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High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia

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World Journal of Pediatric Surgery 2022年第1期5卷 12-17页

作者： Essa A Adawi mazen ahmed ghanem ahmed mazen ghanem Manal A Safan Mohamed G Elsayed Mohammed A Aqeel Urology Jazan UniversityJazanSaudi Arabia Urology Menoufia University Faculty of MedicineAI Rehab CityNew CairoEgypt GP Cairo University Kasr Alainy Faculty of MedicineAI Rehab CityNew CairoEgypt Department of Medical Biochemistry and Molecular Biology Menoufia University Faculty of MedicineAI Rehab CityNew CairoEgypt Pediatric Surgery Jazan UniversityJazanSaudi Arabia Department of Anesthesia and Critical Care Jazan UniversityJazanSaudi Arabia

Objective This study aimed to evaluate the predictive value of platelet volume indices(PVI),such as mean platelet volume(MPV),platelet distribution width(PDW),and plateletcrit(PCT),as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia(SCA)who underwent surgical *** Forty-eight patients with SCA with testicular torsion and 46 male control subjects were enrolled in the *** patients underwent scrotal color Doppler ultrasonography before surgery,and PVI(MPV,PDW,and PCT)values were measured in all *** duration and testicular volume were also *** The testicular salvage rate in patients with SCA was 73%after *** showed that MPV,PDW,and PCT values were significantly higher in torsed SCA as compared with controls(p<0.05).Orchiectomy in patients with SCA showed significantly higher MPV,PDW,and PCT values than the orchiopexy group(p<0.05).The MPV values of orchiectomy patients showed a higher significant cut-off of≥11.5 fL,which is higher than in torsed patients without SCA,as an indicator of testis *** also demonstrated a higher significant cut-off of≥12.7 fL for detorsion outcomes in patients with *** duration of less than 7 hours was also significantly correlated with orchiopexy(p≤0.001).Univariate analysis showed that higher MPV,increased PDW,and symptom duration were indicative of the outcome of testicular detorsion in *** analysis showed that increased PDW and symptom duration are prognostic parameters for testicular viability in *** Increased PDW and symptom duration can be used as parameters for predicting testicular detorsion outcomes in patients with steady-state SCA.

关键词： patients anemia torsion

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Computational Analysis of Novel Extended Lindley Progressively Censored Data

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2571-2596页

作者： Refah Alotaibi mazen Nassar ahmed Elshahhat Department of Mathematical Sciences College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Statistics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Statistics Faculty of CommerceZagazig UniversityZagazigEgypt Faculty of Technology and Development Zagazig UniversityZagazig44519Egypt

A novel extended Lindley lifetime model that exhibits unimodal or decreasing density shapes as well as increasing,bathtub or unimodal-then-bathtub failure rates, named the Marshall-Olkin-Lindley (MOL) model is *** this research, using a progressive Type-II censored, various inferences of the MOL model parameters oflife are introduced. Utilizing the maximum likelihood method as a classical approach, the estimators of themodel parameters and various reliability measures are investigated. Against both symmetric and asymmetric lossfunctions, the Bayesian estimates are obtained using the Markov Chain Monte Carlo (MCMC) technique with theassumption of independent gamma priors. From the Fisher information data and the simulatedMarkovian chains,the approximate asymptotic interval and the highest posterior density interval, respectively, of each unknownparameter are calculated. Via an extensive simulated study, the usefulness of the various suggested strategies isassessedwith respect to some evaluationmetrics such as mean squared errors, mean relative absolute biases, averageconfidence lengths, and coverage percentages. Comparing the Bayesian estimations based on the asymmetric lossfunction to the traditional technique or the symmetric loss function-based Bayesian estimations, the analysisdemonstrates that asymmetric loss function-based Bayesian estimations are preferred. Finally, two data sets,representing vinyl chloride and repairable mechanical equipment items, have been investigated to support theapproaches proposed and show the superiority of the proposed model compared to the other fourteen lifetimemodels.

关键词： Marshall-Olkin-Lindleymodel reliability inference Bayesian and classical inference progressive Type-II censoring

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A Novel Modified Alpha Power Transformed Weibull Distribution and Its Engineering Applications

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2065-2089页

作者： Refah Alotaibi Hassan Okasha mazen Nassar ahmed Elshahhat Department of Mathematical Sciences College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Statistics Faculty of ScienceKing Abdulaziz UniversityJeddah80200Saudi Arabia Department of Mathematics Faculty of ScienceAl-Azhar UniversityNasr CityCairo11884Egypt Department of Statistics Faculty of CommerceZagazig UniversityZagazig44519Egypt Faculty of Technology and Development Zagazig UniversityZagazig44519Egypt

