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Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina（Forssk.） Fiori in cervical and prostate cancer cell lines

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Journal of Integrative Medicine 2019年第6期17卷 410-422页

作者： Maged Mohamed Maher abou-hashem Dina Mohamed abo-elmatty Noha Mostafa Mesbah ahmed Mohamed Abd EL-Mawgoud Faculty of Pharmacy Pharmacognosy DepartmentZagazig UniversityZagazig 44511Egypt Faculty of Pharmacy Biochemistry DepartmentSuez Canal UniversityIsmailia 41522Egypt Egyptian International Pharmaceuticals Industries Company Tenth of Ramadan City 44629Egypt

Objective: This study investigated cytotoxicity and induction of apoptosis in human cervical cancer cells(HELA) and prostate cancer cells(PC-3) using the most active fraction of Moringa peregrina seed ***: Dried and powdered seeds were extracted using 95% ethanol. The total ethanolic extract was further dissolved in distilled water and separated into petroleum ether, chloroform, ethyl acetate and aqueous extracts. Based on the results of in vitro anticancer studies of all extracts, the most highly active extract was selected for evaluation of apoptosis induction and cell cycle analysis on HELA and PC-3 cells at its half maximal inhibitory concentration using flow cytometry;DNA fragmentation by agarose gel electrophoresis and the expression of protein were measured by Western ***: The chloroform fraction from the ethanolic extract of M. peregrina(CFEE) was the most active antitumor fraction. The selectivity index, determined using the normal Vero cell line, indicated that CFEE had a high degree of selectivity against HELA and PC-3 cells. CFEE induced apoptosis, confirmed by cell cycle arrest at sub-G0 phase and DNA fragmentation. CFEE induced an increase in mRNA expression of caspase-3, a decrease in Bcl-2 mRNA expression, and decreased ATP levels. CFEE increased protein expression of caspase-3 and decreased protein expression of poly-ADP-ribose polymerase-1(PARP-1).Flow cytometric analysis showed an appreciable increase in the number of cells in the early apoptotic stage in CFEE-treated HELA and PC-3 cells. CFEE treatment significantly increased lipid peroxidation(malondialdehyde level) in HELA and PC-3 ***: Seed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HELA and PC-3 cells.

关键词： Moringa peregrina Fractionation Antiproliferation Apoptosis

ANFIS-based Sensor Fusion System of Sit-to-stand for Elderly People Assistive Device Protocols

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International Journal of Automation and computing 2013年第5期10卷 405-413页

作者： Omar Salah ahmed A.Ramadan Salvatore Sessa ahmed abo Ismail Makasatsu Fujie Atsuo Takanishi Egypt-Japan University of Science and Technology New Borg-El-Arab City Faculty of Engineering Tanta University Faculty of Science and Engineering Waseda University

This paper describes the analysis and design of an assistive device for elderly people under development at the EgyptJapan University of Science and Technology（E-JUST） named E-JUST assistive device（EJAD）.Several experiments were carried out using a motion capture system（VICON） and inertial sensors to identify the human posture during the sit-to-stand *** EJAD uses only two inertial measurement units（IMUs） fused through an adaptive neuro-fuzzy inference systems（ANFIS） algorithm to imitate the real motion of the *** EJAD consists of two main parts,a robot arm and an active *** robot arm is a 2-degree-of-freedom（2-DOF） planar *** addition,a back support with a passive joint is used to support the patient s *** IMUs on the leg and trunk of the patient are used to compensate for and adapt to the EJAD system motion depending on the obtained patient *** ANFIS algorithm is used to train the fuzzy system that converts the IMUs signals to the right posture of the patient.A control scheme is proposed to control the system motion based on practical measurements taken from the experiments.A computer simulation showed a relatively good performance of the EJAD in assisting the patient.

关键词： Adaptive neuro-fuzzy inference systems(ANFIS) sensor fusion assistive technologies sit-to-stand motion analysis inertial measurement units

4-Port Octagonal Shaped MIMO Antenna with Low Mutual Coupling for UWB Applications

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1999-2015页

作者： Mahmoud A.Abdelghany Mohamed Fathy abo Sree Arpan Desai ahmed A.Ibrahim Electrical Engineering Department College of EngineeringPrince Sattam bin Abdulaziz UniversityWadi Addwasir11991Saudi Arabia Electronic and Communication Department Arab Academy for ScienceTechnology and Maritime TransportCairo11865Egypt Department of Electronics and Communication Engineering CSPITCharotar University of Science and Technology(CHARUSAT)Changa388421India Electronics and Communications Engineering Department Minia UniversityEl-Minia61519Egypt

A4-port multiple-input multiple-output(MIMO)antenna exhibiting lowmutual coupling andUWBperformance is *** octagonal-shaped four-antenna elements are connected with a 50microstrip feed line that is arranged rotationally to achieve the orthogonal polarization for improving the MIMO system *** antenna has a wideband impedance bandwidth of 7.5GHz with S11<−10 dB from(103.44%)3.5–11GHz and inter-element isolation higher than 20 *** validation is carried out by verifying the simulated and measured results after fabricating the *** results in the form of omnidirectional radiation patterns,peak gain(≥4 dBi),and Envelope Correlation Coefficient(ECC)(≤0.01)are extracted to validate the suggested antenna ***,time-domain analysis was investigated to demonstrate the operation of the suggested antenna in wideband ***,the simulated and experimental outcomes have almost similar tendenciesmaking the antenna suitable for its use in UWBMIMOapplications.

