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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic lydia Jiménez-Díaz Juan D.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo adriana Cortés Mercedes lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Removing contaminants from tannery wastewater by chemical precipitation using CaO and Ca(OH)2

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Chinese Journal of Chemical Engineering 2020年第4期28卷 1107-1111页

作者： adriana Reyes-Serrano Joel Elópez-Alejo Manuel AHernández-Cortázar Ignacio Elizalde Instituto Politécnico Nacional Centro Mexicano para la Producción más LimpiaCiudad de México 07340Mexico

The removal of Cr,sulfates and Chemical Oxygen Demand(COD)from industrial tannery wastewater by chemical precipitation was carried out using Calcium oxide(CaO)and Calcium hydroxide(Ca(OH)2).Different doses of alkalis,ranging from deficiency to excess hydroxyl species over the stoichiometric necessary,were used to remove theoretically the 100%of Cr[0.3-3.2 g alkali·(g Cr^3+)^-1].The precipitation was carried out at room temperature,10 min of vigorous stirring,200 r·min^-1 and a settling time of 24 h,followed by separation and characterization of liquid *** result of addition of alkalis,pH underwent increase as did the alkali *** removal of Cr,and sulfates also increased as alkali concentration did,although for first species the changes at higher alkali contents were less *** removal on the other hand,did not follow a unique trend,instead exhibited a *** on our results,selection of a specific dose of alkali was carried out taking as reference the efficiency on total chromium removal,keeping the pH in the range 7 to 9 to ensure Cr precipitation as chromium *** those conditions,jar test was used to produce enough liquid product in order to determine the removal percent of several other *** removal percent of the species was as follows:Cr,SO4^2-,ZnSO4,FeSO4,CN^-1,NiSO4,Fe2[Fe(CN)6]at 99.8%,66.9%,99.6%,21.4%,70.9%,52.8%and 76.4%with CaO,and 99.8%,61.6%,99.9%,7.1%,84.0%,54.4%and 90.5%with Ca(OH)2,respectively.

关键词： Tannery wastewater Alkali Removal Chromium Sulfates Synergistic effect

Recent progress on isospin breaking corrections and their impact on the muon g-2 value

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Chinese Physics C 2010年第6期34卷 712-717页

作者： Gabriel lópez Castro Departamento de Física CinvestavApartado Postal 14-74007000 MxicoD.F Mxico

We describe some recent results on isospin breaking corrections which are of relevance for predictions of the leading order hadronic contribution to the muon anomalous magnetic moment aμ^*** when using τ lepton data. When these corrections are applied to the new combined data on the π^±π^0 spectral function, the prediction for aμ^*** based on τ lepton data gets closer to the one obtained using e^＋e^- data.

关键词： isospin breaking tau decays muon magnetic moment radiative corrections

A new device for deep cervical artificial insemination in gilts reduces the number of sperm per dose without impairing final reproductive performance

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Journal of Animal Science and Biotechnology 2019年第2期10卷 402-409页

作者： Pedro J.llamas-lópez Rebeca lópez-úbeda Gustavo lópez Emily Antinoja Francisco A.García-Vázquez Department of Physiology Faculty of VeterinaryCampus Mare NostrumUniversity of Murcia30100 MurciaSpain Department of Cell Biology and Histology Faculty of MedicineCampus Mare NostrumUniversity of Murcia30100 MurciaSpain Institute for Biomedical Research of Murcia(IMIB-Arrixaca) MurciaSpain Cherkizovo Group LipetskRussia.

Background: The aim of this study was to evaluate the reproductive performance of a new artificial insemination(AI) device specifically designed for gilts(Deep cervical AI, Dp-CAI) by means of which the sperm is deposited deeply in the cervix(8 cm more cranial than in traditional cervical insemination-CAI). New AI techniques have arisen in recent decades in the porcine industry, such as post-cervical artificial insemination(PCAI), which involves depositing the sperm in the body of the uterus [through a catheter(outer tube)-cannula(inner tube)] rather than by CAI. Although the PCAI method has been successfully applied in farm conditions to reduce sperm doses without impairing the reproductive performance, this technique has limitations in gilts mainly because of the difficulty involved in introducing the inner cannula through the cranial part of the cervix. For this reason, the Dp-CAI method described herein may be considered as an alternative to CAI and PCAI methods in ***: Gilts were divided in two experimental groups: 1) Dp-CAI: gilts(n = 1166) inseminated using 1.5 × 109 sperm/45 m l;2) CAI(as a control group): gilts(n = 130) inseminated using 2.5 × 10~9 sperm/85 ml. The Dp-CAI method was successfully applied in 88.90% of the gilts, with no differences detected between gilts with 1 or 2 previous oestrus cycles, although the catheter could be introduced more deeply in 2 oestrus gilts(P length of the insemination device that could not be introduced increased(at the moment of insemination), so the success rate of the Dp-CAI device fell, as did the total number of piglets born. When the reproductive output in CAI and Dp-CAI was compared, none of the parameters analysed [pregnancy and farrowing rates(%), and number of piglets born(total and live)] showed significant ***: The use of the Dp-CAI technique provides a new AI method as an alternative to CAI and PCAI for pigs. The device, especially designed for gilts, was used w

