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The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory

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Oncology Research 2024年第6期32卷 1037-1045页

作者： MAHER KURDI alAA alKHOTANI ABDULRAHMAN SABBAGH EYAD FAIZO ahmed I.LARY ahmed K.BAMAGA MAJID alMANSOURI BADR HAFIZ THAMER alSHARIF SalEH BAEESA Department of Pathology Faculty of MedicineKing Abdulaziz UniversityRabighSaudi Arabia Department of Pathology College of MedicineUmm Al-Qura UniversityMakkahSaudi Arabia Department of Surgery Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Surgery Faculty of MedicineUniversity of TabukTabukSaudi Arabia Section of Neurosurgery Department of SurgeryKing Abdulaziz Medical CityJeddahSaudi Arabia Department of Pediatrics Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Clinical Biochemistry Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Neurosciences King Faisal Specialist Hospital and Research CenterJeddahSaudi Arabia Department of Surgery King Abdulaziz Specialist HospitalTaifSaudi Arabia

Background:The dysregulation of Isocitrate dehydrogenase(IDH)and the subsequent production of 2-Hydroxyglutrate(2HG)may alter the expression of epigenetic proteins in Grade 4 *** interplay mechanism between IDH,O-6-methylguanine-DNA methyltransferase(MGMT)-promoter methylation,and protein methyltransferase proteins-5(PRMT5)activity,with tumor progression has never been ***:A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype *** groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR ***-cohort statistical significance was ***:Both IDH-mutant WHO grade 4 astrocytomas(n=22,64.7%)and IDH-wildtype glioblastomas(n=12,35.3%)had upregulated PRMT5 gene expression except in one *** of the 22 IDH-mutant tumors,10(45.5%)tumors showed MGMT-promoter methylation and 12(54.5%)tumors had unmethylated *** IDH-wildtype tumors had unmethylated *** was a statistically significant relationship between MGMT-promoter methylation and IDH in G4 astrocytoma(p-value=0.006).Statistically significant differences in progression-free survival(PFS)were also observed among all G4 astrocytomas that expressed PRMT5 and received either temozolomide(TMZ)or TMZ plus other chemotherapies,regardless of their IDH or MGMT-methylation status(p-value=0.0014).Specifically,IDH-mutant tumors that had upregulated PRMT5 activity and MGMT-promoter methylation,who received only TMZ,have exhibited longer ***:The relationship between PRMT5,MGMT-promoter,and IDH is not ***,accumulation of D2-hydroxyglutarate(2-HG),which partially activates 2-OG-dependent deoxygenase,may not affect their *** IDH-wildtype glioblastomas,the 2HG-2OG pathway is typically inactive,leading to PRMT5 *** alone,compared to TMZ-plus,can increase PFS in upregulated PRMT5 ***,using a PRMT5 inhibitor in G4

关键词： Grade 4 astrocytoma Glioblastoma Isocitrate dehydrogenase(IDH) O-6-methylguanine-DNA methyltransferase(MGMT) Protein methyltransferase proteins-5(PRMT5) Progression-free survival(PFS)

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An Improved Enterprise Resource Planning System Using Machine Learning Techniques

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Journal of Software Engineering and Applications 2024年第5期17卷 203-213页

作者： ahmed Youssri Zakaria Elsayed Abdelbadea Atef Raslan Tarek ali Mervat Gheith al-Sayed Khater Essam A. Amin Department of Software Engineering Faculty of Graduate Studies for Statistical Research (FGSSR) Cairo University Giza Egypt

