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Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

World Journal of Gastroenterology 2013年第48期19卷 9282-9293页

作者： Fergus Noble Luke Nolan adrian c bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R bateman cancer Sciences Unit Faculty of Medicine University of Southampton Southampton SO16 6YD United Kingdom Department of Surgery University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom Department of cellular Pathology University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom cancer care University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom

AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant ***:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were *** neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 *** to neoadjuvant chemotherapy(NAc)was assessed using TRG,as described by Mandard et *** addition lymph node downstaging was also *** node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAc given prior to surgery,or pN0if surgery *** were followed up for 5 years post *** was defined radiologically,with or without pathological *** association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological ***:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%cI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality *** hundred and thirty-six(62.4%)patients received NAc,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological *** four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(Pc was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,

关键词： Esophageal cancer Gastro-esophageal cancer Neoadjuvant Regression

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Smart cutting Tools and Smart Machining: Development Approaches, and Their Implementation and Application Perspectives

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chinese Journal of Mechanical Engineering 2017年第5期30卷 1162-1176页

作者： Kai cheng Zhi-chao Niu Robin c.Wang Richard Rakowski Richard bateman college of Engineering Design and Physical SciencesBrunel University London

Smart machining has tremendous potential and is becoming one of new generation high value precision manufacturing technologies in line with the advance of Industry 4.0 concepts. This paper presents some innovative design concepts and, in particular, the development of four types of smart cutting tools, including a force-based smart cutting tool, a temperature-based internally-cooled cutting tool, a fast tool servo （FTS） and smart collets for ultra- precision and micro manufacturing purposes. Implemen- tation and application perspectives of these smart cutting tools are explored and discussed particularly for smart machining against a number of industrial application requirements. They are contamination-free machining, machining of tool-wear-prone Si-based infra-red devices and medical applications, high speed micro milling and micro drilling, etc. Furthermore, implementation tech- niques are presented focusing on：（a） plug-and-produce design principle and the associated smart control algo- rithms, （b） piezoelectric film and surface acoustic wave transducers to measure cutting forces in process, （c） critical cutting temperature control in real-time machining, （d） in- process calibration through machining trials, （e） FE-based design and analysis of smart cutting tools, and （f） applica- tion exemplars on adaptive smart machining.

关键词： Smart cutting tool Smart machining Fast toolservo (FFS) Precision machining Micro manufacturing Smart tooling

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Elucidating the Degradation Pathways of Human Insulin in the Solid State

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Journal of Analysis and Testing 2024年第3期8卷 288-299页

作者： Andrew Fagan Lorraine M.bateman Joseph P.O’Shea Abina M.crean SSPc the SFI Centre for Pharmaceutical ResearchSchool of PharmacyUniversity College CorkCork T12 YT20Ireland School of Pharmacy University College CorkCork T12 YT20Ireland Analytical and Biological chemistry Research Facility(ABcRF) University College CorkCork T12 YN60Ireland School of chemistry University College CorkCork T12 YN60Ireland

While there have been significant advances in the development of peptide oral dosage forms in recent years,highlighted by the clinical and commercial success of approved peptides such as Rybelsus®,there remain several barriers in the way of broad range applicability of this approach to peptide *** such barrier includes the poor physical and chemical stability inherent to their structures,which persists in the solid state although degradation typically occurs at different rates and via different pathways in comparison to the solution *** insulin as a model peptide,this work sought to contribute to the development of analytical techniques for investigating common insulin degradation *** denatured,deamidated and aggregated samples were prepared and used to benchmark circular dichroism spectroscopy,reverse phase HPLc and size exclusion chromatography methods for the investigation of unfolding,chemical modifications and covalent aggregation of the insulin molecule *** state degraded samples were prepared by heating insulin powder at 60°c and 75%relative humidity for 1,3,5 and 7 d,and the degradation profiles of the samples were evaluated and compared with those observed in *** no unfolding was observed to occur,significant deamidation and covalent aggregation were *** disulfide bond cleavage using dithiothreitol allowed for separation of the insulin A-and B-chains,offering a facile yet novel means of assessing the mechanisms of deamidation and covalent aggregation occurring in the solid state.

关键词： Insulin Stability Solid state Deamidation covalent aggregation Disulfide cleavage Biopharmaceutical analysis

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Liver biopsy in a district general hospital:changes over two decades

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World Journal of Gastroenterology 2007年第40期13卷 5336-5342页

作者： Wing-Kin Syn caroline Bruckner-Holt Adam Farmer Sarah Howdle Jeffrey bateman Liver and Hepatobiliary Unit Queen Elizabeth HospitalBirminghamB 15 2THUnited Kingdom Department of Gastroenterology Princess Royal HospitalTelfordUnited Kingdom Department of Gastroenterology City HospitalBirminghamUnited Kingdom Department of Radiology Princess Royal HospitalYelfordUnited Kingdom