关键词： Cervix Intrauterine Nulliparous Porcine Post-cervical insemination

The bottlenose dolphin Tursiops truncatus foraging around a fish farm:Effects of prey abundance on dolphins' behavior

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Current Zoology 2009年第4期55卷 243-248页

作者： Bruno A■DZ lópez The Bottlenose Dolphin Research Institute BDRI

The extent to which prey abundance influences both bottlenose dolphin foraging behavior and group size in the presence of human activities has not previously been *** primary aim of this study was to identify and quantify how wild bottlenose dolphins respond,individually and as groups,to the relative abundance of prey around a fish *** views of dolphins' behavior were obtained by focal following individual animals whilst simultaneously collecting surface and underwater behavioral data.A total of 2150 dive intervals were analyzed,corresponding to 342 focal samples,lasting over 34 *** dolphins remained submerged for a mean duration of 46.4 seconds and a maximum of 249 *** study provides the first quantified data on bottlenose dolphin diving behavior in a marine fin-fish farm *** study's results indicate that within a fish farm area used intensively by bottlenose dolphins for feeding,dolphins did not modify dive ***,underwater observations confirmed that dolphins find it easier to exploit a concentrated food source and it appears that hunting tactic and not group size plays an important role during feeding ***,bottlenose dolphins appear capable of modifying their hunting tactics according to the abundance of *** top predators display behavioral responses to activities not directed at them,the task of studying all possible effects of human activities can become even more challenging.

关键词： Bottlenose dolphin Tursiops truncatus Diving behavior Foraging behavior Prey abundance Human activities,Hunting tactics Aquaculture

Tourism versus nature conservation: reconciliation of common interests and objectives——an analysis through Picos de Europa National Park

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Journal of Mountain Science 2018年第11期15卷 2505-2516页

作者： lópez Iván PARDO Mercedes Department of Psychology and Sociology University of Zaragoza Department of Social Analysis University Carlos Ⅲ of Madrid

Nature tourism and particularly tourism in national parks have acquired significant importance in contemporary societies. Post-Fordist consumers have reevaluated the meanings of ‘nature' and ‘natural spaces' and now avoid standardization to seek singularity. Tourism in national parks is a consequence of this tendency and has both positive and negative aspects. The purpose of this sociological research is to describe the most relevant conflicts in the Picos de Europa National Park(Spain) involving the park's conservation, local economic development,and tourism. Seven in-depth interviews and three focus groups were addressed to key local *** this research were identified three chief areas of existing or potential inter-related conflicts and the main actors interacting with them. The first is on population, particularly, the negative consequences of depopulations on the local socio-economic development and the environment. A second source of conflicts identified is caused by the difficult conciliation between commercial exploitation and conservation of the protected natural area. More precisely, this specific form of tourism positively contributes to the economy of local communities whilst problems can arise for the conservation goals of National Parks. Thirdly, in this research is also analyzed the institutional governance and the inter and intra-governmental conflicts as well as with the Park's management body. These findings provide important information for the improved management of tourism and conflicting interests in natural parks.

关键词： National parks Environmental conservation Nature tourism Mountain traditional economy Picos de Europa Spain

A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases

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World Journal of Gastroenterology 2009年第37期15卷 4638-4643页

作者： Fernando Bermejo Santiago García-lópez Digestive Service University Hospital of Fuenlabrada Fuenlabrada Madrid 28942 Spain Digestive Service University Hospital Miguel Servet Zaragoza 50009 Spain

Iron deficiency （ID）, with or without anemia, is often caused by digestive diseases and should always be investigated, except in very specific situations, as its causes could be serious diseases, such as cancer. Diagnosis of ID is not always easy. low serum levels of ferritin or transferrin saturation, imply a situation of absolute or functional ID. It is sometimes difficult to differentiate ID anemia from anemia of chronic diseases, which can coexist. In this case, other parameters, such as soluble transferrin receptor activity can be very useful. After an initial evaluation by clinical history, urine analysis, and serological tests for celiac disease, gastroscopy and colonoscopy are the key diagnostic tools for investigating the origin of ID, and will detect the most important and prevalent diseases. If both tests are normal and anemia is not severe, treatment with oral iron can be indicated, along with stopping any treatment with non-steroidal anti-inflammatory drugs. In the absence of response to oral iron, or if the anemia is severe or clinical suspicion of important disease persists, we must insist on diagnostic evaluation. Repeat endoscopic studies should be considered in many cases and if both still show normal results, investigating the small bowel must be considered. The main techniques in this case are capsule endoscopy, followed by

关键词： Anemia Iron-deficiency Iron deficiency anemia

Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

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Neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo Adolfo lópez-Ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la Cruz Marco Antonio Vargas-Hernández adriana Jiménez laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital Nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of *** brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or ***'s disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several ***,its impairment has barely been considered as a potential therapeutic *** we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ***,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport