pathway

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Journal of Traditional Chinese Medicine 2022年第6期42卷 877-884页

作者： YANG Ye zhang aihui LI Anmao Department of Thoracic Surgery Xi'an Children's HospitalXi'an 710003China

OBJECTIVE: To investigate the in-depth pharmacological mechanisms of celastrol in children neuroblastoma treatment. METHODS: In the current study, we examined the effects of celastrol on children neuroblastoma cells viability and proliferation by cell counting kit-8 assay and colony formation assay. Annexin V-FTIC and PI staining were applied to determine cell apoptosis after celastrol treatment. ROS generation levels were examined by 2′, 7′-dichloroflfluorescin diacetate. RESULTS: We found that celastrol could suppress the proliferation of children neuroblastoma cells with few effects on normal cell lines in vitro. Further mechanisms studies have shown that celastrol inhibited cell cycle progression and induced cell apoptosis in QDDQ-NM and SH-SY5Y cells. In addition, ROS production might involve in celastrol-mediated apoptotic cell death in children neuroblastoma cells by activating caspase death pathway. CONCLUSIONS: Our findings demonstrated that celastrol could promote ROS generation-induced apoptosis in neuroblastoma cell by activating caspase death pathway. These findings suggested that celastrol might be a potential novel anti-neuroblastoma agent with minor cytotoxicity.

关键词： neuroblastoma child celastrol apoptosis poly(ADP-ribose)polymerases

高校防范和化解网络宗教渗透风险的创新机制研究

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科学与无神论 2024年第2期 73-82页

作者：张爱辉高建军江苏财经职业技术学院

随着互联网技术的应用和发展,网络宗教逐步成为世界宗教发展的新样态。西方敌对势力利用网络进行的宗教渗透对我国高校意识形态安全造成极大威胁,因而高校防范、抵御和化解网络宗教渗透的工作既有重要的现实意义又有实践上的紧迫性和必... 详细信息

随着互联网技术的应用和发展,网络宗教逐步成为世界宗教发展的新样态。西方敌对势力利用网络进行的宗教渗透对我国高校意识形态安全造成极大威胁,因而高校防范、抵御和化解网络宗教渗透的工作既有重要的现实意义又有实践上的紧迫性和必要性。网络宗教向高校渗透有其独有的特征和原因。高校应结合自身实际,多管齐下,灵活疏导,创建出防范、抵御和化解网络宗教渗透风险的长效机制。

关键词：高校网络宗教渗透意识形态安全

Single-molecule biotechnology for protein researches

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Chinese Journal of Chemical Engineering 2021年第2期34卷 212-224页

作者： Xiaoyan Zhuang Qian Wu aihui zhang Langxing Liao Baishan Fang Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China The Key Lab for Synthetic Biotechnology of Xiamen City Xiamen UniversityXiamen 361005China The Key Laboratory for Chemical Biology of Fujian Province Xiamen UniversityXiamen 361005China

Cells employ proteins to perform metabolic functions and maintain active physiological state through charge transfer and energy *** processes are carried out in a narrow space precisely and rapidly,which,no doubt,bring great difficulty for their detection and ***,in recent years,the development and expansion of single-molecule technique in protein research make monitoring the dynamical changes of protein at single-molecule level a reality,which also provides a powerful tool for the further exploration of new phenomena and new mechanisms of life *** paper aims to summarize the working principle and essential achievements of single-molecule technique in protein research in recent five *** focus on not only dissecting the difference of nanopores,atomic force microscope,scanning tunneling microscope,and optical tweezers technique,but also discussing the great significance of these single-molecule techniques in investigating intramolecular and intermolecular interactions,electron transport,and conformational ***,the opportunities and challenges of the single-molecule technique in protein research are discussed,which provide a new door for single-molecule protein research.

