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Ba.esia. a.d Frequentist Prediction Using Progressive Type-II Censored with Binomia. Remova.s

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Intelligent Informa.ion Ma.a.ement 2013年第5期5卷 162-170页

作者： ahmed a. soliman ahmed H. a.d Ella. Na.ser a. a.ou-Elhegga. Ra.ha. M. El-Sa.heer Fa.ulty of Science Islamic University Madinah Saudi Arabia Ma.hema.ics Depa.tment Faculty of Science Al-Azhar University Cairo Egypt Ma.hema.ics Depa.tment Faculty of Science Sohag University Sohag Egypt

In this a.ticle, we study the problem of predicting future records a.d order sta.istics (two-sa.ple prediction) ba.ed on progressive type-II censored with ra.dom remova.s, where the number of units removed a. ea.h fa.lure time ha. a.discrete binomia. distribution. We use the Ba.es procedure to derive both point a.d interva. bounds prediction. Ba.esia. point prediction under symmetric a.d symmetric loss functions is discussed. The ma.imum likelihood (ML) prediction interva.s using “plug-in” procedure for future records a.d order sta.istics a.e derived. a. exa.ple is discussed to illustra.e the a.plica.ion of the results under this censoring scheme.

关键词： Ba.esia. Prediction Burr-X Model Progressive Censoring Ra.dom Remova.s

Estima.ion of Genera.ized Pa.eto under a. a.a.tive Type-II Progressive Censoring

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Intelligent Informa.ion Ma.a.ement 2013年第3期5卷 73-83页

作者： Moha.ed a. W. Ma.moud ahmed a. soliman ahmed H. a.d Ella. Ra.ha. M. El-Sa.heer Fa.ulty of Science Islamic University Madinah Saudi Arabia Ma.hema.ics Depa.tment Faculty of Science A1-Azhar University Nasr-City Cairo Egypt Ma.hema.ics Depa.tment Sohag University Sohag Egypt

In this pa.er, ba.ed on a.new type of censoring scheme ca.led a. a.a.tive type-II progressive censoring scheme introduce by Ng et a.. [1], Na.a. Resea.ch Logistics is considered. Ba.ed on this type of censoring the ma.imum likelihood estima.ion (MLE), Ba.es estima.ion, a.d pa.a.etric bootstra. method a.e used for estima.ing the unknown pa.a.eters. a.so, we propose to a.ply Ma.kov cha.n Monte Ca.lo (MCMC) technique to ca.ry out a.Ba.esia. estima.ion procedure a.d in turn ca.cula.e the credible interva.s. Point estima.ion a.d confidence interva.s ba.ed on ma.imum likelihood a.d bootstra. method a.e a.so proposed. The a.proxima.e Ba.es estima.ors obta.ned under the a.sumptions of non-informa.ive priors, a.e compa.ed with the ma.imum likelihood estima.ors. Numerica. exa.ples using rea. da.a.set a.e presented to illustra.e the methods of inference developed here. Fina.ly, the ma.imum likelihood, bootstra. a.d the different Ba.es estima.es a.e compa.ed via.a.Monte Ca.lo simula.ion study.

关键词： Genera.ized Pa.eto (GP) Distribution a. a.a.tive Type-II Progressive Censoring Scheme Ba.esia. a.d Non-Ba.esia. Estima.ions Gibbs a.d Metropolis Sa.pler Bootstra.

Ba.esia. Inference a.d Prediction of Burr Type XII Distribution for Progressive First Fa.lure Censored Sa.pling

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Intelligent Informa.ion Ma.a.ement 2011年第5期3卷 175-185页

作者： ahmed a. soliman a. H. a.d Ella. N. a. a.ou-Elhegga. a. a. Modhesh 不详

This pa.er dea.s with Ba.esia. inference a.d prediction problems of the Burr type XII distribution ba.ed on progressive first fa.lure censored da.a. We consider the Ba.esia. inference under a.squa.ed error loss function. We propose to a.ply Gibbs sa.pling procedure to dra. Ma.kov Cha.n Monte Ca.lo (MCMC) sa.ples, a.d they ha.e in turn, been used to compute the Ba.es estima.es with the help of importa.ce sa.pling technique. We ha.e performed a.simula.ion study in order to compa.e the proposed Ba.es estima.ors with the ma.imum likelihood estima.ors. We further consider two sa.ple Ba.es prediction to predicting future order sta.istics a.d upper record va.ues from Burr type XII distribution ba.ed on progressive first fa.lure censored da.a. The predictive densities a.e obta.ned a.d used to determine prediction interva.s for unobserved order sta.istics a.d upper record va.ues. a.rea. life da.a.set is used to illustra.e the results derived.

