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Efficacy of Essential Trace Elements Supplementation on Mineral Composition,Sperm Characteristics,Antioxidant Status,and Genotoxicity in Testis of Tebuconazole-treated Rats

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Biomedical and Environmental Sciences 2020年第10期33卷 760-770页

作者： Hajer BEN SAAD Fatma BEN ABDALLAH Intidhar BKHAIRIA Ons BOUDAWARA Moncef NASRI ahmed hakim Ibtissem BEN AMARA Laboratory of Enzyme engineering and Microbiology National Engineering School in SfaxUniversity of SfaxB.P.11733038 SfaxTunisia Laboratory of Human Molecular Genetics Faculty of Medicine ofSfaxUniversity of SfaxTunisia Laboratory of Anatomopathology CHU Habib BourguibaUniversity of Sfax3029 SfaxTunisia Laboratory of Pharmacology Faculty of Medicine3029 SfaxUniversity of SfaxTunisia

Objective This research was performed to evaluate the effect of tebuconazole(TBZ)on reproductive organs of male rats and to assess the protective role of combined essential trace elements in alleviating the detrimental effect of TBZ on male reproductive *** For this purpose,48 rats were exposed to 100 mg/kg TBZ,TBZ supplemented with zinc(Zn),selenium(Se),copper(Cu),and iron(Fe),TBZ+(Se+Zn);TBZ+Cu;or TBZ+*** experiment was conducted for 30 consecutive *** TBZ caused a significant perturbation in mineral levels and reduction in reproductive organs weights,plasma testosterone level,and testicular antioxidant enzyme *** TBZ-treated group also showed a significant increase in sperm abnormalities(count,motility,and viability percent),plasma follicle-stimulating hormone and luteinizing hormone concentrations,lipid peroxidation,protein oxidation,and severe DNA degradation in comparison with the ***,TBZ caused testis ***,treatment with trace elements,in combination or alone,improved the reproductive organ weights,sperm characteristics,TBZ-induced toxicity,and histopathological modifications in *** TBZ exerts significant harmful effects on male reproductive *** concurrent administration of trace elements reduces testis dysfunction,fertility,and toxicity induced by TBZ.

关键词： Zinc Selenium Iron Copper Testicular toxicity

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Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats:Modulatory Effects of Selenium and/or Vitamin E

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Biomedical and Environmental Sciences 2012年第3期25卷 340-351页

作者： Ibtissem Ben AMARA Nejla SOUDANI Afef TROUDI ahmed hakim Khaled Mounir ZEGHAL Tahia BOUDAWARA Najiba ZEGHAL Animal Physiology Laboratory Faculty of ScienceBP11713000 SfaxUniversity of SfaxTunisia Laboratory of Pharmacology Faculty of Medicine3029 SfaxUniversity of Sfax Tunisi Anatomopathology Laboratory CHU Habib Bourguiba 3029 SfaxUniversity of SfaxTunisia

Objective To determine the efficiency of selenium and/or vitamin E to alleviate lung oxidative damage induced by dimethoate, an organophosphorus compound. Methods Adult Wistar rats were exposed during 30 days either to dimethoate （0.2 g/L of drinking water）, dimethoate＋selenium （0.5 mg/kg of diet）, dimethoate＋vitamin E （100 mg/kg of diet）, or dimethoate＋selenium＋vitamin E. Results Exposure to dimethoate caused oxidative stress in lung evidenced by an increase of malondialdehyde, protein carbonyl groups and advanced oxidation protein products. An increase in glutathione peroxidase, superoxide dismutase, catalase and a decrease in acetylcholinesterase and butyrylcholinesterase activities, glutathione, non-protein thiols and vitamins C levels were observed. Histopathological changes in lung tissue were noted as emphysema, hemorrhages and hemosiderin deposits. Co-administration of selenium or vitamin E to the diet of dimethoate treated rats ameliorated the biochemical parameters as well as histological impairments. The joint effect of these elements was more powerful in antagonizing dimethoate-induced lung oxidative damage. Conclusion We concluded that selenium and vitamin E ameliorated the toxic effects of this pesticide in lung tissue suggesting their role as potential antioxidants.

