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箔条走廊干扰战术运用研究

现代防御技术 2024年第4期52卷 101-107页

作者：朱爱红孙亮刘明杰姜德胜星火智库甘肃酒泉732750 空军工程大学防空反导学院陕西西安710051

针对箔条走廊分布状况变化复杂、干扰效果无法量化的现状,提出对雷达在箔条走廊背景下探测目标过程进行仿真的方法,建立了箔条走廊的衰减效应模型、扩散模型、雷达波束穿过箔条走廊厚度模型,并采用Matlab进行了实现。通过设置多种场景... 详细信息

针对箔条走廊分布状况变化复杂、干扰效果无法量化的现状,提出对雷达在箔条走廊背景下探测目标过程进行仿真的方法,建立了箔条走廊的衰减效应模型、扩散模型、雷达波束穿过箔条走廊厚度模型,并采用Matlab进行了实现。通过设置多种场景进行仿真,归纳出箔条走廊在长度、宽度及攻击飞机飞行参数选择方面的一般规律,能够定量评估干扰效果,优化箔条走廊干扰的运用策略。

关键词：箔条走廊扩散模型衰减效应雷达威力战术运用效果评估

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Accurate construction of cell membrane biomimetic graphene nanodecoys via purposeful surface engineering to improve screening efficiency of active components of traditional Chinese medicine

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Acta Pharmaceutica Sinica B 2022年第1期12卷 394-405页

作者： Qi Hu Lanlan Jia Xiaolin Zhang aihong zhu Sicen Wang Xiaoyu Xie School of Pharmacy Health Science CenterXi’an Jiaotong UniversityXi'an 710061China Shaanxi Engineering Research Center of Cardiovascular Drugs Screening&Analysis Xi'an 710061China

Biomimetic nanoengineering presents great potential in biomedical research by integrating cell membrane(CM) with functional nanoparticles. However, preparation of CM biomimetic nanomaterials for custom applications that can avoid the aggregation of nanocarriers while maintaining the biological activity of CM remains a challenge. Herein, a high-performance CM biomimetic graphene nanodecoy was fabricated via purposeful surface engineering, where polyethylene glycol(PEG) was used to modifying magnetic graphene oxide(MGO) to improve its stability in physiological solution, so as to improve the screening efficiency to active components of traditional Chinese medicine(TCM). With this strategy, the constructed PEGylated MGO(PMGO) could keep stable at least 10 days, thus improving the CM coating efficiency. Meanwhile, by taking advantage of the inherent ability of He La cell membrane(HM) to interact with specific ligands, HM-camouflaged PMGO showed satisfied adsorption capacity(116.2 mg/g) and selectivity. Finally, three potential active components, byakangelicol, imperatorin,and isoimperatorin, were screened from Angelica dahurica, whose potential antiproliferative activity were further validated by pharmacological studies. These results demonstrated that the purposeful surfaceengineering is a promising strategy for the design of efficient CM biomimetic nanomaterials, which will promote the development of active components screening in TCM.

关键词： Cell membrane Biomimetic nanoengineering Purposeful surface engineering Graphene oxide Dispersity Active components screening Traditional Chinese medicine PEGylation

Biointerface engineering of self-protective bionic nanomissiles for targeted synergistic chemotherapy

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Chinese Chemical Letters 2023年第4期34卷 116-121页

作者： Xueyan Zhen Linhao Li Lanlan Jia aihong zhu Yixuan Yang Sicen Wang Xiaoyu Xie School of Pharmacy Health Science CenterXi’an Jiaotong UniversityXi’an 710061China Shaanxi Engineering Research Center of Cardiovascular Drugs Screening&Analysis Xi’an 710061China

Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficient targeting effect and deficient pharmacokinetic behavior due to the lack of a regulated biointerface to navigate and overcome biological transportation obstacles in solid tumor ***, an anti-epidermal growth factor receptor(EGFR) aptamer(EApt) modified and EM-cloaked chemotherapeutic nanomissile delivery system was constructed. The anchored-EApt acting as a specific EGFR suppressor promotes to inhibit the overexpression of EGFR and initiate the cell apoptosis. Importantly, the resulting PLGA-DOX@EM-EApt orchestrated the bioactivity of each component and provided synergistic cell apoptosis and antitumor effects by precisely suppressing EGFR expression levels and delivering DOX. The in vitro and in vivo experimental results confirmed that the immune escape and active targeting behaviors of PLGA-DOX@EM-EApt could significantly promote its drug retention and tumor inhibition abilities. Our findings propose a novel strategy using the biointerface functionalization technique, demonstrating a promising therapeutic platform via a biomimetic drug delivery system for precise solid tumor recognition and synergistic therapy.

