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HLA class Ⅱ alleles and risk for peripheral neuropathy in type 2 diabetes patients

Neural Regeneration Research 2016年第11期11卷 1839-1844页

作者： ahmad marzban Javad Kiani Mehrdad Hajilooi Hamzeh Rezaei Zohreh Kahramfar Ghasem Solgi Division of Endocrinology Department of Internal MedicineSchool of MedicineHamadan University of Medical Sciences Department of Immunology School of MedicineHamadan University of Medical Sciences Psoriasis Research Center Department of DermatologyFarshchian HospitalHamadan University of Medical Sciences

The potential impact of human leukocyte antigen （HLA） genotype variations on development of diabetic peripheral neuropathy （DPN） is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes （T2D） patients. Totally 106 T2D patients, 49 with DPN and 57 without DPN, and 100 ethnic-matched healthy controls were analyzed. Both groups of the patients were matched based on sex, age, body mass index （BMI） and duration of T2D. Polyneuropathy was diagnosed using electrodiagnostic methods. HLA-DRB1 and DQB1 genotyping was performed in all subjects by the polymerase chain reaction with sequence-specific primers （PCR-SSP） method. T2D patients with DPN showed higher frequencies of HLA-DRB1＊10 and DRB1＊12 alleles compared to control group （P = 0.04）. HLA-DQB1＊02 allele and HLA-DRB1＊07-DQB1＊02 haplotype were associated with a decreased risk for developing DPN in T2D patients （P = 0.02 and P = 0.05 respectively）. Also, patients with severe neuropathy showed higher frequencies of DRB1＊07 （P = 0.003） and DQB1＊02 （P = 0.02） alleles than those with mild-to-moderate form of neuropathy. The distribution of DRB 1 and DQB 1 alleles and haplotypes were not statistically different between all patients and healthy controls. Our findings implicate a possible protective role of HLA-DQB1＊02 allele and HLA-DRB1＊07-DQB1＊02 haplotype against development of peripheral neuropathy in T2D patients. Therefore, variations in HLA genotypes might be used as genetic markers for prediction and potentially management of neuropathy in T2D patients.

关键词： nerve regeneration HLA-DRB1 HLA-DQB1 alleles genotypes haplotypes peripheral neuropathy type 2 diabetes neural regeneration

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Improvement of energy efficiency and environmental impacts of rainbow trout in Iran

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Artificial Intelligence in Agriculture 2019年第2期2卷 13-27页

作者： Behzad Elhami Saeid Shahvarooghi Farahani Afshin marzban Department of Agricultural Machinery and Mechanization Engineering Agriculture Science and Natural Resources University of KhuzestanMollasaniIran

Combination of Life Cycle Assessment(LCA)and other management tools can help production units to improve economic productivity and environmental *** this study,a combination of LCA and Data Envelopment Analysis(DEA)was applied in order to improve the energy efficiency and reduce the environmental burdens of rainbow trout farm in Ardal and Lordegan regions located in Chaharmahal and Bakhtiari Province of *** required data were collected from 60 rainbow trout farms in Ardal region and 38 rainbow trout farms in Lordegan region through face-to-face questionnaire *** Ardal region,total energy inputs,rainbow trout yield and Energy Ratio(ER)were estimated as 60,483.50 MJ ton−1,281.78 ton ha−1 and 0.40,respectively,while for Lordegan region,these estimates were obtained as 77,183.63 MJ ha−1,210.50 kg ha−1 and 0.33,*** results of LCA revealed that rainbow trout production in Ardal region had lower environmental burdens than Lordegan region in all impact ***,Environmental Emissions Final Score(EEFS)in Ardal and Lordegan regions were 1638.88 and 3484.31 ppt ton−1,*** normalized results also showed that Marine Aquatic Ecotoxicity(MAE)had the highest value among all impact categories in both *** DEA results showed that in Ardal and Lordegan regions about 29.28%and 9.59%of the total energy can be saved without reducing the yield,*** highest potential for saving energy was related to feed in both Ardal(24.74%)and Lordegan(9.12%)*** results of LCA coupled with DEA also revealed that there is a higher potential for reduction of environmental impacts in Ardal region compare to Lordegan ***,the EEFS value in Ardal and Lordegan regionswere reduced by 27.34%and 8.85%,***,rainbow trout production in Ardal region had higher energy efficiency,lower environmental burdens and also higher potential to improve energy consumption and reduce the environmental impacts c

关键词： Life cycle assessment Energy ratio Data envelopment analysis Rainbow trout

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A comprehensive study of two-phase flow and heat transfer of water/Ag nanofluid in an elliptical curved minichannel

