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Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation

Light(Science & Applications) 2020年第1期9卷 1418-1429页

作者： Yuzhi Shi Tongtong Zhu Tianhang Zhang Alfredo Mazzulla Din Ping Tsai Weiqiang Ding ai qun liu Gabriella Cipparrone Juan Jose Saenz Cheng-Wei Qiu School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalian 116024China School of Physics Harbin Institute of TechnologyHarbin 150001China CNR-NANOTEC LiCryL and Centre of Excellence CEMIF.CALPonte P.BucciCubo 33B87036 Rende(CS)Italy Department of Electronic and Information Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Physics University of CalabriaPonte P.BucciCubo 33B87036 Rende(CS)Italy Donostia International Physics Center 20018 Donostia-San SebastianSpain

Lateral optical forces induced by linearly polarized laser beams have been predicted to deflect dipolar particles with opposite chiralities toward opposite transversal ***“chirality-dependent”forces can offer new possibilities for passive all-optical enantioselective sorting of chiral particles,which is essential to the nanoscience and drug ***,previous chiral sorting experiments focused on large particles with diameters in the geometrical-optics ***,we demonstrate,for the first time,the robust sorting of Mie(size~wavelength)chiral particles with different handedness at an air–water interface using optical lateral forces induced by a single linearly polarized laser *** nontrivial physical interactions underlying these chirality-dependent forces distinctly differ from those predicted for dipolar or geometrical-optics *** lateral forces emerge from a complex interplay between the light polarization,lateral momentum enhancement,and out-of-plane light refraction at the particle-water *** sign of the lateral force could be reversed by changing the particle size,incident angle,and polarization of the obliquely incident light.

关键词： momentum chiral optics

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Combined analysis of imaging tumor capsule with imaging tumor size guides the width of resection margin for solitary hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 551-558页

作者： Jia-Shuo Chao Qi Zhu De-Sheng Chen Gui-Ming Chen Xue-Qian Xie ai-qun liu Sen-Lin Zhao Hong-Cheng Sun Department of General Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China

Background:The optimal width of resection margin(RM)for hepatocellular carcinoma(HCC)remains *** study aimed to investigate the value of imaging tumor capsule(ITC)and imaging tu-mor size(ITS)in guiding RM width for patients with ***:Patients who underwent hepatectomy for HCC in our center were retrospectively ***(complete/incomplete)and ITS(≤3 cm/>3 cm)were assessed by preoperative magnetic resonance imaging(MRI).Using subgroup analyses based on ITC and ITS,the impact of RM width[narrow RM(3 cm and complete ITC,the narrow RM group exhibited comparable RFS,OS,and incidence of RM recurrence with the wide RM group(P=0.606,0.916,and 0.649,respectively).However,in patients with ITS>3 cm and incomplete ITC,the wide RM group showed better RFS and OS and a lower incidence of RM recurrence compared with the narrow RM group(P=0.037,0.018,and 0.046,respectively).Conclusions:As MRI-based preoperative markers,conjoint analysis of ITC with ITS aids in determining RM width for solitary HCC *** RM is applicable in patients with ITS≤3 cm regardless of ITC status and in those with ITS>3 cm and complete *** RM is preferred in those with ITS>3 cm and incomplete ITC.

关键词： Hepatocellular carcinoma Resection Hepatectomy Magnetic resonance imaging Preoperative imaging

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Urinary Extracellular Vesicle： A Potential Source of Early Diagnostic and Therapeutic Biomarker in Diabetic Kidney Disease

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Chinese Medical Journal 2018年第11期131卷 1357-1364页

作者： Wei-Cheng Xu Ge Qian ai-qun liu Yong-Qiang Li He-qun Zou Department of Nephrology Institute of Nephrology and Urology The Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong 510630 China

Objective： Diabetic kidney disease （DKD） has become one of the major causes of end-stage renal disease. Urinary extracellular vesicles （uEVs） contain rich biological information which could be the ideal source for noninvasive biomarkers of DKD. This review discussed the potential early diagnostic and therapeutic values of proteins and microRNAs in uEVs in DKD. Data Sources： This review was based articles published in PubMed, Embase, Cochrane, and Google Scholar databases up to November 20, 2017, with the following keywords：＂Diabetic kidney disease＂, ＂Extracellular vesicle＂, and ＂Urine＂. Study Selection： Relevant articles were carefully reviewed, with no exclusions applied to tile study design and publication type. Results： There is no ＂gold standard＂ technology to separate and/or purify uEVs. The uEVs contain a variety of proteins and RNAs and participate in the physiological and pathological processes of the kidney. UEVs, especially urinary exosomes, may be useful biomarkers for early diagnosis and treatment to DKD. Furthermore, the uEVs has been used as a therapeutic target for DKD. Conclusion： Proteins and nucleic acids in uEVs represent promising biomarker for the diagnosis and treatment of DKD.

