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Wellbore Cleaning Degree and Hydraulic Extension in Shale Oil Horizontal Wells

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Fluid Dynamics & Materials Processing 2024年第3期20卷 661-670页

作者： Xin ai Mian Chen College of Petroleum Engineering China University of Petroleum(Beijing)BeijingChina Daqing Oil Field Company Limited DaqingChina

The efficient development and exploitation of shale oil depends on long-distance horizontal wells. As the degreeof cleaning of the wellbore plays a key role in these processes, in this study, this problem is investigated experimentallyby focusing on the dimensionless cuttings bed height. A method is proposed to calculate the horizontalwellhydraulic extension taking into account the influence of the wellbore cleaning degree on the wellborepressure distribution and assess the effect of a variety of factors such as the bottom hole pressure, the circulatingpressure drop, the drilling pump performance and the formation properties. The analysis shows that the hydraulicextension of horizontal wells decreases with an increase in the cuttings bed height, and the higher the displacementof drilling fluid, the faster the hydraulic extension declines. The annular pressure drop of the horizontalsection increases with the increase of the cuttings bed height, resulting in a higher bottom-hole pressure. Severalarguments are provided to guide the safe drilling of shale oil horizontal wells and overcome the limits of currenttechnological approaches.

关键词： Shale oil horizontal well hydraulic extension wellbore cleaning degree pressure distribution mechanism analysis

Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics

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Virologica Sinica 2024年第1期39卷 9-23页

作者： Jie-Li Hu ai-Long Huang Key Laboratory of Molecular Biology on Infectious Diseases Ministry of EducationChongqing Medical UniversityChongqing400016China

The achievement of a functional cure for chronic hepatitis B(CHB)remains limited to a minority of patients treated with currently approved *** primary objective in developing new anti-HBV drugs is to enhance the functional cure rates for CHB.A critical prerequisite for the functional cure of CHB is a substantial reduction,or even eradication of covalently closed circular DNA(cccDNA).Within this context,the changes in cccDNA levels during treatment become as a pivotal *** have previously analyzed the factors influencing cccDNA dynamics and introduced a preliminary classification of hepatitis B treatment strategies based on these *** this review,we employ a systems thinking perspective to elucidate the fundamental aspects of the HBV replication cycle and to rationalize the classification of treatment strategies according to their impact on the dynamic equilibrium of *** upon this foundation,we categorize current anti-HBV strategies into two distinct groups and advocate for their combined use to significantly reduce cccDNA levels within a well-defined timeframe.

关键词： Hepatitis B cccDNA Functional cure Dynamics Treatment Strategy

Reliability ensemble averaging reduces surface wind speed projection uncertainties in the 21st century over China

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Advances in Climate Change Research 2024年第2期15卷 222-229页

作者： Zheng-Tai ZHANG Chang-ai XU Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China

Accurate prediction of future surface wind speed(SWS)changes is the basis of scientific planning for wind *** studies have projected SWS changes in the 21st century over China on the basis of the multi-model ensemble(MME)of the 6th Coupled Model Intercomparison Project(CMIP6).However,the simulation capability for SWS varies greatly in CMIP6 multi-models,so the MME results still have large *** this study,we used the reliability ensemble averaging(REA)method to assign each model different weights according to their performances in simulating historical SWS changes and project the SWS under different shared socioeconomic pathways(SSPs)in *** results indicate that REA considerably improves the SWS simulation capacity of CMIP6,eliminating the overestimation of SWS by the MME and increasing the simulation capacity of spatial *** spatial correlations with observations increased from 0.56 for the MME to 0.85 for ***,REA could eliminate the overestimation of the SWS by 33%in *** for southeastern China,the SWS generally decreases over China in the near term(2020-2049)and later term(2070-2099),particularly under high-emission *** SWS reduction projected by REA is twice as high as that by the MME in the near term,reaching-4%to-3%.REA predicts a larger area of increased SWS in the later term,which expands from southeastern China to eastern *** study helps to reduce the projected SWS uncertainties.