关键词： MIMO antenna low mutual coupling time domain analysis UWB antenna

Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 341-349页

作者： Nora A.Elsayed Fatma SM Moawed Esraa SA ahmed ahmed Hammad Omayma AR abo-Zaid Biochemistry and Molecular Biology Department Faculty of Vet.Med.Benha UniversityBenha cityEgypt Health Radiation Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt Radiation Biology Department National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt

Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver ***:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and 25 mg/kg/body weight),and the nicotine groups treated with flavone(10 and 25 mg/kg/body weight).Liver function,oxidative stress,Nrf2 pathway(HO-1,Nrf2,and Keap-1),and inflammatory markers(IL-17,TNF-α,and NF-κB)were ***,a histopathological examination of liver tissues was ***:Nicotine increased liver damage,inflammation,and oxidative ***,flavone suppressed nicotine-induced liver enzymes,oxidative stress,and inflammation,as manifested by increased antioxidants and decreased malondialdehyde level,liver enzymatic activities,and inflammatory ***(10 and 25 mg/kg/body weight)also reduced the level of Keap-1 and increased HO-1 and Nrf2 levels in the liver of nicotine-exposed ***:Flavone has hepatoprotective properties and may slow the progression of liver injury by reducing oxidative stress,liver enzymes,and inflammation possibly via the Nrf2 pathway.

关键词： Flavone Nicotine Liver Nrf2 HO-1 NF-κB

Efficient energy harvesting from PV Panel with reinforced hydrophilic nano-materials for eco-buildings

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Energy and Built Environment 2024年第3期5卷 393-403页

作者： ahmed Elnozahy Heba Abd-Elbary Farag K.abo-Elyousr Department of Electrical Engineering Faculty of EngineeringAssiut UniversityAssiut 71516Egypt

The main target of this research is to allow solar PV to contribute economically to an on-grid energy-efficient building where the dust accumulation is a significant ***-cleaning coatings such as hydrophobic or hy-drophilic materials have recently been introduced to reduce dust deposition on building-integrated PV(BIPV)*** hydrophilic Nano-coated material is examined as a solution to decrease the impact of the dust on the BIPV panels and harvest more solar *** impartial comparison of the BIPV panels performance under natu-ral dust conditions,manual cleaning,and hydrophilic nanomaterial coating is *** an exhaustive and qualitative experimental analysis,the anti-reflection and anti-static properties of the utilized Nano-coated material are *** experimental results show that the hydrophilic Nano-coated material significantly improves the gathered maximum output power by 18%compared to the manually wiped *** calculated efficiencies of the Nano-coated,manual cleaning,and dusty panels are 11%,9%,and 6%,respectively,which highlights the futureproofing of the Nano-coated solar *** to the dusty panels,the ecological and economical results show that the BIPV carbon emissions are desirably dropped by 11%while using Nano-coated PV panels and the payback period is reduced to 3.9 years,which is approximately 12.8%faster.

关键词： Hydrophilic Self-cleaning BIPV panels Nano-coating Techno-economic

Numerical Treatments for Crossover Cancer Model of Hybrid Variable-Order Fractional Derivatives

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1619-1645页

作者： Nasser Sweilam Seham Al-Mekhlafi Aya ahmed Ahoud Alsheri Emad abo-Eldahab Mathematics Department Faculty of ScienceCairo UniversityGiza12613Egypt Mathematics Department Faculty of EducationSana’a UniversitySana’a1247Yemen Mathematics Department Faculty of ScienceHelwan UniversityCairo11795Egypt Department of Mathematics College of ScienceUniversity of BishaAl Namas67398-5644Saudi Arabia

In this paper,two crossover hybrid variable-order derivatives of the cancer model are ***ünwald-Letnikov approximation is used to approximate the hybrid fractional and variable-order fractional *** existence,uniqueness,and stability of the proposed model are *** Bashfourth’s fifth-step method with a hybrid variable-order fractional operator is developed to study the proposed *** studies with generalized fifth-order Runge-Kutta method are *** examples and comparative studies to verify the applicability of the used methods and to demonstrate the simplicity of these approximations are *** have showcased the efficiency of the proposed method and garnered robust empirical support for our theoretical findings.

