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Immune responses elicited by ssRNA(-) oncolytic viruses in the host and in the tumor microenvironment

Journal of Cancer Metastasis and Treatment 2023年第1期9卷 285-306页

作者： Yonina Bykov Gloria Dawodu Aryana Javaheri adolfo garcia-sastre Sara Cuadrado-Castano Department of Microbiology Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Department of Medicine Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Global Health and Emerging Pathogens Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA The Tisch Cancer Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Department of Pathology Molecular and Cell-Based MedicineIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA

Oncolytic viruses(OVs)are at the forefront of biologicals for cancer *** represent a diverse landscape of naturally occurring viral strains and genetically modified viruses that,either as single agents or as part of combination therapies,are being evaluated in preclinical and clinical *** the field gains momentum,the research on OVs has been shifting efforts to expand our understanding of the complex interplay between the virus,the tumor and the immune system,with the aim of rationally designing more efficient therapeutic ***,the potential of an OV platform is no longer defined exclusively by the targeted replication and cancer cell killing capacities of the virus,but by its contribution as an immunostimulator,triggering the transformation of the immunosuppressive tumor microenvironment(TME)into a place where innate and adaptive immunity players can efficiently engage and lead the development of tumor-specific long-term memory *** we review the immune mechanisms and host responses induced by ssRNA(-)(negative-sense single-stranded RNA)viruses as OV *** focus on two ssRNA(-)OV candidates:Newcastle disease virus(NDV),an avian paramyxovirus with one of the longest histories of utilization as an OV,and influenza A(IAV)virus,a well-characterized human pathogen with extraordinary immunostimulatory capacities that is steadily advancing as an OV candidate through the development of recombinant IAV attenuated platforms.

关键词： Oncolytic virus NDV IAV virotherapy paramyxovirus orthomyxovirus ssRNA(-) immunotherapy cancer vaccine ICD in situ vaccination tumor microenvironment

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Optimal Control of Nonlinear Systems Using Experience Inference Human-Behavior Learning

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 90-102页

作者： adolfo Perrusquía Weisi Guo IEEE the School of Aerospace Transport and ManufacturingCranfield UniversityBedfordUK

Safety critical control is often trained in a simulated environment to mitigate *** migration of the biased controller requires further *** this paper,an experience inference human-behavior learning is proposed to solve the migration problem of optimal controllers applied to real-world nonlinear *** approach is inspired in the complementary properties that exhibits the hippocampus,the neocortex,and the striatum learning systems located in the *** hippocampus defines a physics informed reference model of the realworld nonlinear system for experience inference and the neocortex is the adaptive dynamic programming(ADP)or reinforcement learning(RL)algorithm that ensures optimal performance of the reference *** optimal performance is inferred to the real-world nonlinear system by means of an adaptive neocortex/striatum control policy that forces the nonlinear system to behave as the reference *** and convergence of the proposed approach is analyzed using Lyapunov stability *** studies are carried out to verify the approach.

关键词： Experience inference hippocampus learning system linear time-variant(LTV)systems neocortex/striatum learning systems nonlinear systems optimal control

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PLANE WAVES NUMERICAL STABILITY OF SOME EXPLICIT EXPONENTIAL METHODS FOR CUBIC SCHRODINGER EQUATION

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Journal of Computational Mathematics 2016年第4期34卷 385-406页

作者： Begona Cano adolfo Gonzalez-Pachon Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 VaUadolid Spain Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 Valladolid Spain

Numerical stability when integrating plane waves of cubic SchrSdinger equation is thor- oughly analysed for some explicit exponential methods. We center on the following second- order methods： Strang splitting and Lawson method based on a one-parameter family of 2-stage 2nd-order explicit Runge-Kutta methods. Regions of stability are plotted and numerical results are shown which corroborate the theoretical results. Besides, a tech- nique is suggested to avoid the possible numerical instabilities which do not correspond to continuous ones.

关键词： Numerical stability Exponential splitting Lawson methods Projection ontoinvariant quantities Plane waves SchrSdinger equation.