Traditional Enterprise Resource Planning (ERP) systems with relational databases take weeks to deliver predictable insights instantly. The most accurate information is provided to companies to make the best decisions through advanced analytics that examine the past and the future and capture information about the present. Integrating machine learning (ML) into financial ERP systems offers several benefits, including increased accuracy, efficiency, and cost savings. also, ERP systems are crucial in overseeing different aspects of Human Capital Management (HCM) in organizations. The performance of the staff draws the interest of the management. In particular, to guarantee that the proper employees are assigned to the convenient task at the suitable moment, train and qualify them, and build evaluation systems to follow up their performance and an attempt to maintain the potential talents of workers. also, predicting employee salaries correctly is necessary for the efficient distribution of resources, retaining talent, and ensuring the success of the organization as a whole. Conventional ERP system salary forecasting methods typically use static reports that only show the system’s current state, without analyzing employee data or providing recommendations. We designed and enforced a prototype to define to apply ML algorithms on Oracle EBS data to enhance employee evaluation using real-time data directly from the ERP system. Based on measurements of accuracy, the Random Forest algorithm enhanced the performance of this system. This model offers an accuracy of 90% on the balanced dataset.

关键词： ERP HCM Machine Learning Employee Performance Pythonista Pythoneer

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Surface activation of viscose textiles via air,argon,and oxygen dielectric barrier discharge plasma:influence of peak voltage

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Plasma Science and Technology 2024年第7期26卷 134-147页

作者： Shrouk ELASHRY Usama M.RASHED Mostafa A.WAHBA Hend M.ahmed Nabil M.ELSIRAGY Plasma Laboratory Physics DepartmentFaculty of scienceTanta UniversityTanta 31527Egypt Physics Department Faculty of Science(Male)Al-Azhar UniversityCairo 11651Egypt Textile Research Industrial Division National Research CentreDokkiGiza 12622Egypt

This paper discusses the use of atmospheric pressure dielectric barrier discharge(DBD)plasma treatment to enhance the surface qualities of viscose *** study explores the effects of different plasma gases,discharge voltages,and exposure times on the treated *** findings emphasize the importance of optimizing the plasma's peak voltage to achieve the desired surface treatment *** document also presents data on colour strength,wettability,colour fastness,and tensile strength of the treated fabrics,as well as scanning electron microscopy(SEM)analysis of surface morphology and chemical analysis using fouriertransition infrared spectroscopy(FTIR)and energy dispersive X-ray(EDX).The results show that treatment at a peak voltage of 11.83 k V is more efficient,except for the tensile strength which is enhanced at a peak voltage of 8.92 k *** oxygen plasma treatment significantly improves the colour strength,which exhibits an increase from 11 to *** intensified colour was attributed to the significant influence of electrostatic interactions between the charged hydroxyl groups of the oxygen plasma treated viscose textiles and the dye molecules,which enhance the *** oxygen DBD plasma exhibits a higher ability to enhance the properties of textiles when compared to air and argon *** study presents a sustainable,economical,secure,and ecologically friendly approach to explore new fabrics for specific uses.

关键词： Lissajous diagrams printability wettability tensile strength SEM EDX FTIR

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URL Phishing Detection Using Particle Swarm Optimization and Data Mining

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Computers, Materials & Continua 2022年第12期73卷 5625-5640页

作者： Saeed M.alshahrani Nayyar ahmed Khan Jameel almalki Waleed al shehri College of Computing and IT-Shaqra University Shaqra155572Saudi Arabia Department of Computer Science College of Computer in Al-LeithUmm Al-Qura UniversityMakkahSaudi Arabia

The continuous destruction and frauds prevailing due to phishing URLs make it an indispensable area for *** techniques are adopted in the detection process,including neural networks,machine learning,or hybrid techniques.A novel detection model is proposed that uses data mining with the Particle Swarm Optimization technique(PSO)to increase and empower the method of detecting phishing *** selection based on various techniques to identify the phishing candidates from the URL is *** this approach,the features mined from the URL are extracted using data mining *** features are selected on the basis of URL *** classification of these features identified by the data mining rules is done using PSO *** selection of features with PSO optimization makes it possible to identify phishing *** a large number of rule identifiers,the true positive rate for the identification of phishing URLs is maximized in this *** experiments show that feature selection using data mining and particle swarm optimization helps tremendously identify the phishing URLs based on the structure of the URL ***,it can minimize processing time for identifying the phishing website ***,the approach can be beneficial to identify suchURLs over the existing contemporary detecting models proposed before.

