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Asian Journal of Andrology 2011年第6期13卷 862-866页

作者： Zhi-Hong Niu Hui-Juan Shi Hui-Qin zhang ai-jun zhang Yi-Juan Sun Yun Feng IVF Unit Department of Obstetrics and Gynecology Ruijin Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200025 China Shanghai Institute of Planned Parenthood Research Shanghai 200032 China

The aim of this study was to investigate whether the sperm chromatin structure assay （SCSA） results after swim-up are related to fertilization rates, embryo quality and pregnancy rates following in vitrofertilization （IVF）. A total of 223 couples undergoing IVF in our hospital from October 2008 to September 2009 were included in this study. Data on the IVF process and sperm chromatin structure assay results were collected. Fertilization rate, embryo quality and IVF success rates of different DNA fragmentation index （DFI） subgroups and high DNA stainability （HDS） subgroups were compared. There were no significant differences in fertilization rate, clinical pregnancy or delivery rates between the DFI and HDS subgroups. However, the group with abnormal DFI had a lower good embryo rate. So, we concluded that the SCSA variables, either DFI or HDS after swim-up preparation, were not valuable in predicting fertilization failure or pregnancy rate, but an abnormal DFI meant a lower good embryo rate following IVF.

关键词： embryo fertilization in-vitro fertilization sperm chromatin structure assay

Effects of psychological intervention on negative emotions and psychological resilience in breast cancer patients after radical mastectomy

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World Journal of Psychiatry 2024年第1期14卷 8-14页

作者： Jing Wang Dong-Xue Kang ai-jun zhang Bing-Rui Li Department of Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyang 110033Liaoning ProvinceChina Operating Room The Fourth Affiliated Hospital of China Medical UniversityShenyang 110033Liaoning ProvinceChina Department of Central Sterile Supply The Fourth Affiliated Hospital of China Medical UniversityShenyang 110033Liaoning ProvinceChina

Breast cancer(BC)is the most common malignant tumor in women,and the treatment process not only results in physical pain but also significant psychological distress in *** intervention(PI)has been recognized as an important approach in treating postoperative psychological disorders in BC *** has been proven that PI has a significant therapeutic effect on postoperative psychological disorders,improving patients'negative emotions,enhancing their psychological resilience,and effectively enhancing their quality of life and treatment compliance.

关键词： Breast cancer Psychological intervention Negative emotions Psychological resilience Radical surgery

Sperm DNA fragmentation in Chinese couples with unexplained recurrent pregnancy loss

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Asian Journal of Andrology 2020年第3期22卷 296-301页

作者： Xiao-Bin Zhu Qian Chen Wei-Min Fan Zhi-Hong Niu Bu-Fang Xu ai-jun zhang Reproductive Medical Center of Ruijin Hospital Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China

We aimed to study the association between sperm DNA fragmentation and recurrent pregnancy loss(RPL)in the Chinese population via a retrospective observational study of Chinese couples who had experienced RPL between May 2013 and August *** study population included 461 men from couples with RPL and 411 men from a control group(couples with clinical pregnancy via in v/tro fertiIization owing to female causes).Routine semen analysis,sperm chromatin analysis,and microscopic(high-power)morphological analysis were performed using semen *** samples were assessed for volume,sperm count,and *** sperm DNA fragmentation index(DFI)was calculated,and the median DFI was *** were categorized as having normal(37.8%;DFI<15.0%),moderate(33.6%;15.0%

关键词： DNA fragmentation index recurrent pregnancy loss sperm chromatin structure assay

Gastric ulcer treated using an elastic traction ring combined with clip: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11574-11578页

作者： Fei Pang Yan-jun Song Yin-He Sikong ai-jun zhang Xiu-Li Zuo Ru-Yuan Li Department of Gastroenterology Qilu Hospital(Qingdao)Cheeloo College of MedicineShangdong UniversityQingdao 266035Shandong ProvinceChina Department of Hematology Qilu Hospital(Qingdao)Cheeloo College of MedicineShangdong UniversityQingdao 266035Shandong ProvinceChina Department of Gastroenterology Qilu HospitalCheeloo College of MedicineShangdong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND There is a high annual incidence of acute,nonvariceal upper gastrointestinal bleeding in Chinese *** endoscopic intervention can reduce rates of rebleeding,surgery,and *** metal clip is the most common method for establishing homeostasis;however,it possesses several *** patients with bleeding secondary to large gastric ulcers,the clip will often fail to stop the *** article highlights the use of an elastic traction ring as a novel hemostatic method for patients with upper gastrointestinal *** SUMMARY An elderly male presented to the emergency room with complaints of hematemesis and *** examination revealed an ulcer(Forrest IIa)in the lesser curvature of the gastric *** tissue clips and one elastic traction ring were inserted into the stomach cavity to suture the *** patient recovered quickly without postoperative gastrointestinal *** months later,the patient's ulcer was significantly *** To our best knowledge,this is the first report to demonstrate the safety and efficacy of elastic traction rings for upper gastrointestinal *** traction rings should be considered a routine therapeutic modality for patients with upper gastrointestinal bleeds.

