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Producing consistent visually interpreted land cover reference data: learning from feedback

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International Journal of Digital Earth 2021年第1期14卷 52-70页

作者： agnieszka Tarko Nandin-Erdene Tsendbazar Sytze de Bruin Arnold K.Bregt Laboratory of Geo-Information Science and Remote Sensing Wageningen University&ResearchWageningenNetherlands

Reference data for large-scale land cover map are commonly acquired by visual interpretation of remotely sensed *** assure consistency,multiple images are used,interpreters are trained,sites are interpreted by several individuals,or the procedure includes a *** little is known about important factors influencing the quality of visually interpreted *** assessed the effect of multiple variables on land cover class agreement between interpreters and *** analyses concerned data collected for validation of a global land cover map within the Copernicus Global Land Service *** cycles of visual interpretation were conducted,each was followed by review and *** interpreted site element was labelled according to dominant land cover *** assessed relationships between the number of interpretation updates following feedback and the variables grouped in personal,training,and environmental *** importance was assessed using random forest *** variable interpreter identifier and training variable timestamp were found the strongest predictors of update counts,while the environmental variables complexity and image availability had least *** loops reduced updating and hence improved consistency of the *** feedback loops into the visually interpreted data collection increases the consistency of acquired land cover reference data.

关键词： Land cover mapping learning curve validation visual interpretation

Complex Assembly and Metabolic Profiling of Arabidopsis thaliana PlantsOverexpressing Vitamin B6 Biosynthesis Proteins

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Molecular Plant 2010年第5期3卷 890-903页

作者： Jan Erik Leuendorf Sonia Osorio agnieszka Szewczyk Alisdair R. Fernie Hanjo Hellmann Angewandte Genetik Freie Universitat Berlin 14195 Berlin Germany Max-Planck-lnstitut for Molekulare Pflanzenphysiologie Potsdam-Golm 14476 Germany Pharmaceutical Faculty of the Collegium Medicum Jagiellonian University Krakow Poland School of Biological Sciences Washington State University Pullman USA

In plants, vitamin B6 biosynthesis requires the activity of PDX1 and PDX2 proteins. Arabidopsis thaliana encodes for three PDX1 proteins, named PDXI.1, 1.2, and 1.3, but only one PDX2. Here, we show in planta complex assembly of PDX proteins, based on split-YFP and FPLC assays, and can demonstrate their presence in higher complexes of around 750 kDa. Metabolic profiling of plants ectopically expressing the different PDX proteins indicates a negative influence of PDX1.2 on vitamin Be biosynthesis and a correlation between aberrant vitamin B6 content, PDX1 gene expression, and light sensitivity specifically for PDX1.3. These findings provide first insights into in planta vitamin B6 synthase complex assembly and new information on how the different PDX proteins affect plant metabolism.

关键词： Abiotic/environmental stress metabolomics metabolic regulation molecular physiology.

Ultra-low temperature cofired ceramics based on Li_(2)WO_(4)as perspective substrate materials for terahertz frequencies

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Journal of Advanced Ceramics 2023年第3期12卷 526-538页

作者： Dorota Szwagierczak Beata Synkiewicz-Musialska Jan Kulawik Elżbieta Czerwińska Norbert Pałka Kraków Division Łukasiewicz Research Network-Institute of Microelectronics and PhotonicsKraków 30-701Poland Institute of Optoelectronics Military University of TechnologyWarszawa 00-908Poland

