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Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

Neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo Adolfo López-Ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la Cruz Marco Antonio Vargas-Hernández Adriana Jiménez Laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital Nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of transport.Although brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or alpha-synuclein.Alzheimer's disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several groups.However,its impairment has barely been considered as a potential therapeutic target.Here we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ailment.Finally,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport

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Chronic urticaria associated with lung adenocarcinoma—a paraneoplastic manifestation:A case report and literature review

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World Journal of Clinical Cases 2022年第21期10卷 7553-7564页

作者： Luisa Fernanda jiménez Evis adriana Castellón Juan David Marenco JoséMaria Mejía Camilo Andrés Rojas Franklin Torres jiménez Linda Coronell Estefanie Osorio-Llanes Evelyn Mendoza-Torres Faculty of Health Sciences Universidad Libre de ColombiaSeccional BarranquillaBarranquilla 08000Colombia Faculty of Exact and Natural Sciences Universidad Libre de ColombiaSeccional BarranquillaBarranquilla 08000Colombia lty of Health Sciences Universidad Libre De ColombiaSeccional BarranquillaBarranquilla 08000AtlánticoColombia

BACKGROUND Urticaria is one of the most common causes of emergency room visits.It is defined as an acute inflammatory dermatosis,characterized by localized degranulation of mast cells,with consequent dermal microvascular and formation of edematous and pruritic plaques called hives.Urticaria affects the skin and tissues of the superficial mucosa.Sometimes it is accompanied by angioedema,which is characterized by deeper edema of the dermis and subcutaneous cellular tissue known as the urticarial-angioedema syndrome.About 15%-25%of the general population has suffered at least one type of urticaria at some point during their lifetime and hyperpermeability estimated at 7.6%-16%and has experienced acute urticaria that is usually self-limited and spontaneously resolves without requiring medical attention.CASE SUMMARY We present the case of a young male patient who was referred to our department with a clinical picture of 4 mo of pruritus associated with hives of variable sizes,irregular borders,with interlesional confluence,that were non-painful,without involvement of the palms and soles of the feet but with a tendency to progression in a generalized manner.He had multiple emergency room visits and poor response to antihistamines and systemic corticosteroids.Imaging studies demonstrated nodules in the lower lingula segment,at the level of the greater fissure and in the anterior contour of the left anterior basal segment associated with parahiliar adenopathies in the absence of findings suggestive of infectious or autoimmune etiology.Segmental lobectomy was performed by thoracoscopy with resection of a lung nodule in the lingula and biopsy of the para-aortic mediastinal ganglion.The histopathological report showed the presence of poorly differentiated invasive adenocarcinoma with a solid morphological and acinar pattern with immunohistochemical description of lung tissue that expresses strong positive and diffuse reaction for thyroid transcription factor 1(TTF-1)with negativity to P40 for a histopathological diagnosis of

关键词： Urticaria Lung adenocarcinoma Undifferentiated carcinoma Paraneoplastic syndromes Thyroid nuclear factor 1 Case report

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Natural sediment at a dam and its inorganic materials as adsorbents of praseodymium(Pr(Ⅲ))

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International Journal of Sediment Research 2023年第4期38卷 566-575页

作者： Melania jiménez-Reyes Jaime jiménez-Becerril Marcos Solache-Ríos Perla Tatiana Almazán-Sánchez Departamento de Química Instituto Nacional de Investigaciones Nucleares Carretera México-Toluca S/N CONACy T-Instituto Nacional de Investigaciones Nucleares

The sediment deposited behind a dam(DS) and its inorganic materials(IM-DS) were characterized and used for the removal of praseodymium(Pr) from aqueous solutions. Quartz, albite, and kaolinite were found in the sediment by X-ray diffraction. Kinetic data fit well to a pseudo second-order model, the equilibrium time for DS and IM-DS was 2 h and 3 min, respectively, and the adsorption capacity was higher for Pr/DS(qe= 4.91 mg/g) than for Pr/IM-DS(qe= 3.01 mg/g) in these conditions. Pr/DS and Pr/IM-DS data isotherms were in agreement with the Langmuir-Freundlich model and the maximum adsorption capacities were 4.95 and 4.01 mg/g, respectively. Both processes are exothermic(enthalpy change, ΔH0=-22.8 and-21.8 k J/mol for DS and IM-DS, respectively), the increase of the randomness is small, and the feasibility and spontaneity are low. Praseodymium was desorbed by ethylenediaminetetraacetic acid disodium(EDTA-Na2), sodium chloride, nitric, citric, and humic acids solutions, and one hundred percent of praseodymium was desorbed by the EDTA-Na2solution. The Pr2(EDTA)3(praseodymium ethylenediaminetetraacetate) complex was completely desorbed from both materials(DS and IM-DS). Distribution coefficients(KD) depend upon praseodymium concentration,temperature, p H, and the kind of adsorbent. Chemical reactions of praseodymium with kaolinite and iron minerals could explain the adsorption.

