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Jinbei Oral Liquid ameliorates bleomycin-induced idiopathic pulmonary fibrosis in rats via reversion of Th1/Th2 shift

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Chinese Herbal Medicines 2020年第3期12卷 273-280页

作者： Xiao-yan Xing Wei-jie Qiang Jia-le Bao Rui-chuang Yang jun Hou Kai Tao Zhao-qing Meng Jing-hua zhang ai-jun zhang Xiao-bo Sun Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Shandong Hongjitang Pharmaceutical Group Co. Ltd.Jinan 250000China Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription Chinese Academy of Medical SciencesBeijing 100193China Research Center for Clinical and Translational Medicine Fifth Medical CenterGeneral Hospital of Chinese PLABeijing 100039China The Affiliated Hospital of Shandong University of TCM Jinan 250011China

Objective:Idiopathic pulmonary fibrosis(IPF)is a progressive and lethal interstitial lung disease with high *** pivotal role of Th1/Th2 immunological balance in the development and progression of IPF has been demonstrated *** study aimed to evaluate the effect of Jinbei Oral Liquid(JBOL)on IPF and its relationship with Th1/Th2 ***:Rats were divided into six groups:control group,model group(bleomycin),pirfenidone group(positive group,54 mg/kg,i.g.)and JBOL(5.4,10.8 and 21.6 mL/kg,i.g.)*** rat model was established by an intratracheal instillation of bleomycin(BLM,5 mg/kg).One day after injection of BLM,pirfenidone or JBOL was given to rats once daily within 28 consecutive days,*** emission tomography/computed tomography(PET/CT)was performed on the treated *** extent of alveolitis and fibrosis was observed by H&E and Masson trichrome *** contents of TGF-β1,TNF-α,IL-4 and IFN-γwere further quantified by ELISA ***:PET/CT and histopathological evidence showed the ability of JBOL to attenuate bleomycininduced alveolitis and fibrosis extent,and the alveolitis lesion score was markedly decreased compared with the model *** increased expression of inflammatory cytokines TGF-β1 and TNF-αinduced by bleomycin was also suppressed by *** Th1 response was limited by the reduced IFN-γafter BLM administration,and the Th2 response predominated significantly marked by the increased *** could increase the level of IFN-γand markedly increased the ratio of IFN-γ/***:These findings suggested that JBOL may attenuate BLM-induced idiopathic pulmonary fibrosis via reducing inflammatory cell infiltration,pro-inflammatory cytokine release and excessive collagen deposition in *** of the mechanisms is the reversion of Th1/Th2 shift caused by BLM.

关键词： bleomycin cytokines idiopathic pulmonary fibrosis Jinbei Oral Liquid Th1/Th2 shift

Which is the Best Protocol of Ovarian Stimulation Prior to Artificial Insemination by Donor

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Journal of Reproduction and Contraception 2014年第1期25卷 41-48页

作者： Bu-fang XU Guang-yan WANG Wei-min FAN Qian CHEN ai-jun zhang Reproductive Medical Center of Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Objective To compare the different ovarian stimulation protocols, clomiphene citrate （CC）, letrozole, human menopausal gonadotropin （hMG） only or combined with CC or letrozole in women undergoing artificial insemination by donor （aiD）. Methods In this prospective clinical trial, 671 couples prepared for aiD cycles were randomly allocated to 6 groups according to receive different protocols for the first time, natural cycle （group A, n=l14）, CC （group B, n=lOl）, CC and hMG （group C, n=124）, letrozole （group D, n=97）, letrozole and hMG （group E, n=123） and hMG only （group F, n=l12）. Outcomes including total dose of hMG, duration of hMG therapy, dominant follicles number, endometrial thickness, rates of clinical pregnancy, miscarriage, ovarian hyperstimulation syndrome （OHSS）, multiple pregnancy and can- celation were compared among the 6 groups. Results The total doses and duration of administered hMG were significantly lower in group C and group E than in group F. Dominant follicle number was significantly less in group A and more in group C than in other groups. Endometrial thickness of group B was significantly lower than that of other groups. Clinical pregnancy rate, multiple pregnancy rate, miscarriage rate, OHSS rate and cancelation rate were not statistically different among the stimulation groups. Conclusion aiD cycles in which both CC and letrozole had been administered may require shorter duration and a lower total gonadotropin dose, while the clinical out-comes were similar.