关键词： Phishing particle swarm optimization feature selection data mining classification cloud application

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Heating-Cooling Monitoring and Power Consumption Forecasting Using LSTM for Energy-Efficient Smart Management of Buildings: A Computational Intelligence Solution for Smart Homes

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Tsinghua Science and Technology 2024年第1期29卷 143-157页

作者： Omid Akbarzadeh Sahand Hamzehei Hani Attar Ayman Amer Nazanin Fasihihour Mohammad R.Khosravi ahmed A.Solyman Department of Electronics and Telecommunications Politecnico di TorinoTurin 10129Italy Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 262799China Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNisantası UniversityIstanbul 25370The Republic of Turkiye

Energy management in smart homes is one of the most critical problems for the Quality of Life(QoL)and preserving energy *** of the relevant issues in this subject is environmental contamination,which threatens the world's *** computing-enabled Artificial Intelligence(al)algorithms can provide impactful solutions to this *** research proposes using one of the Recurrent Neural Network(RNN)algorithms known as Long Short-Term Memory(LSTM)to comprehend how it is feasible to perform the cloud/fog/edge-enabled prediction of the building's *** parameters of power electricity,power heating,power cooling,and total power in an office/home in cold-climate cities are considered as our features in the *** on the collected data,we evaluate the LSTM approach for forecasting parameters for the next year to predict energy consumption and online monitoring of the model's performance under various *** implementing the al predictive algorithm,several existing tools are *** results have been generated through simulations,and we find them promisingforfutureapplications.

关键词： design-builder Besos smart cities smart building neural network Long Short-Term Memory(LSTM)

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Diagnostic accuracy of ePOS score in predicting DNR labeling after ICU admission:A prospective observational study(ePOS-DNR)

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Journal of Intensive Medicine 2024年第2期4卷 216-221页

作者： Omar E.Ramadan ahmed F.Mady Mohammed A.al-Odat ahmed N.Balshi ahmed W.aletreby Taisy J.Stephen Sheena R.Diolaso Jennifer Q.Gano Waleed Th.aletreby Department of Critical Care King Saud Medical CityRiyadhSaudi Arabia Anesthesia Department Faculty of MedicineAin Shams UniversityCairoEgypt Anesthesia Department Faculty of MedicineTanta UniversityTantaEgypt Faculty of Medicine Alexandria UniversityAlexandriaEgypt Nursing Department King Saud Medical CityRiyadhSaudi Arabia

Background Resuscitation can sometimes be futile and making a do-not-resuscitate(DNR)decision is in the best interest of the *** electronic poor outcome screening(ePOS)score was developed to predict 6-month poor outcomes of critically ill *** explored the diagnostic accuracy of the ePOS score in predicting DNR decisions in the intensive care unit(ICU).Methods This study was conducted at the ICU of a tertiary referral hospital in Saudi Arabia between March and May ***,we calculated ePOS scores for all eligible consecutive admissions after 48 h in the ICU and recorded the DNR *** ability of the score to predict DNR was explored using logistic ***'s ideal cut-off value was calculated using the DeLong method,and different diagnostic accuracy measures were generated with corresponding 95%confidence intervals(CIs).Results We enrolled 857 patients,125 received a DNR order and 732 did *** average ePOS score of DNR and non-DNR patients was 28.2±10.7 and 15.2±9.7,*** score,as a predictor of DNR order,had an area under receiver operator characteristic(AUROC)curve of 81.8%(95%CI:79.0 to 84.3,Pal cut-off value>17 was associated with a sensitivity of 87.2(95%CI:80.0 to 92.5,Palue of 29.2(95%CI:24.6 to 33.8,Palue of 96.7(95%CI:95.1 to 98.3,P17 may help guide clinical decisions to withhold or commence resuscitative measures.

