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A Review of Arctic-Subarctic Ocean Linkages: Past Changes, Mechanisms, and Future Projections

Ocean-Land-Atmosphere Research 2023年第1期2卷 134-172页

作者： Qiang Wang Qi Shu Shizhu Wang agnieszka beszczynska-moeller Sergey Danilov Laura de Steur Thomas W.N.Haine Michael Karcher Craig M.Lee Paul G.Myers Igor V.Polyakov Christine Provost Øystein Skagseth Gunnar Spreen Rebecca Woodgate Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research(AWI) BremerhavenGermany First Institute of Oceanography and Key Laboratory of Marine Science and Numerical ModelingMinistry of Natural ResourcesQingdaoPeople’s Republic of China Shandong Key Laboratory of Marine Science and Numerical Modeling QingdaoPeople’s Republic of China Institute of Oceanology Polish Academy of SciencesSopotPoland Department of Mathematics and Logistics Jacobs UniversityBremenGermany Norwegian Polar Institute Fram CentreTromsøNorway Earth&Planetary Sciences The Johns Hopkins UniversityBaltimoreMDUSA .8Ocean Atmosphere Systems GmbH HamburgGermany Applied Physics Laboratory University of WashingtonSeattleWAUSA. Department of Earth and Atmospheric Sciences University of AlbertaEdmontonABCanada. International Arctic Research Center and College of Natural Science and Mathematics University of Alaska FairbanksFairbanksAKUSA. Finnish Meteorological Institute HelsinkiFinland. Laboratoire LOCEAN-IPSL Sorbonne Université(UPMCUniversity Paris 6)CNRSIRDMNHNParisFrance. Institute of Marine Research and Bjerknes Centre of Climate Research BergenNorway. Institute of Environmental Physics University of BremenBremenGermany.

Arctic Ocean gateway fluxes play a crucial role in linking the Arctic with the global ocean and affecting climate and marine *** reviewed past studies on Arctic-Subarctic ocean linkages and examined their changes and driving *** review highlights that radical changes occurred in the inflows and outflows of the Arctic Ocean during the ***,the Pacific inflow temperature in the Bering Strait and Atlantic inflow temperature in the Fram Strait hit record highs,while the Pacific inflow salinity in the Bering Strait and Arctic outflow salinity in the Davis and Fram straits hit record *** the ocean heat convergence from lower latitudes to the Arctic and the hydrological cycle connecting the Arctic with Subarctic seas were stronger in 2000-2020 than in ***6 models project a continuing increase in poleward ocean heat convergence in the 21st century,mainly due to warming of inflow *** also predict an increase in freshwater input to the Arctic Ocean,with the largest increase in freshwater export expected to occur in the Fram Strait due to both increased ocean volume export and decreased *** Strait sea ice volume export hit a record low in the 2010s and is projected to continue to decrease along with Arctic sea ice *** quantitatively attribute the variability of the volume,heat,and freshwater transports in the Arctic gateways to forcing within and outside the Arctic based on dedicated numerical simulations and emphasize the importance of both origins in driving the variability.

关键词： Arctic ocean Strait

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Erratum to “A Review of Arctic–Subarctic Ocean Linkages: Past Changes, Mechanisms, and Future Projections”

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Ocean-Land-Atmosphere Research 2023年第1期2卷 234-236页

作者： Qiang Wang Qi Shu Shizhu Wang agnieszka beszczynska-moeller Sergey Danilov Laura de Steur Thomas W.N.Haine Michael Karcher Craig M.Lee Paul G.Myers Igor V.Polyakov Christine Provost Øystein Skagseth Gunnar Spreen Rebecca Woodgate Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research(AWI) BremerhavenGermany First Institute of Oceanography and Key Laboratory of Marine Science and Numerical ModelingMinistry of Natural ResourcesQingdaoPeople’s Republic of China Shandong Key Laboratory of Marine Science and Numerical Modeling QingdaoPeople’s Republic of China Institute of Oceanology Polish Academy of SciencesSopotPoland. Department of Mathematics and Logistics Jacobs UniversityBremenGermany. Norwegian Polar Institute Fram CentreTromsøNorway. Earth&Planetary Sciences The Johns Hopkins UniversityBaltimoreMDUSA. Ocean Atmosphere Systems GmbH HamburgGermany. Applied Physics Laboratory University of WashingtonSeattleWAUSA. Department of Earth and Atmospheric Sciences University of AlbertaEdmontonABCanada. International Arctic Research Center and College of Natural Science and Mathematics University of Alaska FairbanksFairbanksAKUSA. Finnish Meteorological Institute HelsinkiFinland. Laboratoire LOCEAN-IPSL Sorbonne Université(UPMCUniversity Paris 6)CNRSIRDMNHNParisFrance. Institute of Marine Research and Bjerknes Centre of Climate Research BergenNorway. Institute of Environmental Physics University of BremenBremenGermany.

