检索结果-南通市图书馆

Nanostructured biohybrid material with wide-ranging antiviral action

Nano Research 2023年第8期16卷 11455-11463页

作者： Noelia Losada-Garcia Angela Vazquez-Calvo David Ortega-Alarcon Olga Abian adrian Velazquez-Campoy Pilar Domingo-Calap Antonio Alcami jose M.Palomo Instituto de Catálisis y Petroleoquímica(ICP) CSICC/Marie Curie 2.Madrid 28049Spain Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas(CSIC)-Universidad Autónoma de Madrid(UAM)Madrid 28049Spain Institute of Biocomputation and Physics of Complex Systems(BIFI) Joint Unit GBsC-CSIC-BIFIUniversity of ZaragozaZaragoza 50018Spain Fundación Instituto de Investigación Sanitaria de Aragón(IIS Aragón) Zaragoza 50009Spain CIBERehd Madrid 28029Spain Instituto de Biología Integrativa de Sistemas I2SyBioUniversitat de València-CSICValència E-46071Spain

Respiratory pathogens kill more people than any other infectious agent each year *** of novel,economically friendly,sustainable,and highly efficient materials against viruses is a major ***,we describe a nanostructured material composed of very small crystalline phosphate copper nanoparticles synthesized using a new biohybrid technology that employs a biological agent for its formation at room temperature in aqueous *** evaluation of different enzymes in the final preparation of the nanomaterial or even in synthetic methods was *** characterization revealed the formation of Cu species in the protein *** best biomaterial synthesized using a lipase called BioCuNPs showed excellent inhibition capacity against functional proteins of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);for example,assent 3-chymotrypsin like protease(3CLpro)complete inhibition was achieved by using 5µg/mL,or acetone(ACE)–spike protein interaction was inhibited by more than 80%in the presence of 400µg/mL of *** these in vitro results into account,an efficacy analysis against human coronavirus 229E(HCoV-E229)coronavirus was performed.A virus reduction of 99%was obtained in 5 ***,SARS-CoV-2 virus was tested to demonstrate high efficiency,with>99%inhibition in 15 min using 500 microgram of *** determine the wide applicability of this nanohybrid against viruses,an evaluation was carried out against a non-enveloped virus such as Human Rhinovirus(HRV-14),obtaining a virus reduction of 99.9%in 5 ***,the virucidal capacity against different bacteriophages was also evaluated,obtaining an excellent inhibition effect against PhageΦX174(99.999%reduction in 5 min).

关键词： antiviral compound coronaviruses copper nanoparticles nanobiotechnology viruses

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NF-κB激活蛋白2(NAP2)诱导白细胞介素-12分泌的研究

引用

细胞与分子免疫学杂志 2003年第4期19卷 403-405页

作者：杨敏刘娜 adrian T TING 第四军医大学基础部生物化学与分子生物学教研室陕西西安710032 美国西奈山医学院免疫学系美国纽约10029

目的 :研究新克隆的编码NF κB激活蛋白 2 (NAP2 )基因的功能及作用机制。方法 :采用NF κB和IL 12启动子荧光素酶报告质粒及胞质内IL 12染色法 ,观察NAP2基因产物在巨噬细胞中对NF κB、IL 12启动子的激活及对IL 12合成的调控。结果 :N... 详细信息

目的 :研究新克隆的编码NF κB激活蛋白 2 (NAP2 )基因的功能及作用机制。方法 :采用NF κB和IL 12启动子荧光素酶报告质粒及胞质内IL 12染色法 ,观察NAP2基因产物在巨噬细胞中对NF κB、IL 12启动子的激活及对IL 12合成的调控。结果 :NAP2可激活NF κB和IL 12启动子 ,而IκBαDN则可抑制他们的活化。在巨噬细胞系j774中 ,NAP2也可诱导IL 12表达。结论 :NAP2基因产物可激活IL 12启动子并诱导IL 12的合成 ,提示NAP2可能是通过调控NF κB转录因子而调节IL

关键词： NAP2 白细胞介素—12 NF—κB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-healable stretchable printed electronic cryogels for in-vivo plant monitoring

