检索结果-南通市图书馆

Does steroid-free immunosuppression improve the outcome in kidney transplant recipients compared to conventional protocols?

引用

World Journal of Transplantation 2021年第4期11卷 99-113页

作者： ahmed aref Ajay Sharma ahmed Halawa Department of Nephrology Sur hospitalSur 411Oman Department of Transplantation Royal Liverpool University HospitalsLiverpool 111United Kingdom Department of Transplantation Sheffield Teaching HospitalsSheffield S57AUUnited Kingdom

Steroids continue to be the cornerstone of immune suppression since the early days of organ *** are key component of induction protocols,maintenance therapy and in the treatment of various forms of *** steroid use resulted in significant side effects on almost all the body organs owing to the presence of steroid receptors in most of the mammalian *** allograft recipients had to accept the short and long term complications of steroids because of lack of effective *** situation changed with the introduction of newer and more effective immune suppression agents with a relatively more acceptable side effect *** a result,the clinicians have been contemplating if it is the time to abandon the unquestionable reliance on maintenance steroids in modern transplantation *** review aims to evaluate the safety and efficacy of various steroid-minimization approaches(steroid avoidance,early steroid withdrawal,and late steroid withdrawal)in kidney transplant recipients.A meticulous electronic search was conducted through the available data resources like SCOPUS,MEDLINE,and Liverpool University library *** articles obtained through our search were included.A total number of 90 articles were eligible to be included in this review[34 randomised controlled trials(RCT)and 56 articles of other research modalities].All articles were evaluating the safety and efficacy of various steroidfree approaches in comparison to maintenance *** will cover only the RCT articles in this *** used in right clinical context,steroid-free protocols proved to be comparable to steroid-based maintenance *** appropriate approach should be tailored individually according to each recipient immunological challenges and clinical condition.

关键词： Kidney transplantation Steroid free Immune suppression Steroid avoidance Steroid withdrawal Outcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pancreatic transplantation: Brief review of the current evidence

引用

World Journal of Transplantation 2019年第4期9卷 81-93页

作者： ahmed aref Tariq Zayan Ravi Pararajasingam Ajay Sharma ahmed Halawa Department of Nephrology Sur HospitalSur 411Oman Faculty of Health and Science Institute of Learning and TeachingUniversity of LiverpoolLiverpool L69 3GBUnited Kingdom Department of Transplantation Sheffield Teaching HospitalsSheffield S5 7AUUnited Kingdom Renal Medicine Royal Liverpool University HospitalsLiverpool L7 8XPUnited Kingdom Department of Transplantation Surgery Sheffield Teaching HospitalsSheffield S5 7AUUnited Kingdom

Kidney transplantation is the treatment of choice for management of end-stage renal ***,in diabetic patients,the underlying metabolic disturbance will persist and even may get worse after isolated kidney *** transplantation in humans was first introduced in *** initial outcome was ***,this was changed after the improvement of surgical techniques together with better patient selection and the availability of potent and better-tolerated immune-suppression like cyclosporine and induction *** kidney and pancreas transplantation will not only solve the problem of organ failure,but it will also stabilise or even reverse the metabolic complications of *** kidney and pancreas transplantation have the best long term outcome in diabetic cases with renal ***,at the cost of an initial increase in morbidity and risk of *** transplantation options include pancreas after kidney transplantation and islet cell *** aim by this work to explore various options which can be offered to a diabetic patient with advanced chronic kidney *** work will provide a simplified,yet up-to-date information regarding the different management options for those diabetic chronic kidney failure patients.

关键词： Combined kidney pancrease transplantation Renal transplantation Diabetic kidney disease Diabetes mellitus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Smoking in Renal Transplantation; Facts Beyond Myth

引用

World Journal of Transplantation 2017年第2期7卷 129-133页

作者： ahmed aref Ajay Sharma ahmed Halawa Department of Nephrology Sur hospital Faculty of Health and Science Institute of Learning and TeachingUniversity of Liverpool Royal Liverpool University Hospital Liverpool L7 8XPUnited Kingdom

Smoking is one of the preventable leading causes of death worldwide. Most of the studies focused on the association between smoking and cardiovascular disease, pulmonary diseases, malignancy and death. However, the direct effect of smoking on the renal system was undermind. There are emerging evidence correlating tobacco use with pathological changes in the normal kidneys. The effect is more obvious on the renal allograft most probably due to the chronic immune suppression status and the metabolic effect of the drugs. Several studies have documented a deleterious effect of smoking on the renal transplant recipients. Smoking was associated with lowering patient and graft survival. Smoking cessation proved to improve graft survival and to a lesser extent recipient survival. Even receiving a renal transplant from a smoker donor increases the risk of death for the recipient and carries a poorer graft survival compared to non-smoking donors. Most of the studies investigating the effect of smoking were based on self-reporting questioners, which may be misleading due to poor recall or the desire to give socially acceptable answers. This made the need of a reliable biomarker of ultimate importance. Cotinine was proposed as a promising biomarker that may help to provide objective evidence regarding the status of smoking and the dose of nicotine exposure, yet there are still some limitations of its use. The aim of this work is to review the current evidence to improve our understanding of this critical topic. Indeed, this will help to guide better-designed studies in the future.

