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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Tsallis agegraphic dark energy model with the sign-changeable interaction

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Communications in Theoretical Physics 2020年第1期72卷 96-101页

作者： y d Xu School of Science Jiangsu Ocean UniversityLianyungang 222005China

In this paper,we study the evolution of a spatially flat universe composed of Tsallis agegraphic dark energy(TAdE)and a pressureless dark matter(dM),by assuming that there is a signchangeable interaction between TAdE and *** density,deceleration parameter and the equation of state parameters(EoS)show satisfactory behaviors in the *** analysis we find that the accelerated expansion of the universe can be achieved at the late time if model parametersδ>2 and-2/3dE model by means of statefinder diagnostic and w–w’analysis.

关键词： Tsallis agegraphic dark energy cosmological evolution statefinder w–w’analysis

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.dongale Atul C.Khot Chenjie yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

A Hybrid Joining Technology for Aluminum/Zinc Coated Steels in Vehicles

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Journal of Materials Science & Technology 2010年第9期26卷 858-864页

作者： C.y.Choi d.C.Kim d.G.Nam y.d.Kim y.d.Park School of Materials Science and Engineering Pusan National UniversityBusan Advanced Welding & Joining R&d division Institute of Industrial Technology Incheon dongnam Technology Service division Korea Institute of Industrial TechnologyBusan department of Advanced Materials Engineering Dong-Eui UniversityBusan

Currently,in the automotive industry,joining of the aluminum alloys with the steel is a crucial problem to be *** joining techniques including resistance spot and gas metal arc welding are not acceptable for those applications due to a number of metallurgical *** investigation was carried out to develop the hybrid joining process combining the resistance spot welding and *** this study,an attempt was made to apply hybrid process to the joining of dissimilar sheet metals,Al-Mg-Si（6000 series） alloy and low carbon steel *** process（resistance spot weld/brazing） using filler metal was found to be effective to overcome the incompatibility between aluminum alloy and *** hybrid joining process of Al alloy sheet and steel sheet did not produce acceptable bond strength,it was proved to have reasonable interfacial bond layer if the optimal process condition was applied.

关键词： Hybrid joining Aluminum alloy Steel Resistance welding Brazing

THEORy OF WATER WAVES IN AN ELASTIC VESSEL

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Acta Mechanica Sinica 2000年第2期16卷 97-112页

作者： d. y. Hsieh division of Applied Mathematics Brown University USA

Recent experiments related to the dragon Wash phenomena showed that axisymmetric capillary waves appear first from excitation, and circumferential capillary waves appear after increase of the excitation strength. Based on this new finding, a theory of parametric resonance is developed in detail to explain the on- set of the prominent circumferential capillary waves. Numerical computation is also carried out and the results agree generally with the experiments. Analysis and nu- merical computation are also presented to explain the generation of axisymmetric low-frequency gravity waves by tile high-frequency external excitation.

关键词： water waves elastic vessel dragon Wash

Structural and mass transport properties of liquid ytterbium in the temperature range 1123 K–1473 K

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Chinese Physics B 2023年第6期32卷 481-488页

作者： d d Satikunvar N K Bhatt B y Thakore department of Physics Sardar Patel UniversityVallabh VidyanagarGujarat 388120India department of Physics Maharaja Krishnakumarsinhji Bhavnagar UniversityBhavnagarGujarat 364001India

We have studied the structural and atomic transport properties of liquid f-shell yb in the temperature range 1123 K–1473 K. Pair interactions between atoms are derived using a local pseudopotential. The potential parameters are fitted to the phonon dispersion curve at room temperature. The local pseudopotential used in the present study is computationally more efficient with only three parameters, and it is found to be transferable to the liquid phase without changing the *** the various computed properties agree with reported theoretical and experimental findings, the adopted fitting scheme is justified. As a significant outcome of the study, we find that(i) the melting in yb is governed by the Lindemann's law,(ii)the mass transport mechanism obeys the Arrhenius law,(iii) the role of the three-particle correlation function in deriving the velocity autocorrelation function is small,(iv) the mean-square atomic displacement is more sensitive to the choice of interaction potential than the other bulk properties, and(v) liquid yb does not show liquid–liquid phase transition within the studied temperature range. Further, due to the good description of the structural and mass transport properties, we propose that yb remains divalent at reduced density.

关键词： transport properties pseudopotential single-particle dynamics ytterbium

AlTiN and AlTiON-coated hot work tool steels for tooling in steel thixoforming

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中国有色金属学会会刊：英文版 2010年第S3期20卷 1022-1028页

作者： y.BIROL d.ISLER Materials Institute Marmara Research CentreGebzeKocaeliTurkey department of Metallurgy and Materials Engineer ing Istanbul Technical UniversityIstanbulTurkey

X32CrMoV33 hot work tool steel samples coated with AlTiN and AlTiON were submitted to thermal cycling under conditions that approximate thixoforming of steels and to sliding wear tests at 750 ℃,measured to be the cavity surface temperature shortly after the steel slurry is forced into the thixoforming *** and AlTiON coatings provide adequate protection against oxidation of the tool steel substrate,but fail to avoid thermal fatigue *** is attributed to the extensive softening of the substrate,the thermal expansion mismatch between the hot work tool steel and the coatings and residual compressive stresses inherited from the deposition *** impact of AlTiN and AlTiON coatings on the high temperature wear resistance,on the other hand,is *** improved wear resistance is attributed to the stable,protective surface oxide films.

关键词： thixoforming physical vapor deposition coating tooling steels thermal fatigue wear

<110> Fiber Texture Evolution of Ferrite Wires during drawn-torsion and drawn-annealing-torsion Process

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Journal of Materials Science & Technology 2012年第11期28卷 1010-1014页

作者： y.d. Liu y.d. Zhang A. Tidul L. Zuo Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education) Northeastern University Shenyang110004 China Letam/Isgmp CNRS Metz 57000 France

In this paper, the texture and microstructure evolution of drawn-torsion and drawn-annealing-torsion ferrite wires are studied by electron back scattering diffraction （EBSd） in order to investigate the special torsion texture evolution. Compared to the simulation results, the stable texture components {110}〈 110 〉 and {110}〈112〉 in both drawn-torsion and drawn-annealing-torsion wires display different evolution processes. The texture of the drawn-annealing-torsion wire fits to the Taylor model. A special texture evolution is found in drawn-torsion wires, related to the grain shape, and the heterogeneous deformation. A new plastic deformation viewpoint is suggested based on the special microstructure of drawn ferrite wire.

关键词： Texture Electron back scattering diffraction (EBSd) Torsion Plastic deformation