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Chinese Journal of Chemical Engineering 2020年第2期28卷 383-402页

作者： Sajad Mir Omid Ali Akbari Davood Toghraie Ghanbarali Sheikhzadeh Ali marzban Saeid Mir Pouyan Talebizadehsardari Department of Mechanical Engineering Aligoudarz BranchIslamic Azad UniversityAligoudarzIran Young Researchers and Elite Club Khomeinishahr BranchIslamic Azad UniversityKhomeinishahrIran Department of Mechanical Engineering Khomeinishahr BranchIslamic Azad UniversityKhomeinishahrIran Department of Mechanical Engineering University of KashanKashanIran Department for Management of Science and Technology Development Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Applied Sciences Ton Duc Thang UniversityHo Chi Minh CityVietnam

In this research,laminar flow and heat transfer of two-phase water/Ag nanofluid with 0–6%volume fraction of nanoparticles at Re=150–700 in a curved geometry are simulated using finite volume *** geometry is an elliptical curved minichannel with curvature angle of 180°.Forced and natural flow of two-phase nanofluid is simulated at Gr=15000,35000 and *** estimation of nanofluid flow behavior,two-phase mixture method is *** second-order discretization and SIMPLEC algorithm are used for solving governing *** results indicate that the increase of volume fraction of nanoparticles leads to the enhancement of the temperature of central line of *** increase of Grashof number(Gr^75000)has a great effect on reduction of dimensionless temperature in central line of *** of thermal boundary layer at Re=500 and after the angle of 30°becomes *** low Grashof numbers(Gr^15000),due to the great effects of temperature gradients close to wall,these regions have significant entropy generation.

关键词： Elliptical minichannel Mixed convection Numerical study Nanofluid Finite volume method Friction factor

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Interaction between climate and management on beta diversity components of vegetation in relation to soil properties in arid and semi-arid oak forests, Iran

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Journal of Arid Land 2019年第1期11卷 43-57页

作者： Heydari MEHDI Aazami FATEMEH Faramarzi marzban Omidipour REZA Bazgir MASOUD Pothier DAVID Prévosto BERNARD Department of Forest Science College of Agriculture Ilam University Department of Rangeland and Watershed Management College of Agriculture Ilam University Department of Rangeland and Watershed Management College of Natural Resources and Earth Sciences Shahrekord University Department of Soil Science College of Agriculture Ilam University Department of Wood and Forest Sciences Centre for Forest Research Laval University Irstea-National Research Institute of Science and Technology for Environment and Agriculture

This study aimed to investigate the interaction between regions with different climatic conditions(arid vs. semi-arid) and management(protected vs. unprotected) on the turnover and nestedness of vegetation in relation to physical, chemical and biological properties of soils in the Ilam Province of Iran. In each of the two regions, we sampled 8 sites(4 managed and 4 unmanaged sites) within each of which we established 4 circular plots(1000 m^2) that were used to investigate woody species, while two micro-plots(1 m×1 m) were established in each 1000-m^2 plot to analyze herbaceous species. In each sample unit, we also extracted three soil samples(0–20 cm depth) for measuring soil properties. The results indicated that the interaction between region and conservational management significantly affected the percent of canopy cover of Persian oak(Quercus brantii Linddl), soil respiration, substrate-induced respiration, as well as beta and gamma diversities and turnover of plant species. The percent of oak canopy cover was positively correlated with soil silt, electrical conductivity, available potassium, and alpha diversity, whereas it was negatively correlated with plant turnover. In addition, plant turnover was positively related to available phosphorus, while nestedness of species was positively related to organic carbon and total nitrogen. According to these results, we concluded that physical, chemical, and biological characteristics of limited ecological niche generally influenced plant diversity. Also, this study demonstrated the major contribution of the beta diversity on gamma diversity, especially in semi-arid region, because of the higher heterogeneity of vegetation in this area.

关键词： climatic conditions conservation management beta diversity oak forests physical-chemical property semi-arid region

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Effects of butternut squash extract on dentate gyrus cell proliferation and spatial learning in male adult rats

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Neural Regeneration Research 2011年第24期6卷 1855-1859页

作者： Mohsen marzban Sara Soleimani Asl Hassan Fallah Huseini Mahdi Tondar Samira Choopani Mehdi Mehdizadeh M.Sc of Anatomical Sciences Tehran University of Medical Sciences Anatomical Department Medicine FacultyHamedan University of Medical Sciences Institute of Medicinal Plants Jihad University (ACECR)Tehran Young Researcher Club Tehran Physiological & Pharmacological Department Pasture InstituteTehran Research Institute for Islamic and Complementary Medicine (RICM) Tehran University of Medical SciencesTehran Anatomical Department Medicine FacultyTehran University of Medical SciencesTehran