关键词： smoking kidney donor kidney recipient renal transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Utility of central venous pressure measurement in renal transplantation: Is it evidence based?

引用

World Journal of Transplantation 2018年第3期8卷 61-67页

作者： ahmed aref Tariq Zayan Ajay Sharma ahmed Halawa Department of Nephrology Sur hospital Faculty of Health and Science Institute of Learning and Teaching University of Liverpool Department of Transplantation Surgery Royal Liverpool University Hospital Department of Transplantation Surgery Sheffield Teaching Hospitals

Adequate intravenous fluid therapy is essential in renal transplant recipients to ensure a good allograft perfusion. Central venous pressure(CVP) has been cons-idered the corners-tone to guide the fluid therapy for decades; it was the only available simple tool worldwide. However, the revolutionary advances in assessing the dynamic preload variables together with the availability of new equipment to precisely measure the effect of intravenous fluids on the cardiac output had created a question mark on the future role of CVP. Des-pite the critical role of fluid therapy in the field of tra-nsplantation. There are only a few clinical studies that compared the CVP guided fluid therapy with the other modern techniques and their relation to the outcome in renal transplantation. Our work sheds some light on the available published data in renal transplantation, together with data from other disciplines evaluating the utility of central venous pressure measurement. Although lager well-designed studies are still required to consolidate the role of new techniques in the field of renal transplantation, we can confidently declare that the new techniques have the advantages of providing more accurate haemodynamic assessment, which results in a better patient outcome.

关键词： Fluid monitoring Central venous pressure Renal transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr2TiAlC2 saturable absorber

引用

Optoelectronics Letters 2025年第1期21卷 7-12页

作者： ahmed Shakir AL-HITI Hiba HASSAN Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of MAX phase material, chromium titanium aluminum carbide（Cr2TiAlC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

引用

Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implementation of a Petrographical and Petrophysical Workflow Protocol for Studying the Impact of Heterogeneity on the Rock Typing and Reservoir Quality of Reefal Limestone:A Case Study on the Nullipore Carbonates in the Gulf of Suez

引用

Acta Geologica Sinica(English Edition) 2021年第5期95卷 1746-1762页

作者： Mona G.SAFA Bassem S.NABAWY ahmed M.K.BASAL Mohammad A.OMRAN aref LASHIN Geology Department Faculty of ScienceDamietta UniversityNew Damietta CityEgypt Department of Geophysical Sciences National Research CentreDokkiCairoEgypt Petroleum and Natural Gas Engineering Department College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia Benha University Faculty of ScienceGeology DepartmentBenhaEgypt

This study focuses on the heterogeneity of the middle Miocene syn-rift Belayim nullipore(reefal)marine sequences in the Gulf of Suez and its impacts on reservoir *** sequences consist of coralline algal reef limestones with a highly complex dual-porosity system of primary and secondary porosities of widely varying *** achieve a precise mathematical modeling of these reservoir sequences,a workflow protocol was applied to separate these sequences into a number of hydraulic flow units(HFUs)and reservoir rock types(RRTs).This has been achieved by conducting a conventional core analysis on the nullipore marine *** illustrate the heterogeneity of the nullipore reservoir,the Dykstra-Parsons coefficient(V)has been estimated(V=0.91),indicating an extremely heterogeneous reservoir.A slight to high anisotropy(λ_(k))has been assigned for the studied nullipore sequences.A stratigraphic modified Lorenz plot(SMLP)was applied to define the optimum number of HFUs and barriers/baffles in each of the studied *** the permeability-porosity,reservoir quality index-normalized porosity index(RQI-NPI)and the RQI-flow zone indicator(RQIFZI)plots,the discrete rock types(DRT)and the R35 techniques enable the discrimination of the reservoir sequences into 4 RRTs/*** RRT4 packstone samples are characterized by the best reservoir properties(moderate permeability anisotropy,with a good-to-fair reservoir quality index),whereas the RRT1 mudstone samples have the lowest flow and storage capacities,as well as the tightest reservoir quality.

关键词： reservoir heterogeneity nullipore rock typing hydraulic flow units Dykstra-Parsons coefficient stratigraphic modified Lorenz plot(SMLP)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic Interaction Analysis of Coupled Axial-Torsional-Lateral Mechanical Vibrations in Rotary Drilling Systems

引用

Structural Durability & Health Monitoring 2025年第1期19卷 77-103页

作者： Sabrina Meddah Sid ahmed Tadjer Abdelhakim Idir Kong Fah Tee Mohamed Zinelabidine Doghmane Madjid Kidouche Applied Automation Laboratory Faculty of Hydrocarbons and ChemistryUniversity of BoumerdesBoumerdes35000Algeria Institute of Electrical and Electronic Engineering(IGEE) University of BoumerdesBoumerdes35000Algeria Laboratory of the Electrification of Industrial Enterprises University of BoumerdesBoumerdes35000Algeria Electrical Engineering Department Mohamed Boudiaf University of M’silaM’sila28000Algeria Department of Civil and Environmental Engineering King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Construction and Building Materials King Fahd University of Petroleum&Minerals(KFUPM)Dhahran31261Saudi Arabia