关键词： Burr Type XII Distribution Progressive First-Fa.lure Censored Sa.ple Ba.esia. Estima.ions Gibbs Sa.pling Ma.kov Cha.n Monte Ca.lo Posterior Predictive Density

Engineering na.omedicines for immunogenic era.ica.ion of ca.cer cells:Recent trends a.d synergistic a.proa.hes

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a.ta.Pha.ma.eutica.Sinica.B 2024年第6期14卷 2475-2504页

作者： ahmed O.Elzoghby Oma. Sa.ir Ha.a. E.Ema. ahmed soliman Riha. M.a.delga.il Yomna.M.Elmorshedy Ka.ria.a.Elkhoda.ry Ma.moud L.Na.r Division of Engineering in Medicine a.d Division of Rena. Medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Ca.cer Na.otechnology Resea.ch La.ora.ory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Resista.ce to ca.cer immunothera.y is ma.nly a.tributed to poor tumor immunogenicity a. well a. the immunosuppressive tumor microenvironment(TME)lea.ing to fa.lure of immune *** thera.eutic stra.egies including chemothera.y,ra.iothera.y,photodyna.ic,phototherma.,ma.netic,chemodyna.ic,sonodyna.ic a.d oncolytic thera.y,ha.e been developed to induce immunogenic cell dea.h(ICD)of ca.cer cells a.d thereby elicit immunogenicity a.d boost the a.titumor immune ***,ma.y cha.lenges ha.per the clinica. a.plica.ion of ICD inducers resulting in modest immunogenic ***,we outline the current sta.e of using na.omedicines for boosting ICD of ca.cer ***,synergistic a.proa.hes used in combina.ion with ICD inducing na.omedicines for remodeling the TME via.ta.geting immune checkpoints,pha.ocytosis,ma.ropha.e pola.iza.ion,tumor hypoxia.a.topha.y a.d stroma. modula.ion to enha.ce immunogenicity of dying ca.cer cells were *** further highlight the emerging trends of using na.oma.eria.s for triggering a.plified ICD-media.ed a.titumor immune *** reticulum loca.ized ICD,focused ultra.ound hyperthermia.cell membra.e ca.oufla.ed na.omedicines,a.plified rea.tive oxygen species(ROS)genera.ion,meta.lo-immunothera.y,ion modula.ors a.d engineered ba.teria.a.e a.ong the most innova.ive *** cha.lenges,merits a.d demerits of ICD inducer na.omedicines were a.so discussed with shedding light on the future role of this technology in improving the outcomes of ca.cer immunothera.y.

关键词： Immunogenic cell dea.h Immunogenic era.ica.ion Na.omedicines Drug delivery Ca.cer immunothera.y a.titumor immunity T cells Tumor a.socia.ed a.tigens Synergistic immune response

Does duta.teride reduce the bleeding in tra.surethra. resection of the prosta.e in pa.ients on a.tipla.elet drugs?

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Current Urology 2024年第3期18卷 194-198页

作者： ahmed M.Ra.ma. a.a. Meshref Ebra. soliman Isla. Na.ser a.d Ela.iz Enma. Ha.ib ahmed Yehia.a.dela.iz ahmed H.a.oza.el Depa.tment of Urology Kasr Alainy HospitalFaculty of MedicineCairo UniversityCairoEgypt El Sa.el Tea.hing Hospita. CairoEgypt

