检索结果-南通市图书馆

the response of P50 sensory gating in substantia Nigra on estrogen against dopaminergic neurons depleted by oxidative stress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The response of P50 sensory gating in substantia Nigra on es...

Application of biomarkers in sentinel lymph node biopsy for the management of breast cancer

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Jinlan MENG~(1,2),Yuanyi MA~(1,3),Haiyun LUO~1,Min HE~(1*) 1 Department of Physiology,Kunming Medical College,Kunming,Yunnan 650031,China 2 Department of Physiology,Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China 3 Fourth Military Medical University press,Xian,Shanxi 710032,China

＜正＞Estrogen as a natural antioxidant of membrane phospholipids peroxidation can block the damage of dopaminergic neurons in substantia nigra（SN） lesioned by exotic toxicant like 6-hydroxydopamine（6-OHDA） to protect dopaminergic neurons in *** now researching the relationship between estrogen and the system of dopaminergic neurons in SN generally adopt ex vivo and acute animal microdialysis experiments which can not reflect estrogen’s internal proptection of antioxidative stress to dopaminergic neurons.A lot of substantial evidences strongly implied that P50 sensory gating （P50） and dopaminergic neurotransmitter have affinities,P50 can be recorded in a quite and awake *** the present P50 sensory gating in SN was studied in normal group（F-INt）,Parkinson’s disease model group with 6-OHDA lesioned SN（FPD）, ovariectomy + 6-OHDA Parkinson’s disease model group（F-OVX-PD） and ovariectomy + estrogen replacement + 6- OHDA Parkinson’s disease model group（F-OVX-E2-PD） to determine the change of P50 sensory gating in SN on estrogen against dopaminergic neurons depleted by oxidative stress.P50 auditory evoked potentials by two brief acoustic stimuli were recorded in the SN and the number of tH immunohistochemistry stained dopaminergic neurons in the SN was investigated after the determination of *** results demonstrated that:（1） the testing/conditioning（t/C） ratio of P50 is decreased significantly in F-PD group（0.399±0.074,n=15） as compared to F-INt group（0.667±0.037,n=21）（P＜0.01）;（2） the t/C ratio of P50 is decreased significantly in F-OVX-PD group（0.219±0.059,n=12） as compared to F-PD group and FOVX -E2-PD group（0.498±0.166,n=15）（P＜0.01）;（3） the t/C ratio of P50 is no difference between F-OVX-E2-PD group and F-PD group（P＞0.05）.（4） the number of tH+ cells in right SN（lesioned by 6-OHDA） of F-OVX-PD group decreased about 57.14%and 60.86%as compared to F-PD group and F-OVX-E2-PD group（P＜0.05）.the number of tH+ cells in right SN is decreased significantly as compared

关键词： P50 sensory gating estrogen dopaminergic neurons oxidative stress

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中华乳腺病杂志（电子版） 2012年第6期6卷 11-15页

作者： Qing Liu Wings tjing Yung Loo adrian Yun San Yip Louis Wing Cheong Chow Elizabeth Lam Yan Ng Mary Ngan Bing Cheung UNIMED Medical Institute Organization for Oncology and translational Research

Objective Sentinel lymph node in breast cancer is a predictor of the tumor's metastatic *** emerging from antitumor immune response might also target sentinel lymph node (SLN).In this study,we evaluated the cytokine profile including interleukin-8 (IL-8),interleukin-12 (IL-12),interferon-gamma (IFN-γ),and tumor necrosis factor alpha (tNF-α) for the t-cell *** From January 2008 to August 2010,35 patients with breast mass underwent SLN biopsy in UNIMED Medical *** specimens were formalin-fixed and paraffin-embedded for hematoxylin and eosin staining and immunohistochemistry with following markers:IL-8,IL-12,IFN-γ and tNF-α.the staining intensity was scored according to four grades:negative (-),weak expression (+),moderately positive expression (+ +),strong positive expression (+ + +).the correlation between the expression of cytokines and pathological characteristics were also analyzed using the Spearman Rank Correlation *** Out of 35 patients,SLN metastases were observed in 20 patients and among them,75% (15 /20) were strongly stained (+ + +) with IL-8 and moderately stained (+ +) with IL-12,but only 25% (5 /20) were strongly stained (+ + +) with IFN-γ and tNF-α.the expression of IL-8 was significantly associated with all tumor grades (r=0.639,P=0.00),estrogen receptor (r=0.778,P=0.01),progesterone receptor (r=0.759 P=0.00) and HER-2 /neu receptor (r=0.863 P=0.00).Conclusion the strong association between IL-8 expression and SLN metastases might highlight the prognostic significance of IL-8 in SLN.