关键词： Gastric ulcer Elastic traction ring Acute nonvariceal upper gastrointestinal bleeding Endoscopic hemostasia Tissue clips Case report

Intestinal tuberculosis with small bowel stricture and hemorrhage as the predominant manifestation: Three case reports

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 248-256页

作者： Gang Huang Kang-Kang Wu Xiao-Na Li Jing-Hua Kuai ai-jun zhang Department of Gastroenterology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Intestinal tuberculosis is a chronic disease caused by Mycobacterium tuberculosis that mainly affects the ileum and *** bowel tuberculosis,characterized by predominant involvement of the small intestine,is an extremely rare condition with highly atypical clinical presentations,making diagnosis even more *** SUMMARY We report three cases of small intestinal tuberculosis,two of the patients pre-sented primarily with abdominal pain,and one presented with gastrointestinal *** patients underwent blood tests and imaging *** bowel endoscopy(SBE)revealed that the main lesions in these patients were in-testinal stenosis or gastrointestinal bleeding caused by small intestinal *** patient ultimately underwent surgical *** a complex diagnostic process and comprehensive analysis,all patients were confirmed to have small intestinal tuberculosis and received standard antituberculosis treatment,leading to an improvement in their *** Patients with SBTs present with nonspecific symptoms such as abdominal pain,weight loss,and occasional gastrointestinal *** diagnosis requires a thorough evaluation of clinical symptoms and various tests to avoid misdiagno-sis and complications.

关键词： Intestinal tuberculosis Gastrointestinal hemorrhage Small bowel endoscopy Case report

Epidermal growth factor receptor-targeted immune magnetic liposomes capture circulating colorectal tumor cells efficiently

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World Journal of Gastroenterology 2018年第3期24卷 351-359页

作者： Jing-Hua Kuai Qing Wang ai-jun zhang Jing-Yu zhang Zheng-Feng Chen Kang-Kang Wu Xiao-Zhen Hu Department of gastroen- terology Qilu Hospital of Shandong University Department of general Surgery Qilu Hospital of Shandong University

aiM To compare the capacity of newly developed epidermal growth factor receptor(EGFR)-targeted immune magnetic liposomes(EILs) vs epithelial cell adhesion molecule(Ep CAM) immunomagnetic beads to capture colorectal circulating tumor cells(CTCs).METHODS EILs were prepared using a two-step method, and the magnetic and surface characteristics were confirmed. The efficiency of capturing colorectal CTCs as well as the specificity were compared between EILs and Ep CAM magnetic beads. RESULTS The obtained EILs had a lipid nanoparticle structure similar to cell membrane. Improved binding with cancer cells was seen in EILs compared with the method of coupling nano/microspheres with antibody. The binding increased as the contact time extended. Compared with Ep CAM immunomagnetic beads, EILs captured more CTCs in peripheral blood from colorectal cancer patients. The captured cells showed consistency with clinical diagnosis and pathology. Mutation analysis showed same results between captured CTCs and cancer tissues. CONCLUSION EGFR antibody-coated magnetic liposomes show high efficiency and specificity in capturing colorectal CTCs.

关键词： Epidermal growth factor receptor Immune magnetic liposomes Epithelial cell adhesion molecule Circulating tumor cells Colorectal cancer

Submucosal esophageal abscess evolving into intramural submucosal dissection:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10695-10700页

作者： Yang Jiao Yin-He Sikong ai-jun zhang Xiu-Li Zuo Pu-Yue Gao Qing-Guo Ren Ru-Yuan Li Department of General Surgery Shandong University of Qilu Hospital(Qingdao)Qingdao 266000Shandong ProvinceChina Department of Gastroenterology Shandong University of Qilu Hospital(Qingdao)Qingdao 266000Shandong ProvinceChina Department of Gastroenterology Qilu Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Radiology Shandong University of Qilu HospitalShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Here we report a rare case of submucosal esophageal abscess evolving into intramural submucosal *** SUMMARY An 80-year-old woman was admitted to our emergency department with a chief complaint of dysphagia and *** tests showed mild leukocytosis and elevated C-reactive protein *** tomography showed thickening of the esophageal *** endoscopy showed a laceration of the esophageal mucosa and a submucosal *** drainage occurred,and we could see purulent exudate from the *** closed the laceration with endoscopic *** patient did not remember swallowing a foreign body;however,she ate crabs before the symptoms *** prescribed the patient with antibiotic,and the symptoms were gradually *** months later,upper endoscopy showed that the laceration was healed,and the submucosal abscess ***,intramural esophageal dissection was *** performed endoscopic incision of the septum using dual-knife *** In conclusion,we are the first to report the case of esophageal submucosal abscess evolving into intramural esophageal *** significance of this case lies in clear presentation of the evolution process between two *** addition,we recommend that endoscopic incision be considered as one of the routine therapeutic modalities of intramural esophageal dissection.