关键词： Praseodymium Sediment Adsorption process parameters Desorption

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Sex differences in Alzheimer's disease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel jiménez-Herrera Ana Contreras Juan D.Navarro-López Lydia jiménez-Díaz Neurophysiology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

Due to increasing life expectancy,the amount of people with dementia worldwide is expected to experience a substantial rise,with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the year 2050.Among the various forms of dementia.Alzheimer's disease(AD)stands out as the predominant and most prevalent.

关键词： Alzheimer predominant estimates

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Heat dissipating upper body compression garment:Thermoregulatory,cardiovascular, and perceptual responses

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Journal of Sport and Health Science 2019年第5期8卷 450-456页

作者： Iker Leoz-Abaurrea Nicholas Tam Roberto Aguado-jiménez Department of Health Sciences Public University of NavarreNavarre 31500Spain UCT/MRC Research Unit for Exercise Science and Sports Medicine Department of Human BiologyUniversity of Cape TownCape Town 7725South Africa

Purpose:The aim of the present study was to determine the effects of an upper body compression garment(UBCG)on thermoregulatory responses during cycling in a controlled laboratory thermoneutral environment(~23℃).A secondary aim was to determine the cardiovascular and perceptual responses when wearing the garment.Methods:Sixteen untrained participants(age:21.3±5.7 years;peak oxygen consumption(V02 peak):50.88±8.00 mL/min/kg;mean±SD)performed 2 cycling trials in a thermoneutral environment(~23℃)wearing either UBCG or control(Con)garment.Testing consisted of a 5-min rest on a cycle ergometer,followed by 4 bouts of cycling for 14-min at ~50%VO2 peak,with 1-min rest between each bout.At the end of these bouts there was 10-min of passive recovery.During the entire protocol rectal temperature(Trec),skin temperature(Tskin),mean body temperature(Tbody),and heat storage(HS)were measured.Heart rate(HR),VO2,pH,hematocrit(Hct),plasma electrolytes,weight loss(Wloss),and perceptual responses were also measured.Results:There were no significant differences between garments for Tskin,HS,HR,VO2,pH,Hct,plasma electrolyte concentration,Wloss,and perceptual responses during the trial.Trec did not differ between garment conditions during rest,exercise,or recovery although a greater reduction in Trec wearing UBCG(p=0.01)was observed during recovery.Lower Tbody during recovery was found when wearing UBCG(36.82℃±0.30℃ vs.36.99℃±0.24℃).Conclusion:Wearing a UBCG did not benefit thermoregulatory,cardiovascular,and perceptual responses during exercise although it was found to lower Tbody during recovery,which suggests that it could be used as a recovery tool after exercise.

关键词： Body temperature Compression garment Cycling Heat dissipation Thermoregulation

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Multi-temporal NDVI analysis using UAV images of tree crowns in a northern Mexican pine-oak forest

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林业研究:英文版 2023年第6期34卷 1855-1867页