关键词：临床治疗乳腺疾病医学

脂肪移植的研究：第二部分注射设备对脂肪物质属性的影响

在线全文

学校读者我要写书评

暂无评论

中国美容整形外科杂志 2014年第10期25卷 I0013-I0018页

作者： David Atashroo Jordan Raphel Michael t. Chung Kevin J. Paik Andreina Parisi-Amon adrian McArdle Kshemendra Senarath-Yapa Elizabeth R. Zielins Ruth tevlin Chris Duldulao Graham G. Walmsley Michael S. Hu Arash Momeni Brian Domecus Joe R. Rimsa Lauren Greenberg Geoffrey C. Gurtner Michael t. Longaker Derrick C. Wan 魏峰高景恒张晨斯坦福大学医学院Hagey儿科再造医学实验室整形再造外科中心外科部干细胞生物学与再生医学中心美国加利福尼亚州斯坦福斯坦福大学材料科学、工程学及生物工程学部门洛帕克 tautona研究组门洛帕克帕洛阿尔托外科中心帕洛阿尔托《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

目的尽管脂肪移植可以治疗多种软组织缺陷，但其结果仍有一定的不确定性。本研究中，我们将对使用一种自动、低剪切力装置或改良Coleman技术注射脂肪的物理性质进行对比。方法从9例患者处提取脂肪抽吸物，经过处理后采取改良Coleman技... 详细信息

目的尽管脂肪移植可以治疗多种软组织缺陷，但其结果仍有一定的不确定性。本研究中，我们将对使用一种自动、低剪切力装置或改良Coleman技术注射脂肪的物理性质进行对比。方法从9例患者处提取脂肪抽吸物，经过处理后采取改良Coleman技术或一种自动、低剪切力装置进行脂肪注射。通过一种2mm口径套管注入脂肪，并与微处理的脂肪进行对比。当组织开始失去其固态性质时，利用血流速度计测量其存储模量及剪切速率。同时，对脂肪组织的黏性进行测量，并通过载玻片实验定性评估每个治疗组的总产量。结果利用自动、低剪切力装置注射的脂肪，其物理性质与微处理的脂肪最接近。该自动装置组的脂肪存储模量（G’）比改良Coleman技术组高，而强度极限更延后。同样，测得该自动装置组的脂肪黏性与微处理组相当，比改良Coleman技术组的高。结论与改良Coleman技术相比，利用连于2mm插管的自动、低剪切力装置处理的脂肪抽吸物可以更好地保留脂肪组织完整的物理性质。本研究通过流变数据证实，该自动装置比改良Coleman技术对脂肪组织的损伤更小，其应用可能会增加移植脂肪的完整性。

关键词：脂肪移植注射脂肪软组织缺陷脂肪抽吸物物理性质低剪切力物质设备

Bright,high-repetition-rate water window soft X-ray source enabled by nonlinear pulse self-compression in an antiresonant hollow-core fibre

