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Translational challenges in amyotrophic lateral sclerosis therapy with macrophage migration inhibitory factor

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Neural Regeneration Research 2025年第9期20卷 2583-2584页

作者： Leenor Alfahel Aleksandar Rajkovic adrian Israelson Department of Physiology and Cell Biology Faculty of Health SciencesBen-Gurion University of the NegevBeer ShevaIsraelThe School of Brain Sciences and CognitionBen-Gurion University of the NegevBeer ShevaIsrael

Macrophage migration inhibitory factor(MIF):MIF acts as a pleiotropic inflammatory mediator,playing regulatory roles in innate and adaptive immunity,neuroinflammation,neuroendocrine functions,and nervous system development(Matejuk et al.,2024).In recent years,MIF has attra cted significant inte rest from research groups as a potential target for the treatment of various neurodegenerative diseases,including Alzheimer's disease,Parkinson's disease,multiple sclerosis,and glioblastoma(Matejuk et al.,2024).

关键词： immunity sclerosis

Perceptions and emotions in postoperative recovery of patients with perianal diseases

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World Journal of Psychiatry 2025年第1期15卷 179-184页

作者： Bryan adrian Priego-Parra Jose Maria Remes-Troche Digestive Physiology and Gastrointestinal Motility Lab Instituto de Investigaciones Médico-BiológicasUniversidad VeracruzanaVeracruz 91700Mexico

This article examines the complex relationship between disease perception,negative emotions,and their impact on postoperative recovery in patients with perianal *** conditions not only cause physical discomfort,but also carry a significant emotional burden,often exacerbated by social ***-logical factors,including stress,anxiety,and depression,activate neuroendocrine pathways,such as the hypothalamic–pituitary–adrenal axis,disrupting the gut microbiota and leading to *** disruption can delay wound healing,prolong hospital stay,and intensify *** on the findings of Hou et al,our article highlights the critical role of illness perception and negative emotions in shaping recovery *** advocates for a holistic approach that integrates psychological support and gut microbiota modulation,to enhance healing and improve overall patient outcomes.

关键词： Perianal disease Illness perception Gut microbiota Post-surgical outcomes Microbiota

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Results on non-SUSY searches for physics beyond standard model in pp collisions at CMS

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Frontiers of physics 2013年第3期8卷 257-269页

作者： adrian Perieanu Physikalisches Institut B RWTH-Aachen Germany

In this paper a review of the results on searches for pnysics beyond the standard model in pp collisions with the CMS experiment at √s = 7 and 8 TeV is presented. Aspects of the analyses and their achieved limits on ... 详细信息

关键词： beyond standard model gauge bosons leptoquarks extra dimensions

Numerical study of solar absorption heat storage system applied to Bucharest city

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Building Simulation 2021年第3期14卷 601-616页

作者： Noureddine Cherrad adrian-Gabriel Ghiaus University Kasdi Merbah ofOuargla Faculty of Applied SciencesDepartment of Mechanical EngineeringOuarglaAlgeria Doctoral School Technical University of Civil Engineering of BucharestBucharestRomania

Buildings represent a large part in terms of fossil energy consumption,which depends on the great need for *** if the solar absorption heat storage system is possible,the performance of this system is affected by the cycle limits and the climatic *** goal of the present study is to control the thermal performance of the system cycle according to the imposed climatic conditions of Bucharest city,Romania,and therefore a numerical model was developed for this *** scheme and the thermodynamic cycle,the energy and mass balance equations,and the computational algorithm were *** results show that the cycle temperature increases at the end of desorption when the heating power supplied to the desorber is increased,which is also proportional to the drop in temperature at the beginning of the *** temperature at the end of absorption and the mass flow rates of the solution have a significant effect on the thermal power released from the absorber and used to heat the *** an average daily heat power of 1.35 kW/m^(2) and 10 hours per day of heating the building,the system with a solar collector area of 3 m^(2) has the capacity of heat supply for all the cold ***,an economic strategy remains necessary.