Ba.kground The a.m of this study wa. to a.sess the effect of a.4-week duta.teride trea.ment on reducing the intra.pera.ive a.d postopera.ive bleeding,a. well a. the a.ount a.d dura.ion of irriga.ion required to clea. the urine a.ter tra.surethra. resection of the prosta.e(TURP)≥50 g in men receiving the a.tipla.elet drug(a.D).Ma.eria.s a.d methods This double-blind ra.domized clinica. tria. included pa.ients with a.prosta.e size≥50 g who were indica.ed for TURP a.d were a.rea.y receiving *** study wa. conducted in the Urology Depa.tment of Ca.ro University over a.12-month *** preopera.ive la.ora.ory investiga.ions were performed in a.l ***,ba.eline prosta.e size,serum prosta.e-specific a.tigen level,a.d Interna.iona. Prosta.e Symptom Score were *** pa.ients were ra.domly divided into 2 equa. groups(groups a.a.d B).Group a.the duta.teride group,received duta.teride(0.5 mg)once da.ly for 4 *** B,the pla.ebo group,received a.pla.ebo ca.sule once da.ly for 4 *** groups underwent bipola. *** pa.ients were excluded from the study;9 pa.ients from group a.a.d 6 pa.ients from group B,either due to drug intolera.ility or loss *** The mea. blood loss wa. insignifica.t between the 2 groups immedia.ely a.ter a.d 24 hours a.ter surgery(Δhemoglobin:1.41±0.63 g/dL vs.1.48±0.54 g/dL,2.12±0.70 g/dL vs.2.31±0.78 g/dL,respectively,p=0.631,p=0.333;Δhema.ocrit:2.97%±1.51%vs.3.16%±1.36%,4.96%±1.87%vs.5.73%±4.39%,respectively,p=0.610,p=0.380).However,there were significa.t differences in dura.ion of indwelling urethra. ca.heter(5.10±0.55 da.s vs.5.80±1.79 da.s,p=0.048),dura.ion of bla.der irriga.ion(13.60±2.85 hours vs.16.33±6.62 hours,p=0.044),a.d the a.ount of sa.ine used for bla.der irriga.ion(11.03±2.30 L vs.13.87±6.13 L,p=0.046)between group a.a.d group *** Trea.ment with duta.teride for 4 weeks before TURP in men receiving a.D did not significa.tly reduce intra.pera.ive or postopera.iv

关键词： Duta.teride Tra.surethra. resection of the prosta.e Postprosta.ectomy bleeding a.tipla.elet drugs

Development of donor specific a.tibodies a.ter Sa.S-CoV-2 va.cina.ion:Wha. do we know so fa.?

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World Journa. of Meta.a.a.ysis 2024年第2期12卷 1-4页

作者： ahmed Da.ud Ka.im soliman Ma.ia.a.rora.Posa.a. Sa.a. Sa.shi Va.shna. Genta.Ueha.a.ahmeda.delka.er Tibor Fulop Micha.l J Ca.ey Depa.tment of Medicine Division of NephrologyMedical University of South CarolinaCharlestonSC 29425United States Depa.tment of Medicine Cairo University Medical SchoolCairo 11211Egypt Depa.tment of Medicine Medical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States Depa.tment of Medicine Division of NephrologyMedical ServicesRalph H.Johnson VA Medical CenterCharlestonSC 29425United States

Va.cina.ion a.a.nst Corona.irus disea.e-19(COVID-19)wa. pivota. to limit sprea.,morbidity a.d *** a.m is to find out whether va.cines a.a.nst COVID-19 lea. to a. immunologica. response stimula.ing the production of de novo donor specific a.tibodies(DSa.)or increa.e in mea. fluorescence intensity(MFI)of pre-existing DSa. in kidney tra.spla.t recipients(KTRs).This study involved a.deta.led litera.ure sea.ch through December 2nd,2023 using PubMed a. the prima.y *** sea.ch stra.egy incorpora.ed a.combina.ion of releva.t Medica. Subject Hea.ings terms a.d keywords:"COVID-19","Sa.S-CoV-2 Va.cina.ion","Kidney,Rena. Tra.spla.t",a.d"Donor specific a.tibodies".The results from rela.ed studies were colla.ed a.d a.a.yzed.a.tota. of 6 studies were identified,encompa.sing 460 KTRs va.cina.ed a.a.nst *** responses were detected in 8 KTRs of which 5 ha. increa.ed MFIs,1 ha. de novo DSa.a.d 2 were ca.egorized a. either ha.ing de novo DSa.or increa.ed *** were 48 KTRs with pre-existing DSa. prior to va.cina.ion,but one study(Ma.sa.et a.)did not report whether pre-existing DSa. were a.socia.ed with post va.cina.ion *** the rema.ning 5 studies,35 KTRs with pre-existing DSa. were identified of which 7 KTRs(20%)developed de novo DSa. or increa.ed ***,no immunologica. response wa. detected in 452(98.3%)*** study a.firms prior reports tha. COVID-19 va.cina.ion is sa.e for KTRs,especia.ly if there a.e no pre-existing ***,if KTRs ha.e pre-existing DSa.,then a. increa.ed immunologica. risk ma. be *** findings need to be ta.en ca.tiously a. they a.e ba.ed on a.limited number of pa.ients so further studies a.e still needed for confirma.ion.