作者： JoséLuis Gallardo-Salazar Marcela Rosas-Chavoya Marín Pompa-García Pablito Marcelo López-Serrano Emily García-Montiel Arnulfo Meléndez-Soto Sergio Iván jiménez-jiménez Instituto de Investigaciones Agropecuarias y Forestales Universidad Michoacana de San Nicolás de Hidalgo(UMSNH)58330 MoreliaMichoacánMexico Programa Institucional de Doctorado en Ciencias Agropecuarias y Forestales Universidad Juárez del Estado de DurangoRío Papaloapan y Blvd.DurangoValle del Sur s/n34120 DurangoDurangoMéxico Facultad de Ciencias Forestales Universidad Juárez del Estado de DurangoRío Papaloapan y Blvd.DurangoValle del Sur s/n34120 DurangoDurangoMéxico Instituto de Silvicultura e Industria de la Madera Universidad Juárez del Estado de DurangoBoulevard del Guadiana 501Ciudad UniversitariaTorre de Investigación34120 DurangoMéxico INIFAP-CENID RASPA Centro Nacional de Investigación Disciplinaria en Relación Agua-Suelo-Planta-Atmósfera Margen derecha canal Sacramento km 6.5Zona industrial35140 Gómez PalacioDurangoMexico

The use of unmanned aerial vehicles(UAV)for forest monitoring has grown significantly in recent years,providing information with high spatial resolution and temporal versatility.UAV with multispectral sensors allow the use of indexes such as the normalized difference vegetation index(NDVI),which determines the vigor,physiological stress and photo synthetic activity of vegetation.This study aimed to analyze the spectral responses and variations of NDVI in tree crowns,as well as their correlation with climatic factors over the course of one year.The study area encompassed a 1.6-ha site in Durango,Mexico,where Pinus cembroides,Pinus engelmannii,and Quercus grisea coexist.Multispectral images were acquired with UAV and information on meteorological variables was obtained from NASA/POWER database.An ANOVA explored possible differences in NDVI among the three species.Pearson correlation was performed to identify the linear relationship between NDVI and meteorological variables.Significant differences in NDVI values were found at the genus level(Pinus and Quercus),possibly related to the physiological features of the species and their phenology.Quercus grisea had the lowest NDVI values throughout the year which may be attributed to its sensitivity to relative humidity and temperatures.Although the use of UAV with a multispectral sensor for NDVI monitoring allowed genera differentiation,in more complex forest analyses hyperspectral and LiDAR sensors should be integrated,as well other vegetation indexes be considered.

关键词： Multispectral images Normalized diff erence Vegetation index Phenology Unmanned aerial vehicles Multitemporal analysis

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Effect of intensity and duration of anthropic noises on European mink locomotor activity and fecal cortisol metabolite levels

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Current Zoology 2022年第6期68卷 688-699页

作者： Lorena ORTIZ-jimEnez Carlos IGLESIAS-MERCHAN Alba Itzel MARTınez-SALAZAR Isabel BARJA Department of Biology Zoology UnitUniversidad Autonoma de MadridMadrid28049Spain Department of Forest and Environmental Engineering and Management Universidad Politecnica de MadridMadridSpain Geographic Information Systems Laboratory Institute of BiologyUniversidad Nacional Autonoma de MexicoMexico CityMexico Biodiversity and Global Change Research Centre(CIBC-UAM) Universidad Autonoma de MadridMadridSpain

Human activities involving noise emission can affect wild animals.European mink was exposed to road noise and human voice playbacks to analyze how sound intensity level and duration of both noises altered the time that individuals were active and if their fecal cortisol metabolite(FCM)levels varied.A Hierarchical Analysis Cluster was performed to establish 2 mink groups with respect to both noise source type:short duration/low intensity(SL)and long duration/high intensity(LH).We performed general linear mixed models to evaluate the variation in locomotor activity duration(s)and FCM(nanogram per gram)levels,respectively.The results showed both road noise and human voices decreased locomotor activity duration in SL more sharply compared with LH,and human voices were the triggers that induced the most pronounced response to both exposure conditions.FCM(ng/g)levels increased in SL compared with LH during road noise while the opposite happened during human voices.Differences based on sex and age of individuals were observed.In conclusion,noise characteristics given by the sound type determined the variations in locomotor activity duration while noise exposure level determined the variations in FCM(ng/g)levels.Attention should be paid to noisy activities(e.g.,recreational activities for visitors in protected natural areas)and loud groups of people to conserve wildlife,especially noise sensitive species.