关键词： Aptamer Self-protective Biointerface Targeted drug delivery Synergistic chemotherapy

Unveiling evapotranspiration patterns and energy balance in a subalpine forest of the Qinghai-Tibet Plateau:observations and analysis from an eddy covariance system

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Journal of Forestry Research 2024年第3期35卷 175-188页

作者： Niu zhu Jinniu Wang Dongliang Luo Xufeng Wang Cheng Shen Ning Wu Ning Zhang Binghui Tian aihong Gai Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041People's Republic of China College of Resources and Environmental Sciences Gansu Agricultural UniversityLanzhou 730070People's Republic of China Mangkang Ecological Monitoring Station Tibet Ecological Security Barrier Ecological Monitoring NetworkQamdo 854500People's Republic of China Northwest Institute of Eco Environmental Resources Chinese Academy of SciencesLanzhou 730000People's Republic of China

Evapotranspiration is an important parameter used to characterize the water cycle of *** under-stand the properties of the evapotranspiration and energy balance of a subalpine forest in the southeastern Qinghai-Tibet Plateau,an open-path eddy covariance system was set up to monitor the forest from November 2020 to October 2021 in a core area of the Three Parallel Rivers in the Qing-hai-Tibet *** results show that the evapotranspira-tion peaked daily,the maximum occurring between 11:00 and 15:*** factors had significant effects on evapotranspiration,among them,net radiation the greatest(R^(2)=0.487),and relative humidity the least(R^(2)=0.001).The energy flux varied considerably in different seasons and sensible heat flux accounted for the main part of turbulent *** energy balance ratio in the dormant season was less than that in the growing season,and there is an energy imbalance at the site on an annual time scale.

关键词： Evapotranspiration Energy balance Subalpine forest Three Parallel Rivers region Southeast Qinghai-Tibet Plateau

基于遗传算法和粒子群优化的列车自动驾驶速度曲线优化方法

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计算机应用 2022年第2期42卷 599-605页

作者：张京朱爱红兰州交通大学自动化与电气工程学院兰州730070

针对列车自动驾驶(ATO)过程中的精准停车、准时性、舒适性以及能耗问题,提出一种基于遗传算法与粒子群优化(GAPSO)算法结合的ATO速度曲线优化方法。首先,建立列车ATO运行多目标优化模型,将列车过分相区断电惰行纳入控制策略,并对运行控... 详细信息

针对列车自动驾驶(ATO)过程中的精准停车、准时性、舒适性以及能耗问题,提出一种基于遗传算法与粒子群优化(GAPSO)算法结合的ATO速度曲线优化方法。首先,建立列车ATO运行多目标优化模型,将列车过分相区断电惰行纳入控制策略,并对运行控制策略进行分析;其次,对粒子群优化(PSO)算法进行改进,采用非线性动态惯性权重和改进的加速度系数,并将遗传算子融入其中,从而构成一种全新的GAPSO算法,且验证了GAPSO算法在全局搜索和局部搜索能力以及收敛速度上的优越性。最后,通过GAPSO算法对工况转换点进行寻优,以获取一组满足多目标优化的工况转换点速度,进而得到最优目标速度曲线。仿真实验结果表明,所提优化方法在总体运行时间满足准时性要求的前提下,使能耗降低了13.29%,舒适性提高了26.62%,停车误差降低了21.62%。由此可见,优化后的列车目标速度曲线能够满足多目标要求,该方法为列车ATO多目标优化提供了一种可行的解决方案。

关键词：列车自动驾驶多目标优化分相区目标速度曲线遗传算子粒子群优化算法

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考虑认知不确定性的列控中心可靠性评估

安全与环境学报 2023年第9期23卷 2993-3001页

作者：朱爱红董国庆兰州交通大学自动化与电气工程学院兰州730070

针对列控中心系统中因设备故障信息不完善、失效机理不明确等因素产生的认知不确定性,以及动态失效、共因失效、恢复机制问题,提出了将证据理论和动态贝叶斯网络相结合的动态证据网络方法,并对列控中心系统进行了可靠性评估及重要度影... 详细信息

针对列控中心系统中因设备故障信息不完善、失效机理不明确等因素产生的认知不确定性,以及动态失效、共因失效、恢复机制问题,提出了将证据理论和动态贝叶斯网络相结合的动态证据网络方法,并对列控中心系统进行了可靠性评估及重要度影响分析。在分析系统各单元功能逻辑关系的基础上建立故障树,并将故障树转化为动态贝叶斯网络。通过动态贝叶斯网络正向推理,并结合信任测度和似然测度得到了列控中心系统的可靠度区间以及讨论共因失效对系统可靠性的影响。此外,通过动态贝叶斯网络反向推理得到了列控中心系统薄弱环节。最后,通过求解重要度的大小,探究底事件可靠度变化和认知不确定性对系统可靠度的影响程度。结果表明:动态证据网络能够较好地处理系统可靠性评估中的不确定信息。相比于在完全信息条件下,运用动态证据网络方法得到的可靠性评估结果较为合理,也更加符合实际。

