检索结果-南通市图书馆

Treatment of Helicobacter pylori with potassium competitive acid blockers:A systematic review and meta-analysis

World Journal of Gastroenterology 2024年第9期30卷 1213-1223页

作者： Joseph edwin Kanu Jonathan Soldera Post Graduate Program at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Helicobacter pylori(***)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric *** *** is crucial for treating and preventing these *** conventional proton pump inhibitor(PPI)-based triple therapy is effective,there’s growing interest in longer acid suppression *** competitive acid blocker(P-CAB)triple and dual therapy are new regimens for *** *** used in Asian populations,vonoprazan(VPZ)has been recently Food and Drug Administration-approved for *** *** To assess the efficacy of regimens containing P-CABs in eradicating *** *** This study,following PRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potassium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of P-CABs-based treatment to classical PPIs in eradicating *** were *** criteria included case reports,case series,unpublished trials,or conference *** variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and *** eradication method were gathered by two independent ***-analysis was performed in R software,and forest plots were *** A total of 256 references were initially retrieved through the search ***,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing P-CAB triple therapy to PPI triple *** intention-to-treat analysis involved 8049 patients,with 4471 in the P-CAB intervention g

关键词： Helicobacter pylori infection Potassium competitive acid blockers Proton pump inhibitors Vonoprazan Amoxicillin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Basis for the diversity and extent in loss of digestible nutrients created by dietary phytin: Emphasis on fowl and swine

引用

Animal Nutrition 2024年第1期16卷 422-428页

作者： edwin T.Moran Michael R.Bedford Poultry Science Department Auburn University AB Vista Woodstock Court Blenheim Road

Phytin is the Ca2+-Mg2+-K+salt of phytic acid that is created and deposited in the aleurone layer and/or germ of grains and legumes. Its high presence in feedstuffs for fowl and swine diets results in it being a universal and significant impediment to optimum performance. Phytin impairs gastrointestinal recovery of a wide array of nutrients, the effect varying with the nutrient concerned. On exposure to low pH during gastric digestion, phytin dissociates into phytic acid and solubilized Ca2+. Even at low gastric pH,phytic acid is negatively charged which forms the basis of its anti-nutritive behavior. Pepsinogen has extensive basic amino acids on its activation peptide that are presented as cations at low pH which are targeted by pepsin for activation. Partially crystalized Ca2+near the enzyme?s active site further stabilizes its newly formed structure. Thus, phytic acid appears to interfere with gastric digestion by several mechanisms; interfering with pepsinogen activation by binding to the polypeptide?s basic amino acids;coordinating free Ca2+, destabilizing pepsin; binding some dietary proteins directly, further compromising gastric proteolysis. Upon digesta attaining neutrality in the duodenum, Ca2+and other cations rebind with accessible anions, phytic acid being a significant contender. Phytate not only binds free cations but can also strip them from enzymes(e.g. Ca2+, Zn2+) which reduces their structural resistance to autolysis and ability as co-factors(e.g. Zn2+) to increase enzyme activity. Goblet cells initially employ Ca2+as an electronic shield between mucin layers enabling granule formation and cell storage. After mucin granule release, Ca2+is progressively displaced by Na+to free the viscous mucins enabling its translocation. Mucin entangles with the glycocalyx of adjacent enterocytes thereby constructing the unstirred water layer（USWL）. Excessive removal of Ca2+from mucin by phytic acid increases its fluidity facilitating its loss from the USWL with

关键词： Digestive enzyme Calcium Endogenous protein Mucin Phytin

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

胰岛素对昆虫病原线虫生长发育、生殖力及致病力的影响

引用

中国生物防治学报 2024年第4期 856-865页

作者：钱秀娟孙丹臧建成 edwin E.Lewis 甘肃农业大学植物保护学院/甘肃省农作物病虫害生物防治工程实验室西藏农牧学院植物科学学院美国爱达荷大学农业与生命科学学院昆虫学植物病理学及线虫学系

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命均有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经... 详细信息

