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Dysphagia induced by a cervical osteophyte: a case report of cervical spondylosis

中华医学杂志(英文版) 2004年第3期 159-161页

作者： Kaan Uzunca,Murat Birtane,ahmet tezel Department of Physical Medicine and Rehabilitation Faculty of Medicine Trakya University Department of Physical Medicine and Rehabilitation Faculty of Medicine Trakya University Department of Gastroenterology Faculty of Medicine Trakya University Edirne Turkey Edirne Turkey Edirne Turkey

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Cerebral sinus thrombosis in patients with inflammatory bowel disease: A case report

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World Journal of Gastroenterology 2005年第34期11卷 5404-5407页

作者： Hasan Umit Talip Asil Yahya Celik ahmet tezel Gulbin Dokmeci Nermin Tuncbilek Ufuk Utku Ali Riza Soylu Department of Gastroenterology Trakya University Faculty of Medicine Edirne 22030 Turkey Department of Neurology Trakya University Faculty of Medicine Edirne 22030 Turkey Department of Radiology Trakya University Faculty of Medicine Edirne 22030 Turkey Department of Gastroenterology Trakya University Faculty of Medicine Edime 22030 Turkey

Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the gastrointestinal tract. The pathophysiology of IBD is probably the result of the complex interaction of genetic susceptibility and environmental influences. There is a well-known risk of thrombosis in patients with IBD. We present the case of a 53-year-old man with ulcerative colitis, who spontaneously developed intracranial sinus thrombosis that was treated with low molecular weight heparin. Literature was searched to assess the frequency and characteristics of cerebral sinus thrombosis in IBD and the role of certain etiopathological factors in such thrombotic patients.

关键词： Inflammatory bowel disease Cerebrovascular thrombosis Cerebral sinus thrombosis

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Dysphagia induced by a cervical osteophyte: a case report of cervical spondylosis

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Chinese Medical Journal 2004年第3期117卷 478-480页

作者： Kaan Uzunca Murat Birtane ahmet tezel Department of Physical Medicine and Rehabilitation Faculty of Medicine Trakya UniversityDepartment of Physical Medicine and Rehabilitation Faculty of Medicine Trakya UniversityDepartment of Gastroenterology Faculty of Medicine Trakya University EdirneTurkey EdirneTurkey EdirneTurkey

Mechanical oesophageal dysphagia is caused by either an extrinsic compression of oesophageal lumen or intrinsic pathologies of oesophageal wall. The oesophagus may be compressed externally by an enlarged thyroid gland, vascular pathologies, a mediastinal mass, or a retropharyngeal abscess.1 In addition, skeletal pathologies such as anterior osteophytic bridges due to diffuse idiopathic skeletal hyperostosis (DISH), degenerative osteophytes, congenital bone bars, atlantoaxial dislocation, anterior herniation of calcified nucleus pulposus, rheumatoid pannus of the cervical spine, and ankylosing spondylitis causing anterior longitudinal ligament calcification can all produce external compression of the oesophagus and consequent dysphagia.2,3

关键词： dysphagia cervical osteophyte

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Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats

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World Journal of Gastroenterology 2006年第42期12卷 6835-6841页

作者： Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit ahmet tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak Division of Gastroenterology Trakya University Edirne Turkey Department of Physiology Trakya University Edirne Turkey Department of Pediatric Surgery Trakya University Edirne Turkey Department of Pathology Trakya University Edirne Turkey Division of Gastroenterology Gumussuyu Military Hospital Istanbul Turkey Department of Biochemistry Kas?mpasa Naval Hospital Istanbul Turkey Department of Pathology Haydarpasa GATA/ Education Hospital Istanbul Turkey Department of Biostatistics Trakya University Edirne Turkey

AIM： To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bilian/obstructed rats. METHODS： Fifty Wistar albino rats were randomly assigned to 5 groups （10 rats in each）. Bile duct was ligated in 40 rats and they were treated as follows： group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated （BDL, control） group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS： Despite being higher than sham group, hepatic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups （32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 ）μg collagen/mg protein, respectively） compared to BDL （48.3 ± 0.6 mg collagen/g protein）（P 〈 0.001 for each vitamin group）. Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supplementation prevented the increase in hepatic collagen surface density （7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively） compared to BDL （17.4% ± 5.6%）（P 〈 0.05 for each）. The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group （P 〈 0.001）. The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treatment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group （vit EC： 2.4 ± 0.8 vs BDL： 3.1 ± 0.7; P 〈 0.05）. CONCLUSION： Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in bi

关键词： Hepatic fibrosis Biliary obstruction Collagen Vitamin E Vitamin C

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