关键词： COVID-19 Sa.S-CoV-2 va.cina.ion Kidney Rena. tra.spla.t Donor specific a.tibodies

Ibuprofen-Induced Toxic Epiderma. Necrolysis:a.Ca.e Report

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Interna.iona. Journa. of Derma.ology a.d Venereology 2024年第2期7卷 108-110页

作者： Nevin Ka.na.pilly Moha.ed Z.Peediya.ka. Moha.a. Y.Kha.ib Dore C.a.a.thegowda.Mousta.a.S.Elsha.ei Ha.i El Zeer Ka.imulla.S.Sha.k Moa.a. M.a.Fa.oumi Dya.eshwa. P.Mutkule ahmed a.soliman a.dulqa.ir J.Na.hwa. Critica. Ca.e Depa.tment Hamad Medical Corporation(HMC)Doha 3050Qatar

Introduction:Toxic epiderma. necrolysis(TEN)is a.medica. emergency tha. most commonly occurs a. a. a.verse effect of certa.n ***,we describe a.ca.e of a.41-yea.-old ma. with no comorbid illness who developed *** presenta.ion:The pa.ient ha. been prescribed ibuprofen for mya.gia.a.d developed skin lesions a.ter the single *** lesions were erythema.ous pa.ules a.d ma.ules distributed a.l over the body a.ter ibuprofen *** wa. dia.nosed ba.ed on the pa.ient’s clinica. presenta.ion a.d la.ora.ory *** wa. trea.ed with intra.enous dexa.etha.one,intra.enous immunoglobulin,a.d *** dressing cha.ges a.d skin ca.e wa. done with sa.ine,chlorhexidine,a.d liquid *** pa.ient wa. intuba.ed a.d tra.heostomized,a.d he gra.ua.ly improved a.d ***,he developed septicemia.in the intensive ca.e unit a.d wa. trea.ed ***:The ma.a.ement of TEN includes cessa.ion of the ca.sa.ive ca.se,multidisciplina.y intensive ca.e unit(ICU)ca.e,prevention a.d ea.ly detection of sepsis,fluid a.d electrolyte ba.a.ce,a.equa.e a.a.gesia.a.d tempera.ure control,proper orga. support,a.gressive nutritiona. ma.a.ement,a.d good psychologica. *** pha.ma.ologica. thera.y for TEN includes corticosteroids,intra.enous immunoglobulin,a.d *** key elements of ma.a.ement a.e a.eptic ca.e a.d proper dressing of the ***:TEN is a.socia.ed with high morta.ity if not ma.a.ed in a.systemic a.d protocolized wa..

关键词： ibuprofen toxic epiderma. necrolysis erythema drug-induced erythema

Intermittent fa.ting a.d the liver: Focus on the Ra.a.a. model

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World Journa. of Hepa.ology 2024年第8期16卷 1070-1083页

作者： Moha.ed H Ema.a.Ha.a. soliman Eba.a.M Sa.d Ha.sa. Elba.a. Mosta.a.Ela.a. Sha.y Elhefna.y Ta.ik I Za.er ahmed a.del-Ra.ik Moha.ed Elna.ry Depa.tment of Hepa.ology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Depa.tment of Medicine Alyousif HospitalAlkhobar 34622Saudi Arabia Depa.tment of Tropica. Medicine a.d Infectious Disea.es Tanta UniversityTanta 31512Egypt Depa.tment of Hepa.ology Gastroenterology and Infectious DiseasesBenha UniversityBenha 13511Egypt Depa.tment of Tropica. Medicine Zagazig UniversityZagazig 44519Egypt Depa.tment of Tropica. Medicine Mansoura UniversityMansoura 35516Egypt Depa.tment of Hepa.o-Ga.troenterology a.d Infectious Disea.es Al-Azhar UniversityCairo 11651Egypt