关键词： Dimethoate Selenium Vitamin E Rats Lung Antioxidant status Histopathological studies

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Potassium Bromate-induced Changes in the Adult Mouse Cerebellum Are Ameliorated by Vanillin

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Biomedical and Environmental Sciences 2018年第2期31卷 115-125页

作者： Hajer Ben Saad Dorra Driss Imen Jaballi Hanen Ghozzi Ons Boudawara Michael Droguet Christian Magne Monsef Nasri Khaled Mounir Zeghal ahmed hakim Ibtissem Ben Amara Laboratory of Pharmacology University of SfaxFaculty of Medicine3029 SfaxTunisia Laboratory of Enzyme engineering and Microbiology National Engineering School in SfaxUniversity of SfaxB.P.11733038 SfaxTunisia Centre of Biotechnology of Sfax P.O.Box 11773018 SfaxTunisia Anatomopathology Laboratory University of SfaxHabib Bourguiba Hospital3029 SfaxTunisia EA 4324 ORPHY Faculty of MedicineUniversity of Brest29238 Brest CedexFrance EA 2219 Geoarchitecture University of BrestUFR Sciences&Techniques29238 Brest Cedex 3France

Objective The current study aimed to elucidate the effect of vanillin on behavioral changes, oxidative stress, and histopathological changes induced by potassium bromate （KBrO3）, an environmental pollutant, in the cerebellum of adult *** The animals were divided into four groups： group 1 served as a control, group 2 received KBrO3, group 3 received KBrO3 and vanillin, and group 4 received only vanillin. We then measured behavioral changes, oxidative stress, and molecular and histological changes in the *** We observed significant behavioral changes in KBrO3-exposed mice. When investigating redox homeostasis in the cerebellum, we found that mice treated with KBrO3 had increased lipid peroxidation and protein oxidation in the cerebellum. These effects were accompanied by decreased Na＋-K＋ and Mg2＋ ATPase activity and antioxidant enzyme gene expression when compared to the control group. Additionally, there was a significant increase in cytokine gene expression in KBrO3-treated mice. Microscopy revealed that KBrO3 intoxication resulted in numerous degenerative changes in the cerebellum that were substantially ameliorated by vanillin supplementation. Co-administration of vanillin blocked the biochemical and molecular anomalies induced by *** Our results demonstrate that vanillin is a potential therapeutic agent for oxidative stress associated with neurodegenerative diseases.

关键词： Cerebellum Behavior Potassium bromate Vanillin ATPases Genes expression

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Model variables identification of a gas turbine using a subspace approach based on input/output data measurements

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Control Theory and Technology 2021年第2期19卷 183-196页

作者： hakim Bagua ahmed Hafaifa Abdelhamid Iratni Mouloud Guemana Applied Automation and Industrial Diagnostics Laboratory Faculty of Science and TechnologyUniversity of Djelfa17000DjelfaAlgeria Gas Turbine Joint Research Team University of Djelfa17000DjelfaAlgeria Faculty of Science and Technology University of Bordj Bou Arreridj34000Bordj Bou ArreridjAlgeria

This paper deals with a state model identification of a gas turbine used for gas transport, using a subspace approach of the state space model. This method provides a reliable and robust state representation of the model, taking advantage of its benefits in the control, monitoring, and supervision of this machine. The model for each variable is set so that the state matrices associated with the gas turbine model are determined from their real input/output data. The comparison of the obtained identification results with those of the actual turbine operation serves to validate the proposed model in this work. This numerical algorithm of the subspace identification method is full of information and more accurate in terms of residual modeling error, and expresses a very high level of confidence in the identified turbine system dynamics. Hence, the controllability and observability tests of turbine operation for different input/output variables allowed to validate the real-time operating stability of the turbine.

关键词： System identification Subspace identification State space model Gas turbine N4SID algorithm

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Current Status and Outlook of Porous Zn-based Scaffolds for Bone Applications: A Review

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Journal of Bionic Engineering 2022年第3期19卷 737-751页

作者： Abdul hakim Md Yusop Mokhamad Fakhrul Ulum ahmed Al Sakkaf Hadi Nur Center for Sustainable Nanomaterials Ibnu Sina Institute for Scientific and Industrial ResearchUniversiti Teknologi Malaysia81310Johor BharuMalaysia Faculty of Veterinary Medicine Bogor Agricultural UniversityBogor16680Indonesia School of Mechanical Engineering Universiti Teknologi Malaysia81310Johor BharuMalaysia Center of Advanced Materials for Renewable Energy(CAMRY) Universitas Negeri MalangMalang65145Indonesia

Over the past 5 years,many works have been performed to reveal the potentials of Zinc(Zn)-based materials as temporary bone scaffolds with the expectation that their emergence could address some of the main concerns associated with magnesium-and iron-based *** to the emerging Additive Manufacturing(AM)technology,it facilitates the optimization of the design and production of topological porous Zn-based materials suited for bone *** the studies on the porous Zn-based scaffolds are on the rise,we provide the most current progress in the development of porous Zn-based scaffolds for bone *** impacts of recently developed topological design from the AM as well as the advanced dynamic-flow corrosion on their corrosion,mechanical properties,and in vitro biocompatibility are also ***,we identify a number of research gaps and the challenges encountered in adopting porous Zn-based scaffolds for orthopedic applications and suggest some promising areas for future research.