关键词： Do-not-resuscitate(DNR) Resuscitation Intensive care unit(ICU) Diagnostic accuracy Sensitivity Specificity

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Kaoline-based catalyst for a high stability desulfurization of sour heavy naphtha in a three-phase oscillatory baffled reactor

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Particuology 2024年第1期84卷 249-260页

作者： Hassan M.Hmood Saba A.Gheni Safaa M.R.ahmed Mudheher M.ali Hamid Yonis Saleh Mohammed H.Mohammed Awad E.Mohammed Marwan A.Mahomood Hiba R.Mohammed ahmed A.Hassan Adam Harvey North Refineries Company Ministry of OilIraq Chemical Engineering Department Tikrit UniversityIraq Ministry of Oil Iraq al-Hawija Technical Institute Northern Technical UniversityMoselIraq School of Engineering Newcastle UniversityUK

To meet the rapidly increasing demand for energy and the dramatic depletion of conventional crude oil,it is imperative to utilize sour *** no coke being produced,oxidative desulfurization(ODS)of naphtha lowers its sulfur content and average molecular *** this article,we outline a method for heavy naphtha non-extractive ODS using a very stable *** technique involves the use of a solid catalyst with oxygen gas as the *** necessitated relatively high mixing intensities;hence a three-phase Oscillatory Baffled Reactor(OBR)was *** catalyst was based on the zeolite ZSM-5,prepared from natural kaolin by a series of delamination and activation steps and impregnated with Fe.A TiO2 nanolayer was applied,using the sol-gel method,to prevent rapid *** reactor performance was evaluated to minimize the sulfur content in the naphtha *** to the protective coating,the sulfur conversion stabilized at 90%.The results of this work establish the use of natural clay-based catalysts in a continuous,three-phase ODS,particularly with regard to proving long-term *** also showed that modest ODS can be achieved using an environmentally friendly oxidant,at mild operating conditions,whilst maintaining stability.

关键词： Natural kaoline Desulfurization Three-phase Oscillatory baffled reactor

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Phytochemical profiling and anticancer potential of Cymbopogon citratus extract

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Asian Pacific Journal of Tropical Biomedicine 2024年第10期14卷 448-460页

作者： Bader O.almutairi Mikhlid H.almutairi Badr A.al-Dahmash Saad alkahtani Saud alarifi ahmed Rady Department of Zoology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

Objective:To evaluate the anticancer potential of Cymbopogon citratus ***:GC-MS analysis was used to identify phytocomponents in the methanolic extract of Cymbopogon citratus.A fractionation method was employed to isolate and assess the bioactivity of different fractions and their cytotoxic activities against cancer cell lines HCT116,LoVo,Caco-2,and HT-29 were investigated.A dual staining method with acridine orange and ethidium bromide was used to assess the effect of the extract on cell ***,the expression levels of Bax and TP53 were quantified using real-time PCR in Caco-2 cells treated with the ethyl acetate fraction of Cymbopogon citratus extract.A protein array was employed to profile key pro-and anti-apoptotic proteins in Caco-2 ***,molecular docking studies were conducted to investigate the interactions between key compounds of Cymbopogon citratus extract and specific apoptosis-related protein domains(PDB IDs:7wql and 4bkx).Results:A significant growth inhibition was observed in Caco-2 cells treated with Cymbopogon citratus *** the seven fractions of the plant extract,the ethyl acetate fraction showed the highest cytotoxicity against Caco-2 cells with an IC50 value of(6.16±0.01)μg/*** immunofluorescence assay showed that the ethyl acetate fraction could induce apoptosis of Caco-2 ***,the fraction upregulated the gene expressions of Bax and TP53 in a dose-dependent *** docking analysis demonstrated the interaction of five compounds isolated from the ethyl acetate fraction with key proteins in Caco-2 cells,indicating their anticancer ***:Cymbopogon citratus extract shows anticancer activity against Caco-2 cells by inducing *** may be a promising candidate for the treatment of colon cancer,which needs further investigation.