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2021年第3期10卷 313-319页

作者： M.Gebhardt t.Heuermann R.Klas C.Liu A.Kirsche M.Lenski Z.Wang C.Gaida J.E.Antonio-Lopez A.Schülzgen R.Amezcua-Correa J.Rothhardt J.Limpert Institute of Applied Physics Abbe Center of PhotonicsFriedrich-Schiller-Universitat JenaAlbert-Einstein-Str.1507745 JenaGermany Helmholtz-Institute Jena Frobelstieg 307743 JenaGermany CREOL College of Optics and PhotonicsUniversity of Central FloridaOrlandoFL 32816USA Fraunhofer Institute for Applied Optics and Precision Engineering Albert-Einstein-Str.707745 JenaGermany Active Fiber Systems GmbH Ernst-Ruska-Ring 1707745 JenaGermany

Bright,coherent soft X-ray radiation is essential to a variety of applications in fundamental research and life *** date,a high photon flux in this spectral region can only be delivered by synchrotrons,free-electron lasers or high-order harmonic generation sources,which are driven by kHz-class repetition rate lasers with very high peak ***,we establish a novel route toward powerful and easy-to-use SXR sources by presenting a compact experimentin which nonlinear pulse self-compression to the few-cycle regime is combined with phase-matched high-orderharmonic generation in a single,helium-illed antiresonant hollow-core *** enables the first 100 kHz-classrepetition rate,table-top soft X-ray source that delivers an application-relevant flux of 2.8×10^6 photon s^-1 eV^-1 around 300 *** fibre integration of temporal pulse self-compression(leading to the formation of the necessarystrong-field waveforms)and pressure-controlled phase matching will allow compact,high-repetition-rate lasertechnology,including commercially available systems,to drive simple and cost-effective,coherent high-flux softX-ray sources.

关键词： pulse repetition fibre

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

我的九条命首发会纪要

技术经济与管理研究 2003年第3期 7-8页

作者： N.t.WANG 美国哥伦比亚大学著名教授

***出回忆录业已于本刊《世界名教授论苑》连载。其英文版也由Writers Club press出版，并可在网上，***，阅读或订购。 2002年4月22日美国哥伦比亚大学东亚研究所举办该书首发会，参加者非常踊跃，作者别出心裁，富哲理于诙谐，博... 详细信息

***出回忆录业已于本刊《世界名教授论苑》连载。其英文版也由Writers Club press出版，并可在网上，***，阅读或订购。 2002年4月22日美国哥伦比亚大学东亚研究所举办该书首发会，参加者非常踊跃，作者别出心裁，富哲理于诙谐，博得笑声满堂，皆大欢喜。特此记要。……

关键词：发展中国家名字不发达国家地区法官法律工作者美国哥伦比亚大学哥伦比亚大学学识渊博

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

印欧语比较语法入门(上)

南阳师范学院学报 2008年第1期7卷 35-52页

作者： t.HUDSON-WILLIAMS 冯蒸首都师范大学文学院北京100089

《印欧语比较语法入门》(A Short Introduction to the Study of Comparative Grammar[Indo-European],1935,Cardiff,University of Wales press)一书为英国印欧语学研究者t.哈德逊-威廉姆斯(***-Williams,1873—1961)教授所著,是一本关于印欧语历史比较语言学的入门书,简明扼要地介绍了印欧语学理论与方法以及印欧语语音、形态和词汇的构造与演变。该书内容对原始汉藏语和上古汉语的语音、形态与词源学研究多有启发,我国的著名语言学家王静如、傅懋勣、周达甫等先生都曾研习过此书,并十分推重。首都师范大学文学院教授、著名音韵学家冯蒸先生师从王静如先生(1903.6—1990.10.2)学习音韵学和历史比较语言学时曾仔细研读此书,深感获益匪浅。该书出版于1935年,后于1951、1961、1966年三次重印,今由冯蒸教授根据1966年重印本译成汉语,作为我国第一本全面介绍印欧语学研究成果的专著,奉献给读者。

关键词：入门语法首都师范大学语言学研究成果古汉语词源学历史

在线全文

学校读者我要写书评

暂无评论

不列颠及其意识形态十字军对阵法国大革命

四川大学学报（哲学社会科学版） 2015年第1期 35-45页

作者：哈里.狄金森辛旭英国爱丁堡大学历史与古典学学院四川大学历史文化学院

1789年法国大革命对英国的政治实践及理念具有深远的影响。尽管一些激进的英国作家们深刻同情法国大革命,并期望大革命的政纲能在英国传播,但绝大多数知识人则投入到规模巨大的舆论战中,意在说服英国民众相信法国革命的信念对英国宪法... 详细信息