Previous studies reported that some plants, including butternut squash, exert positive effects on the brain. However, few studies have examined the effects of butternut squash on learning, memory, and neurogenesis. This study studied the effects of butternut squash extract on spatial learning and cell proliferation in the dentate gyrus of healthy male rats. Thirty-five male Wistar rats were intraperitoneally injected with 0, 50, 100, 200 and 400 mg/kg butternut squash extract once daily for 2 months. After the last administration, rat＇s spatial memory was studied using the Morris water maze. Finally, rats were sacrificed and hippocampal sections were prepared for light microscopy and bromodeoxyuridine immunohistochemistry studies. The results revealed that escape latency and swim distance decreased in all treatment groups compared with the control rats, and that the number of bromodeoxyuridine-positive cells in the dentate gyrus was significantly increased in the treatment groups compared with the controls. These findings suggest that butternut squash extract improves the learning and memory abilities of male rats, and increases the proliferation of dentate gyrus cells.

关键词： butternut squash spatial learning and memory cell proliferation dentate gyrus

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The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation

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International Journal of Oral Science 2022年第1期14卷 71-79页

作者： Muhammad Irfan Ji-Hyun Kim Hassan marzban David AReed Anne George Lyndon FCooper Seung Chung Department of Oral Biology University of Illinois at ChicagoChicagoUSA Department of Human Anatomy and Cell Science University of ManitobaWinnipegCanada

Therapeutic dentin regeneration remains difficult to achieve,and a majority of the attention has been given to anabolic strategies to promote dentinogenesis directly,whereas,the available literature is insufficient to understand the role of inflammation and inflammatory complement system on *** aim of this study is to determine the role of complement C5a receptor(C5aR)in regulating dental pulp stem cells(DPSCs)differentiation and in vivo dentin *** DPSCs were subjected to odontogenic differentiation in osteogenic media treated with the C5aR agonist and C5aR *** vivo dentin formation was evaluated using the dentin injury/pulp-capping model of the C5a-deficient and wildtype *** vitro results demonstrate that C5aR inhibition caused a substantial reduction in odontogenic DPSCs differentiation markers such as DMP-1 and DSPP,while the C5aR activation increased these key odontogenic genes compared to control.A reparative dentin formation using the C5a-deficient mice shows that dentin regeneration is significantly reduced in the C5a-deficient *** data suggest a positive role of C5aR in the odontogenic DPSCs differentiation and tertiary/reparative dentin *** study addresses a novel regulatory pathway and a therapeutic approach for improving the efficiency of dentin regeneration in affected teeth.

关键词： C5a vivo inflammation

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A Review beyond the borders: Proteomics of microclonial black fungi and black yeasts

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Natural Science 2013年第5期5卷 640-645页

作者： Gorji marzban Donatella Tesei Katja Sterflinger Department of Biotechnology Austrian Center of Biological Resources and Applied Mycology University of Life Sciences and Natural Resources Vienna Austria Department of Biotechnology Plant Biotechnology Unit VIBT University of Life Sciences and Natural Resources Vienna Austria

Black microcolonial fungi and black yeasts are inhabitants of extreme environments like vulcanic, desert and polar regions, where they are exposed to enhanced temperature alterations and desiccation. They have developed, therefore, extraordinary biologic characteristics which are mainly based on the expression of proteins, however, these are rarely studied and known. The review article presented here is focused on the obstacles and solutions for the proteomic analyses of this very particular fungal species.

关键词： Sample Preparation Protein Solubilities Extremophiles Fungi

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Modeling of a SiGeSn quantum well laser

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Photonics Research 2021年第7期9卷 1234-1254页

作者： BAHAREH marzban DANIELA STANGE DENIS RAINKO ZORAN IKONIC DAN BUCA JEREMY WITZENS Institute of Integrated Photonics RWTH Aachen University52074 AachenGermany Jülich-Aachen Research Alliance(JARA) Fundamentals of Future Information TechnologiesGermany Peter Grünberg Institute 52428 JulichGermany University of Leeds School of Electronic and Electrical EngineeringWoodhouseLeeds LS29JTUK