With the development of low dielectric permittivity materials having an ultra-low sintering temperature,testing their dielectric properties at terahertz frequencies suitable for 6G communication systems and implementation of the fabricated materials in ultra-low temperature cofired ceramics(ULTCC)were the main goals of the *** tungstate Li_(2)WO_(4)was synthesized by a solid-state reaction and used for the preparation of green tapes and test structures with cofired internal conductive layers,which are destined for substrates of microwave and submillimeter wave *** behavior,thermal effects,and mass changes of the green tapes during heating were studied using a hot-stage microscope,differential thermal analysis,and thermogravimetry.A single-phase composition was revealed for being undoped and doped with AlF3–CaB_(4)O_(7)*** impact of frequency,temperature,the addition of AlF3–CaB_(4)O_(7)and CuBi_(2)O_(4)dopants,and sintering temperature was the subject of in-depth characterization of dielectric properties in a terahertz region.A glass-free composition,ultra-low sintering temperature of 590–630℃,low roughness of the green tapes,dense microstructure,compatibility with Ag conductors,low and stable dielectric permittivity of 5.0–5.8 in a broad range of 0.2–2 THz,and low dielectric loss of 0.008–0.01 at 1 THz are the main advantages of the developed ULTCC substrates.

关键词： Li_(2)WO_(4) ultra-low temperature cofired ceramics(ULTCC) tape casting dielectric properties terahertz frequency range

Piezoresponse force microscopy and dielectric spectroscopy study of Ba_(0.6)Sr_(0.4)TiO_(3)thin films

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Journal of Advanced Dielectrics 2019年第3期9卷 29-35页

作者： Dionizy Czekaj Agata Lisińska-Czekaj Department of Materials Engineering and Welding Faculty of Mechanical Engineering Gdansk University of Technology 11/12 Narutowicza St.Gdansk 80-233Poland

Research on synthesis,characterization and determination of processing-structure-property relationships of commercially important ferroelectric thin films has been *** sol-gel type solution deposition technique was applied to produce good quality thin films of Ba_(0.6)Sr_(0.4)TiO_(3)(BST60/40)chemical composition on the stainless steel *** thin films were characterized in terms of their microstructure,crystal structure,phase composition,piezoelectric and dielectric *** was found that the BST60/40 thin film adopted the cubic structure at room temperature with an elementary cell parameter a-3:971e8TÅ.Morphology of the thin film surface was studied with Atomic Force Microscopy(AFM).Average roughness of the thin films surface was found(Sa=0:055μm).Piezoresponse Force Microscopy(PFM)was applied for the thin film *** piezoelectric regions were found in BST60/40 thin ***,dielectric response measured at room temperature was studied in assumption of piezoelectric electric equivalent circuit.

关键词： Thin film Ba_(0.6)Sr_(0.4)TiO_(3) crystal structure dielectric spectroscopy piezoresponse force microscopy

Should mitral valve prolapse be considered as one of the risk factors for open angle glaucoma? A preliminary observation

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 346-351页

作者： Ewa Grudzińska Malgorzata Peregud-Pogorzelska Daniel Zaborski Monika Modrzejewska Second Department of Ophthalmology Pomeranian Medical UniversitySzczecin 70-111Poland Department of Cardiology Pomeranian Medical UniversitySzczecin 70-111Poland Laboratory of Biostatistics West Pomeranian University of TechnologySzczecin 71-270Poland

AIM:To assess the incidence of mitral valve prolapse in patients with newly diagnosed primary open angle ***:The study included 12 patients without any other comorbidities or taking any general or local *** patient underwent a full ophthalmological examination with visual field assessment and optical computed tomography of the macula and optic nerve *** Doppler ultrasound was performed to exclude impaired blood flow in this region and transthoracic echocardiography with assessment of the function and morphology of the heart ***:In the study group,mitral valve prolapse was found in seven patients(58.3%),while mitral valve regurgitation in 11 patients(91.7%).One case of normal pressure glaucoma and four cases of juvenile glaucoma were *** were also other risk factors for glaucoma:myopia(58.3%),migraine headaches(41.7%),a positive family history of glaucoma(16.7%).CONCLUSION:Mitral valve prolapse could be indicated as a new risk factor for *** seems reasonable to conduct screening tests for glaucoma in patients with mitral valve prolapse in the course of echocardiography.