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命均有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经卡森斯氏线虫Steinernemakraussei0657L和短尾异小杆线虫Heterorhabditisbrevicaudis0641TY侵染的大蜡螟Galleriamellonella注射不同浓度胰岛素，观测昆虫病原线虫的生活史及其对大蜡螟的致病力，以明确胰岛素对昆虫病原线虫生长发育、生殖力、致病力的影响。结果表明：胰岛素干预时间和干预浓度均可对卡森斯氏线虫0657L在寄主昆虫体内的生长发育产生影响，侵染当天（t）干预和高浓度（1:500）干预，会明显缩短其发育历期；侵染当天无论是高浓度还是低浓度的胰岛素干预，均会明显缩短短尾异小杆线虫0641TY的发育历期，且相比较卡森斯氏线虫0657L，胰岛素促进短尾异小杆线虫0641TY发育历期的效果更明显。在卡森斯氏线虫0657L侵染大蜡螟10 d后，注射低浓度的胰岛素，可显著提高其生殖力；在短尾异小杆线虫0641TY侵染大蜡螟1d后，注射低浓度的胰岛素，可显著提高其生殖力。胰岛素对卡森斯氏线虫0657L致病力有影响，在24 h内高浓度胰岛素可显著缩短寄主昆虫的死亡时间，但是侵染36 h后，各处理间差异不显著；而对短尾异小杆线虫0641TY致病力无影响。综上所述，胰岛素对卡森斯氏线虫0657L和短尾异小杆线虫0641TY的发育和生殖力均有影响，且对卡森斯氏线虫致病力有影响。

关键词：胰岛素昆虫病原线虫生长发育生殖力致病力

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Mining Threats to Ancient Anthropogenic Soils and other Resources Associated to Indigenous Food Security in the Middle Caqueta River, Colombia

引用

Journal of Earth Science and Engineering 2014年第6期4卷 372-377页

作者： Clara P. Pena-Venegas Acosta Luis Eduardo Verschoor Gerard Logreira-Buitrago Camilo Esteban agudelo edwin Terra Preta Program Wageningen University Wageningen 6700 The Netherlands Instituto Amazonico de lnvestigaciones Cientificas Sinchi Leticia 910001 Amazonas Colombia

Mining is encroaching upon Protected Areas and Indigenous Reserves in the Colombian Amazon. In the Middle Caqueta region small-scale, illegal gold mining is eroding riverbanks, affecting water quality, and jeopardizing the livelihoods of indigenous peoples. In addition, mining also threatens the integrity of pre-Columbian anthropogenic soils (terra preta) created between 500 years to 2,000 years B. P. on the bluffs of the Caqueta River. These soils are the only, non-flooded fertile soils present in the region, and as such are important for local indigenous communities. In Colombia, there is little knowledge about Terra Preta soils. This work assesses the present and potential dangers artisanal mining has for terra preta soils and other natural resources that are central to indigenous peoples" food security. Results posit that more knowledge is needed about the way terra preta soils are related to the livelihoods of indigenous people so that informed policy decisions can be made about the desirability of mining in the region.

关键词：哥伦比亚粮食安全中东地区自然资源土著人人为土矿业威胁

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modelling and Characterization of Basalt/Vinyl Ester/SiC Micro-and Nano-hybrid Biocomposites Properties Using Novel ANN–GA Approach

引用

Journal of Bionic Engineering 2024年第2期21卷 938-952页

作者： Yesudhasan Thooyavan Lakshmi Annamali Kumaraswamidhas Robinson Dhas edwin Raj Joseph Selvi Binoj Bright Brailson Mansingh Antony Sagai Francis Britto Alamry Ali Department of Mechanical Engineering Indian Institute of Technology Dhanbad(ISM)DhanbadJharkhand826004India Gati Shakti Vishwavidyalaya(GSV-A Central University Funded By GoI in the Ministry of Railways) LalbaugVadodaraGujarat390004India Institute of Mechanical Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennaiTamilnadu602105India Metal Joining Research Centre Department of Mechanical EngineeringSri Ramakrishna Engineering CollegeCoimbatoreTamilnadu641022India Department of Mechanical Engineering Rohini College of Engineering and TechnologyPalkulamTamil Nadu629401India Department of Mechanical Engineering College of Engineering in Al-KharjPrince Sattam Bin Abdulaziz University11942Al-KharjSaudi Arabia

