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Evaluation of Early Warning Indicators of ARV Resistance to HIV in the Hospital of tivaouane from 2008 to 2016

Advances in Infectious diseases 2018年第2期8卷 54-63页

作者： agbogbenkou tévi déla-dem lawson Ndeye Astou lakhe Haby dione Papa Souleymane toure Mamadou Ba Ndeye Biram Niang Bernard Marcel diop Sylvie Audrey diop-Nyafouna department of Health Thies University Thies Senegal Infectious and tropical diseases department Fann Teaching University Hospital Dakar Senegal

Introduction: HIV resistance to antiretroviral is currently a global concern, and requires increased surveillance in a context of widespread ARV treatment. Objective: to evaluate early warning indicators of HIV resistance to ARVs in the Hospital of tivaouane (Senegal) where viral load was not routinely available. Methods: this is a cross-sectional retrospective study from 2008-2016. the etraction tool (May 2010 version) was used to analyze the EWI. Results: We collected 360 HIV positive patients followed on average for 3.57 years ± 3.02. 2009, 2010 and 2012 recorded 100% ARV prescribing rates. throughout the study period, the percentage of patients lost to follow-up during the first 12 months of treatment was less than 20%. virtually, all patients were still under primary ARVt over 12-month treatment. All patients (100%) withdrew their ARV drugs on time. No stock storage regarding various classes of ARVs was noted during the study period. Conclusion: At the end of this study we recommend to maintain regular follow-up of EWI, and combine it with the achievement of viral load.

关键词： HIV Resistance EWI tivaouane

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the Epidemiological, Clinical, Paraclinical and Prognostic Aspects of Severe Malaria at the Regional Hospital of thies

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Advances in Infectious diseases 2018年第3期8卷 162-171页

作者： agbogbenkou tévi déla-dem lawson Madoky Magatte diop viviane Marie Pierre Cisse Stéphanie Akanni Adama Berthe Papa Souleymane toure Bernard Marcel diop Mamadou Mourtalla Ka department of Health Thies University Thies Senegal Internal Medicine department Thies Regional Hospital Center Thies Senegal Infectious and tropical diseases department Fann Teaching University Hospital Dakar Senegal

Introduction: Malaria, the first parasitical endemic disease in the world, is a serious disease with 407,000 deaths in Africa in 2016. It is the main cause of morbidity and mortality in Senegal [1] [2]. Methods: Our retrospective study carried out from 1st January 2010 to 31 december 2013, at the department of internal medicine in the regional hospital of thies was aimed at studying the epidemiological, clinical, paraclinical and prognostic profile of severe malaria in the autochthonous adults with 15 years and more. Results: Over this 3-year period, 57 patients were hospitalized in 1275 patients due to severe malaria that is to say a hospital prevalence of 4.47%. the average age was 64.21. A clear male predominance has been observed, around 61% (34/57) against 39% (23/57) with a sex ratio of 1.6. the highest malarial infestation rate was found at the end of the rainy season and at the beginning of the dry season (September to November). the clinical picture which predominates is the neurological affection which represented 33.3% of the cases. the different aspects of this neurological affection were of coma type, convulsion and prostration in 87%;21.7% and 8.6% respectively. the cerebral malaria was associated or not with other symptoms of severity that are anemia in 41.6%;icterus was represented in 21% of the cases, cardio-vascular collapse in 15.8% and hypoglycemia in 5.5% of the cases. the complications were observed during the hospitalization in 73.6% of the cases with the type of bacterial pneumonia (47.6%) and urinary infections (26.2%). the curative treatment was based on quinine salts through intravenous track in 100% of the case with a shift to the Artemisinin combination therapy (ACt) associated with intense care measures. In our study the whole lethality is 17%. Conclusion: the results of our study shows that the severe forms of malaria are still affecting our tropical endemic area, in spite of the prevention efforts made to fight against this plague. th

关键词： Malaria Severe Malaria Quinine ACt

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Ipsilateral proximal and shaft femoral fractures

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Chinese Journal of traumatology 2017年第3期20卷 155-157页

作者： Eric lawson Soumaila Madougou Pascal Chigblo Gildas Quenum Abdourahmane Ouangre Fiacre tidjani Oswald Goukodadja Aristote Hans-Moevi Akue department of Orthopaedic and traumatology Surgery Cotonou Teaching Hospital Jericho Cotonou Benin

OBJECtIVE:to study the management and evaluate anatomical and functional outcomes of patients with ipsilateral proximal and shaft femoral fractures.;MEtHOdS:A retrospective, descriptive and analytic study lasted for ten years and a half ranging from January 1, 2005 to June 30, 2015. the following parameters were studied: epidemiology, fracture characteristics, therapeutic, anatomical and functional outcomes. the correlation between different parameters was analyzed with Fischer test. the significant threshold was defined for p value tS:ten medical files were registered. there were 7 men and 3 women, with a sex ratio of 2.33. the average age was 46 years (range: 29-62 years). It was about traffic road accidents in all cases. Motorcycle-motorcycle and motorcycle-car collision were most frequent. Average admission delay was 7 h (range: 1.5-24 h). Left side was most reached in 8 cases. According to Garden classification, there was type III cervical fracture in 2 cases, type II in 1 case and type IV in 1 case. According to Ender classification, there was type I trochanteric fracture in 3 cases, type vi in 2 cases and type viI in 1 case. According to AO classification, there was type A shaft fracture in 6 cases (A2 in 4 cases and A3 in 2 cases), type B in 2 cases (B1 in 1 case and B2 in 1 case) and type C in 2 cases (C1 in 1 case and C2 in 1 case). Average surgical delay was 28.7 days (range: 11-61 days). For proximal femoral fracture, Moore prosthesis was used in 1 case, blade plate 130° in 2 cases, long Gamma nail in 4 cases, double screwing in 2 cases and dynamic hip screw in 1 case. For shaft femoral fracture, blade plate 95° was used in 3 cases, low compressive plate in 2 cases. Osseous contention was achieved in 4 cases with long Gamma nail and in 1 case with long blade plate 130°. Nonunion of cervical fracture was achieved in 2 cases. the average osseous healing delay was 5.14 months (range: 3-12 months) for proximal femoral fracture and 5 months (range

关键词：股骨骨折平均年龄延迟时间性别分类 Gamma 种植体摩托车不愈合

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