关键词： Biomarker Diabetic Kidney Disease Diagnosis Extracellular Vesicles Therapy

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Rapid tooth movement through distraction osteogenesis of the periodontal ligament in dogs

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Chinese Medical Journal 2008年第5期121卷 455-462页

作者： ai Hong XU Qing-feng LU Hong-fei Mai Zhi-hui AN ai-qun liu Guo-ping Department of Stomatology Affiliated Hospital Guangzhou Sun Yat-sen University Third Guangdong 510630 China

Background Animal models are needed for the study of rapid tooth movement into the extraction socket through distraction osteogenesis of the periodontal ligament. Methods Modified distraction devices were placed on eight dogs between the first and third mandibular premolars on the left sides; similar placement of traditional straight wise appliances on the right sides served as the control. The experimental distractors were activated （0.25 mm/d） twice a day and the control devices were activated （100 g） for two weeks with consolidation periods at weeks two, three, six, and ten. Two dogs were sacrificed at each consolidation time point; rates and patterns of tooth movement, loss of anchorage, and periapical films were evaluated, and the affected premolars and surrounding periodontal tissues were decalcified and examined histologically. General observations, X-ray periapical filming and histology examination were performed. Results Distal movement （（3.66±0.14） mm） measured two weeks after modified distraction exceeded that achieved using the traditional device （（1.15±0.21） mm; P 〈0.05）. Loss of anchorage was minimally averaged （0.34±0.06） mm and （0.32±0.07） mm in the experimental and control sides, respectively. By radiography, apical and lateral surface root resorptions on both sides were minimal. Alveolar bone lesions were never evident. Fibroblasts were enriched in periodontal ligaments and bone spicules formed actively along directions of distraction. Conclusions The canine model is suitable for the study of rapid tooth movement through distraction osteogenesis of the periodontal ligament. The technique accelerates tooth movement, periodontal remodeling, alveolar bone absorption, and may induce fibroblast formation, as compared to the traditional orthodontic method, without adversely affecting root absorption, bone loss, tooth mobility and anchorage loss.

关键词： animal model distraction osteogenesis periodontal ligament rapid tooth movement bone formation

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3D printed multicore fiber-tip discriminative sensor for magnetic field and temperature measurements

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Light(Advanced Manufacturing) 2024年第1期5卷 82-92页

作者： Cong Xiong Caoyuan Wang Ruowei Yu Wei Ji Yu Qin Yichun Shen Wei Chen ai-qun liu Limin Xiao Advanced Fiber Devices and Systems Group Key Laboratory of Micro and Nano Photonic Structures(MoE)Key Laboratory for Information Science of Electromagnetic Waves(MoE)Shanghai Engineering Research Center of Ultra-Precision Optical ManufacturingSchool of Information Science and TechnologyFudan UniversityShanghaiChina Zhongtian Technology Advanced Materials Co. Ltd.NantongJiangsuChina Key laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced CommunicationShanghai University.ShanghaiChina Department of Electrical and Electronic Engineering The Hong Kong Polytechnic UniversityHong KongChina

Miniaturized fiber-optic magnetic field sensors have attracted considerable interest owing to their superiorities in anti-electromagnetic interference and ***,the intrinsic thermodynamic properties of the material make temperature cross-sensitivity a challenging problem in terms of sensing accuracy and *** this study,an ultracompact multicore fiber(MCF)tip sensor was designed to discriminatively measure the magnetic field and temperature,which was subsequently evaluated *** novel 3D printed sensing component consists of a bowl-shaped microcantilever and a polymer microfluid-infiltrated microcavity on the end-facet of an MCF,acting as two miniaturized Fabry-Perot *** magnetic sensitivity of the microcantilever was implemented by incorporating an iron micro ball into the microcantilever,and the microfluid-infiltrated microcavity enhanced the capability of highly sensitive temperature *** this tiny fiber-facet device in the two channels of an MCF allows discriminative measurements of the magnetic field and temperature by determining the sensitivity coefficient matrix of two *** device exhibited a high magnetic field intensity sensitivity,approximately 1805.6 pm/mT with a fast response time of~213 ms and a high temperature sensitivity of 160.3 pm/℃.Moreover,the sensor had a low condition number of 11.28,indicating high reliability in two-parameter *** proposed 3D printed MCF-tip probes,which detect multiple signals through multiple channels within a single fiber,can provide an ultracompact,sensitive,and reliable scheme for discriminative *** bowl-shaped microcantilever also provides a useful platform for incorporating microstructures with functional materials,extending multi-parameter sensing scenarios and promoting the application of MCFs.