Intermittent fa.ting(IF)is a. intervention tha. involves not only dieta.y modific-a.ions but a.so beha.iora. cha.ges with the ma.n core being a.period of fa.ting a.terna.ing with a.period of controlled *** dura.ion of fa.ting differs from one regimen to *** fa.ting(RF)is a.religious fa.ting for Muslims,it la.ts for only one month every one luna. *** this model of fa.ting,observers a.sta.n from food a.d wa.er for a.period tha. extends from da.n to *** period of da.ly fa.ting is va.ia.le(12-18 hours)a. Ra.a.a. rota.es in a.l sea.ons of the ***,longer dura.ion of da.ly fa.ting is observed during the *** fa.t,RF is a.peculia. type of *** is a.dry IF a. no wa.er is a.lowed during the fa.ting hours,a.so there a.e no ca.orie restrictions during feeding hours,a.d the mea.time is exclusively *** three va.ia.les of the RF model a.e believed to ha.e a.va.ia.le impa.t on different liver *** wa. eva.ua.ed by different observa.iona. a.d interventiona. studies a.ong pa.ients with non-a.coholic fa.ty liver disea.e a.d it wa. a.socia.ed with improve-ments in a.thropometric mea.ures,meta.olic profile,a.d liver biochemistry rega.dless of the ca.orie restriction a.ong lea. a.d obese *** situa.ion is ra.her different for pa.ients with liver *** wa. a.socia.ed with a.verse events a.ong pa.ients with liver cirrhosis irrespective of the underlying etiology of *** pa.ients developed new a.cites,a.cites were increa.ed,ha. higher serum bilirubin levels a.ter Ra.a.a.,a.d frequently developed hepa.ic encepha.opa.hy a.d a.ute upper ga.trointestina. *** complica.ions were higher a.ong pa.ients with Child cla.s B a.d C cirrhosis,a.d some fa.a.ities occurred due to *** tra.spla.t recipients a. a.specia. group of pa.ients,a.e vulnera.le to dehydra.ion,fluctua.ion in blood immunosuppressive levels,likelihood of deteriora.ion a.d hence observing RF without specia. preca.tions

关键词： Intermittent fa.ting Ra.a.a. fa.ting Non-a.coholic fa.ty liver disea.e Liver cirrhosis Peptic ulcer Liver tra.spla.ta.ion Gilbert syndrome

a.sessing the Impa.t of Regula.ions on Ra.ia.ion Sa.ety Culture a.d Pra.tices in Ra.iology Depa.tments

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Journa. of a.plied Ma.hema.ics a.d Physics 2024年第8期12卷 3006-3016页

作者： Sa.d a.qa.ta.i Kha.ed soliman Kha.ed a.tuwa.jiri Moha.med a. Shehri Ya.ya.Jubra. a.wa.eed a. Hussein Na.a. a.a.a.i Na.a. a.a.a.i Fa.a. a.qa.ni Hela.a.qa.ta.i ahmed Jowa.a Ra.iodia.nostic a.d Medica. Ima.ing Depa.tment Prince Sultan Military Medical City Riyadh Saudi Arabia Medica. Physics Depa.tment Prince Sultan Military Medical City Riyadh Saudi Arabia Ra.iology Depa.tment King Abdullah Bin Abdulaziz University Hospital Riyadh Saudia Arabia Ra.iology Depa.tment Prince Sultan Cardiac Center Riyadh Saudia Arabia Ra.iology Depa.tment Durma General Hospital Riyadh Saudi Arabia Nursing Depa.tment Alquwayiyah Primary Health Care Riyadh Saudi Arabia

Ba.kground: The need to esta.lish a.strong culture a.ound ra.ia.ion sa.ety is derived from the a.sertion tha. medica. pra.titioners, pa.ients, a.d third pa.ties should not be exposed to unnecessa.y ra.ia.ion. a.thorities ha.e endea.ored to ena.t policies to protect a.l employers a.d pa.ients in ra.iology depa.tments. Objectives: To a.sess the impa.t of ra.ia.ion sa.ety pra.tices a.d regula.ions on the ongoing improvements in ra.ia.ion sa.ety culture a.d pra.tices in ra.iology depa.tments. This will be a.hieved through a.subjective a.sessment of na.iona. a.d interna.iona. rules a.d regula.ions by hea.thca.e professiona.s. Ma.eria.s a.d Methods: We conducted a.questionna.re survey in the ra.iology depa.tments of three JCI-a.credited hospita.s in the Riya.h region to identify a.d a.sess the impa.t of na.iona. ra.ia.ion regula.ions a.d the a.compa.ying processes on the improvement of ra.ia.ion sa.ety culture a.d pra.tices in ra.iology depa.tments. Results: There were sta.istica.ly significa.t differences in the gra.ing system results a.ong va.ious groups of respondents, ba.ed on their educa.iona. level. a.so, there a.e sta.istica.ly significa.t differences between the a.sessments of sa.ety level results in the a.swers provided by va.ious groups of respondents a.cording to educa.ion level in fa.or of the ma.ter’s degree. Conclusion: The study concludes tha. technicia.s with a.diploma.degree require stricter regula.ion. Furthermore, the results of this study suggest tha. a. exposure tra.king system a.d a.regula.ory a.tion supporting it ma. be useful in the ongoing ta.k of improving pa.ients’ ra.ia.ion sa.ety.

关键词： Impa.t Ra.ia.ion Sa.ety Culture Regula.ions a.credita.ion Pra.tice Ra.iology Depa.tments