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Inhibition of SLC26A4 regulated by electroacupuncture suppresses the progression of myocardial ischemia-reperfusion injury

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BIOCELL 2024年第4期48卷 665-675页

作者： FEI KONG QIYUAN TIAN BINGLIN kuang LILI SHANG XIAOXIAO ZHANG DONGYANG LI YING KONG Department of Endocrinology Heilongjiang University of Chinese MedicineHarbin150040China Department of Cardiology Heilongjiang University of Chinese MedicineHarbin150040China College of Clinical Medicine Heilongjiang University of Chinese MedicineHarbin150040China Department of Nephrology Beijing Hospital of Integrated Traditional Chinese and Western MedicineBeijing100039China College of Acupuncture and Massage Heilongjiang University of Chinese MedicineHarbin150040China Department of Acupuncture Heilongjiang University of Chinese MedicineHarbin150040China

Introduction:Myocardial ischemia-reperfusion(IR)injury has received widespread attention due to its damaging ***(EA)pretreatment has preventive effects on myocardial IR ***26A4 is a Na+independent anion reverse transporter and has not been reported in myocardial IR ***:Toﬁnd potential genes that may be regulated by EA and explore the role of this gene in myocardial IR ***:RNA sequencing and bioinformatics analysis were performed to obtain the differentially expressed genes in the myocardial tissue of IR rats with EA *** infarction size was detected by TTC *** CK,creatinine kinase-myocardial band,Cardiac troponin I,and lactate dehydrogenase levels were determined by *** effect of SLC26A4 on cardiomyocyte apoptosis was explored by TUNEL staining and western *** effects of SLC26A4 on inﬂammation were determined by HE staining,ELISA,and real-time *** effect of SLC26A4 on the NF-κB pathway was determined by western ***:SLC26A4 was up-regulated in IR rats but downregulated in IR rats with EA *** with IR rats,those with SLC26A4 knockdown exhibited improved cardiac function according to decreased myocardial infarction size,reduced serum LDH/CK/CK-MB/cTnI levels,and elevated left ventricular ejection fraction and fractional ***26A4 silencing inhibited myocardial inﬂammation,cell apoptosis,phosphorylation,and nuclear translocation of NF-κB ***:SLC26A4 exhibited promoting effects on myocardial IR injury,while the SLC26A4 knockdown had an inhibitory effect on the NF-κB *** results further unveil the role of SLC26A4 in IR injury.

关键词： Myocardial ischemia Reperfusion SLC26A4 NF-κB pathway

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A Compact UHF Antenna Based on Hilbert Fractal Elements and a Serpentine Arrangement for Detecting Partial Discharg

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Energy Engineering 2024年第5期121卷 1127-1141页

作者： Xiang Lin Jian Fang Ming Zhang kuang Yin Yan Tian Yingfei Guo Qianggang Wang Guangzhou Power Supply Bureau of Guangdong Power Grid Co. Ltd.China Southern Power GridGuangzhou510620China State Key Laboratory of Power Transmission Equipment Technology School of Electrical EngineeringChongqing UniversityChongqing400044China

Efforts to protect electric power systems from faults have commonly relied on the use of ultra-high frequency(UHF)antennas for detecting partial discharge(PD)as a common precursor to ***,the effectiveness of existing UHF antennas suffers from a number of challenges such as limited bandwidth,relatively large physical size,and low detection *** present study addresses these issues by proposing a compact microstrip patch antenna with fixed dimensions of 100 mm×100 mm×1.6 *** results of computations yield an optimized antenna design consisting of 2nd-order Hilbert fractal units positioned within a four-layer serpentine arrangement with a fractal unit connection distance of 3.0 ***,the optimized antenna design achieves a detection bandwidth for which the voltage standing wave ratio is less than 2 that is approximately 97.3%of the UHF frequency range(0.3–3 GHz).Finally,a prototype antenna is fabricated using standard printed circuit board technology,and the results of experiments demonstrate that the proposed antenna is capable of detecting PD signals at a distance of 8 m from the discharge source.