关键词： Surface wind speed Uncertainty Multi-model ensemble Reliability ensemble averaging CMIP6

Adsorption and Decomposition of NH3 on Ni/Pt（111） and Ni/WC（001） Surfaces： A First-Principles Study

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Chinese Journal of Chemical Physics 2016年第6期29卷 710-716,I0002页

作者： ai-ai Shen Yi-lin Cao Schoolof:ChemistryandChemicalEnEineerin~.HenanNormalUniversity.Xinxi~n~453007.China

密度功能的理论被用来在 Ni 单层上学习 NH 3 行为盖住的磅(111 ) 和 WC (001 ) 。NH 3 的表面的电子结构，和吸附和分解计算、比较。在单层的 Ni 原子表现与那不同在 Ni (111 ) 。更多的 d 在单层的 Ni 的 z 2 电子盖住系统与 Ni (111... 详细信息

密度功能的理论被用来在 Ni 单层上学习 NH 3 行为盖住的磅(111 ) 和 WC (001 ) 。NH 3 的表面的电子结构，和吸附和分解计算、比较。在单层的 Ni 原子表现与那不同在 Ni (111 ) 。更多的 d 在单层的 Ni 的 z 2 电子盖住系统与 Ni (111 ) 相比被转移到另外的区域，这上的充电密度弄空轨道对 NH 3 关键吸附。 NH 3比在 Ni ( 111 )上在 Ni/Pt ( 111 )和 Ni/WC ( 001 )上绑更多的马厩，第一 N-H 契约切断的精力障碍比在 Ni ( 111 )上在 Ni/Pt ( 111 )和 Ni/WC ( 001 )上是显然更低的，这些对 NH 3分解重要。N 再结合是限制率的步，高反应障碍暗示 N 2 仅仅在高温度被生产。尽管 WC 有类似的性质到磅，电子结构和催化活动的差别为 Ni/Pt ( 111 )和 Ni/WC ( 001 )被观察，为率坚定的步的精力障碍在 Ni/WC ( 001 )上增加而不是在 Ni/Pt ( 111 )上减少什么时候与 Ni ( 111 )相比。到更便宜的设计和更好的催化剂，由修改 Ni/WC (001 ) 减少 N 再结合障碍是要解决的一个批评问题。

关键词：和分解第一性原理 Ni WC 吸附表面镍铂

基于AHP-CRITIC法结合星点设计优选壮药骆芡愈巴布剂成型工艺

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湖北农业科学 2024年第4期63卷 141-147,196页

作者：谢孟姣郭勇秀赖信宏李芳婵黄茵黄艾艾王雅琴黄雪婷蒋林广西中医药大学药学院南宁530001 广西中医药大学壮瑶药工程技术中心南宁530001

以初黏力、持黏力及综合感官评价为考察指标,通过AHP-CRITIC混合加权法确定各指标的权重并计算综合评分,采用星点设计-响应面法优选壮药骆芡愈巴布剂的最佳成型工艺。结果表明,壮药骆芡愈巴布剂空白基质最佳处方为NP-7001.6 g、微粉硅胶... 详细信息

以初黏力、持黏力及综合感官评价为考察指标,通过AHP-CRITIC混合加权法确定各指标的权重并计算综合评分,采用星点设计-响应面法优选壮药骆芡愈巴布剂的最佳成型工艺。结果表明,壮药骆芡愈巴布剂空白基质最佳处方为NP-7001.6 g、微粉硅胶1.0 g、甘羟铝0.8 g、甘油12.0 g、卡波姆9400.5 g、CMC-Na 0.5 g、EDTA-2Na 26 mg、去离子水10 mL;制备方法为NP-700、微粉硅胶、甘羟铝置于甘油中溶胀,作为A相,EDTA-2Na溶于去离子水中,加卡波姆940、CMC-Na溶胀,作为B相,将A相加入B相中搅拌均匀,得到的空白基质与处方量药膏搅拌均匀即得。优选得到的制备工艺稳定可行,实际生产可操作性大,可用于壮药骆芡愈巴布剂的制备。

关键词：壮药骆芡愈巴布剂 AHP-CRITIC 星点设计成型工艺

Design of an automated robotic microinjection system for batch injection of zebrafish embryos and larvae

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Microsystems & Nanoengineering 2024年第1期10卷 89-103页

作者： Zhongyi Guo Nana ai Wei Ge Qingsong Xu Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina Department of Biomedical Sciences and Centre of Reproduction Development and Aging(CRDA)Faculty of Health SciencesUniversity of MacaoMacaoChina