关键词： anthropic disturbances European mink fecal cortisol metabolites noise exposure locomotor activity behavioral response

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超临界合成Pt修饰的TiO_2用于光催化CO_2还原制备太阳能燃料（英文）

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Chinese Journal of Catalysis 2017年第4期38卷 636-650页

作者： Susana Tostón Rafael Camarillo Fabiola Martínez Carlos jiménez Jesusa Rincón 亚拉曼查大学环境科学与生物化学学院化工系

考察了超临界条件下合成TiO_2基光催化剂的性质,尤其是在超临界CO_2下得到的分散在TiO_2上Pt的特性,并与商品化TiO_2性能进行了比较.另外,所得催化剂的光催化活性用CO_2光还原制太阳能燃料进行了评价.结果表明,该催化剂可得到具有比商用... 详细信息

考察了超临界条件下合成TiO_2基光催化剂的性质,尤其是在超临界CO_2下得到的分散在TiO_2上Pt的特性,并与商品化TiO_2性能进行了比较.另外,所得催化剂的光催化活性用CO_2光还原制太阳能燃料进行了评价.结果表明,该催化剂可得到具有比商用TiO_2更好或类似的性能(高比表面积、结晶度、表面羟基浓度,大的孔容、增强的可见光吸收、高的甲烷生成速率)而用于CO_2还原制备燃料的反应中.这可归因于该催化剂超临界介质合成过程.

关键词：二氧化钛铂光催化剂金属分散度光还原二氧化碳

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Heart failure in the elderly

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Journal of Geriatric Cardiology 2021年第3期18卷 219-232页

作者： Pablo Díez-Villanueva César jiménez-Méndez Fernando Alfonso Cardiology Department Hospital Universitario La PrincesaUniversidad Autónoma de MadridCIBER-CVMadridSpain

Heart failure(HF)is a clinical syndrome caused by structural and/or functional cardiac abnormalities,resulting in a reduced cardiac output and/or elevated intracardiac filling pressures at rest or during stress.HF is a major public health problem with high prevalence and incidence,involving both high morbidity and mortality,but also high economic costs.The incidence of HF progressively increases with age,reaching around 20%among people over 75 years old.Indeed,HF represents the leading cause of hospitalization in patients older than 65 years in Western countries.Hence,some authors even consider HF a geriatric syndrome,entailing worse prognosis and high residual disability,and often associating some complex comorbidities,common in older population,that may further complicate the course of the disease.On the other hand,however,clinical course and prognosis may be often difficult to predict.In this article,main pathophysiological issues related to the aging heart are addressed,together with key aspects related to both diagnosis and prognosis in elderly patients with HF.Besides,main geriatric conditions,common in the elderly population,are reviewed,highlighting the importance of a comprehensive and multidisciplinary approach.

关键词： diagnosis elevated mortality

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Origin of light emission and enhanced Eu^(3+) photoluminescence in tin-containing glass

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Journal of Rare Earths 2015年第1期33卷 27-32页

作者： José A.jiménez Esteban Rosim Fachini Department of Chemistry University of North FloridaJacksonville FL 32224 USA Department of Physical Sciences General Studies Faculty University of Puerto RicoRío Piedras PR 00931 USA

A barium-phosphate glass matrix was co-doped with Sn O and Eu2O3 for investigating on material luminescent properties. Optical absorption and X-ray photoelectron spectroscopy（XPS） were employed in the characterization of tin species. The prevalence of divalent tin was indicated by the XPS data in accord with a conspicuous absorption band detected around 285 nm ascribed to twofold-coordinated Sn centers（isoelectronic with Sn^2＋）. Photoluminescence（PL） excitation spectra obtained by monitoring Eu^3＋ emission from the 5D0 state revealed a broad excitation band from about 250 to 340 nm, characteristic of donor/acceptor energy transfer. Under excitation of such at 290 nm, the co-doped material exhibited a bright whitish luminescence, and a four-fold enhanced Eu3＋ emission relative to a purely Eu-doped reference. Time-resolved PL spectra recorded under the excitation at 290 nm exposed a broad band characteristic of the twofold-coordinated Sn centers and emission bands of Eu^3＋ ions, which appeared well separated in time in accord with their emission decay dynamics. The data suggested that light absorption took place at the Sn centers（donors） followed by energy transfer to Eu^3＋ ions（acceptors） which resulted in populating the 5D0 emitting state. Energy transfer pathways likely resulting in the enhanced Eu3＋ photoluminescence and the consequential light emission were discussed.

关键词： energy transfer glasses luminescence optical materials rare earths

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