引用

npj Flexible Electronics 2023年第1期7卷 59-69页

作者： Eloïse Bihar Elliot j.Strand Catherine A.Crichton Megan N.Renny Ignacy Bonter Tai Tran Madhur Atreya adrian Gestos jim Haseloff Robert R.McLeod Gregory L.Whiting Paul M.Rady Department of Mechanical Engineering University of Colorado Boulder1111 Engineering DriveBoulderCO 80309USA Materials Science and Engineering University of Colorado Boulder4001 Discovery DriveBoulderCO 80303USA Department of Plant Sciences University of CambridgeDowning StreetCambridge CB23EAUK Materials Instrumentation and Multimodal Imaging Core Facility University of Colorado Boulder1111 Engineering Drive BoulderBoulderCO 80309USA Department of Electrical Computerand Energy EngineeringUniversity of Colorado Boulder1111 Engineering DriveBoulderCO 80309USA

A key challenge in bioelectronics is to establish and improve the interface between electronic devices and living tissues,enabling a direct assessment of biological *** integrated with plant tissue can provide valuable information about the plant itself as well as the surrounding environment,including air and soil *** obstacle in developing interfaces to plant tissue is mitigating the formation of fibrotic tissues,which can hinder continuous and accurate sensor operation over extended *** systems that utilize suitable biocompatible materials alongside appropriate fabrication techniques to establish plantelectronic interfaces could provide for enhanced environmental understanding and ecosystem management *** meet these demands,this study introduces an approach for integrating printed electronic materials with biocompatible cryogels,resulting in stable implantable hydrogel-based bioelectronic devices capable of long-term operation within plant *** inkjet-printed cryogels can be customized to provide various electronic functionalities,including electrodes and organic electrochemical transistors(OECTs),that exhibit high electrical conductivity for embedded conducting polymer traces(up to 350 S/cm),transconductance for OECTs in the mS range,a capacitance of up to 4.2mF g−1 in suitable structures,high stretchability(up to 330%strain),and selfhealing *** biocompatible functionalized cryogel-based electrodes and transistors were successfully implanted in plant tissue,and ionic activity in tomato plant stems was collected for over two months with minimal scar tissue formation,making these cryogel-based printed electronic devices excellent candidates for continuous,in-situ monitoring of plant and environmental status and health.

关键词： electronic utilize integrating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

北美科迪勒拉的形态构造分析:由大地构造、地貌地球物理、地质及成矿作用揭示的迹象

引用

世界地质 1991年第1期10卷 151-152页

作者： finn V.j. 陈华

形态结构分析揭示出基底岩块中发育有同心环形、卵形或线性断裂(dislocation),它们被沉积-火山盖层所覆盖或被变形事件或侵入事件所淹没。这种分析揭示了基底岩石的演化及覆于基底断块之上并影响到它们的一些事件而且还构绘出这些断块... 详细信息

形态结构分析揭示出基底岩块中发育有同心环形、卵形或线性断裂(dislocation),它们被沉积-火山盖层所覆盖或被变形事件或侵入事件所淹没。这种分析揭示了基底岩石的演化及覆于基底断块之上并影响到它们的一些事件而且还构绘出这些断块的周期性抬升和沉降运动。这些基底断块与线性不连续带的交汇部位是地壳深部区或地幔物质(岩浆、气体或含矿物流体)喷发地带。这些断层或基底断块的存在,其规模及其形态可以利用地形、目前的隆起和起伏情况、水系型式、地质分布、古构造型式、相型式、卫星图象的线性特点、构造特征、地球物理异常及矿化分布等方面进行确定。同心构造或穹窿的规模可以是Ⅰ级或全球规模(直径1500～2000km)、区域规模(900～1200km)、亚区域规模(500～800km)、省级规模(300～450km)、直至地区规模(80～200km)。线性构造或断层带标志着基底线性断层带((?)isl(?)catio(?)s)带,其规模也可由全球规模(Ⅰ级)至局部范围。全球线性构造(宽300～500km,长1000～10000km,间隔500km)可以将深部流体穿过地壳,并限定了侵入体的位置。

关键词：形态构造大地构造地貌地质成矿

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Teaching European History Today

Teaching European History Today

引用

北京论坛（2005）文明的和谐与共同繁荣——全球化视野中亚洲的机遇与发展

作者： adrian Shubert Professor of History and Associate Vice-President International York University Toronto OntarioM3J 1P3Canada