This paper presents the design of a vision-based automated robotic microinjection system for batch injection of both zebrafish embryos and larvae.A novel visual recognition algorithm based on an automatic threshold and excessive dilatation is introduced to accurately identify the center of zebrafish embryos and larval yolks.A corresponding software system is developed using the producer-consumer model as the framework structure,and a friendly user interface is designed to allow operators to choose from a range of desired functions according to their different *** addition,a novel microstructural agarose device is designed and fabricated to simultaneously immobilize mixed batches of embryos and ***,a prototype microinjection system is fabricated by integrating hardware devices with visual *** experimental study is conducted to verify the performance of the robotic microinjection *** results show that the reported system can accurately identify zebrafish embryos and larvae and efficiently complete batch microinjection tasks of the mixtures with an injection success rate of 92.05%in 13.88 s per *** with manual and existing microinjection systems,the proposed system demonstrates the merits of versatility,excellent efficiency,high success rate,high survival rate,and sufficient stability.

关键词： zebra automated hardware

Combustion mechanism of benzene in iron ore sintering process:experimental and simulation

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Journal of Iron and Steel Research(International) 2024年第1期31卷 195-203页

作者： Zhi-gang Que Jin-ming Shi Xian-bin ai Institute of Energy Research Jiangxi Academy of ScienceNanchang330096JiangxiChina Jiangxi Carbon Neutralization Research Center Nanchang330096JiangxiChina

Benzene is a typical component of volatile organic compounds(VOCs)in the iron ore sintering flue *** combustion behavior of benzene directly affects the emission of VOCs in iron ore sintering *** effects of temperature,benzene,and oxygen concentrations on the conversion ratio of benzene were investigated by experiments and numerical *** experiments were carried out in a tube reactor at temperatures of 773-1098 K,benzene concentrations of 0.01-0.03 vol.%,and oxygen concentrations of 10-21 vol.%.The numerical simulation was performed with the plug flow model in the CHEMKIN program based on a kinetic model that consists of 132 chemical species and 772 elementary step-like *** experimental results reveal that increasing the temperature and benzene concentration could signifi-cantly promote benzene *** is attributed to the increase in the reaction rates of all steps in the pathway for forming CO_(2)and H_(2)*** addition,due to the large equivalent ratio of oxygen to benzene,the conversion ratio of benzene remained constant at different oxygen *** simulation results were in good agreement with the experimental results and indicated that six elementary reactions dominated the formations of CO_(2)and H_(2)*** oxidations of C_(6)H_(5)O,CO,and C_(5)H_(4)O intermediates to CO_(2)were the limiting steps in the reaction pathways.

关键词： Benzene Volatile organic compound Iron ore sinter Combustion Simulation Temperature Oxygen

Statistical Analysis of the Asphalt Mixtures Volumetric Properties

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Journal of Wuhan University of Technology(Materials Science) 2010年第6期25卷 1082-1090页

作者：谭忆秋 ai ai-Hadidy School of Transportation Science and Engineering Harbin Institute of Technology Department of Civil Engineering Department University of Mosul

Based on statistics principle,random error and systematic error were considered and the volumetric properties of the two mixtures types,namely A and B,were statistically analyzed using different distribution ***-two samples of mixture A and fifty-two of mixture B were fabricated using the Marshall *** probability distributions were compared on the basis of goodness of *** model was found to be most appropriate model for describing the asphalt mixtures volumetric properties *** two-parameter Weibull distribution function applied well to model the bulk specific gravity and voids filled with asphalt data,whereas,the three-parameter Weibull distribution appeared to be more appropriate in the discussing of air voids and voids in mineral *** experimetal results is revealed that compared with the mean value,the peak value of Weibull distribution was suggested as an alternative and more powerful parameter for describing the test data distribution *** analysis of test results also revealed that there were significant differences in the volumetric properties of the two tested mixtures for the same confidence *** confidence interval decreased with the decreasing in reliability.

关键词： asphalt mixture volumetric properties statistical analysis Weibull distribution evaluation index reliability

Nanoscale Reorganization of Glutamate Receptors Underlies Synaptic Plasticity and Pathology

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Neuroscience Bulletin 2024年第6期40卷 840-844页

作者： Jia-Hui Chen ai-Hui Tang Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research Center and Biomedical Sciences and Health Laboratory of Anhui ProvinceUniversity of Science and Technology of ChinaHefei230027China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei230088China

Excitatory synapses serve as the primary sites for information transmission between neurons in the *** work over the past decades has identified and revealed multiple compositions and functions of the synaptic proteome in the postsynaptic density(PSD),including receptors,scaffold proteins,and signaling molecules,which work together to ensure stable and effective synaptic transmission.

关键词： Receptor scale Glutamate