关键词：安全工程列控中心认知不确定性证据理论重要度可靠性评估

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新型列控系统列车追踪间隔的优化及效能评估

重庆大学学报 2023年第7期46卷 86-96页

作者：朱爱红何明明袁小梅舒豪兰州交通大学自动化与电气工程学院兰州730070 西安铁路集团西安高铁基础设施段西安710018 兰州铁路集团银川电务段银川750021

为了解决地铁列车运力不足,缩短列车追踪间隔,提出了新型列控系统、相对移动闭塞和协同运行三者相结合的方法,构建了列车通信协同运行模型。在该模型下,精细化前后列车冲突区域,对正线和站后折返最小追踪间隔分别优化建模,提出缩短追踪... 详细信息

为了解决地铁列车运力不足,缩短列车追踪间隔,提出了新型列控系统、相对移动闭塞和协同运行三者相结合的方法,构建了列车通信协同运行模型。在该模型下,精细化前后列车冲突区域,对正线和站后折返最小追踪间隔分别优化建模,提出缩短追踪间隔的行车策略。经实际线路仿真计算,相比基于通信的列车运行控制系统(communication based train control,CBTC)列车通过能力提升了32.3%,且4A编组可以满足79.9 s的行车间隔。考虑缩短行车间隔对运营效能的影响,将运营效能量化为运输率、满载率、单位能耗、等车时间,对不同行车方案进行评估。结果表明,对于单向小时断面客流量小于6.4万的线路,通过调节行车间隔,4A编组在满足满载率下,比6A、8A编组能耗更小,等车时间更短。

关键词：新型列控系统城市轨道交通优化模型追踪间隔效能评估

Stress-strain relationship for reactive powder concrete with recycled powder under uniaxial compression

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1015-1027页

作者： Peng zhu Yunming zhu Wenjun QU Liyu XIE College of Civil Engineering Tongji UniversityShanghai 200092China Key Laboratory of Performance Evolution and Control for Engineering Structures of Ministry of Education Tongji UniversityShanghai 200092China

The recycled powder(RP)from construction wastes can be used to partially replace cement in the preparation of reactive powder *** this paper,reactive powder concrete mixtures with RP partially replacing cement,and natural sand instead of quartz,are *** curing is used,instead of steam curing that is normally requested by standard for reactive powder *** influences of RP replacement ratio(0%,10%,20%,30%),silica fume proportion(10%,15%,20%),and steel fiber proportion(0%,1%,2%)are *** effects of RP,silica fume,and steel fiber proportion on compressive strength,elastic modulus,and relative absorption energy are analyzed,and theoretical models for compressive strength,elastic modulus,and relative absorption energy are established.A constitutive model for the uniaxial compressive stress-strain relationship of reactive powder concrete with RP is *** the increase of RP replacement ratio from 0% to 30%,the compressive strength decreases by 42% and elastic modulus decreases by 24%.

关键词： recycled powder reactive powder concrete elastic modulus relative absorbed energy stress-strain relationship

Carbon Emission Effects Driven by Evolution of Chinese Dietary Structure from 1987 to 2020

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Chinese Geographical Science 2024年第1期34卷 181-194页

作者： zhu Yuanyuan ZHANG Yan zhu Xiaohua Key Laboratory of Geographic Process Analysis&Simulation Hubei Province Central China Normal UniversityWuhan430079China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing100101China

Exploring carbon emission effects based on the evolution of residents’ dietary structure to achieve the carbon neutrality goal and mitigate climate change is an important *** study took China as the research object(data excluding Hong Kong,Macao and Taiwan) and used the carbon emission coefficient method to quantitatively measure the food carbon emissions from 1987–2020,then analyzed the carbon emission effects under the evolution of dietary *** results showed that during the study period,the Chinese dietary structure gradually changed to a high-carbon consumption *** dietary structure of urban residents developed to a balanced one,while that of rural residents developed to a high-quality *** the study period,the per capita food carbon emissions and total food consumption of Chinese showed an increasing *** per capita food carbon emissions of residents in urban and rural showed an overall upward *** total food carbon emissions in urban increased significantly,while that in rural increased first and then *** influence of beef and mutton on carbon emissions is the highest in dietary *** with the balanced dietary pattern,the food carbon emissions of Chinese residents had not yet reached the peak,but were evolving to a high-carbon consumption pattern.

关键词： dietary structure structural evolution carbon emission effects carbon neutrality China