This paper suggests a new modified version of the traditional Weibull distribution by adding a new shape parameter utilising the modified alpha power transformed *** refer to the new model as modified alpha power transformed Weibull *** attractiveness and significance of the new distribution lie in its power to model monotone and non-monotone failure rate functions,which are quite familiar in environmental *** hazard rate function can be decreasing,increasing,bathtub and upside-down then bathtub *** structural properties of the proposed model are acquired including quantile function,moments,entropies,order statistics,residual life and reversed failure rate *** parameters of the distribution were estimated using the maximum likelihood *** maximum likelihood method is employed to estimate the model parameters and the approximate confidence intervals are also *** a simulation study,the performance of the point and interval estimates are compared using different *** real lifetime data sets,we verify that the offered model furnishes a better fit than some other lifetime models including Weibull,gamma and alpha powerWeibull models.

关键词： Weibull distribution modified alpha power transformationmethod maximum likelihood entropy order statistics

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Reliability Analysis of HEE Parameters via Progressive Type-II Censoring with Applications

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Computer Modeling in Engineering & Sciences 2023年第12期137卷 2761-2793页

作者： Heba S.Mohammed mazen Nassar Refah Alotaibi ahmed Elshahhat Department of Mathematical Sciences College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Statistics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Statistics Faculty of CommerceZagazig UniversityZagazigEgypt Faculty of Technology and Development Zagazig UniversityZagazig44519Egypt

A new extended exponential lifetime model called Harris extended-exponential(HEE)distribution for data modelling with increasing and decreasing hazard rate shapes has been *** the reliability context,researchers prefer to use censoring plans to collect data in order to achieve a compromise between total test time and/or test sample ***,this study considers both maximum likelihood and Bayesian estimates of the Harris extended-exponential distribution parameters and some of its reliability indices using a progressive Type-II censoring *** the premise of independent gamma priors,the Bayesian estimation is created using the squared-error and general entropy loss *** to the challenging form of the joint posterior distribution,to evaluate the Bayes estimates,samples from the full conditional distributions are generated using Markov Chain Monte Carlo *** each unknown parameter,the highest posterior density credible intervals and asymptotic confidence intervals are also *** a simulated study,the usefulness of the various suggested strategies is *** optimal progressive censoring plans are also shown,and various optimality criteria are *** actual data sets,taken from engineering and veterinary medicine areas,are analyzed to show how the offered point and interval estimators can be used in practice and to verify that the proposed model furnishes a good fit than other lifetimemodels:alpha power exponential,generalized-exponential,Nadarajah-Haghighi,Weibull,Lomax,gamma and exponential *** evaluations revealed that in the presence of progressively Type-II censored data,the Bayes estimation method against the squared-error(symmetric)loss is advised for getting the point and interval estimates of the HEE distribution.

关键词： Harris extended-exponential model progressive Type-II censoring reliability maximum likelihood MCMC techniques Monte Carlo experiments

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Application of microalgal-ZnO-NPs for reusing polyester/cotton blended fabric wastes after modification by cellulases enzymes

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Waste Disposal and Sustainable Energy 2023年第4期5卷 471-482页

作者： Osama M.Darwesh Naser G.Al-Balakocy ahmed ghanem Ibrahim A.Matter Agricultural Microbiology Department National Research Centre33 EL-Buhouth St.DokkiCairo12622Egypt Protenic and Manmade Fibers Department National Research CentreDokkiCairo12622Egypt Packaging Materials Department National Research CentreCairo12622Egypt

Polyester/cotton(PET/C)blended fabric wastes are produced daily in huge amounts,which constitutes an economic loss and an environmental threat if it is not reused *** textile waste recycling technologies put much effort into developing fabric materials with unique properties,such as bioactivity or new optical goods based on modern technologies,especially *** this study,zinc oxide nanoparticles(ZnO-NPs)were biosynthesized using the aqueous extract of Dunaliella *** immobilized on PET/C waste fabrics after enzymatically activated with *** produced Dunaliella-ZnO-NPs(10–20 nm with a spherical shape)were characterized by High-resolution transmission electron microscopy(HRTEM),Fourier-transform infrared spectroscopy(FTIR),X-Ray diffraction analysis(XRD),and Scanning electron microscopy-energy dispersive X-ray analyzer(SEM-EDAX),and some functional groups,such as CH,CO,NH,and CN(due to the presence of carboxyl,proteins and hydroxyl groups),were detected,revealing the biosynthesis of *** analysis showed that the resulting ZnO-NPS had potent antimicrobial effects,Ultraviolet(UV)protection capabilities,and no cytotoxic effects on the normal human fibroblast cell line(BJ1).On the other hand,enzymatic treatments of PET/C fabric waste with cellulases enhanced the immobilization of biosynthetic nanoparticles on their *** PET/C fabrics loaded with Dunaliella-ZnO-NPs showed antibacterial and UV protection capabilities making them an eco-friendly and cost-effective candidate for numerous *** applications can include the manufacture of active packaging devices,wastewater treatment units,and many other environmental applications.

