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Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer

World Journal of Gastroenterology 2011年第16期17卷 2109-2112页

作者： Ozgur kemik ahu sarbay kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan Department of General Surgery Yuzuncu Y1l University Medical Faculty Department of Biochemistry Cerrahpasa Medical Faculty University of Istanbul Department of Gastroenterology Medical FacultyUniversity of Yüzüncü Y1l Department of Endocrinology Okmeydani Education and Research Hospital Department of Internal Medicine Medical FacultyUniversity of Yüzüncü Y1l Department of Biostatistics Istanbul Medical FacultyUniversity of Istanbul II.General Surgery Haseki Education and Research Hospital

AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric ***:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this *** serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent ***:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological *** were not significantly associated with age,gender,tumor location,or histological ***:Increased MMP-1 and TIMP-1 were associated with gastric *** these markers are not good markers for diagnosis,these markers show in advanced gastric cancer.

关键词： Gastric cancer Matrix metalloproteinase-1 Tissue matrix metalloproteinase-1

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Effects of glutamine and curcumin on bacterial translocation in jaundiced rats

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World Journal of Gastroenterology 2010年第34期16卷 4313-4320页

作者： Oguzhan Karatepe Ersin Acet Muharrem Battal Gokhan Adas ahu kemik Merih Altiok Gulcin Kamali Safiye Koculu Atahan Catay Sedat Kamali Servet Karahan Department of Surgery Okmeydani Education and Research Hospital Department of Biochemistry Istanbul Faculty of Medicine Istanbul 34725 Turkey Department of Infectious Disease Istanbul Faculty of Medicine Istanbul 34715 Turkey

AIM: To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used. METHODS: Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, GroupⅠ received oral normal saline, Group Ⅱ received oral glutamine and Group Ⅲ received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage. RESULTS: We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy. CONCLUSION: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice.

关键词： Obstructive jaundice Bacterial translocation Oxidative damage Glutamine Curcumin

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Effect of growth hormone,hyperbaric oxygen and combined therapy on the gastric serosa

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World Journal of Gastroenterology 2013年第19期19卷 2904-2912页

作者： Gokhan Adas Mine Adas Soykan Arikan ahu kemik Sarvan Akin Savas TokluDepartment of Underwater and Hyperbaric Medicine Istanbul Faculty of Medicine 34091 Istanbul Turkey Selva Mert Gul Barut Sedat Kamali Bora Koc Firat Tutal Department of Surgery Bakirkoy Dr.Sadi Konuk Training and Research Hospital34147 IstanbulTurkey Department of Endocrinology Okmeydani Training and Research Hospital34384 IstanbulTurkey Department of Surgery Istanbul Training and Research Hospital34098 IstanbulTurkey Department of Biochemistry Istanbul Faculty of Medicine34091 IstanbulTurkey Department of Underwater and Hyperbaric Medicine Istanbul Faculty of Medicine34091 IstanbulTurkey Department of Pathology Haseki Training and Research Hospital34096 IstanbulTurkey Department of Surgery Okmeydani training and Research Hospital34384 IstanbulTurkey

AIM:To investigate the role of growth hormone(GH),hyperbaric oxygen therapy(HBOT) and combined therapy on the intestinal neomucosa formation of the gastric ***:Forty-eight male Wistar-albino rats,weighing 250-280 g,were used in this *** rats were divided into four groups(n = 12):Group 1,control,gastric serosal patch;Group 2,gastric serosal patch + GH;Group 3,gastric serosal patch + HBOT;and Group 4,gastric serosal patch + GH + *** access was achieved through a midline incision,and after the 1-cm-long defect was created in the jejunum,a 1 cm × 1 cm patch of the gastric corpus was anastomosed to the jejunal *** blood samples were taken to determine the insulin-like growth factor 1(IGF-1) and insulin-like growth factor binding protein 3(IGFBP-3) basal *** was performed in Groups 3 and *** Groups 2 and 4,human GH was given subcutaneously at a dose of 2 mg per kg/d for 28 d,beginning on the operation *** animals were sacrificed 60 d after *** jejunal segment and the gastric anastomotic area were excised for histological *** inflammatory process,granulation,collagen deposition and fibroblast activity at the neomucosa formation were studied and ***,the villus density,villus height,and crypt depth were counted and *** measurements of villus height and crypt depth were calculated with an ocular *** vessel growth was determined by calculatingeach new vessel in a 1 mm 2 ***:In the histological comparison of groups,no significant differences were observed between the control group and Groups 2 and 3 with respect to epithelialization,granulation,fibroblastic activity and the inflammatory process,but significant differences were present between the control group and all others groups(Groups 2-4) with respect to angiogenesis(P < 0.01) and collagen deposition(P < 0.05,P < 0.01).Significant differences between the control group and Group 4 were also observed with respe

关键词： Growth hormone Hyperbaric oxygen Neomucosa Short bowel syndrome Hypoxia

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