关键词： Cancer diseases hybrid variable-order fractional derivatives adams bashfourth fifth step generalized fifth order Runge-Kutta method

Gut virome:New key players in the pathogenesis of inflammatory bowel disease

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World Journal of Methodology 2025年第2期15卷 27-43页

作者： Helal F Hetta Rehab ahmed Yasmin N Ramadan Hayam Fathy Mohammed Khorshid Mohamed M Mabrouk Mai hashem Department of Medical Microbiology and Immunology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Division of Microbiology Immunology and BiotechnologyFaculty of pharmacyUniversity of TabukTabuk 71491Saudi Arabia Division of Microbiology Immunology and BiotechnologyDepartment of Natural Products and Alternative MedicineFaculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Internal Medicine Division HepatogastroenterologyAssiut UniversityAssiut 71515Egypt Department of Clinical Research Egyptian Developers of Gastroenterology and Endoscopy FoundationCairo 11936Egypt Department of Internal Medicine Faculty of Medicine.Tanta UniversityTanta 31527Egypt Department of Tropical Medicine Gastroenterology and HepatologyAssiut University HospitalAssiut 71515Egypt

Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the *** the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immunological response,environmental exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major *** gut virome is a group of viruses found in great frequency in the gastrointestinal tract of *** gut virome varies greatly among individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and *** majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the *** conducted this review to highlight the viral communities in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关键词： Inflammatory bowel disease Pathogenesis Gut virome Bacteriophage Eukaryotic viruses

Rescue effects of aqueous seed extracts of Foeniculum vulgare and Carum carvi against cadmium-induced hepatic, renal and gonadal damage in female albino rats

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1123-1133页

作者： ahmed Abdel-Wahab Abdel-Razik hashem Abdel-Razik Rabie Lotfy Abdel Aziz Physiology Department Faculty of Veterinary MedicineMinia University61519 El-MiniaEgypt Histology Department Faculty of Veterinary MedicineBeni-Suef University62512 Beni-SuefEgypt Department of Theriogenology Faculty of Veterinary MedicineBeni-Suef University62512 Beni-SuefEgypt

Objective: To investigate the protective effects of aqueous seed extracts of fennel"Foeniculum vulgare"(FVE) and caraway "Carum carvi"(CCE) on liver, kidney and reproductive organs in female rats against cadmium chloride(CC) ***: A total of 36 adult female rats were divided into six groups, six in each *** group(fed normal diet), CC-treated group(50 mg CC/kg diet), CCE-treated group(150 mg CCE/kg diet), CCE + CC group, FVE(150 mg/kg diet) and FVE + CC. One month later, all rats were sacrificed and all samples were collected at proestrus ***: The toxic effects of CC were confirmed biochemically by significant increase of serum concentration of liver enzymes(P < 0.05), and creatinine(P < 0.001). Moreover,CC increased significantly the serum level of malondialdehyde(MDA) and decreased the total antioxidant capacity(TAC)(P < 0.001). In addition, serum concentrations of estrogen, progesterone, follicle-stimulating hormone(FSH) and luteinizing hormone(LH)were significantly decreased(P < 0.01). Histopathologically, CC-treated group revealed marked pathological changes in renal, hepatic, ovarian and uterine tissues. All toxic findings observed in liver and kidney with CC treatment were found to be ameliorated markedly after co-treatments with FVE or CCE. Furthermore, co-treatment of FVE with CC improved significantly all studied reproductive parameters(P < 0.01).Conclusions: Both FVE and CCE could be used as efficient treatments for liver and kidney against CC intoxication. Moreover, FVE could be utilized as a potent treatment to protect and improve female fertility from cadmium intoxication.

关键词： Cadmium Carum carvi Foeniculum vulgare Liver Kidney Fertility

Development of Machine Learning Regression Models for Predicting the Performance of Nanofibrous Scaffolds for Skin Tissue Engineering

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生物组学研究杂志(英文) 2024年第3期7卷 97-104页

作者： Salem Dina ahmed Moharam Mohamed Hussein hashem Esraa Mamdouh Computer Engineering Department Misr University for Science and Technology (MUST University)th of October Egypt Communication Engineering Department Misr University for Science and Technology (MUST University)th of October Egypt Biomedical Engineering Department Misr University for Science and Technology (MUST University)th of October Egypt

Tissue engineering is a branch of regenerative medicine that harnesses biomaterials and stem cells to utilize the body’s natural healing responses to regenerate tissue and organs. Skin components can be rebuilt by safeguarding their structure and function with the help of advanced scaffold manufacturing techniques. It is important to combine medical concerns with the vast explosion of artificial intelligence concepts to preserve human life and improve health. Currently, machine learning can make reliable contributions to critical decision-making in a wide range of applications. Regression machine learning models rely on correlations, associations, and other relationships between a dependent variable and a group of features. The main objective of this research was to study the effects of applying machine learning techniques on the performance of nanoscaffolds. A regression tree, a random forest, Adaboost, and a gradient boosting algorithm were applied to the dataset and clustering data. By comparing our proposed models with the relevant studies to verify each machine learning model’s optimal performance, the Adaboost technique was shown to have the highest accuracy (98.58%, 99.6%, 98.51%, and 98.85%), with a mean absolute percentage error of 1.41% and anR2 value of 0.999, which indicates a strong correlation between the predicted and actual values for the whole dataset and all subgroups.

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