Maintaining the integrity and longevity of structures is essential in many industries,such as aerospace,nuclear,and *** achieve the cost-effectiveness of large-scale systems in petroleum drilling,a strong emphasis on structural durability and monitoring is *** study focuses on the mechanical vibrations that occur in rotary drilling systems,which have a substantial impact on the structural integrity of drilling *** study speciﬁcally investigates axial,torsional,and lateral vibrations,which might lead to negative consequences such as bit-bounce,chaotic whirling,and high-frequency *** events not only hinder the efﬁciency of drilling but also lead to exhaustion and harm to the system’s components since they are difﬁcult to be detected and controlled in real *** study investigates the dynamic interactions of these vibrations,speciﬁcally in their high-frequency modes,usingﬁeld data obtained from measurement while ***ﬁndings have demonstrated the effect of strong coupling between the high-frequency modes of these vibrations on drilling sys-tem *** obtained results highlight the importance of considering the interconnected impacts of these vibrations when designing and implementing robust control ***,integrating these compo-nents can increase the durability of drill bits and drill strings,as well as improve the ability to monitor and detect ***,by exploiting theseﬁndings,the assessment of structural resilience in rotary drilling systems can be ***,the study demonstrates the capacity of structural health monitoring to improve the quality,dependability,and efﬁciency of rotary drilling systems in the petroleum industry.

关键词： Rotary drilling systems mechanical vibrations structural durability dynamic interaction analysis ﬁeld data analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Monitoring of coastline changes along the Red Sea,Yemen based on remote sensing technique

引用

Global Geology 2011年第4期14卷 241-248页

作者： aref A.Sagheer ahmed Humade aref M.O.Al-Jabali Marine Science and Environment Faculty Hodeidah UniversityYemen Geological Survey and Mineral Resources Board Sana'aYemen

The coastline changes along Yemen＇s the Red Sea （Al-muka, Al-khohah, Al-tiaf, Ras Katib and Al- Urji spits） were studied using a series of landsat images （MSS, TM and ETM ＋ , 1972, 1989, 2000, 2006）, coupled with geomorphological, sedimentological and meteorological findings. Comparison of satellite images provided a viable means for establishing long-term coastal changes （accretion and erosion） as observed in the studied spits （Al-Urj, Ras Sham, Ras Maemoon, Ras Katib, Al-Mandar, Nukhaylah, Mujamilah, Ras Ashab Abu-Zahr and Mukha）. The rate of the spit accretion has the greatest value up to 89 pixel/year corresponding to 72 290 m2/year in Mukha, while the spit erosion shows greatest value up to 131 pixel/year corresponding to 106 404 m2/year in Mujamilab. The patterns of accretion and erosion along the spits depend on the spit direction, natural processes mainly of wave-induced longshore currents, the sediments supply and depth of sea.

关键词： coastline change landsat images Yemen Red Sea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fast photocurable thiol-ene elastomers with tunable biodegradability,mechanical and surface properties enhance myoblast differentiation and contractile function

引用

Bioactive Materials 2021年第7期6卷 2120-2133页

作者： Mohamed Alaa Mohamed aref Shahini Nika Rajabian Julia Caserto ahmed M.A.El-Sokkary Magda A.Akl Stelios T.Andreadis Chong Cheng Department of Chemical and Biological Engineering University at BuffaloThe State University of New YorkBuffaloNY14260USA Chemistry Department College of ScienceMansoura UniversityMansoura35516Egypt Department of Biomedical Engineering University at BuffaloThe State University of New YorkBuffaloNY14260USA Center of Excellence in Bioinformatics and Life Sciences BuffaloNY14263USA

Biodegradable elastomers are important emerging biomaterials for biomedical applications,particularly in the area of soft-tissue engineering in which scaffolds need to match the physicochemical properties of native ***,we report novel fast photocurable elastomers with readily tunable mechanical properties,surface wettability,and *** elastomers are prepared by a 5-min UV-irradiation of thiol-ene reaction systems of glycerol tripentenoate(GTP;a triene)or the combination of GTP and 4-pentenyl 4-pentenoate(PP;a diene)with a carefully chosen series of di-or *** the subsequent application study,these elastomers were found to be capable of overcoming delamination of myotubes,a technical bottleneck limiting the in vitro growth of mature functional *** glycerol-based elastomers supported the proliferation of mouse and human myoblasts,as well as myogenic differentiation into contractile *** notably,while beating mouse myotubes detached from conventional tissue culture plates,they remain adherent on the elastomer *** results suggest that these elastomers as novel biomaterials may provide a promising platform for engineering functional soft tissues with potential applications in regenerative medicine or pharmacological testing.

关键词： Biodegradable elastomers Cell culture substrate Skeletal muscle regeneration Thiol-ene synthesis Tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：