关键词： ultrasonography Doppler echocardiography heart valves mitral valve insufficiency

GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer

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Current Medical Science 2021年第3期41卷 522-528页

作者： Sylwia Mielcarska Kamila Stopifnska Miriam Dawidowicz agnieszka Kula Pawel Kicamer Alicja Prawdric Senkowska Ewa Nowakowska Zajde Katarzyna Walkiewicz Dariusz Waniczek Elzbieta Swietochowska Department of Medical and Molecular Biology Faculry of Medical Sciences in ZabrceMedical University of SilesicaZabrce41-808.Polard Department and Chair of Pathomorphology.Faculty of Medical Sciences in Zabrze Medical University of SilesiaZabrce 41-800Polardl Department of Nutrition Related Disease Prevention Department of Metabolic Disease PreventionSschool of Public Heath inByron.Medical Universiry of SilesiaByrom 41-902Polandd Department of Surgical Nursing cand Ssurgery Propedeutics.Chair of General.Colorectal and Trauma Surgery SHS in Katowice.Medical Universiry of SilesiaBytom 41-902Poland

Colorectal cancer(CRC)is the third most frequently diagnosed cancer worldwide,responsible for over 880000 deaths each ***/differentiation factor 15(GDF-15)is reported to be a promising diagnostic and prognostic factor in *** induces pleiotropic effects in tumor cells:proliferation,sternness,invasion and *** studies indicate that GDF-15 may stimulate angiogenesis in malignant ***,it has not been investigated in CRC *** aim of our study was to determine the level of GDF-15 and the concentrations of hypoxia-inducible factor-la(HIF-1α),VEGF-A and chemokine-like receptor 1(CMKLR1)in tumor and margin specimens of CRC in relation to histological grade and TNM *** study comprised 33 samples of tumor and margin tissues obtained from CRC *** assess the concentration of GDF-15,HIF-1α,VEGF-A and CMKLR1,commercially available enzyme-linked immunosorbent assay(ELISA)kits were *** found significantly increased levels of GDF-15 and CMKLR1 in tumor tissue compared to margin tissue and higher concentrations of HIF-1α and VEGF-A in margin tissue than in tumor *** levels of GDF-15 and HIF-1α were significantly correlated with VEGF-A and CMKLR1 in margin *** CRC,the increased level of GDF-15 might stimulate angiogenesis through upregulation of HIF-1α,VEGF A and CMKLR1 *** study is the first one to reveal the correlation between the levels of GDF-15 and CMKLR1 in *** elevated levels of HIF-1α and VEGF-A in tumor-free margin tissues suggest that noncancer cells in the tumor microenvironment are an important source of proangiogenic factors.

关键词： colorectal cancer growth/differentiation factor 15(GDF-15) chemokine-like receptor 1(CMKLR1) VEGF-A angiogenesis

Antimicrobial activity of water and acetone extracts of some Eucomis taxa

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 892-895页

作者： Malgorzata Mizielińska Piotr Salachna Magdalena Ordon Lukasz Lopusiewicz Center of Bioimmobilisation and Innovative Packaging Materials Faculty of Food Sciences and Fisheries West Pomeranian University of Technology Szczecin Department of Horticulture West Pomeranian University of Technology Szczecin

Objective: To evaluate the antibacterial and antifungal properties of acetone and water extracts of selected Eucomis ***: The bulbs of Eucomis bicolor, Eucomis comosa(E. comosa) and E. comosa cv. were dried and examples from each experimental treatment were ground separately into powder. Each sample was divided into two groups with equal amounts of powder,and respectively extracted with water and a 70% solution of aqueous acetone. The crude water extracts were then filtered through a 0.2 mm filter. The 70% aqueous acetone extracts were next concentrated at 40C. After the evaporation of the acetone, the samples were additionally filtered through a 0.2 mm filter. The antibacterial and antifungal activities of the extracts against chosen microorganisms were then ***: The results of the study demonstrated that the water and acetone extracts of Eucomis bulbs have an influence on the viability of Staphylococcus aureus and Bacillus atrophaeus strains. In the case of mediums containing E. comosa and E. comosa ***, a decrease in the number of gram-positive bacteria was dependent on the extract concentration. The best results were obtained in the case of the 25% extracts. The water and acetone extracts of Eucomis bulbs did not cause a decrease in the number of Escherichia coli cells. Additionally, antifungal activity against Aspergillus niger, Botrytis cinerea, Stachybotrys chartarum, Mucor circinelloides and Rhizopus oryzae cells were also not ***: The tested gram-negative and fungi microorganisms show resistance towards acetone and water extracts of Eucomis bulbs. The highest activity is found in the case of Aspergillus clavatus, Staphylococcus aureus and Bacillus atrophaeus strains,which shows water and acetone extracts of 25%.