1789年法国大革命对英国的政治实践及理念具有深远的影响。尽管一些激进的英国作家们深刻同情法国大革命,并期望大革命的政纲能在英国传播,但绝大多数知识人则投入到规模巨大的舆论战中,意在说服英国民众相信法国革命的信念对英国宪法、政治传统、社会体制、宗教、公共秩序乃至个人财产都是威胁应予以拒斥。他们认为,法国大革命的政治信念是对秩序与稳定的威胁,它会摧毁贵族与君主制,也会威胁私有财产,并由此导致混乱、暴力与恐怖活动。1793到1802年英法开战,英国保守派政治宣传家们力劝对英国政治、社会、经济产生影响的人们认同他们对法国大革命信念的反对立场,从而支持他们在法国恢复旧秩序的战争诉求。本文即探讨并追溯由保守派宣传家们发动的、以其最知名者埃德蒙·伯克领导的这场颇具才干及影响力的政治争论。

关键词：法国大革命法国战争爱德蒙·伯克政治宣传出版物社会秩序

Observation of a single protein by ultrafast X-ray diffraction

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第1期13卷 80-90页

作者： tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke adrian P.Mancuso tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor timneanu Sergey Usenko Daniel Westphal tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany the Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

the idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

What factors influence patient experience in orthopedic oncology office visits?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2020年第3期11卷 136-142页

作者： Alan t Blank Sara Shaw Connor J Wakefield Yue Zhang Wei J Liu Kevin B Jones R Lor Randall Department of Orthopedic Surgery Division of OncologyRush University Medical CenterChicagoIL 61011United States Department of Orthopedics University of UtahSalt Lake CityUT 84122United States Department of Family&Preventive Medicine University of UtahSalt Lake CityUT 84108United States Scientific Computing and Image Institute University of UtahSalt Lake CityUT 84108United States Department of Orthopaedic Surgery University of California-Davis Medical CenterSacramentoCA 95817United States

BACKGROUND Patient satisfaction and reported outcomes are becoming increasingly important in determining the efficacy of clinical *** date no study has evaluated the patient experience in the orthopedic oncology outpatient setting to determine which factors of the encounter are priorities to the *** to evaluate what factors impact patient experience and report satisfaction in an outpatient orthopedic oncology *** press Ganey®patient surveys from a single outpatient orthopedic oncology clinic at a tertiary care setting were prospectively collected per routine medical *** orthopedic oncology patients who were seen in clinic and received electronic survey were *** survey responses were submitted within one month of clinic *** approval was obtained to retrospectively collect survey responses from 2015 to *** demographic data along with survey category responses were collected and statistically *** One hundred sixty-two patient surveys were *** patient age was 54.4 years(SD=16.2 years)and were comprised of 51.2% female and 48.4%male.64.2%of patients were from *** of state residents were more likely to recommend both the practice and attending *** likelihood to recommend attending physician was positively associated with MD friendliness/courtesy(OR=14.4,95%CI:2.5-84.3),MD confidence(OR=48.2,95%CI:6.2-376.5),MD instructions follow-up care(OR=2.5,95%CI:0.4-17.4),and sensitivity to needs(OR=16.1,95%CI:1-262.5).Clinic operations performed well in the categories of courtesy of staff(76%)and cleanliness(75%)and less well in ease of getting on the phone(49%),information about delays(36%),and wait time(37%).CONCLUSION Orthopedic specialties can utilize information from this study to improve care from the patient *** studies may be directed at how to improve these areas of care which are most valued by the patient.

关键词： press Ganey^(█) survey Orthopedic oncology Outpatient clinic Patient experience Patient satisfaction Patient reported outcomes