关键词： Wastewater remediation Polyester/cotton wastes Cytotoxicity Microalgal-ZnO-NPs Dunaliella sp. Microbial nanotechnology

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The role of varicocele sclerotherapy in men with severe ol igo-astheno-teratozoos perm ia

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Asian Journal of Andrology 2011年第6期13卷 867-871页

作者： mazen A ghanem Manal A Safan Ashraf A ghanem Gert R Dohle Department of Urology Menoufiya University 3481 Shebin EI-Kom Egypt Department of Urology Erasmus MC 3000 CA Rotterdam The Netherlands Department of Clinica Biochemistry Menoufiya University 3481 Shebin EI-Kom Egypt Department of Gynaecology and Obstetrics Mansoura University 35515 Mansoura Egypt

The aim of this study was to verify the role of antegrade scrotal sclerotherapy for the treatment of varicoceles in infertile men with severe oligo-astheno-teratozoospermia （OAT）. The 59 patients with severe OAT in this study underwent antegrade scrotal sclerotherapy for the treatment of varicoceles. The outcome was assessed in terms of improvement in semen parameters and spontaneous conception rate. Semen parameters and reproductive hormones were evaluated before antegrade sclerotherapy （AS） and 6 months after AS. After an average follow-up time of 34.8_＋3.2 months, significant improvement was noted in the mean sperm concentration, motility and morphology in 36 patients （61%）. Spontaneous pregnancy occurred in nine couples （15%）. Six months after treatment, inhibin B levels were significantly higher （P〉0.04）, whereas follicle-stimulating hormone （FSH） levels were significantly lower （P〈0.001） than before treatment. Antegrade internal spermatic vein sclerotherapy can significantly improve seminal parameters and hormonal parameters in men with severe OAT and may even result in spontaneous pregnancy in couples who would otherwise be candidates for intracytoplasmic sperm injection （ICSI）.

关键词： infertility Inhibin B oligo-astheno-teratozoospermia sclerotherapy semen parameters varicocele

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Frailty in end-stage liver disease:Understanding pathophysiology,tools for assessment,and strategies for management

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World Journal of Gastroenterology 2023年第46期29卷 6028-6048页

作者： mazen Elsheikh ahmed El Sabagh Islam B Mohamed Megha Bhongade Manal M Hassan Prasun Kumar Jalal Department of Gastroenterology and Hepatology Baylor College of MedicineHoustonTX 77030United States Department of Epidemiology Division of Cancer Prevention and Population SciencesThe University of TexasMD Anderson Cancer CenterHoustonTX 77030United States

Frailty and sarcopenia are frequently observed in patients with end-stage liver *** is a complex condition that arises from deteriorations across various physiological systems,including the musculoskeletal,cardiovascular,and immune systems,resulting in a reduced ability of the body to withstand *** condition is associated with declined resilience and increased vulnerability to negative outcomes,including disability,hospitalization,and *** cirrhotic patients,frailty is influenced by multiple factors,such as hyperammonemia,hormonal imbalance,malnutrition,ascites,hepatic encephalopathy,and alcohol *** frailty is crucial in predicting morbidity and mortality in cirrhotic *** can aid in making critical decisions regarding patients’eligibility for critical care and ***,in turn,can guide the development of an individualized treatment plan for each patient with cirrhosis,with a focus on prioritizing exercise,proper nutrition,and appropriate treatment of hepatic complications as the primary lines of *** this review,we aim to explore the topic of frailty in liver diseases,with a particular emphasis on pathophysiology,clinical assessment,and discuss strategies for preventing frailty through effective treatment of hepatic ***,we explore novel assessment and management strategies that have emerged in recent years,including the use of wearable technology and telemedicine.

