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Hyperthyroidism Due to Papillary Thyroid Carcinoma Associated with Ductal Breast Carcinoma

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Case Reports in Clinical Medicine 2014年第8期3卷 479-486页

作者： maria de Fátima Borges Ilka Mara Borges botelho Modolo Rodrigo Gimenez Pissutti Modolo Lilian Carla Silva Luciene Mayumi Sato Rogério Costa Tiveron Delcio Scandiuzzi Marcus Aurelho Lima Discipline of Endocrinology Federal University of Triangulo Mineiro Uberaba Brazil

Thyroid tumors are usually associated with euthyroidism, and hyper functioning tumors are rare. There are few reports of carcinomas associated with hyperthyroidism. The aim of this study is to describe a case of hyper functioning papillary carcinoma associated with breast carcinoma. We present a 46-year-old woman that was referred for investigation of thyroid and breast nodules detected by routine ultrasound. She presented with hyperthyroidism and enlarged left thyroid lobe with fibroelastic consistency. Investigation demonstrated papillary carcinoma with follicular hyperactivity and invasive ductal carcinoma of the breast. The patient developed metastases 6 months later and died. This study demonstrates that hot thyroid nodules may harbor malignant tumors and should be punctured. The association with breast adenocarcinoma and the unfavorable outcome suggest higher aggressiveness of this tumor in the presence of hyperthyroidism.

关键词： Papillary Carcinoma Hyperthyroidism Breast Carcinoma Thyroid Metastasis

Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital

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World Journal of Clinical Cases 2023年第8期11卷 1761-1770页

作者： Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Hospital Geral de Vitória da Conquista Vitória da Conquista 45030-160BahiaBrazil Departamento de Ciências da Saúde Universidade Estadual do Sudoeste da Bahia(UESB)Vitória da Conquista 45083-900BahiaBrazil Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern *** that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and *** To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease *** This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian *** The patients had a median age of 65.60±15.78 *** was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the *** least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with *** and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective *** This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected *** associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features.

关键词： COVID-19 Epidemiology Symptoms Comorbidities Laboratory parameters

Phenotypic and Enzymatic Analyses of Upland Rice Lines Seeds under No-Tillage

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American Journal of Plant Sciences 2015年第12期6卷 1981-1989页

作者： Heloisa Oliveira dos Santos Flávia Barbosa Silva botelho Ricardo Kenji Uenojo Ana Cláudia de Amorim Fonseca Marcela Pedroso Mendes Edila Vilela de Resende Von Pinho maria Laene Moreira de Carvalho Department of Agriculture Federal University of Lavras Lavras Brazil

Over 40% of the agricultural area in Brazil corresponds to no-tillage farming. Although it is evident the importance of obtaining upland rice cultivars adapted to this cropping system, researches in this sense are still incipient and breeders do not have cultivars available to recommend with enough security. The aim of this study was to evaluate phenotypic characters favorable to the no-tillage system in order to establish the basis for upland rice breeding programs interested in this cropping system. The seeds of twenty elite inbred lines from the Upland Rice Breeding Program from the Brazilian research institutions UFLA, EMBRAPA and EPAMIG were evaluated at the Central Seeds Lab from the Agriculture Department of UFLA following a randomized block design with four replicates. The characters evaluated were seedlings emergence (SE), green matter yield (GM), dry matter yield (DM), photosynthetic activity (PA), and superoxide dismutase activity (SOD). The quality parameters evaluated were obtained by a germination test (GT), germination first count (GFC), emergence test (E), initial stand (IS), and alpha-amylase expression. The lines CMG 2074, CMG 1967, CMG 2017, BRSMG Caravera and CMG 2097 showed higher SOD content in the enzymatic analyses, and consequently higher tolerance to abiotic stresses that could be caused by no-tillage. Considering the evaluation of agronomic traits, the line CMG 1967 showed the best performance in no-tillage soil and, therefore, should receive higher attention in Upland Rice Breeding Programs.

关键词： Oriza sativa Physiologic Quality Enzymatic Expression Cropping System Vigor

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氯己定漱口液作为防龋剂的系统评价

中国口腔医学继续教育杂志 2018年第3期21卷 140-145页

作者： Ana Sofia Estima Cunha Coelho Teresa maria Palmeirao Carrilho maria Filomena Rabaca Roque botelho 马张珂(译) 张珊珊(审) 郑树国(审) 不详北京大学口腔医学院·口腔医院预防保健科北京市海淀区中关村南大街22号100081

目的：评价在中高危息龋风险患者中使用氯己定漱口液中减少致龋菌的有效性。材料与方法：利用Cochrane Library、Embase、PubMed、Scopus和Web of Science完成文献系统评价。检索截止到2017年1月发表的英语、西班牙语和葡萄牙语文章。根... 详细信息

目的：评价在中高危息龋风险患者中使用氯己定漱口液中减少致龋菌的有效性。材料与方法：利用Cochrane Library、Embase、PubMed、Scopus和Web of Science完成文献系统评价。检索截止到2017年1月发表的英语、西班牙语和葡萄牙语文章。根据PICO策略设计检索问题。利用Cochrane干预系统评价手册的指南做偏倚风险评估。结论：所有作者都发现了在使用氯己定漱口液过程中及之后，变异链球菌水平有统计上的显著差异。尽管这些结果有启发性,但是仍有必要开展新的高质量长随访周期的研究以评估这些结果能否转化用于减缓龋齿的发展，从而评估这些产品是否应纳入防龋方案。

关键词：文献系统评价漱口液氯己定防龋剂 Cochrane 风险评估 PubMed 变异链球菌

Novel avocado oil-functionalized yogurt with anti-obesity potential:Technological and nutraceutical perspectives

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Food Bioscience 2022年第6期50卷 161-170页

作者： Manuela Machado Sérgio Sousa Pilar Morais Arménio Miranda Luís M.Rodriguez-Alcalá Ana maria Gomes Manuela Pintado Universidade Católica Portuguesa CBQF Centro de Biotecnologia e Química Fina-Laboratório AssociadoEscola Superior de BiotecnologiaRua Diogo Botelho 13274169-005PortoPortugal Frulact S.ARua do Outeiro589Gemunde4475-150MaiaPortugal

Studies on bioactive lipids have been increasing in the last years due to their proven health *** purpose of this research work was to develop a yogurt with bioactive lipids with anti-obesity *** this purpose,yogurts were produced with avocado oil in free form or encapsulated as a *** presence of avocado oil enhanced the nutritional quality of yogurts through a reduction(more than 75%)of their atherogenic and thrombogenic *** high nutritional value was particularly evident in samples with bigel,as these yogurts presented eight-fold higher levels of total fatty acids than the yogurts with avocado oil in free *** addition,yogurts with avocado bigel presented better stability throughout the gastrointestinal tract-results showed a higher recovery percentage of oleic acid(47.2%)when compared to 24%in the yogurts with avocado in free *** results from the in vitro studies demonstrated that these functional yogurts can increase the lipolytic rate in adipocytes,translated by an increase of ca.20%in glycerol release in yogurts with ***,the hepatic lipid accumulation in cells subjected to steatosis induced by chloroquine was reduced by 35%in cells treated with yogurt digested *** results showed the potential of these functional yogurts to modulate obesity-related metabolism.

关键词： Lipid metabolism Obesity Dairy products Functional foods