AIM： To study liver biopsy practice over two decades in a district general hospital in the United Kingdom.METHODS： We identified all patients who had at least one liver biopsy between 1986 and 2006 from the databases of the radiology and gastroenterology departments. Subjects with incomplete clinical data were excluded from the study.RESULTS： A total of 103 liver biopsies were performed. clinical data was available for 88 patients, with 95 biopsies. Between 1986 and 1996, 18 （95%） out of the 19 liver biopsies performed were blind and 6 （33%） were for primary biliary cirrhosis. Between 1996 and 2006, 14 （18%） out of 76 biopsies were blind; and the indications were abnormal liver tests （33%）, hepatitis c （12%） and targeted-biopsies （11%）. Liver biopsies were unhelpful in 5 （50） subjects. Pain was the most common complication of liver biopsy （5%）. No biopsy-related mortality was reported. There was a trend towards more technical failures and complications with the blind biopsy technique.cONcLUSION： Liver biopsies performed in small district hospitals are safe and useful for diagnostic and staging purposes. Abnormal liver tests, non-alcoholic fatty liver disease and targeted biopsies are increasingly common indications. Ultrasound-guided liver biopsies are now the preferred method and are associated with fewer complications.

关键词： complication District general Indication Liver biopsy Non-alcoholic fatty liver

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美国加州内华达山脉岩基中段的深成作用(摘要)

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国外花岗岩类地质与矿产 1994年第3期 28-31页

作者： P.c.bateman 杨俊龙

内华达山脉岩基由中生代侵入岩组成,它们构成了内华达山脉的绝大部分。这宏伟的山脉是在新生代时由于巨大的地壳块体向西掀斜而形成的。在山脉的西部变质岩带中和山脉东部的本顿山地以及怀特山和伊尼欧山一带,有一些零散的卫星式侵入体... 详细信息

内华达山脉岩基由中生代侵入岩组成,它们构成了内华达山脉的绝大部分。这宏伟的山脉是在新生代时由于巨大的地壳块体向西掀斜而形成的。在山脉的西部变质岩带中和山脉东部的本顿山地以及怀特山和伊尼欧山一带,有一些零散的卫星式侵入体,严格地说它们已不是岩基的组成部分,但所有这些侵入岩在成因上都是有联系的。岩基沿着北美古生代克拉通的西部边界分布,岩基的西部边缘则为古生代和早中生代的洋壳。岩基侵位于强变形但弱变质的元古宇到白垩纪的地层中。

关键词：脉岩基深成作用侵入岩

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Management : competing in the new era / Thomas S. bateman, Scott A. Snell. 5th ed.

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2002年

作者： Thomas S. bateman, Scott A. Snell.

来源：畅想之星图书光盘版（南... 评论

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Plasma Edge Kinetic-MHD Modeling in Tokamaks Using Kepler Workflow for code coupling,Data Management and Visualization

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communications in computational Physics 2008年第8期4卷 675-702页

作者： J.cummings A.Pankin N.Podhorszki G.Park S.Ku R.Barreto S.Klasky c.S.chang H.Strauss L.Sugiyama P.Snyder D.Pearlstein B.Ludascher G.bateman A.Kritz the cPES Team california Institute of Technology PasadenaCA 91125 Lehigh University BethlehemPA 18015 University of california at Davis DavisCA 95616 courant Institute of Mathematical Sciences New York UniversityNY 10012 Oak Ridge National Laboratory Oak RidgeTN 37830 Massachusetts Institute of Technology CambridgeMA 02139 General Atomics San DiegoCA 92186 Lawrence Livermore National Laboratory LivermoreCA 94550 SciDAc FSP center for Plasma Edge Simulation

A new predictive computer simulation tool targeting the development of the H-mode pedestal at the plasma edge in tokamaks and the triggering and dynamics of edge localizedmodes(ELMs)is presented in this *** tool brings together,in a coordinated and effective manner,several first-principles physics simulation codes,stability analysis packages,and data processing and visualization tools.A Kepler workflow is used in order to carry out an edge plasma simulation that loosely couples the kinetic code,XGc0,with an ideal MHD linear stability analysis code,ELITE,and an extended MHD initial value code such as M3D or ***0 includes the neoclassical ion-electron-neutral dynamics needed to simulate pedestal growth near the *** Kepler workflow processes the XGc0 simulation results into simple images that can be selected and displayed via the Dashboard,a monitoring tool implemented in AJAX allowing the scientist to track computational resources,examine running and archived jobs,and view key physics data,all within a standard Web *** XGc0 simulation is monitored for the conditions needed to trigger an ELM crash by periodically assessing the edge plasma pressure and current density profiles using the ELITE *** an ELM crash is triggered,the Kepler workflow launches the M3D code on a moderate-size Opteron cluster to simulate the nonlinear ELM crash and to compute the relaxation of plasma profiles after the *** process is monitored through periodic outputs of plasma fluid quantities that are automatically visualized with AVS/Express and may be displayed on the ***,the Kepler workflow archives all data outputs and processed images using HPSS,as well as provenance information about the software and hardware used to create the *** complete process of preparing,executing and monitoring a coupled-code simulation of the edge pressure pedestal buildup and the ELM cycle using the Kepler scientific workflow system is described