关键词： Two-photon polymerization Multicore fiber-tip sensor Magnetic field sensing Discriminative sensing

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Recent progress in quantum photonic chips for quantum communication and internet

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Light(Science & Applications) 2023年第8期12卷 1544-1565页

作者： Wei Luo Lin Cao Yuzhi Shi Lingxiao Wan Hui Zhang Shuyi Li Guanyu Chen Yuan Li Sijin Li Yunxiang Wang Shihai Sun Muhammad Faeyz Karim Hong Cai Leong Chuan Kwek ai qun liu Quantum Science and Engineering Centre(QSec) Nanyang Technological UniversitySingapore 639798Singapore Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji University200092 ShanghaiChina School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China610054 ChengduChina School of Electronics and Communication Engineering Sun Yat-Sen University518100 ShenzhenGuangdongChina Institute of Microelectronics A*STAR(Agency for ScienceTechnology and Research)Singapore 138634Singapore Centre for Quantum Technologies National University of Singapore3 Science Drive 2Singapore 117543Singapore National Institute of Education Nanyang Technological UniversitySingapore 637616Singapore

Recent years have witnessed significant progress in quantum communication and quantum internet with the emerging quantum photonic chips,whose characteristics of scalability,stability,and low cost,flourish and open up new possibilities in miniaturized ***,we provide an overview of the advances in quantum photonic chips for quantum communication,beginning with a summary of the prevalent photonic integrated fabrication platforms and key components for integrated quantum communication *** then discuss a range of quantum communication applications,such as quantum key distribution and quantum ***,the review culminates with a perspective on challenges towards high-performance chip-based quantum communication,as well as a glimpse into future opportunities for integrated quantum networks.

关键词： quantum stability communication

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Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation

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World Journal of Gastroenterology 2019年第37期25卷 5630-5640页

作者： Jia-Shuo Chao Sen-Lin Zhao Si-Wen Ou-yang Yong-Bing Qian ai-qun liu Hua-Mei Tang Lin Zhong Zhi-Hai Peng Jun-Ming Xu Hong-Cheng Sun Department of General Surgery Shanghai Organ Transplantat Medical CenterShanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Colorectal Surgery Fudan UniversityShanghai Cancer CenterShanghai 200032China Division of Critical Care Department of Liver SurgeryRenji HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200127China Department of Radiology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Pathology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China

BACKGROUND Tumor recurrence after orthotopic liver transplantation(OLT)remains a serious threat for long-term survival of the recipients with hepatocellular carcinoma(HCC),since very few factors or measures have shown impact on overcoming HCC recurrence after *** infection suppresses tumor recurrence and improves patient survival in lung cancer and malignant glioma probably via stimulating the immune ***-transplant infection(PTI),a common complication,is deemed to be harmful for the liver transplant recipients from a short-term ***,whether PTI inhibits HCC recurrence after OLT and prolongs the long-term survival of HCC patients needs to be *** To investigate the potential influence of PTI on the survival and tumor recurrence of patients with HCC after *** A total of 238 patients with HCC who underwent OLT between August 2002 and July 2016 at our center were retrospectively included and accordingly subdivided into a PTI group(53 patients)and a non-PTI group(185 patients).Univariate analyses,including the differences of overall survival(OS),recurrence-free survival(RFS),and post-recurrence survival(PRS),between the PTI and non-PTI subgroups as well as survival curve analysis were performed by the Kaplan-Meier method,and the differences were compared using the log rank *** variables with a P-value<0.1 in univariate analyses were included in the multivariate survival analysis by using a Cox proportional-hazards *** The 1-,3-,and 5-year OS and RFS rates of the whole cohort were 86.6%,69.0%,and 63.6%,and 75.7%,60.0%,and 57.3%,*** 1-,3-,and 5-year OS rates for the PTI patient group(96.0%,89.3%,and 74.0%)were significantly higher than those for the non-PTI group(84.0%,63.4%,and 60.2%)(P=0.033).The absence of PTI was an independent risk factor for dismal OS(relative risk[RR]=2.584,95%CI:1.226-5.449)and unfavorable RFS(RR=2.683,95%CI:1.335-5.390).Subgroup analyses revealed that PTI remark

关键词： Liver transplantation Liver cancer Infection Survival Tumor recurrence

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Smart ring resonator–based sensor for multicomponent chemical analysis via machine learning

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Photonics Research 2021年第2期9卷 I0031-I0037页