关键词： Single-molecule protein Enzyme Nanopore Atomic force microscope Scanning tunneling microscope Optical tweezers Biotechnology Imaging

西北旱区大型灌区实施深度节水的生态发展模式探究

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中国水利 2024年第6期 61-67页

作者：张爱辉徐梓曜王冉尚毅梓水利部综合开发管理中心北京100053 中国水利水电科学研究院北京100038

节水会改变灌区原有水循环状态,进而影响水循环伴生的生态与环境过程,节水力度越强、规模越大、范围越广,对生态环境系统的影响也就越大。节水必须保证区域生态稳定。针对我国西北地区水资源紧缺、生态环境脆弱的现状,综合深度节水控水... 详细信息

节水会改变灌区原有水循环状态,进而影响水循环伴生的生态与环境过程,节水力度越强、规模越大、范围越广,对生态环境系统的影响也就越大。节水必须保证区域生态稳定。针对我国西北地区水资源紧缺、生态环境脆弱的现状,综合深度节水控水与保护生态环境两方面,提出灌区实施深度节水的生态发展模式,为缓解西北干旱区的缺水形势提供参考。

关键词：节水地下水水位生态约束节水潜力

Aptamer-based cell-free detection system to detect target protein

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Synthetic and Systems Biotechnology 2021年第3期6卷 209-215页

作者： Junhong Chen Xiaoyan Zhuang Jiyang Zheng Ruofan Yang Fei Wu aihui zhang Baishan Fang XMU-China Team Xiamen UniversityXiamen361005PR China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen361005PR China The Key Laboratory for Chemical Biology of Fujian Province Key Lab for Synthetic Biotechnology of Xiamen CityXiamen UniversityXiamen361005PR China

Biomarkers of disease,especially protein,show great potential for diagnosis and *** detecting a certain protein,a binding assay implementing antibodies is commonly ***,antibodies are not thermally stable and may cause false-positive when the sample composition is *** recent years,a functional nucleic acid named aptamer has been used in many biochemical analysis cases,which is commonly selected from random sequence libraries by using the systematic evolution of ligands by exponential enrichment(SELEX)*** to antibodies,the aptamer is more thermal stable,easier to be modified,conjugated,and ***,an Aptamer-Based Cell-free Detection(ABCD)system was proposed to detect target protein,using epithelial cell adhesion molecule(EpCAM)as an *** combined the robustness of aptamer in binding specificity with the signal amplification ability of CRISPR-Cas12a′s trans-cleavage activity in the ABCD *** also demonstrated that the ABCD system could work well to detect target protein in a relatively low limit of detection(50-100 nM),which lay a foundation for the development of portable detection *** work highlights the superiority of the ABCD system in detecting target protein with low abundance and offers new enlightenment for future design and development.

关键词： Aptamer CRISPR-Cas Protein detection Biomarker

米诺环素对耐阿奇霉素重症支原体肺炎患儿炎症反应及凝血功能的影响

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分子诊断与治疗杂志 2024年第9期16卷 1779-1783页

作者：王文秀许晓霞张爱辉陈晓春喜雷北京市通州区妇幼保健院普儿科北京101100

目的探究米诺环素对耐阿奇霉素重症支原体肺炎患儿炎症反应及凝血功能的影响。方法选取2023年1至12月期间北京市通州区妇幼保健院收治的112例重症支原体肺炎患儿进行分析,根据治疗方案差异分为观察组(n=60)与对照组(n=52)。对照组予以... 详细信息

目的探究米诺环素对耐阿奇霉素重症支原体肺炎患儿炎症反应及凝血功能的影响。方法选取2023年1至12月期间北京市通州区妇幼保健院收治的112例重症支原体肺炎患儿进行分析,根据治疗方案差异分为观察组(n=60)与对照组(n=52)。对照组予以常规对症治疗,观察组使用米诺环素治疗。比较两组的临床疗效、治疗后的症状改善情况(肺部啰音消失时间、喘息消失时间、咳嗽缓解时间、肺部阴影消失时间)以及治疗期间的不良反应情况;比较两组治疗前后的炎症指标水平[中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、降钙素原(PCT)]以及凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、血浆D-二聚体(D-D)、凝血酶时间(TT)]。结果两组临床疗效对比,观察组总有效率显著更高,差异有统计学意义(χ^(2)=7.078,P0.05)。结论针对耐阿奇霉素重症支原体肺炎患儿应用米诺环素的疗效显著且安全性良好,可能与其调节机体内凝血功能及炎症相关因子有关。