关键词： Power system fault partial discharge UHF antenna fractal antenna micro-strip antenna

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Surface Topological Glycosylation-Mediated Mucoadhesion of Bacteria

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Chinese Journal of Chemistry 2024年第13期42卷 1447-1455页

作者： Xiao kuang Xiaobing Liu Ju Chen Wenyan Lv Mengmeng Zhang Huan Chen Feng Wu Jinyao Liu School of Life Sciences Shanghai UniversityShanghai 200444China Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine Institute of Molecular MedicineState Key Laboratory of Systems Medicine for CancerRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Materials Science Shanghai Normal UniversityShanghai 200234China

Sugar moieties present on bacterial surface serve as pivotal regulators of bacterial *** adjusting the abundance and distribution of surface sugar moieties can offer an important approach to manipulating bacterial behavior,but has been proven to be ***,surface topological glycosylation is reported to mediate the interaction of bacteria with mucous *** functionalized by sugar moieties with different branching are synthesized through iterative Michael addition and amide condensation *** a copper-catalyzed azide-alkyne cycloaddition,the resulting compounds with different branching structures can be attached onto bacterial surface that is modified with azido *** a proof-of-concept study,a set of topologically glycosylated probiotics(TGPs)is prepared using linear,two-branched,and tetra-branched compounds,*** interaction between mucin and TGPs was studied and the results demonstrate that,compared to unmodified bacteria,TGPs exhibit an enhanced adhesive capacity to mucin,which increases with the branching *** binding trend is observed in ex vivo colonic mucus adhesion experiments and bacteria glycosylated with tetra-branched compounds display the highest binding *** work proposes a chemical method to tune the abundance and distribution of sugar moieties on bacteria,providing unique significant insights into the manipulation of bacterial behavior through surface modification.

关键词： Topochemistry Bacteria Glycosylation Surface modification Mucoadhesion Click chemistry

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Multifaceted role of microRNAs in gastric cancer stem cells: Mechanisms and potential biomarkers

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 300-313页

作者： Qian-Hui Sun Zi-Yu kuang Guang-Hui Zhu Bao-Yi Ni Jie Li Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Department of Oncology Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina

MicroRNAs(miRNAs)have received much attention in the past decade as potential key epigenomic regulators of tumors and cancer stem cells(CSCs).The abnormal expression of miRNAs is responsible for different phenotypes of gastric cancer stem cells(GCSCs).Some specific miRNAs could be used as promising biomarkers and therapeutic targets for the identification of *** review summarizes the coding process and biological functions of miRNAs and demon-strates their role and efficacy in gastric cancer(GC)metastasis,drug resistance,and apoptosis,especially in the regulatory mechanism of *** shows that the overexpression of onco-miRNAs and silencing of tumor-suppressor miRNAs can play a role in promoting or inhibiting tumor metastasis,apart from the initial formation of *** also discusses the epigenetic regulation and potential clinical applications of miRNAs as well as the role of CSCs in the pathogenesis of *** believe that this review may help in designing novel therapeutic approaches for GC.

关键词： Gastric cancer,Cancer stem cells MicroRNAs Epigenetics Therapeutic target

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Association between Meeting 24-Hour Movement Guidelines and Psychological Features of Chinese Emerging Adults

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International Journal of Mental Health Promotion 2024年第5期26卷 399-406页

作者： Yanjie Zhang Jin kuang Xun Luo Mengxian Zhao Xiaolei Liu Physical Education Unit School of Humanities and Social ScienceChinese University of Hong Kong–ShenzhenShenzhen518172China Physical Activity and Health Promotion Laboratory Chinese University of Hong Kong–ShenzhenShenzhen518172China Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen518060China School of Physical Education Shenzhen UniversityShenzhen518060China Chinese Traditional Regimen Exercise Intervention Research Center Beijing Sport UniversityBeijing100084China