关键词： Cymbopogon citratus Anticancer Caco-2 cell Apoptosis Colon cancer

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Surface morphology and cell viability of samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide/polycaprolactone targeting wound dressing

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Journal of Rare Earths 2024年第3期42卷 555-561,I0005页

作者： Muteb H.alshammari ahmed Onayzan alshammari Mohamed Tharwat Elabbasy Rafat Zreiq Faris Mohammed albati M.A.El-Morsy A.A.Menazea Department of Health Informatics College of Public Health and Health InformaticsUniversity of Ha'ilHa'ilSaudi Arabia Department of Surgery College of MedicineUniversity of Ha'ilHa'ilSaudi Arabia Department of Public Health College of Public Health and HealthInformaticsHalUniversityHa'il2440Saudi Arabi Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Applied Science Research Center Applied Science Private UniversityAmman541350Jordan College of Shariah and Law Ha'il UniversityHa'il2440Saudi Arabia College of Science and Humanities in al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamittaNew Damietta34517.Egyp Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt

Combinations of metal and lanthanide oxides have been done through casted films for potential medical applications. In this regard, samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide(GO)/polycaprolactone(PCL) based films nano-composites(NCs) were fabricated, pointing their utilization as a biological scaffold for wound dressing purposes. also, samarium(Ⅲ) oxide and chromium(Ⅲ) oxide have been merged as promising optical constituents due to their unique optical behavior. The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD), Raman, and field emission scanning electron microscopy(FESEM). The Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL NC exhibits a surface with a lower roughness degree owing to the presence of GO. Cr_(2)O_(3)shows size reduction upon GO insertion to reach 1.2 μm as the average grain size, whilst Sm_(2)O_(3)records an average grain size of less than 1 μm. As well, the polymeric nano-compositions exhibit variation in contact angle values that hit 29.76°± 3.52°for Sm_(2)O_(3)/PCL, and 48.62°± 1.37°for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL as the second lowest contact angle. The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCL, to 2.65 eV for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL. Regarding biological responses, the cell exposed to 2.5 μg/m L of Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL shows cell viability of 119.31%, while 5 μg/m L hits 99.6%. Additionally, the resulting cell attachment micrographs show layers of fibroblast tissue, besides the proliferation and growth of cultivated cells. Thus, the Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.

关键词： Wound healing Wound dressing Polycaprolactone Sm_(2)O_(3) Cr_(2)O_(3) Rare earths

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Optoelectronic and thermoelectric properties of spinel chalcogenides HgLa2X4（X=S and Se）:A first-principles study

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Journal of Rare Earths 2024年第10期42卷 1927-1936页

作者： Aparna Dixit Inas A.ahmed Jisha Annie Abraham Zeinhom M.El-Bahy Mumtaz Manzoor Sajad Ahmad Dar Ramesh Sharma Department of Basic Science and Humanities Pranveer Singh Institute of Technology Department of Chemistry Faculty of ScienceKing Khalid University Department of Physics National Defence Academy Department of Chemistry Faculty of ScienceAl-Azhar University Institute of Physics Slovak Academy of Sciences Department of Physics Motilal Vigyan Mahavidyalya College Department of Applied Science Feroze Gandhi Institute of Engineering and Technology

We investigated spinel chalcogenides HgLa2（S/Se）4by using density function theory,and scrutinized the structural,optical,electrical,mechanical and thermoelectric transport characteristics of HgLa2（S/Se）4spinel *** enthalpy of formation,energy of cohesion,and energy volume optimum plots were used to obtain the stability as well as the perfect ground state of these *** ductility of these materials was the best illustrated with the help of Poisson's and Pugh's *** band gap results were obtained using Trans and Blaha modified Becke-Johanson potential（TB-mBJ）.Both the materials present semi-conducting nature with direct band gap equal to 1.449 and 0.892 eV respectively for HgLa2S4and *** were also made for optical characteristics with the values of dielectric function,absorption coefficient,optical conductivity,reflectivity,and refractive *** to the findings,both of these materials are suitable for infrared optoelectronic *** materials were found to have promising optoelectronic and thermoelectric applications after their optical properties and transport aspects were *** tiny levels of temperature conductivities,substantial am ounts of power conductivities,the figure of merit（more than unity）,as well as Seebecs coefficients all point to the potential use of both the materials in thermoelectric power generators.

关键词： Density functional theory Direct band gap Optoelectronic Power factor Semiconductors Thermoelectric

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