关键词：米诺环素炎症反应耐阿奇霉素重症支原体肺炎凝血功能

Strongly Coupled Ag/Sn-SnO_(2)Nanosheets Toward CO_(2)Electroreduction to Pure HCOOH Solutions at Ampere‑Level Current

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Nano-Micro Letters 2024年第3期16卷 212-226页

作者： Min zhang aihui Cao Yucui Xiang Chaogang Ban Guang Han Junjie Ding Li‑Yong Gan Xiaoyuan Zhou College of Physics and Center of Quantum Materials and Devices Chongqing UniversityChongqing 401331People’s Republic of China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences(CAS)Fuzhou 350002People’s Republic of China College of Materials Science and Engineering Chongqing UniversityChongqing 400044People’s Republic of China Institute of New Energy Storage Materials and Equipment Chongqing 401135People’s Republic of China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044People’s Republic of China

Electrocatalytic reduction of CO_(2) converts intermittent renewable electricity into value-added liquid products with an enticing prospect,but its practical application is hampered due to the lack of high-performance ***,we elaborately design and develop strongly coupled nanosheets composed of Ag nanoparticles and Sn-SnO_(2) grains,designated as Ag/Sn-SnO_(2) nanosheets(NSs),which possess optimized electronic structure,high electrical conductivity,and more accessible *** a result,such a catalyst exhibits unprecedented catalytic performance toward CO_(2)-to-formate conversion with near-unity faradaic efficiency(≥90%),ultrahigh partial current density(2,000 mA cm^(−2)),and superior long-term stability(200 mA cm^(−2),200 h),surpassing the reported catalysts of CO_(2) electroreduction to ***,in situ attenuated total reflection-infrared spectra combined with theoretical calculations revealed that electron-enriched Sn sites on Ag/Sn-SnO_(2)NSs not only promote the formation of*OCHO and alleviate the energy barriers of*OCHO to*HCOOH,but also impede the desorption of H*.Notably,the Ag/Sn-SnO_(2)NSs as the cathode in a membrane electrode assembly with porous solid electrolyte layer reactor can continuously produce~0.12 M pure HCOOH solution at 100 mA cm^(−2)over 200 *** work may inspire further development of advanced electrocatalysts and innovative device systems for promoting practical application of producing liquid fuels from CO_(2).

关键词： Electrochemical CO_(2)reduction Coupled Ag/Sn-SnO_(2)nanosheets Electronic structure Porous solid electrolyte Pure

Degradation strategies of pesticide residue:From chemicals tosynthetic biology

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Synthetic and Systems Biotechnology 2023年第2期8卷 302-313页

作者： Bi Ruomeng Ou Meihao Zhou Siru Geng Shichen Zheng Yixian Chen Junhong Mo Ruijie Li Yuan Xiao Gezhi Chen Xingyu Zhai Shiyi zhang aihui Fang Baishan XMU-China Team Innovative Practice Platform for Genetic Engineering Machine DesignXiamen UniversityXiamenFujian361005PR China College of Chemistry and Chemical Engineering Xiamen UniversityXiamenFujian361005PR China School of Public Health Xiamen UniversityXiamenFujian361005PR China College of Energy Xiamen UniversityXiamenFujian361005PR China School of Life Sciences Xiamen UniversityXiamenFujian361005PR China School of Pharmaceutical Science Xiamen UniversityXiamenFujian361005PR China Shenzhen Research Institute of Xiamen University Shenzhen518000PR China

The past 50 years have witnessed a massive expansion in the demand and application of ***,pesticides are difficult to be completely degraded without intervention hence the pesticide residue could pose a persistent threat to non-target organisms in many *** aim at the problem of the abuse of pesticide products and excessive pesticide residues in the environment,chemical and biological degradation methods are widely developed but are scaled and insufficient to solve such a *** recent years,bio-degradative tools instructed by synthetic biological principles have been further studied and have paved a way for pesticide *** the customized design strategy and standardized assembly mode,the engineering bacteria for multi-dimensional degradation has become an effective tool for pesticide residue *** review introduces the mechanisms and hazards of different pesticides,summarizes the methods applied in the degradation of pesticide residues,and discusses the advantages,applications,and prospects of synthetic biology in degrading pesticide residues.

关键词： Synthetic biology Degradation Remediation Biological engineering Pesticide residue