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Safflower (Carthamus Tinctorius L.) a Potential Source of Drugs against Cryptococcal Infections, Malaria and Leishmaniasis

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Phyton-International Journal of Experimental Botany 2020年第1期89卷 137-146页

作者： Aknur Turgumbayeva Gulbaram Ustenova Ubaidilla Datkhayev Khairolla Rahimov Silvijus Abramavicius agile tunaityte Kairat Zhakipbekov Kaldanay Kozhanova Saken Tulemissov Ozikhan Ustenova Gulmira Datkayeva Edgaras Stankevicius School of Pharmacy Asfendiyarov Kazakh National Medical UniversityAlmaty050000Kazakhstan National Center for Natural Product Research University of MississippiMS38677USA Department of Clinical Pharmacology Asfendiyarov Kazakh National Medical UniversityAlmaty050000Kazakhstan Institute of Physiology and Pharmacology Lithuanian University of Health SciencesKaunasLT44307Lithuania Intensive Care Unit Republican Vilnius University HospitalVilnius04130Lithuania Department of Pharmaceutical Disciplines Astana Medical UniversityAstana010000Kazakhstan Department of Chemistry and Biology Kazakhstan University of Peoples friendshipShymkent160000Kazakhstan Sub-Faculty of Tourism and Service Narxoz UniversityAlmaty050035Kazakhstan Department of General Clinical Disciplines and Ambulance Akhmet Yassawi International Kazakh-Turkish UniversityTurkestan161200Kazakhstan Institute of Cardiology Lithuanian University of Health SciencesKaunasLT44307Lithuania

In this research we present that Carthamus Tinctorius L.(***,otherwise known as Safflower)(Fig.1)may contain agents active in Cryptococcal infections,malaria and Leishmaniasis,as treatment options are becoming scarce due to drug resistance *** and pharmacological activities(antimicrobial,antimalarial,antileishmanial)of *** *** *** composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector(GC-FID)and in vitro sensitivity assays were performed to assess biological activity.8 known and 3 unknown compounds were detected in the extract(Fig.1).Then the Safflower ointment was manufactured and its acute toxicity study on rats was *** volatile oil of *** L exhibited activity against Cryptococcus neoformans,Plasmodium falciparum and Leishmania *** volatile oil has anticryptococcal,antimalarial and antileishmanial *** prepared ointment had an excellent acute toxicity safety profile.

关键词： Carthamus tinctorius L. Safflower volatile oil GC-FID biological activity

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