Basalt fiber reinforcement in polymer matrix composites is becoming more and more popular because of its environmental friendliness and mechanical qualities that are comparable to those of synthetic *** fiber strengthened vinyl ester matrix polymeric composite with filler addition of nano-and micro-sized silicon carbide(SiC)element spanning from 2 weight percent to 10 weight percent was studied for its mechanical and wear *** application of Artificial Neural Network(ANN)to correlate the filler addition composition for optimum mechanical properties is required due to the non-linear mechanical and tribological features of *** stuffing blend and composition of the composite are optimized using the hybrid model and Genetic Algorithm(GA)to maximize the mechanical and wear-resistant *** predicted and tested ANN–GA optimal values obtained for the composite combination had a tensile,flexural,impact resilience,hardness and wear properties of 202.93 MPa,501.67 MPa,3.460 J/s,43 HV and 0.196 g,respectively,for its optimum combination of filler and *** can be noted that the nano-sized SiC filler particle enhances most of the properties of the composite which diversifies its *** predicted mechanical and wear values of the developed ANN–GA model were in closer agreement with the experimental values which validate the model.

关键词： Hybrid polymer composite Prediction Process modelling Artificial neural networks Genetic algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tracking Development

引用

ChinAfrica 2024年第5期16卷 42-43页

作者： edwin NYIRONGO 不详

Malawi is expected to generate hundreds of jobs,thanks to the railway project China Railway Signal and Communication *** will undertake in the ***’s Minister of Transport and Public Works Jacob Hara made the comment after returning from the third Road and Belt Forum for International Cooperation that took place in Beijing in October 2023.

关键词： hundreds law railway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Origin of Electric Charge in Quantum Gravity

引用

Journal of Modern Physics 2024年第4期15卷 511-535页

作者： edwin Eugene Klingman Cybernetic Micro Systems Inc. San Gregorio CA USA

A model fermion has been produced in a theory of quantum gravity that establishes the existence of a mass gap and half-integral spin. The third requirement for the fermion is electric charge. We herein develop a dualism-based analysis that explains the origin of charge at the fermion scale in a primordial field theory of quantum gravity.

关键词： Duality Topology Parallel Transport Particle Genesis Primordial Field Self-Interaction Equations Yang-Mills Gravity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Origin of Quarks in Quantum Gravity

引用

Journal of Modern Physics 2024年第8期15卷 1229-1245页

作者： edwin Eugene Klingman Cybernetic Micro Systems Inc. San Gregorio USA

A theory of quantum gravity has recently been developed by the author based on the concept that all forces converge to one at the moment of Creation. This primordial field can only interact with itself, as no other field exists, contrasting with the Standard Model of Particle Physics in which each elementary particle is an excitation in its own quantum field. The primordial field theory of quantum gravity has produced a model of a fermion with a mass gap, ½-integral spin, discrete charge, and magnetic moment. The mass gap is based on an existence theorem that is anchored in Yang-Mills, while Calabi-Yau anchors ½-integral spin, with charge and magnetic moment based on duality. Based on N-windings, this work is here extended to encompass fractional charge, with the result applied to quarks, yielding fermion mass and charge in agreement with experiment and novel size correlations and a unique quantum gravity-based ontological understanding of quarks.

关键词： Duality Calabi-Yau Topology Fermion Charge Primordial Field Self-Interaction Equations Yang-Mills Gravity Quantum Gravity Ontology of Quarks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Going Digital Clarion Call

引用

ChinAfrica 2024年第2期16卷 40-41页

作者： edwin NYIRONGO 不详

Rejoice Banda,a student from the University of Malawi,sees herself as a digitally transformed person.A student of computer network equipment,she has recently acquired cutting-edge skills related to information and com... 详细信息

关键词： law has she

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Calabi-Yau Topology of Primordial Fermions

引用

Journal of Modern Physics 2024年第1期15卷 132-158页

作者： edwin Eugene Klingman Cybernetic Micro Systems Inc. San Gregorio CA USA

Quantum field theory creates fermions via abstract operators exciting abstract fields, with a specific field for each type of specific particle. This operator algebra lends itself well to quantum statistics, nevertheless, our physical understanding of this process is nonintuitive at best. In this paper we analyze the creation of fermions from primordial gauge field quantum gravity loops in the context of Calabi-Yau manifold theory. I extend a prior mass-gap treatment based on Yang-Mills gauge theory of higher order self-interaction to include the half-integral spin of fermions.

关键词： Calabi-Yau Topology Fermion Spin Particle Genesis Primordial Field Self-Interaction Equations Yang-Mills Gravity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：