In the Review Article"A Review of Arctic–Subarctic Ocean Linkages:Past Changes,Mechanisms,and Future Projections"[1],the x-axis in Figure 4B and y-axis in Figure 8F were skewed during picture beautification by an ***... 详细信息

关键词： Arctic arctic Figure

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Effects of small molecules on neurogenesis:Neuronal proliferation and differentiation

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Acta Pharmaceutica Sinica B 2024年第1期14卷 20-37页

作者： MichałK Jastrze˛bski Piotr Wo´jcik Piotr Ste˛pnicki agnieszka A.Kaczor Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory Medical University of LublinFaculty of PharmacyLublin PL-20093Poland School of Pharmacy University of Eastern FinlandKuopio FI-70211Finland

Neurons are believed to be non-proliferating ***,neuronal stem cells are still present in certain areas of the adult brain,although their proliferation diminishes with *** as with other cells,their proliferation and differentiation are modulated by various *** mechanisms are foundational to the strategies developed to induce neuronal proliferation and differentiation,with potential therapeutic applications for neurodegenerative *** most common among these diseases are Parkinson's disease and Alzheimer's disease,associated with the formation ofβ-amyloid(Aβ)aggregates which cause a reduction in the number of *** such as LiCl,4-aminothiazoles,Pregnenolone,ACEA,harmine,D2AAK1,methyl 3,4-dihydroxybenzoate,and shikonin may induce neuronal proliferation/differentiation through the activation of pathways:MAPK ERK,PI3K/AKT,NFκB,Wnt,BDNF,and ***,combinations of these compounds can potentially transform somatic cells into *** transformation process involves the activation of neuron-specific transcription factors such as NEUROD1,NGN2,ASCL1,and SOX2,which subsequently leads to the transcription of downstream genes,culminating in the transformation of somatic cells into *** diseases are not the only conditions where inducing neuronal proliferation could be ***,the impact of pro-proliferative compounds on neurons has also been researched in mouse models of Alzheimer's disease.

关键词： Neurogenesis Proliferation Differentiation Maturation Small-molecules Drug coctail Alzheimer’s disease Parkinson’s disease

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Flat-footed Females and Missing Males:A New Genus and Species of Pleciofungivoridae(Diptera:Bibionomorpha)Represents the First Record of the Family from Mid-Cretaceous Kachin Amber

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 541-547页

作者： ZHANG Qingqing Wiesław KRZEMINSKI Jan SEVCIK Vladimir BLAGODEROV agnieszka SOSZYNSKA Kornelia SKIBINSKA Yunnan Key Laboratory for Palaeobiology Institute of PalaeontologyYunnan UniversityKunming 650500China MEC International Joint Laboratory for Palaeobiology and Palaeoenvironment Yunnan UniversityKunming 650500China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China Institute of Systematics and Evolution of Animals Polish Academy of Sciences52551 KrakówPoland University of Ostrava Faculty of ScienceDepartment of Biology and EcologyChittussiho 10CZ-71000 OstravaCzech Republic National Museums Scotland EdinburghUK Natural History Museum LondonUK University of Lodz Faculty of Biology and Environmental ProtectionDepartment of Invertebrate Zoology and HydrobiologyBanacha 12/1690-237ŁódźPoland

A new genus and species,Cretopleciofungivora simpsoni *** ***.,from the extinct family Pleciofungivoridae(Diptera:Bibionomorpha),is discovered in mid-Cretaceous Kachin ***,this family was known only from imprints in sedimentary rocks of the Jurassic and the Lower *** of a representative of Pleciofungivoridae in Kachin amber confirms the presence of the family in the Upper *** new species has a unique structure of fore tarsus,with lobed and extended tarsal segments Ⅱ to Ⅳ,a feature hitherto known only in a few species of extant *** not particularly rare,the new species is currently known only from female *** reasons for this phenomenon,very unusual in Sciaroidea,are briefly discussed,including parthenogenesis as a potentially plausible hypothesis.

关键词： fungus gnats Sciaroidea Upper Cretaceous Burmese amber swollen tarsomeres

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Convergent Data-Driven Regularizations for CT Reconstruction

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1342-1368页

作者： Samira Kabri Alexander Auras Danilo Riccio Harmut Bauermeister Martin Benning Michael moeller Martin Burger Helmholtz Imaging Deutsches Elektronen-Synchrotron DESYNotkestr.8522607 HamburgGermany Institute for Vision and Graphics University of SiegenAdolf-Reichwein-StraBe 2a57076 SiegenGermany School of Mathematical Sciences Queen Mary University of LondonMile End RoadLondon E14NSUK The Alan Turing Institute British Library96 Euston RdLondon NW12DBUK Fachbereich Mathematik Universitat HamburgBundesstrasse 5520146 HamburgGermany