关键词： Porous Zn Corrosion Mechanical properties In vitro biocompatibility Additive manufacturing

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Graph-Based Feature Learning for Cross-Project Software Defect Prediction

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Computers, Materials & Continua 2023年第10期77卷 161-180页

作者： ahmed Abdu Zhengjun Zhai hakim A.Abdo Redhwan Algabri Sungon Lee School of Software Northwestern Polytechnical UniversityXi’anChina School of Computer Science Northwestern Polytechnical UniversityXi’anChina Department of Computer Science Hodeidah UniversityPO Box 3114Al-HudaydahYemen Research Institute of Engineering and Technology Hanyang UniversityAnsanKorea Department of Robotics Hanyang UniversityAnsanKorea

Cross-project software defect prediction(CPDP)aims to enhance defect prediction in target projects with limited or no historical data by leveraging information from related source *** existing CPDP approaches rely on static metrics or dynamic syntactic features,which have shown limited effectiveness in CPDP due to their inability to capture higher-level system properties,such as complex design patterns,relationships between multiple functions,and dependencies in different software projects,that are important for *** paper introduces a novel approach,a graph-based feature learning model for CPDP(GB-CPDP),that utilizes NetworkX to extract features and learn representations of program entities from control flow graphs(CFGs)and data dependency graphs(DDGs).These graphs capture the structural and data dependencies within the source *** proposed approach employs Node2Vec to transform CFGs and DDGs into numerical vectors and leverages Long Short-Term Memory(LSTM)networks to learn predictive *** process involves graph construction,feature learning through graph embedding and LSTM,and defect *** evaluation using nine open-source Java projects from the PROMISE dataset demonstrates that GB-CPDP outperforms state-of-the-art CPDP methods in terms of F1-measure and Area Under the Curve(AUC).The results showcase the effectiveness of GB-CPDP in improving the performance of cross-project defect prediction.

关键词： Cross-project defect prediction graphs features deep learning graph embedding

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Adsorption and desorption of acetone by TiO_(2) clusters:Transition state theory and sensing analysis

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ChemPhysMater 2023年第4期2卷 351-355页

作者： Mudar ahmed Abdulsattar Tasneem Hassan Mahmood Hussein hakim Abed Hayder M.Abduljalil Department of Pharmacy Al-Rasheed University CollegeBaghdad 10011Iraq Ministry of Science and Technology Baghdad 10011Iraq Department of Physics College of Science for WomenUniversity of BaghdadBaghdad 10011Iraq Department of Physics College of ScienceUniversity of BabylonBabylon 51005Iraq

TiO_(2) cluster sensitivity to acetone adsorption using transition state theory is ***_(10)O_(20) cluster is used to perform the calculations using density functional theory with dispersion *** state and transition state are calculated via thermodynamic energies,i.e.,Gibbs free energy of adsorption and *** rate,response,response time,and recovery time as a function of temperature and acetone concentration are *** burning in the air due to autoignition is considered using a logistic *** results of the theory are compared with available experimental findings that revealed the quality of both theoretical and experimental *** response time decreases with respect to acetone *** the other hand,the recovery time in the desorption phase increases with acetone *** temperature of maximum response is 356℃,while the maximum response value is 2.9.

关键词： TiO_(2) Acetone Transition state Sensor Density functional theory

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Ultralong hydroxyapatite-based forward osmosis membrane for freshwater generation

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 37-49页

作者： Mohamed Gamal Gomaa Hamdy Maamoun Abdel-Ghafar Francesco Galiano Francesca Russo Alberto Figoli El-Sayed Ali Abdel-Aal Abdel-hakim Taha Kandil Bahaa ahmed Salah Central Metallurgical Research and Development Institute(CMRDI) 11421 CairoEgypt Chemistry Department Faculty of ScienceHelwan University11795 CairoEgypt Institute on Membrane Technology(CNR-ITM) 87036 RendeItaly