关键词： Antibacterial Antifungal Medicinal plants Pineapple lily

Impact of corneal parameters on intraocular pressure measurements in different tonometry methods

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1853-1858页

作者： Aleksandra Zakrzewska Marta P.Wi?cek Anna Machalińska First Department of Ophthalmology Pomeranian Medical University

AIM: To evaluate the impact of central corneal thickness(CCT) and corneal curvature on intraocular pressure(IOP) measurements performed by three different tonometers. METHODS: IOP in 132 healthy eyes of 66 participants was measured using three different tonometry techniques: Goldmann applanation tonometer(GAT), Pascal dynamic contour tonometer(DCT), and ICare rebound tonometer(RT). CCT and corneal curvature were assessed. RESULTS: In healthy eyes, DCT presents significantly higher values of IOP than GAT(17.34±3.69 and 15.27±4.06 mm Hg, P<0.0001). RT measurements are significantly lower than GAT(13.56±4.33 mm Hg, P<0.0001). Compared with GAT, DCT presented on average 2.51 mm Hg higher values in eyes with CCT<600 μm and 0.99 mm Hg higher results in eyes with CCT≥600 μm. The RT results were lower on average by 1.61 and 1.95 mm Hg than those obtained by GAT, respectively. Positive correlations between CCT in eyes with CCT<600 μm were detected for all IOP measurement techniques, whereas a similar relationship was not observed in eyes with thicker corneas. A correlation between IOP values and keratometry in the group with CCT<600 μm was not detected with any of the tonometry methods. In thicker corneas, a positive correlation was found for GAT and mean keratometry values(R=0.369, P=0.005). CONCLUSION: The same method should always be chosen for routine IOP control, and measurements obtained by different methods cannot be compared. All analysed tonometry methods are dependent on CCT;thus, CCT should be taken into consideration for both diagnostics and monitoring.

关键词： intraocular pressure Goldmann applanation tonometer Pascal dynamic contour tonometer ICare rebound tonometer central corneal thickness corneal curvature healthy individuals

Adjuvant therapy for renal cell carcinoma

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 686-694页

作者： Paramvir Sawhney Suyanto Suyanto agnieszka Michael Hardev Pandha Department of Oncology University College London Cancer InstituteLondon WC1E 6DDUK St Luke’s Cancer Centre Royal Surrey County HospitalGuildford GU27XXUK

Recent advances in the treatment of metastatic renal cell carcinoma expose a gap in the treatment of less advanced,localized *** kinase inhibitors,which revolutionized the treatment of metastatic disease,have not provided a similar survival benefit in the adjuvant setting and currently only sunitinib is approved by the Food and Drug Administration for adjuvant treatment in patients with high-risk of recurrence based on S-TRAC disease-free survival *** advent of immune checkpoint inhibitors has offered a fresh hope in the field of adjuvant treatment after encouraging results are seen with combination of immune checkpoint inhibitors as well as with targeted therapy in the metastatic *** studies are investigating these combinations in the adjuvant setting,and it is hoped that they will bring about a better outcome for a largely unmet need in kidney cancer treatment.

关键词： Localized renal cell carcinoma adjuvant immunotherapy tyrosine kinase inhibitors prognosis clinical trials predictive model risk stratification