关键词： Plasma simulation magnetohydrodynamic and fluid equation gyrofluid and gyrokinetic simulations hybrid methods

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美研究表明新冠大流行对职业女性伤害最大

美研究表明新冠大流行对职业女性伤害最大

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作者： Nicole bateman Martha Ross 李梓涵清研智库

＜正＞经过几十年的斗争,《宪法》第19条修正案赋予美国女性投票权。这项来之不易的权利预示着女性不仅有投票权,而且可以工作的场所也越来越多。到今年年初,即第19条修正案批准100周年时,女性的劳动力参与率达到58%,自1920年以来几乎...

＜正＞经过几十年的斗争,《宪法》第19条修正案赋予美国女性投票权。这项来之不易的权利预示着女性不仅有投票权,而且可以工作的场所也越来越多。到今年年初,即第19条修正案批准100周年时,女性的劳动力参与率达到58%,自1920年以来几乎增加了三倍。如果没有越来越多地女性参加工作,自1970年代末以来,中产阶级的家庭收入增长将基本停滞不前。

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哮喘处理袖珍参考2008

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中华临床免疫和变态反应杂志 2010年第1期4卷 70-76页

作者： c. van Weel E.D. bateman J. Bousquet J. Reid L. Grouse T. Schermer E. Valovirta N. Zhong 崔乐（译）尹佳（审校） Prof. c. van Weel Department of General Practice University Medical Centre Nijmegen Nijmegen Netherlands 中国医学科学院北京协和医学院北京协和医院变态反应科

哮喘是一种常见的慢性呼吸道疾病,患病率日渐增高。基层医生（或全科医生）通常是哮喘患者就诊时最先接触的人。用以循证医学为基础的医疗指南指导如何管理疾病,能获得更好的预后,但是这些指南通常比较复杂，并且建议使用的措施在基层... 详细信息

哮喘是一种常见的慢性呼吸道疾病,患病率日渐增高。基层医生（或全科医生）通常是哮喘患者就诊时最先接触的人。用以循证医学为基础的医疗指南指导如何管理疾病,能获得更好的预后,但是这些指南通常比较复杂，并且建议使用的措施在基层医疗条件下可能无法实现。

关键词：哮喘患者慢性呼吸道疾病基层医疗条件全科医生基层医生医疗指南循证医学患病率

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发展和评估一项新的X线胸片阅读和记录系统在结核病及肺部疾病流行病学调查中的价值

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国际结核病与肺部疾病杂志 2006年第3期1卷 107-114页

作者： S. Den Boon E. D. bateman D. A. Enarson M. W. Borgdorff S. Verver c. J. Lombard E. Irusen N. Beyers N. W. White 马玙（译）杨杭旦（校）张立兴（审） Department of Paediatrics and child Health Desmond Tutu TB Centre Stellenbosch University Cape Town South Africa Department of Infectious Diseases Tropical Medicine and AIDS Academic Medical Centre Amsterdam KNcV Tuberculosis Foundation The Hague The Netherlands Division of Pulmonology Department of Medicine University of Cape Town Cape Town South Africa International Union Against Tuberculosis and Lung Disease Paris France Biostatistics Unit Medical Research Council Cape Town Department of Internal Medicine Stellenbosch University Cape Town South Africa 不详

目的:发展和评估一项新的X线胸片阅读和记录系统(cRRS)在社区结核病及肺部疾病调查中的价值。设计:采用新发展的X线胸片阅读和记录系统(cRRS),一名有经验的肺病专家共阅读了为调查结核病患病率而拍摄的胸片2608张。在2608张X线胸片中,... 详细信息

目的:发展和评估一项新的X线胸片阅读和记录系统(cRRS)在社区结核病及肺部疾病调查中的价值。设计:采用新发展的X线胸片阅读和记录系统(cRRS),一名有经验的肺病专家共阅读了为调查结核病患病率而拍摄的胸片2608张。在2608张X线胸片中,分层随机抽取810张胸片(31％)由第二位阅片者阅读报告。计算两位阅片者间一致性的kappa值(κ)。分层随机抽取104张X线胸片再次阅读和报告,计算同一阅片者两次阅读间一致性的κ值。结果:两阅片者间在符合结核病异常阴影判定的一致性的κ值为0．69(95％cI:0．64-0．74)、任何异常者的一致性的κ值为0．47(95%cI:0．42-0．53)。同一阅片者对符合结核病异常及任何异常的二次判定结果一致率的κ值各为0．90(95％cI:0．81-0．99)及0．85(95％cI:0．74-0．95)．结论:此标准化的X线胸片阅读及记录系统提供了满意的阅片者间及同一阅片者二次阅片间的一致性,适用于在社区进行结核病及其它肺部疾病的调查。还可用于各种不同调查所获结果的比较。

关键词：结核病 X线胸片 kappa统计值双重阅读重复性

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