The reconstruction of images from their corresponding noisy Radon transform is a typical example of an ill-posed linear inverse problem as arising in the application of computerized tomography(CT).As the(naive)solution does not depend on the measured data continuously,regularization is needed to reestablish a continuous *** this work,we investigate simple,but yet still provably convergent approaches to learning linear regularization methods from *** specifically,we analyze two approaches:one generic linear regularization that learns how to manipulate the singular values of the linear operator in an extension of our previous work,and one tailored approach in the Fourier domain that is specific to *** prove that such approaches become convergent regularization methods as well as the fact that the reconstructions they provide are typically much smoother than the training data they were trained ***,we compare the spectral as well as the Fourier-based approaches for CT-reconstruction numerically,discuss their advantages and disadvantages and investigate the effect of discretization errors at differentresolutions.

关键词： Inverse problems Regularization Computerized tomography(CT) Machine learning

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Compact and effective photon-resolved image scanning microscope

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Advanced Photonics 2024年第1期6卷 84-95页

作者： Giorgio Tortarolo Alessandro Zunino Simonluca Piazza Mattia Donato Sabrina Zappone agnieszka Pierzyńska-Mach Marco Castello Giuseppe Vicidomini Istituto Italiano di Tecnologia Molecular Microscopy and SpectroscopyGenoaItaly Genoa Instruments GenoaItaly University of Genoa Dipartimento di InformaticaBioingegneriaRobotica e Ingegneria dei SistemiGenoaItaly Istituto Italiano di Tecnologia Nanoscopy and NIC@IITGenoaItaly École Polytechnique Fédérale de Lausanne Laboratory of Experimental BiophysicsLausanneSwitzerland

Fluorescence confocal laser-scanning microscopy(LSM)is one of the most popular tools for life science *** popularity is expected to grow thanks to single-photon array detectors tailored for *** detectors offer unique single-photon spatiotemporal information,opening new perspectives for gentle and quantitative superresolution ***,a flawless recording of this information poses significant challenges for the microscope data acquisition(DAQ)*** present a DAQ module based on the digital frequency domain principle,able to record essential spatial and temporal features of *** use this module to extend the capabilities of established imaging techniques based on single-photon avalanche diode(SPAD)array detectors,such as fluorescence lifetime image scanning ***,we use the module to introduce a robust multispecies approach encoding the fluorophore excitation spectra in the time ***,we combine time-resolved stimulated emission depletion microscopy with image scanning microscopy,boosting spatial *** results demonstrate how a conventional fluorescence laser scanning microscope can transform into a simple,information-rich,superresolved imaging system with the simple addition of a SPAD array detector with a tailored data acquisition *** expected a blooming of advanced single-photon imaging techniques,which effectively harness all the sample information encoded in each photon.

关键词： fluorescence lifetime image scanning microscopy digital frequency domain single photon

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Evaluating implicit gender bias at Canadian otolaryngology meetings through use of professional title

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 12-17页

作者： Kylen Van Osch agnieszka Dzioba Khadija Ahmed Andrew MacDonald Jamila Skinner Harley Williams Julie E.Strychowsky M.Elise Graham Department of Otolaryngology-Head&Neck Surgery Schulich School of Medicine&DentistryWestern UniversityLondonOntarioCanada Department of Otolaryngology London Health Sciences Centre Children's HospitalLondonOntarioCanada Faculty of Medicine Schulich School of Medicine&DentistryWestern UniversityLondonOntarioCanada

Objectives:Increasing numbers of women enter medical school *** number of female physicians in leadership positions has been much slower to *** are also well‐documented differences in the treatment of women as compared to men in professional *** presenters are less likely to be introduced by their professional title(“Doctor”)for grand rounds and conferences,especially with a man performing the *** study reviewed the Canadian Society of Otolaryngology–Head and Neck Surgery(CSOHNS)meetings from 2017 to 2020 to determine the proportion of presenters introduced by their professional title and whether this varied by ***:Recordings from CSOHNS meetings were reviewed and coded for introducer and presenter demographics,including leadership positions and ***‐squared tests of proportion and multivariate logistic regression was used to compare genders and identify factors associated with professional versus unprofessional forms of ***:No significant association was found between professional title use and introducer or presenter *** presenters were introduced with professional title 69.6%of the time,while male presenters were introduced with professional title 67.6%of the time(P=0.69).Residents were introduced with a professional title with the most frequency(75.8%),while attending staff were introduced with a professional title with the least frequency(63.0%)(P=0.02).Conclusions:The lack of gender bias in speaker introductions at recent CSOHNS meetings demonstrates progress in achieving gender equity in *** efforts should continue to define additional forms of unconscious bias that may be contributing to gender inequity in leadership positions.