Background:Emerging adulthood is a pivotal life stage,presenting significant psychological and social changes,such as decreased sociability,depression,and other mental health *** studies have associated these changes with an unhealthy *** 24-h movement guidelines for healthy lifestyles have been developed to promote appropriate health behaviors and improve individual ***,the relationship between adherence to the 24-h movement guidelines and different characteristics of Chinese emerging adults is yet to be *** cross-sectional study aimed to investigate the association between adherence to the 24-h movement guidelines and four characteristics(self-exploration,instability,possibilities,and responsibility)of Chinese emerging ***:Overall,1,510 Chinese emerging adults aged 18–29 years were included in this *** participant completed a self-administered questionnaire that included questions on adherence to the 24-h movement guidelines(physical activity,sedentary behavior,and sleep)and the inventory of dimensions of emerging *** logistic regression analysis was employed to investigate the associations between adherence to the 24-h movement guidelines and each of the four ***:The proportion of participants who adhered to the 24-h movement guidelines was 31.72%.Multiple regression analysis revealed a significantly negative relationship between adhering to more guidelines and instability(β=−0.51,p<0.001).A statistically significant association was observed between instability and meeting only sedentary behavior(β=−1.27,95%confidence interval[CI]:[−2.32,−0.24],p=0.02),sedentary behavior+sleep(β=−1.30,95%CI:[−2.24,−0.35],p<0.01),and physical activity+sedentary behavior(β=−1.08,95%CI:[1.94,−0.21],p=0.02)***,positive and significant associations were observed between possibilities and meeting the guidelines for only physical activity(β=0.70,95%CI:[0.14,1.27),p=0.0

关键词： 24-h movement behavior physical activity sedentary behavior sleep psychological health emerging adults

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Intelligent Shipbuilding: Into the Main Battefield of Digital Transformation

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船舶经济贸易 2024年第1期 71-76页

作者： kuang Zhanting 不详

Whattechnical routeto be taken to promote the new type of industrialization and accelerate the building of a manufacturing and shipbuilding power?The consensus of industry experts is:taking intelligent manufacturing(IM)as the main *** present,accelerating the intelligent transformation has becomean inevitable choice for China's shipbuilding industry to promote the transformation and upgrading,and realize high-quality *** theinitiatory automation equipment application and information technology(IT)promotion,to today,the intelligent transformation of China's shipbuilding industry has entered a new stage of development.

关键词： Transformation promotion industry

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Cruise Economy Speeds up,Local Industry to Rise up

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船舶经济贸易 2024年第8期 68-74页

作者： kuang Zhanting 不详

On July 23,Carnival Cruises announced that it has ordered three 230,000 GT LNG carriers from Italian cruise giant Fincantieri,adding another fire to the sudden heating-up newbuilding market this year.

关键词： Italian adding Economy

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Giant reversible barocaloric effects with high thermal cycle stability in epoxybonded(MnCoGe)_(0.96)(CuCoSn)_(0.04) composite

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International Journal of Minerals,Metallurgy and Materials 2024年第11期31卷 2528-2534页

作者： Yafei kuang Kun Tao Bo Yang Peng Tong Yan Zhang Zhigang Sun Kewei Zhang Dunhui Wang Jifan Hu Liang Zuo College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Shanxi Key Laboratory of Magnetic and Electric Functional Materials and Applications Taiyuan University of Science and TechnologyTaiyuan 030024China Key Laboratory of Materials Physics Institute of Solid State PhysicsChinese Academy of SciencesHefei 230031China Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China

Hexagonal MnMX-based(M=Co or Ni,X=Si or Ge)alloys exhibit giant reversible barocaloric ***,giant volume expansion would result in the as-cast MnMX ingots fragmenting into powders,and inevitably bring the deterioration of mechanical properties and *** fragmentation can bring degradation of structural transformation entropy change during cyclic application and removal of *** this paper,giant reversible barocaloric effects with high thermal cycle stability can be achieved in the epoxy bonded(MnCoGe)0.96(CuCoSn)0.04 *** reversible isothermal entropy change of 43.0 J·kg^(−1)·K^(−1) and adiabatic temperature change from barocaloric effects(ΔT_(BCE))of 15.6 K can be obtained within a wide temperature span of 30 K at 360 MPa,which is mainly attributed to the integration of the change in the transition temperature driven by pressure of−101 K·GPa^(−1) and suitable thermal hysteresis of 11.1 ***,the variation of reversibleΔ_(TBCE) against the applied hydrostatic pressure reaches up to 43 K·GPa^(−1),which is at the highest level among the other reported giant barocaloric *** importantly,after 60 thermal cycles,the composite does not break and the calorimetric curves coincide well,demonstrating good thermal cycle stability.