Increasing global water shortages are accelerating the pace of membrane manufacturing,which generates many environmentally harmful *** challenges need a radical rethink of developing innovative membranes that can address freshwater production without generating environmentally harmful *** work utilized the synthesized ultra-long hydroxyapatite(UHA)by the solvothermal method using the green solvent oleic acid in preparing UHA-based forward osmosis *** membranes were developed using different loading ratios of graphene oxide(GO)by vacuum-assisted filtration *** prepared GO/UHA membranes were identified using X-ray diffraction,scanning electron microscope,Fourier-transform infrared spectroscopy,and X-ray photoelectron *** contact angle and pore size distribution were determined for the obtained GO/UHA *** obtained hierarchical porous structure in the prepared membranes with interconnected channels results in a stable water flux with reverse salt *** best water flux rate of 42±2 L·m^(–2)·h^(–1)was achieved using the 50 mg GO/UHA membrane,which is 3.3 times higher than the pristine membrane,and a reverse salt flux of 67 g·m^(-2)·h^(–1).The obtained results showed a promising capability of a new generation of sustainable inorganic-based membranes that can be utilized in freshwater generation by energy-efficient techniques such as forward osmosis.

关键词： forward osmosis ultra-long hydroxyapatite graphene oxide inorganic-based membrane

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Role of endoscopic ultrasound in pediatric patients: A single tertiary center experience and review of the literature

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World Journal of Gastrointestinal Endoscopy 2020年第10期12卷 355-364页

作者： ahmed Youssef Altonbary Hazem hakim Wagdi Elkashef Department of Gastroenterology and Hepatology Mansoura Specialized Medical HospitalMansoura UniversityMansoura 35516Egypt Department of Pathology Mansoura UniversityMansoura 35111Egypt

BACKGROUND Although endoscopic ultrasound(EUS)is now widely available and has an established role in adults,the utility of EUS and EUS-guided fine needle aspiration(EUS-FNA)in pediatrics is insufficiently described compared to adults and is supported by only a few *** To report the experience of a single tertiary center in the use of EUS and EUS-FNA in a pediatric population and to further assess its safety,feasibility,and clinical impact on *** A retrospective study of 13 children(aged 18 years or younger)identified from our medical database was conducted.A retrospective review of demographic data,procedure indications,EUS findings,and the clinical impact of EUS on the subsequent management of these patients was *** During the 4-year study period,a total of 13(1.7%)pediatric EUS examinations out of 749 EUS procedures were performed in our *** mean age of these 8 females and 5 males was 15.6 years(range:6-18).Six of the 13 EUS examinations were pancreatobiliary(46.1%),followed by mediastinal 2/13(15.4%),peri-gastric 2/13(15.4%),abdominal lymphadenopathy 1/13(7.7%),tracheal 1/13(7.7%)and rectal 1/13(7.7%).Overall,EUS-FNA was performed in 7 patients(53.8%)with a diagnostic yield of 100%.The EUS results had a significant impact on clinical care in 10/13(77%)*** complications occurred in these patients during or after any of the *** EUS and EUS-FNA in the pediatric population are safe,feasible,and have a significant clinical impact on the subsequent management;thus avoiding invasive and unnecessary procedures.

关键词： Endoscopic ultrasound Endoscopic ultrasound-guided fine needle aspiration Pediatric

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Pancreatic injury in patients with septic shock: A literature review

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World Journal of Gastrointestinal Oncology 2016年第7期8卷 526-531页

作者： Anis Chaari Karim Abdel hakim Kamel Bousselmi Mahmoud Etman Mohamed El Bahr ahmed El Saka Eman Hamza Mohamed Ismail Elsayed Mahmoud Khalil Vipin Kauts William Francis Casey Department of Intensive Care King Hamed University Hospital

Sepsis and septic shock are life threatening condition associated with high mortality rate in critically-ill patients. This high mortality is mainly related to the inadequacy between oxygen delivery and cellular demand leading to the onset of multiorgan dysfunction. Whether this multiorgan failure affect the pancreas is not fully investigated. In fact, pancreatic injury may occur because of ischemia, overwhelming inflammatory response, oxidative stress, cellular apoptosis and/or metabolic derangement. Increased serum amylase and/or lipase levels are common in patients with septic shock. However, imaging test rarely reveal significant pancreatic damage. Whether pancreatic dysfunction does affect the prognosis of patients with septic shock or not is still a matter of debate. In fact, only few studies with limited sample size assessed the clinical relevance of the pancreatic injury in this group of patients. In this review, we aimed to describe the epidemiology and the physiopathology of pancreatic injury in septic shock patients, to clarify whether it requires specific management and to assess its prognostic value. Our main finding is that pancreatic injury does not significantly affect the outcome in septic shock patients. Hence, increased serum pancreatic enzymes without clinical features of acute pancreatitis do not require further imaging investigations and specific therapeutic intervention.

关键词： Septic shock Pancreas Lipase Amylase Prognosis

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