关键词： attitude of health personnel gender identity Otolaryngology women

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The transcriptional landscape of the developmental switch from regular pollen maturation towards microspore-derived plant regeneration in barley

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The Crop Journal 2024年第4期12卷 1064-1080页

作者： Anna Nowicka Martin Kovacik Anna Maksylewicz Przemysław Kopec Ewa Dubas Monika Krzewska agnieszka Springer Robert E.Hoffie Diaaeldin S.Daghma Zbynek Milec Ales Pecinka Jochen Kumlehn Iwona Zur The Franciszek Górski Institute of Plant Physiology Polish Academy of Sciences Niezapominajek 2130-239 KrakówPoland Institute of Experimental Botany of the Czech Academy of Sciences Centre of Plant Structural and Functional GenomicsŠlechtitelu3177900 OlomoucCzech Republic Department of Cell Biology and Genetics Faculty of SciencePalacky UniversityŠlechtitelu°2777900 OlomoucCzech Republic Malopolska Centre of Biotechnology Jagiellonian University30-387 KrakówPoland Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)Gatersleben Corrensstraße 306466 Stadt SeelandGermany Institute for Breeding Research on Horticultural Crops Julius Kühn Institute(JKI)-Federal Research Centre for Cultivated PlantsErwin-Baur Straße 2706484 QuedlinburgGermany Global Change Research Institute Czech Academy of Sciences Beˇlidla 986/4a60300 BrnoCzech Republic

Plant formation from in vitro-cultivated microspores involves a complex network of internal and environmental ***/doubled haploids(DHs)derived from in vitro-cultured microspores are widely used in plant breeding and genetic ***,the mechanism underlying the developmental switch from regular pollen maturation towards microspore-derived plant regeneration remains poorly ***,RNA-sequencing was employed to elucidate the transcriptional landscapes of four early stages of microspore embryogenesis(ME)in barley cultivars Golden Promise and Igri,which exhibit contrasting responsiveness to microspore-derived plant *** experiments revealed fundamental regulatory networks,specific groups of genes,and transcription factor(TF)families potentially regulating the developmental *** identified a set of candidate genes crucial for genotype-dependent responsiveness/recalcitrance to *** high-resolution temporal transcriptome atlas provides an important resource for future functional studies on the genetic control of microspore developmental transition.

关键词： Hordeum vulgare Marker gene Microspore embryogenesis Stress response Transcriptome analysis

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Britanin–a beacon of hope against gastrointestinal tumors?

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World Journal of Clinical Oncology 2024年第4期15卷 523-530页

作者： agnieszka Kajdanek Damian Kołat Lin-Yong Zhao Mateusz Kciuk Zbigniew Pasieka Żaneta Kałuzińska-Kołat Department of Biomedicine and Experimental Surgery Medical University of LodzLodz 90-136LodzkiePoland Department of Functional Genomics Medical University of LodzLodz 90-752LodzkiePoland Department of General Surgery&Laboratory of Gastric Cancer State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Gastric Cancer Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Molecular Biotechnology and Genetics University of LodzLodz 90-237LodzkiePoland

Britanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant *** also exhibits significant anti-tumor activity,suppressing tumor growth in vitro and in *** current body of research on Britanin includes thirty papers predominantly related to neoplasms,the majority of which are gastrointestinal tumors that have not been summarized *** drive academic debate,the present paper reviews the available research on Britanin in gastrointestinal *** also outlines novel research directions using data not directly concerned with the digestive system,but which could be adopted in future gastrointestinal *** was found to counteract liver,colorectal,pancreatic,and gastric tumors,by regulating proliferation,apoptosis,autophagy,immune response,migration,and *** confirmed in pancreatic,gastric,and liver cancer,its most commonly noted molecular effects include nuclear factor kappa B and B-cell lymphoma 2 downregulation,as well as Bcl-2-associated X protein ***,it has been found to induce the Akt kinase and Forkhead box O1 axis,activate the AMP-activated protein kinase pathway,elevate interleukin-2 and peroxisome proliferator-activated receptor-γlevels,reduce interleukin-10,as well as downregulate matrix metalloproteinase-9,Twist family bHLH transcription factor 1,and *** also inhibits Myc–HIF1αinteraction and programmed death ligand 1 transcription by interrupting the Ras/RAF/MEK/ERK pathway and mTOR/P70S6K/4EBP1 *** research should aim to unravel the link between Britanin and acetylcholinesterase,mast cells,osteolysis,and ischemia,as compelling data have been provided by studies outside the gastrointestinal *** the cytotoxicity of Britanin on noncancerous cells is significantly lower than that on tumor cells,while still being effective against the latter,further in-depth studies with the use of animal models are *** compound exhi

关键词： Britanin Sesquiterpene lactones Chemotherapeutics Gastrointestinal tumors In vitro In vivo

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Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

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