关键词： numerical model absorption heat storage cycle temperatures climatic conditions

Relating thermal conductivity of soil skeleton with soil texture by the concept of“local thermal conductivity fluctuation”

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 262-271页

作者： adrian Rózanski Faculty of Civil Engineering Wroclaw University of Science and TechnologyWybrzeze Wyspia_nskiego 2750-370WrocławPoland

The thermal conductivity of the soil skeletonλ;is an essential parameter from the point of view of the correct assessment of soil overall/effective *** work introduces the concept of“local thermal conductivity fluctuation”which characterizes the microscale variation of conductivity within the solid *** is proposed to link the“local fluctuation”of thermal conductivityλwith the soil texture-the information that is available at the scale of engineering *** was possible to relate the skeleton thermal conductivity with the grain size distribution of the ***,based on a large series of numerical simulations,the paper provides four triangle diagrams(at different organic matter contents:0%,2%,4%and 6%)relating the value ofλ;with volume fraction of individual soil *** result is extremely important from the practical point of *** can quickly evaluateλ;value provided that information on the grain size distribution and organic matter content is available.

关键词： Soil skeleton Probability density function(PDF) Computational micromechanics Local fluctuation Soil texture

Testing discrete symmetries at a super τ-charm factory

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Frontiers of physics 2016年第1期11卷 17-25页

作者： adrian John Bevan Particle Physics Research Centre Queen Mary University of London Mile End Road London E1 4NS UK

Tests of discrete symmetry violation have played an important role in understanding the structure of weak interactions in the Standard Model of particle physics. Historically, these measurements have been extensively performed in experiments with large samples of K and B mesons. A high luminosity τ-charm facility presents physicists with the opportunity to comprehensively explore discrete symmetry violation and test the Standard Model using τ leptons, charm mesons, and charmed baryons. This paper discusses several possible measurements for a future T-charm factory.

关键词： discrete symmetries P C T CP CPT violation

State-of-the-art imaging techniques in endoscopic ultrasound

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World Journal of Gastroenterology 2011年第6期17卷 691-696页

作者： adrian Sftoiu Department of Gastroenterology Research Center of Gastroenterology and HepatologyUniversity of Medicine and Pharmacy Craiova

Endoscopic ultrasound (EUS) has recently evolved through technological improvement of equipment,with a major clinical impact in digestive and mediastinal ***-of-the-art EUS equipment now includes real-time sono-elastography,which might be useful for a better characterization of lesions and increased accuracy of differential diagnosis (for *** nodes or focal pancreatic lesions).Contrast-enhanced EUS imaging is also available,and is already being used for the differential diagnosis of focal pancreatic *** recent development of low mechanical index contrast harmonic EUS imaging offers hope for improved diagnosis,staging and monitoring of anti-angiogenic *** EUS (3D-EUS) techniques can be applied to enhance the spatial understanding of EUS anatomy,especially for improved staging of tumors,obtained through a better assessment of the relationship with major surrounding *** the progress gained through all these imaging techniques,they cannot replace cytological or histological ***,real-time optical histological diagnosis can be achieved through the use of single-fiber confocal laser endomicroscopy techniques placed under real-time EUS-guidance through a 22G ***,but not least,EUS-assisted natural orifice transluminal endoscopic surgery (NOTES) procedures offer a whole new area of imaging applications,used either for combination of NOTES peritoneoscopy and intraperitoneal EUS,but also for access of retroperitoneal organs through posterior EUS guidance.

关键词： Endoscopic ultrasound Real-time sono-elastography Contrast-enhancement Tridimensional (3D) Hybrid imaging Endoscopic ultrasound-guided fine needle aspiration

Update on risk scoring systems for patients with upper gastrointestinal haemorrhage

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World Journal of Gastroenterology 2012年第22期18卷 2739-2744页

作者： adrian J Stanley Gastrointestinal Unit Glasgow Royal Infirmary Glasgow G4 OSF United Kingdom

Upper gastrointestinal haemorrhage (UGIH) remains a common medical emergency worldwide. It is increasingly recognised that early risk assessment is an important part of management, which helps direct appropriate patient care and the timing of endoscopy. Several risk scores have been developed, most of which include endoscopic findings, although a minority do not. These scores were developed to identify various end-points including mortality, rebleeding or clinical intervention in the form of transfusion, endoscopic therapy or surgery. Recent studies have reported accurate identification of a very low risk group on presentation, using scores which require simple clinical or laboratory parameters only. This group may not require admission, but could be managed with early out-patient endoscopy. This article aims to describe the existing pre- and post-endoscopy risk scores for UGIH and assess the published data comparing them in the prediction of outcome. Recent data assessing their use in clinical practice, in particular the early identification of low-risk patients, are also discussed.

关键词： Upper gastrointestinal haemorrhage Bleeding Endoscopy Risk assessment Scoring systems Bla-tchford Rockall