关键词： Submucosal esophageal abscess Intramural esophageal dissection Endoscopic incision Case report

Design,synthesis and biological evaluation of 1,4-dihydrothieno[3′,2′:5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists

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Chinese Chemical Letters 2011年第3期22卷 256-259页

作者： Rui Sun Jing Song Si Jie Liu Hui Zhao Chun Li Yan ai jun zhang Diwa Koirala Da Wei Li Chun Hu Key Laboratory of Structure-Based Drug Design & Discovery Ministry of Education China Department of Organic Chemistry School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China School of Pharmacy Shanghai Jiao Tong University Shanghai 300193 China

The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women,osteoporosis, reproductive cancers such as breast cancer,uterine cancer and prostate cancer.1,4-Dihydrothieno[3＇,2＇：5,6]thiopyrano[4,3- c]pyrazole-3-carboxylic amide derivatives were designed,synthesized and biological evaluated as potential estrogen receptor antagonists.

关键词： Estrogen receptor antagonists Synthesis Biological activity Thiophene Pyrazole Thiopyran Piperazine

Which is the Best Protocol of Ovarian Stimulation Prior to Artificial Insemination by Donor

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Journal of Reproduction and Contraception 2014年第1期25卷 41-48页

作者： Bu-fang XU Guang-yan WANG Wei-min FAN Qian CHEN ai-jun zhang Reproductive Medical Center of Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Objective To compare the different ovarian stimulation protocols, clomiphene citrate （CC）, letrozole, human menopausal gonadotropin （hMG） only or combined with CC or letrozole in women undergoing artificial insemination by donor （aiD）. Methods In this prospective clinical trial, 671 couples prepared for aiD cycles were randomly allocated to 6 groups according to receive different protocols for the first time, natural cycle （group A, n=l14）, CC （group B, n=lOl）, CC and hMG （group C, n=124）, letrozole （group D, n=97）, letrozole and hMG （group E, n=123） and hMG only （group F, n=l12）. Outcomes including total dose of hMG, duration of hMG therapy, dominant follicles number, endometrial thickness, rates of clinical pregnancy, miscarriage, ovarian hyperstimulation syndrome （OHSS）, multiple pregnancy and can- celation were compared among the 6 groups. Results The total doses and duration of administered hMG were significantly lower in group C and group E than in group F. Dominant follicle number was significantly less in group A and more in group C than in other groups. Endometrial thickness of group B was significantly lower than that of other groups. Clinical pregnancy rate, multiple pregnancy rate, miscarriage rate, OHSS rate and cancelation rate were not statistically different among the stimulation groups. Conclusion aiD cycles in which both CC and letrozole had been administered may require shorter duration and a lower total gonadotropin dose, while the clinical out-comes were similar.

关键词： intrauterine insemination clomiphene citrate (CC) letrozole human menopausalgonadotropin (hMG)

An Impact of Suspected Peritubal Adhesions by Hysterosalpingography on Outcomes of Intrauterine Insemination

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Journal of Reproduction and Contraception 2013年第3期24卷 173-180页

作者： Dan-dan WU Zhi-hong NIU ai-jun zhang Rui-huan GU Yun FENG Center of Reproductive Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Objective To assess the fertility prospect of women with suspected peritubal adhesions diagnosed by hysterosalpingography （HSG） treated with intrauterine insemination （IUI）. Methods The study group consisted of 93 patients diagnosed as bilateral suspected peritubal adhesions by HSG, and 175 patients with no tubal pathology were classified as control group. A total of 496 cycles of lUI were finished in 268 infertile women. Results There were no differences in basic clinical parameters between the two groups. Cumulative pregnancy rates after two cycles of lUI were 19.4%for the study group, and 34.3%for the control. Cumulative pregnancy rate in the women with abnormal contrast media loculation was significantly lower than that in women of the control （7.4% vs 34.3%, P=0.037）. The cumulative pregnancy rates were similar between the women with abnormal tubal contour and the normal ones （36. 7% vs 34.3%, P=0.800）. Conclusion Suspected peritubal adhesions in HSG were worthy more attention, since the outcome of lUI in women with loculation of contrast material, combined with or without abnormal tubal contour resulted in a significantly lower pregnancy rate than the normal ones. IUI should be delayed before tubal patency was confirmed during these patients.

关键词： hysterosalpingography peritubal adhesion ovulation induction intrauterine insemination