关键词： intrauterine insemination clomiphene citrate (CC) letrozole human menopausalgonadotropin (hMG)

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可见光-近红外通道数据大气校正方法研究

计算机仿真 2017年第4期34卷 220-226,452页

作者：陈爱军张鑫南京信息工程大学大气物理学院江苏南京210044

针可见光-近红外通道数据进行大气校正,提升可见光-近红外通道数据的可靠性。进行大气校正时,应获取可见光-近红外光谱响应函数,建立可见光-近红外通道数据校正所需的查找表,但传统方法不能获取精确的对可见光-近红外光谱响应函数,进行... 详细信息

针可见光-近红外通道数据进行大气校正,提升可见光-近红外通道数据的可靠性。进行大气校正时,应获取可见光-近红外光谱响应函数,建立可见光-近红外通道数据校正所需的查找表,但传统方法不能获取精确的对可见光-近红外光谱响应函数,进行大气校正时出现较大偏差。提出一种基于6S模型的Himawari-8可见光-近红外通道数据的大气校正方法。在6S大气辐射传输模型中加入可见光与近红外光谱响应函数,进行辐射传输模拟并对所需输入的参数做敏感性分析后,建立包含太阳天顶角、卫星天顶角、相对方位角、气溶胶光学厚度、臭氧含量、水汽含量、表观反射率等参数的查找表。利用查找表对Himawari-8可见光与近红外波段数据进行逐像元大气校正。从反射率值、归一化植被指数(NDVI)、MODIS地表反射率三个方面,分析6S模型查找表法大气校正的效果。仿真结果表明:选用的校正方法有效,校正后Himawari-8可见光与近红外波段数据范围加宽,各波段反射率更平滑,能区分的地物信息更多;校正后各波段NDVI和MODIS值更接近实际情况,说明选用方法具有较高的校正精度。

关键词：大气校正大气辐射传输模型地表反射率

An Impact of Suspected Peritubal Adhesions by Hysterosalpingography on Outcomes of Intrauterine Insemination

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Journal of Reproduction and Contraception 2013年第3期24卷 173-180页

作者： Dan-dan WU Zhi-hong NIU ai-jun zhang Rui-huan GU Yun FENG Center of Reproductive Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Objective To assess the fertility prospect of women with suspected peritubal adhesions diagnosed by hysterosalpingography （HSG） treated with intrauterine insemination （IUI）. Methods The study group consisted of 93 patients diagnosed as bilateral suspected peritubal adhesions by HSG, and 175 patients with no tubal pathology were classified as control group. A total of 496 cycles of lUI were finished in 268 infertile women. Results There were no differences in basic clinical parameters between the two groups. Cumulative pregnancy rates after two cycles of lUI were 19.4%for the study group, and 34.3%for the control. Cumulative pregnancy rate in the women with abnormal contrast media loculation was significantly lower than that in women of the control （7.4% vs 34.3%, P=0.037）. The cumulative pregnancy rates were similar between the women with abnormal tubal contour and the normal ones （36. 7% vs 34.3%, P=0.800）. Conclusion Suspected peritubal adhesions in HSG were worthy more attention, since the outcome of lUI in women with loculation of contrast material, combined with or without abnormal tubal contour resulted in a significantly lower pregnancy rate than the normal ones. IUI should be delayed before tubal patency was confirmed during these patients.

关键词： hysterosalpingography peritubal adhesion ovulation induction intrauterine insemination

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min zhang ai-jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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大功率振动压路机对涵洞振动影响的试验研究

安全与环境学报 2016年第6期16卷 116-120页

作者：陈爱军张家生中南大学土木工程学院长沙410075 湖南工程学院建筑工程学院湖南湘潭411108

鉴于大功率振动压路机在路基填筑施工时对地下涵洞等结构物的振动影响较大,测试不同碾压工况时涵洞各测点的振动加速度,来分析涵洞各部位的振动变化特性,以便提出适合于大功率振动压路机碾压涵洞上部填土的施工方案。结果表明:压路机垂... 详细信息