作者： ZHENYU LI HUI ZHANG BINH THI THANH NGUYEN SHAOBO LUO PATRICIA YANG liu JUN ZOU YUZHI SHI HONG Cai ZHENCHUAN YANG YUFENG JIN YILONG HAO YI ZHANG ai-qun liu National Key Laboratory of Science and Technology on Micro/Nano Fabrication Institute of MicroelectronicsPeking University Quantum Science and Engineering Centre Nanyang Technological University Institute of Microelectronics A*STAR Agency for ScienceTechnology and Research School of Mechanical and Aerospace Engineering Nanyang Technological University

We demonstrate a smart sensor for label-free multicomponent chemical analysis using a single label-free ring resonator to acquire the entire resonant spectrum of the mixture and a neural network model to predict the composition for multicomponent analysis. The smart sensor shows a high prediction accuracy with a low rootmean-squared error ranging only from 0.13 to 2.28 mg/m L. The predicted concentrations of each component in the testing dataset almost all fall within the 95% prediction bands. With its simple label-free detection strategy and high accuracy, the smart sensor promises great potential for multicomponent analysis applications in many fields.

关键词： Smart neural smart

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Fabrication of flake-like NiCo_(2)O_(4)/reduced graphene oxide/melamine-derived carbon foam as an excellent microwave absorber

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 556-565页

作者： Konghu Tian Hang Yang Chao Zhang Ruiwen Shu qun Shao Xiaowei liu Kaipeng Gao The First Affiliated Hospital of Anhui University of Science and Technology(Huainan First People’s Hospital) Huainan 232001China Analysis and Test Center Anhui University of Science and TechnologyHuainan 232001China School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Carbon-based foams with a three-dimensional structure can serve as a lightweight template for the rational design and control-lable preparation of metal oxide/carbon-based composite microwave absorption *** this study,a flake-like nickel cobaltate/re-duced graphene oxide/melamine-derived carbon foam(FNC/RGO/MDCF)was successfully fabricated through a combination of solvo-thermal treatment and high-temperature *** indicated that RGO was evenly distributed in the MDCF skeleton,providing ef-fective support for the load growth of FNC on its *** S3,the FNC/RGO/MDCF composite prepared by solvothermal method for 16 h,exhibited a minimum reflection loss(RL_(min))of-66.44 dB at a thickness of 2.29 *** the thickness was reduced to 1.50 mm,the optimal effective absorption bandwidth was 3.84 *** of the absorption mechanism of FNC/RGO/MDCF revealed that its excellent absorption performance was primarily attributed to the combined effects of conduction loss,multiple reflection,scattering,in-terface polarization,and dipole polarization.

关键词： carbon foam reduced graphene oxide flake-like nickel cobaltate microwave absorbing materials

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Advances in lithium niobate photonics:development status and perspectives

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Advanced Photonics 2022年第3期4卷 40-82页

作者： Guanyu Chen Nanxi Li Jun Da Ng Hong-Lin Lin Yanyan Zhou Yuan Hsing Fu Lennon Yao Ting Lee Yu Yu ai-qun liu Aaron J.Danner National University of Singapore Department of Electrical and Computer EngineeringSingapore A*STAR(Agency for Science Technology and Research)Institute of MicroelectronicsSingapore Huazhong University of Science and Technology School of Optical and Electronic InformationWuhan National Laboratory for OptoelectronicsWuhanChina Nanyang Technological University Quantum Science and Engineering CentreSingapore

Lithium niobate(LN)has experienced significant developments during past decades due to its versatile properties,especially its large electro-optic(EO)*** example,bulk LN-based modulators with high speeds and a superior linearity are widely used in typical fiber-optic communication ***,with everincreasing demands for signal transmission capacity,the high power and large size of bulk LN-based devices pose great challenges,especially when one of its counterparts,integrated silicon photonics,has experienced dramatic developments in recent *** long ago,high-quality thin-film LN on insulator(LNOI)became commercially available,which has paved the way for integrated LN photonics and opened a hot research area of LN photonics *** allows a large refractive index contrast,thus light can be confined within a more compact *** with other properties of LN,such as nonlinear/acousto-optic/pyroelectric effects,various kinds of high-performance integrated LN devices can be demonstrated.A comprehensive summary of advances in LN photonics is *** LN photonics has experienced several decades of development,our review includes some of the typical bulk LN devices as well as recently developed thin film LN *** this way,readers may be inspired by a complete picture of the evolution of this *** first introduce the basic material properties of LN and several key processing technologies for fabricating photonics *** that,various kinds of functional devices based on different effects are ***,we give a short summary and perspective of LN *** hope this review can give readers more insight into recent advances in LN photonics and contribute to the further development of LN related research.

关键词： lithium niobate etching photonics integrated optics nanotechnology devices.

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