There are two substantial shortcomings to the way that European history has been conceived and taught in the Western world,and particularly in North America,what we might call"the west of the West".On the one hand,the prevalent conception of the geographic content of"Europe"has long been,and still remains,surprisingly *** most departments of History in North

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Plagiarized and inaccurate papers in the World journal of Gastroenterology

引用

World journal of Gastroenterology 2004年第19期10卷 2925-2925页

作者： Thomas E.adrian Northwestern University Feinberg School of Medicine 303 E.Chicago AvenueTarry 4-711ChicagoIL 60611USA Professor

I was astonished to find this paper [Dong ML, Ding XZ, CollinP, adrian TE. Red oil A5 inhibits proliferation and inducesapoptosis in pancreatic cancer cells. World j Gastroenterol2004; 10(1): 105-111] published in your journal. This has beendone without my knowledge or the other coauthor, Dr. *** are numerous errors. These include (1) the exclusion

关键词：抄袭错误文章世界肠胃病杂志胰腺癌分芽增殖

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multiscale assessment of ground,aerial and satellite spectral data for monitoring wheat grain nitrogen content

引用

Information Processing in Agriculture 2023年第4期10卷 504-522页

作者： joel Segarra Fatima Zahra Rezzouk Nieves Aparicio jon González-Torralba Iker Aranjuelo adrian Gracia-Romero jose Luis Araus Shawn C.Kefauver Integrative Crop Ecophysiology Group Plant Physiology SectionFaculty of BiologyUniversity of BarcelonaBarcelona 08028Spain AGROTECNIO(Center for Research in Agrotechnology) Lleida 251981Spain Agro-technological Institute of Castilla y León(ITACyL) Valladolid 47071Spain Grupo AN Tajonar 31192NavarreSpain Instituto de Agrobiotecnología(IdAB) CSIC-Gobierno de NavarraMutilva Baja 31192PamplonaNavarreSpain

Wheat grain quality characteristics have experienced increasing attention as a central factor affecting wheat end-use products quality and human ***,in the last decades a reduction in grain quality has been ***,it is central to develop efficient quality-related phenotyping *** this sense,one of the most relevant wheat features related to grain quality traits is grain nitrogen content,which is directly linked to grain protein content and monitorable with remote sensing ***,the relation between nitrogen fertilization and grain nitrogen content(protein)plays a central role in the sustainability of *** aiming to develop efficient phenotyping tools using remote sensing instruments and to advance towards a field-level efficient and sustainable monitoring of grain nitrogen status,this paper studies the efficacy of various sensors,multispectral and visible red-greenblue(RGB),at different scales,ground and unmanned aerial vehicle(UAV),and phenological stages(anthesis and grain filling)to estimate grain nitrogen *** models were calculated using vegetation indices at each sensing level,sensor type and phenological ***,this study explores the up-scalability of the best performing model to satellite level Sentinel-2 equivalent *** found that models built at the phenological stage of anthesis with UAV-level multispectral cameras using red-edge bands outperformed grain nitrogen content estimation(R2=0.42,RMSE=0.18%)in comparison with those models built with RGB imagery at ground and aerial level,as well as with those built with widely used ground-level multispectral *** also demonstrated the possibility to use UAV-built multispectral linear models at the satellite scale to determine grain nitrogen content effectively(R2=0.40,RMSE=0.29%)at actual wheat fields.

关键词： Wheat Remote sensing Sentinel-2 Grain nitrogen content Phenotyping

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental increases in diversity and evenness improve productivity and reduce weed invasion in grassland swards over three years across 12 European sites

Experimental increases in diversity and evenness improve pro...

引用

ⅩⅪ International Grassland Congress and the Ⅷ International Rangeland Congress

作者： L Kirwan C Brophy RP Collins j Connolly j A finn A Helgadottir A Lscher C Porqeuddu MT Sebastia Eugene Lawler Graduate School of Computing Waterford Institute of TechnologyIreland. UCD School of Mathematical Sciences Ecological and Environmental Modelling Group University College DublinDublin 4Ireland.