We present comprehensive modeling of a Si GeSn multi-quantum well laser that has been previously experimentally shown to feature an order of magnitude reduction in the optical pump threshold compared to bulk *** combine experimental material data obtained over the last few years with k·p theory to adapt transport,optical gain,and optical loss models to this material system (drift-diffusion,thermionic emission,gain calculations,free carrier absorption,and intervalence band absorption). Good consistency is obtained with experimental data,and the main mechanisms limiting the laser performance are discussed. In particular,modeling results indicate a low non-radiative lifetime,in the 100 ps range for the investigated material stack,and lower than expectedΓ-L energy separation and/or carrier confinement to play a dominant role in the device properties. Moreover,they further indicate that this laser emits in transverse magnetic polarization at higher temperatures due to lower intervalence band absorption losses. To the best of our knowledge,this is the first comprehensive modeling of experimentally realized Si GeSn lasers,taking the wealth of experimental material data accumulated over the past years into account. The methods described in this paper pave the way to predictive modeling of new (Si)GeSn laser device concepts.

关键词： laser polarization pump

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Global Proteomics of the Extremophile Black Fungus <i>Cryomyces antarcticus</i>Using 2D-Electrophoresis

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Natural Science 2014年第12期6卷 978-995页

作者： Kristina Zakharova Katja Sterflinger Ebrahim Razzazi-Fazeli Katharina Noebauer Gorji marzban Austrian Center of Biological Resources and Applied Mycology Department of Biotechnology University of Natural Resources and Life Sciences Vienna Austria Plant Biotechnology Unit Department of Biotechnology University of Natural Resources and Life Sciences Vienna Austria Proteomics Unit VetCore Facility for Research University of Veterinary Medicine Vienna Austria

The microcolonial black fungus Cryomyces antarcticus is an extremophile organism growing on and in rock in the Antarctic desert. Ecological plasticity and stress tolerance make it a perfect model organism for astrobiology. 2D-gel electrophoresis and MALDI-TOF/TOF mass spectrometry were performed to explore the protein repertoire, which allows the fungus to survive in the harsh environment. Only a limited number of proteins could be identified by using sequence homologies in public databases. Due to the rather low identification rate by sequence homology, this study reveals that a major part of the proteome of C. antarcticus varies significantly from other fungal species.

关键词： Microcolonial Fungi Extremophiles Proteomics Protein Characterization

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Identification of Panton-Valentine leukocidin virulence gene in methicillin-resistant Staphylococcus aureus isolated from clinical specimens of burn patients in Zare Hospitals of Sari, Iran

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Journal of Acute Disease 2020年第3期9卷 121-125页

作者： Atefeh Ranjkesh Zahra Salari Mehrab Nejati Emad Behboudi Ali Ramezani Milad Zandi Mahmood marzban Hadis Kiani Mina Bavi Mehdi Rabiei Roodsari Yousef Esvand Zibaee Samaneh Abbasi Maryam Mohammadi Elyasi Mehdi Parsanahad Shahram Jalilian SiminMohammadi Gorji Mina Owrang Faculty of Medicine Sari BranchIslamic Azad UniversitySariIran School of Medicine Bam University of Medical SciencesBamIran Department of Microbiology Faculty of MedicineGolestan University of Medical SciencesGorganIran Virology Department School of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Nursing School of Tabas Birjand University of Medical SciencesBirjandIran Department of Virology School of Public HealthTehran University of Medical SciencesTehranIran Department of Laboratory Sciences Borujerd Branch Islamic Azad UniversityBorujerdIran Abadan Faculty of Medical Sciences AbadanIran School of Paramedical Sciences Dezful University of Medical SciencesDezfulIran

Objective:To identify the pathogenic gene of Panton-Valentine leukocidin in methicillin-resistant Staphylococcus aureus strain isolated from clinical specimens of burn patients in Shaheed Zare Burn ***:A total of 104 samples of Staphylococcus were collected and 78 aureus samples were isolated from Zare Hospital patients from November 2016 to July *** isolates were identified using a standard biochemical and laboratory methodology in accordance with CLSI principles,and disk agar diffusion antibiogram were performed to identify methicillin resistant *** the presence of the Panton-Valentine leukocidin gene was tested by ***:Of the methicillin-resistant Staphylococcus aureus samples,80%were negative for the Panton-Valentine leukocidin gene,and only 20%of the samples had Panton-Valentine leukocidin *** and female patients showed no significant difference in the positivity rate of Panton-Valentine leukocidin gene(16.12%vs.33.33%)(P=0.25).Besides,there was no significant difference in bacterial resistance or susceptibility to antibiotics between samples with or without the Panton-Valentine leukocidin ***:In recent years,increased resistance has been a serious *** resistance or susceptibility of Staphylococcus aureus strains to different antibiotics is different in different geographical locations.

关键词： Methicillin Resistance Panton-Valentine leukocidin PCR Staphylococcus aureus

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