关键词： barocaloric effects cycle stability reversible isothermal entropy change reversible adiabatic temperature change MnCoGe alloys

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Impacts of thermal and electric contact resistance on the material design in segmented thermoelectric generators

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Energy Storage and Saving 2024年第1期3卷 5-15页

作者： Junwei Zhao Zhengfei kuang Rui Long Zhichun Liu Wei Liu School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China Wuhan Second Ship Design and Research Institute Wuhan430074China

Segmented thermoelectric generators(STEGs)can exhibit present superior performance than those of the conventional thermoelectric *** and electrical contact resistances exist between the thermoelectric material interfaces in each thermoelectric *** may significantly hinder performance *** this study,a five-layer STEG with three pairs of thermoelectric(TE)materials was investigated considering the thermal and electrical contact resistances on the material contact *** STEG performance under different contact resistances with various combinations of TE materials were *** relationship between the material sequence and performance indicators under different contact resistances is established by machine *** on the genetic algorithm,for each contact resistance combination,the optimal material sequences were identified by maximizing the electric power and energy conversion *** reveal the underlying mechanism that determines the heat-to-electrical performance,the total electrical resistance,output voltage,ZT value,and temperature distribution under each optimized scenario were *** STEG can augment the heat-to-electricity performance only at small contact resistances.A large contact resistance significantly reduces the *** an electrical contact resistance of RE=10^(-3) K⋅m^(2)⋅W^(-1) and thermal contact resistance of RT=10-8Ω⋅m^(2),the maximum electric power was reduced to 5.71 mW(90.86 mW without considering the contact resistance).And the maximum energy conversion efficiency is lowered to 2.54%(12.59%without considering the contact resistance).

关键词： Segmented thermoelectric generator Contact resistance Material design Machine learning

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TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer's disease

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Science China Chemistry 2024年第4期67卷 1360-1372页

作者： Meiru Lu Changlong Hao Liguang Xu Feng Yu Jiwei Jiang Yanli Wang Jun Xu Hua kuang Chuanlai Xu Maozhong Sun International Joint Research Laboratory for Biointerface and Biodetection State Key Laboratory of Food Science and ResourcesSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Institute of Life Sciences Jiangsu UniversityZhenjiang 212013China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China National Clinical Research Center for Neurological Diseases Beijing 100070China

Tripartite motif 21(TRIM21)is an E3 ubiquitin ligase that shows great promise for protein degradation through ***,ultrasmall chiral gold nanoparticles(D-or L-NPs)modified by D-or L-glutathione ligands were *** conjugated with an NLR family pyrin domain-containing protein 3(NLRP3)antibody(D-NP-a NLRP3 or L-NP-a NLRP3),DNP-a NLRP3 showed effective delivery efficiency of the antibody into microglia and prevented Aβ-mediated microglia senescence,and p16^(ink4a),a marker of senescence,in the microglia was reduced by 90.3%±7.8% while L-NP-a NLRP3 decreased by 48.01%±3.1%.Mechanistic investigations revealed that the D-NP-a NLRP3((1.5±0.3)×10^(7)M^(-1))exhibited sixteen-fold larger binding affinity to transmembrane glycoprotein SLC3A2 than L-type((9.5±2.7)×10^(5)M^(-1)),which led to a high efficiency of antibody delivery and TRIM21-dependent NLRP3 ***,the blood-brain barrier(BBB)-crossing ability of chiral NP-a NLRP3 as well as NLRP3 degradation was demonstrated in *** APP/PS1 Alzheimer's disease(AD)model mice experiments exhibited a reduction of 89.7%±6.8% for the NLRP3 protein and 84.2±7.5% for p16^(ink4a)following the intravenous administration of D-NP-a NLRP3 once a week for 60 ***,the levels of the AD markers Aβ and phosphorylatedTau in the brains were reduced by 86.2%±8.2% and 81.6%±9.1%;these were 2.1-fold and 1.9-fold higher than those treated with L-NP-a NLRP3,*** studies provide a method to rescue AD-like pathologies and prevent senescence.

关键词： chiral gold nanoparticles amyloid-β NLRP3 TRIM21 senescence Alzheimer's disease

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