鉴于大功率振动压路机在路基填筑施工时对地下涵洞等结构物的振动影响较大,测试不同碾压工况时涵洞各测点的振动加速度,来分析涵洞各部位的振动变化特性,以便提出适合于大功率振动压路机碾压涵洞上部填土的施工方案。结果表明:压路机垂直涵洞轴线行驶时,涵洞侧壁的振动从上至下依次减小,近距离时顶板侧边的振动大于顶板中部,强振碾压的安全距离为2 m;压路机在涵洞3 m之外平行涵洞轴线方向行驶时,涵洞侧壁和顶板的振动加速度均小于安全阈值;压路机的振动传播具有方向差异性,沿行驶方向的纵向振动大于垂直行驶方向的横向振动。提出盖板涵顶部回填1 m后的碾压方案为:涵洞2 m以外,可采用大功率振动压路机强振碾压;涵洞2 m以内,可采用大功率振动压路机弱振或其他小型压实机械碾压。

关键词：安全工程振动压路机涵洞加速度安全距离

抗苗勒管激素在预测卵泡发育与卵母细胞质量的研究进展

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生殖与避孕 2016年第6期36卷 495-499页

作者：王静文张爱军上海交通大学医学院附属瑞金医院生殖医学中心上海200025

抗苗勒管激素(anti-Müllerian hormone,AMH)由自分泌、旁分泌产生,主要通过II型跨膜丝氨酸/苏氨酸激酶受体发挥作用,可以抑制原始卵泡募集,阻碍卵泡生长发育,并参与调节颗粒细胞类固醇生成。卵泡液AMH不仅在小窦卵泡中表达,在排卵前大... 详细信息

抗苗勒管激素(anti-Müllerian hormone,AMH)由自分泌、旁分泌产生,主要通过II型跨膜丝氨酸/苏氨酸激酶受体发挥作用,可以抑制原始卵泡募集,阻碍卵泡生长发育,并参与调节颗粒细胞类固醇生成。卵泡液AMH不仅在小窦卵泡中表达,在排卵前大窦卵泡中仍持续表达,通过直接调节各种细胞因子的表达,参与调控卵母细胞成熟的最后阶段,即AMH表达量逐渐减少是卵泡优势化的必备条件,从而影响卵母细胞的质量,在预测卵巢储备方面发挥重要作用,也是预测卵泡发育和卵母细胞质量的重要指标。而血清AMH与卵母细胞质量之间的关系仍存在争议。

关键词：抗苗勒管激素(AMH) 卵母细胞质量妊娠率胚胎质量辅助生殖

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渣油中沥青质分子颗粒尺寸及其胶粒模型研究

燃料化学学报 2004年第4期32卷 429-434页

作者：王治卿王宗贤郭爱军姜阿娜张会军石油大学重质油国家重点实验室山东东营257061

分别以苯和硝基苯为溶剂测定了大庆、胜利、孤岛和辽河减压渣油沥青质、胶质和芳香分的分子量;依据球形分子模型计算了这些物质的分子尺寸;构筑了渣油中沥青质胶粒(胶团)模型,并依此计算了渣油中沥青质胶粒尺寸。结果表明,以硝基苯为溶... 详细信息

分别以苯和硝基苯为溶剂测定了大庆、胜利、孤岛和辽河减压渣油沥青质、胶质和芳香分的分子量;依据球形分子模型计算了这些物质的分子尺寸;构筑了渣油中沥青质胶粒(胶团)模型,并依此计算了渣油中沥青质胶粒尺寸。结果表明,以硝基苯为溶剂所测沥青质分子量更能反应沥青质化学结构的实质;就原始沥青质来说,以苯为溶剂测得的沥青质分子直径为3.8nm～5.0nm,以氯代苯为溶剂测得的分子直径为3.2nm～3.7nm,以硝基苯为溶剂测得的分子直径为2.8nm～3.2nm;辽河、胜利与大庆减压渣油中沥青质的胶粒直径为10.0nm～11.0nm,孤岛减压渣油中沥青质的胶粒直径为9.0nm～10.0nm。

关键词：沥青质分子量胶粒尺寸渣油

An Optimizing Method based on Water-Filling for Case Attribute Weight

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An Optimizing Method based on Water-Filling for Case Attribu...