＜正＞Introduction Increased emphasis on the multifunctionality of European agriculture has called for a re-investigation of the use of mixtures in productive *** research suggests that increased species diversity in species-poor intensive grassland systems may potentially provide multiple *** present results from the COST 852 multisite Agrodiversity Grassland Experiment,where we test a number of basic questions in agronomic diversity-function *** was hypothesised that（1） mixtures can outperform monocultures both in terms of productivity and weed suppression（2） the diversity benefits will be persistent through time（3） the diversity benefits will be consistent across a wide geographical scale.

关键词： diversity-function evenness persistence of diversity effects

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

EXPERIMENTAL STUDY ON BED SHEAR STRESS AND SEDIMENT TRANSPORT IN A MEANDERING LABORATORY CHANNEL

引用

International journal of Sediment Research 2002年第1期17卷 1-19页

作者： L. YILMAZ1, Vijay P. SINGH2, S.K. MISHRA3, D. D. adrian2 and j. j. SANSALONE2 1 Civil Engineering Faculty, Hydraulic Division, Technical University of Istanbul, 80626, Maslak, Istanbul, Turkey Civil Engineering Faculty Hydraulic Division Technical University of Istanbul 80626 Maslak Istanbul Turkey Dept. of Civil and Environmental Engineering Louisiana State University Baton Rouge LA 70803-6405 U. S. A. National Institute of Hydrology Roorkee-247 667 Uttaranchal India

An experimental study was carried out to investigate bed shear stress of a flow boundary layer with meandering features and sediment transport in a meandering channel. By measuring the shear stress distribution with hot-film sensors, the stability of the fluid-bed interface and the characteristics of the bed features were investigated experimentally in a laboratory model for free-surface flow over an erodible bed. The experimental results are presented in two parts. First, experimental observations of meander evolution due to inhomogeneous distribution of boundary layer meander features are qualitatively described in terms of the shear stress distribution. Second, an empirical relation is proposed for the shear stress distribution measured with WTG-50 hotfilmanemometer at the wavy iron bed. The sediment transport rate measured in the meandering channel in a laboratory flume was used to evaluate and compare the sediment transport formulae of Shield (1936), Meyer-Peter and Mller (1948), Einstein (1950), and Bagnold (1966). The sedimentation rates computed using these formulae were found to be generally higher than those observed in the laboratory. However, the Einstein formula yields these rates closest to the measured ones but with an over-prediction of 64.5% in general. Using the experimental observations, empirical formulae were also developed for predicting the sediment transport rate and the meander planforms for a specific condition.

关键词： Bed shear stress Sediment transport Meandering channel Stability Boundary layer

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

From river blindness control to elimination:bridge over troubled water

引用

Infectious Diseases of Poverty 2018年第1期7卷 215-229页

作者： Robert Colebunders Maria-Gloria Basanez Katja Siling Rory j.Post Anke Rotsaert Bruno Mmbando Patrick Suykerbuyk adrian Hopkins Global Health Institute University of AntwerpAntwerpBelgium London Centre for Neglected Tropical Disease Research Imperial College LondonLondonUK Institute of Tropical Medicine AntwerpBelgium London School of Hygiene&Tropical Medicine LondonUK Liverpool john Moores University LiverpoolUK National Institute for Medical Research TangaTanzania Neglected and Disabling diseases of Poverty Consultant GravesendKentUK

Background:An estimated 25 million people are currently infected with onchocerciasis(a parasitic infection caused by the filarial nematode Onchocerca volvulus and transmitted by Simulium vectors),and 99%of these are in sub-Saharan *** African Programme for Onchocerciasis Control closed in December 2015 and the World Health Organization has established a new structure,the Expanded Special Project for the Elimination of Neglected Tropical Diseases for the coordination of technical support for activities focused on five neglected tropical diseases in Africa,including onchocerciasis ***:In this paper we argue that despite the delineation of a reasonably well-defined elimination strategy,its implementation will present particular difficulties in *** aim to highlight these in an attempt to ensure that they are well understood and that effective plans can be laid to solve them by the countries concerned and their international ***:A specific concern is the burden of disease caused by onchocerciasis-associated epilepsy in hyperendemic zones situated in countries experiencing difficulties in strengthening their onchocerciasis control *** difficulties should be identified and programmes supported during the transition from morbidity control to interruption of transmission and elimination.

关键词： Onchocerciasis Control Elimination Monitoring&evaluation Community drug distributors Epilepsy Prevalence Incidence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：