关键词： End-stage liver disease Frailty Liver cirrhosis Malnutrition Sarcopenia

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Susceptibility patterns and virulence genotypes of Helicobacter pylori affecting eradication therapy outcomes among Egyptian patients with gastroduodenal diseases

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World Journal of Gastroenterology 2023年第19期29卷 2950-2960页

作者： ahmed Morad Asaad Gasser El-Azab Eman Abdelsameea Osama Elbahr ahmed Kamal Mohamed Abdel-Samiee ahmed Abdelfattah Heba Abdallah Doha Maher ahmed El-Refaie Samar Ebrahim ghanem Shamshul Ansari Samah Mohammed Awad Department of Microbiology College of MedicineZagazig UniversityZagazig 44519Egypt Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Clinical Pathology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Pathology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Clinical Biochemistry and Molecular Diagnostics National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Health Sciences Higher Colleges of TechnologyAbu Dhabi Women's CollegeAbu Dhabi 25026United Arab Emirates Department of Clinical Microbiology and Immunology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt

BACKGROUND Helicobacter pylori(***)is a significant human pathogen that is responsible for a variety of illnesses,including mucosa-associated lymphoid tissue lymphoma,gastric cancer,peptic ulcers,and *** To investigate the frequency of *** infection and its resistance patterns among Egyptian patients and to determine the influence of *** virulence genetic determinants on the eradication success of 14-d triple therapy *** *** infections were investigated in 72 patients with gastroduodenal complications suggestive of *** *** cagA and vacA genotypes of cultured strains were studied using polymerase chain *** patients underwent 14 d of triple-therapy *** treatment response was examined using histology and a rapid urease test 6 wk after therapy *** The intention-to-treat eradication rate was 59.2%(95%CI:48.2%-70.3%).Rates of *** resistance to clarithromycin,amoxicillin,and metronidazole were 52.8%,81.9%,and 100%,*** eradication of *** was more significantly associated with vacA s1-positive strains[adjusted odds ratio(aOR)=0.507,95%CI:0.175-0.822].A significant association was found between failed eradication rate and *** strains resistant to clarithromycin(aOR=0.204,95%CI:-0.005 to 0.412)and amoxicillin(aOR=0.223,95%CI:0.026-0.537).CONCLUSION This study’s low *** eradication rate following 14-d triple therapy is concerning and *** pan-resistance to metronidazole followed by the high resistance to ciprofloxacin,amoxicillin,and clarithromycin in this research is challenging and of great concern.

关键词： Helicobacter pylori Eradication therapy Virulence Clarithromycin resistance cagA gene vacA gene

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Factors that influence adult neurogenesis as potential therapy

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Translational Neurodegeneration 2018年第1期7卷 24-42页

作者： Belal Shohayeb Mohamed Diab mazen ahmed Dominic Chi Hiung Ng School of Biomedical Science Faculty of MedicineUniversity of QueenslandSt LuciaQLD 4067Australia Faculty of Pharmacy Pharos University in AlexandriaP.O.Box Sidi GaberAlexandria 21311Egypt

Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the *** phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult *** potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative *** addition,adult neurogenesis might also play a role in mood and affective *** factors that regulate adult neurogenesis have been broadly ***,the underlying molecular mechanisms of regulating neurogenesis are still not fully *** this review,we will provide critical analysis of our current understanding of the factors and molecular mechanisms that determine *** will further discuss pre-clinical and clinical studies that have investigated the potential of modulating neurogenesis as therapeutic intervention in neurodegeneration.

关键词： Niche Neurotrophins Cytokines Transcription factors Stem cells Extrinsic factors Therapy

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Modeling Liver Cancer and Leukemia Data Using Arcsine-Gaussian Distribution

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Computers, Materials & Continua 2021年第5期67卷 2185-2202页

作者： Farouq Mohammad A.Alam Sharifah Alrajhi mazen Nassar ahmed Z.Afify Department of Statistics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Statistics Faculty of CommerceZagazig UniversityZagazig44511Egypt Department of Statistics Mathematics and InsuranceBenha UniversityBenha13511Egypt

The main objective of this paper is to discuss a general family of distributions generated from the symmetrical arcsine *** considered family includes various asymmetrical and symmetrical probability distributions as special cases.A particular case of a symmetrical probability distribution from this family is the Arcsine–Gaussian *** statistical properties of this distribution including quantile,mean residual life,order statistics and moments are *** Arcsine–Gaussian parameters are estimated using two classical estimation methods called moments and maximum likelihood methods.A simulation study which provides asymptotic distribution of all considered point estimators,90%and 95%asymptotic confidence intervals are performed to examine the estimation efficiency of the considered methods *** simulation results show that both biases and variances of the estimators tend to zero as the sample size increases,i.e.,the estimators are asymptotically ***,when the sample size increases the coverage probabilities of the confidence intervals increase to the nominal levels,while the corresponding length decrease and approach *** real data sets from the medicine filed are used to illustrate the flexibility of the Arcsine–Gaussian distribution as compared with the normal,logistic,and Cauchy *** proposed distribution is very versatile to fit real applications and can be used as a good alternative to the traditional gaussian distribution.

关键词： Liver cancer data leukemia data normal distribution moments estimation maximum likelihood estimation

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