Safflower (Carthamus Tinctorius L.) a Potential Source of Drugs against Cryptococcal Infections, Malaria and Leishmaniasis

作     者：Aknur Turgumbayeva Gulbaram Ustenova Ubaidilla Datkhayev Khairolla Rahimov Silvijus Abramavicius Agile Tunaityte Kairat Zhakipbekov Kaldanay Kozhanova Saken Tulemissov Ozikhan Ustenova Gulmira Datkayeva Edgaras Stankevicius 

作者机构：School of PharmacyAsfendiyarov Kazakh National Medical UniversityAlmaty050000Kazakhstan National Center for Natural Product ResearchUniversity of MississippiMS38677USA Department of Clinical PharmacologyAsfendiyarov Kazakh National Medical UniversityAlmaty050000Kazakhstan Institute of Physiology and PharmacologyLithuanian University of Health SciencesKaunasLT44307Lithuania Intensive Care UnitRepublican Vilnius University HospitalVilnius04130Lithuania Department of Pharmaceutical DisciplinesAstana Medical UniversityAstana010000Kazakhstan Department of Chemistry and BiologyKazakhstan University of Peoples friendshipShymkent160000Kazakhstan Sub-Faculty of Tourism and ServiceNarxoz UniversityAlmaty050035Kazakhstan Department of General Clinical Disciplines and AmbulanceAkhmet Yassawi International Kazakh-Turkish UniversityTurkestan161200Kazakhstan Institute of CardiologyLithuanian University of Health SciencesKaunasLT44307Lithuania 

出 版 物：《Phyton-International Journal of Experimental Botany》 (国际实验植物学杂志（英文）)

年 卷 期：2020年第89卷第1期

页      面：137-146页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Kazakhstan Government National Center for Natural Product Research, University of Mississippi 

主　　题：Carthamus tinctorius L. Safflower volatile oil GC-FID biological activity 

摘      要：In this research we present that Carthamus Tinctorius L.(***,otherwise known as Safflower)(Fig.1)may contain agents active in Cryptococcal infections,malaria and Leishmaniasis,as treatment options are becoming scarce due to drug resistance *** and pharmacological activities(antimicrobial,antimalarial,antileishmanial)of *** *** *** composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector(GC-FID)and in vitro sensitivity assays were performed to assess biological activity.8 known and 3 unknown compounds were detected in the extract(Fig.1).Then the Safflower ointment was manufactured and its acute toxicity study on rats was *** volatile oil of *** L exhibited activity against Cryptococcus neoformans,Plasmodium falciparum and Leishmania *** volatile oil has anticryptococcal,antimalarial and antileishmanial *** prepared ointment had an excellent acute toxicity safety profile.