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A novel approach to the dynamic response analysis of Euler-Bernoulli beams resting on a Winkler soil model and subjected to impact loads

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 389-401页

作者： adolfo Foriero Filippo Santucci de Magistris Giovanni Fabbrocino Département de génie civil et de génie des eaux Pavillon Adrien-PouliotUniversitéLavalQuébecCanada Dipartimento di Bioscienze e Territorio Universitàdegli Studi del MoliseCampobassoItaly Construction Technologies Institute National Research CouncilITC-CNRL’AquilaItaly

This work presents a novel approach to the dynamic response analysis of a Euler-Bernoulli beam resting on a Winkler soil model and subjected to an impact *** approach considers that damping has much less importance in controlling the maximum response to impulsive loadings because the maximum response is reached in a very short time,before the damping forces can dissipate a significant portion of the energy input into the *** development of two sine series solutions,relating to different types of impulsive loadings,one involving a single concentrated force and the other a distributed line load,are *** study revealed that when a simply supported Euler-Bernoulli beam,resting on a Winkler soil model,is subject to an impact load,the resulting vertical displacements,bending moments and shear forces produced along the span of the beam are considerably *** particular,the quantification of this effect is best observed,relative to the corresponding static solution,via an amplification *** computed impact amplification factors,for the sub-grade moduli used in this study,were in magnitude greater than 2,thus confirming the multiple-degree-of-freedom nature of the problem.

关键词： beam-Winkler-soil model sub-grade moduli impact load impact distributed line load dynamic solution impact amplification factor

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Training,Certification and Qualification of Translators and Interpreters:reflections on the present and the future

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中国翻译 2016年第6期37卷 48-52页

作者： adolfo Gentile 澳大利亚翻译资格认证局

We are in a world of instantaneous communication where professional and academic connections are only a clic *** I do not believe we can say that we have a unitary approach to the concept of Translation and therefore to training,certification and *** Gambier and Ubaldo Stecconi have embarked on a proj ect called World Atlas of Translation

关键词：英语翻译方法阅读知识阅读材料

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Reconstructing the puzzle of the role of therapeutic endoscopy in the management of post-bariatric surgery complications

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World Journal of Gastroenterology 2022年第23期28卷 2633-2635页

作者： Konstantinos Argyriou adolfo Parra-Blanco Department of Gastroenterology University Hospital of LarisaLarisa GR41110Greece Department of Gastroenterology Nottingham University Hospitals NHS TrustNottingham NG51PBUnited Kingdom

We have recently read with interest the mini-review article"Therapeutic endoscopy for the treatment of post-bariatric surgery complications".The abovementioned article is a brief overview of the different endoscopic modalities employed in the management of bariatric surgery complications and represents an important decision support tool for clinicians to improve their current *** we appreciate the endeavor of Larsen and Kozarek,based on our indepth analysis,we came across several minor issues in this article;thus,we present our comments in this *** case the authors contemplate these comments in their relevant research,we believe that their contribution would be considerable for future studies.

关键词： Endoscopic treatment Bariatric surgery Complications Obesity Sleeve gastrectomy Roux-en-Y gastric bypass

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Evidence-based considerations on bowel preparation for colonoscopy

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World Journal of Gastroenterology 2022年第31期28卷 4463-4466页

作者： Konstantinos Argyriou adolfo Parra-Blanco Department of Gastroenterology University Hospital of LarisaLarisa GR41334Greece Department of Gastroenterology Nottingham University Hospitals NHS TrustNottingham NG51PBUnited Kingdom

We recently read with interest the article,“Novel frontiers of agents for bowel cleansing for colonoscopy”.This is a practical narrative review,which could be of particular importance to clinicians in order to improve their current *** we appreciate the venture of our colleagues,based on our in-depth analysis,we came across several minor issues in the article;hence,we present our comments in this *** the authors consider these comments further in their relevant research,we believe that their contribution would be of considerable importance for future studies.

关键词： Colonoscopy Bowel preparation Polyethylene glycol Post-polypectomy syndrome Post-polypectomy complications

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Direct and cross-generational effects of reproduction on fitness and behavioral variability in male-biased environments

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Current Zoology 2023年第3期69卷 339-353页

作者： Iago Sanmartin-Villar Xin Yu adolfo Cordero-Rivera Universidade de Vigo ECOEVO LabEscola de Enxenaria ForestalCampus Universitario A Xunqueira36005 PontevedraGalizaSpain College of Life Sciences Chongqing Normal UniversityDaxuecheng Middle RdShapingba DistrictChongqing 401333China

Population structure determines individuals’interactions and trade-offs with evolutionary ***-biased populations increase intrasexual competition and intersexual harassment,reducing female resource acquisition,and thus,resources availability for the following *** analyzed direct and cross-generational effects of male harassment in two generations of damselflies(Odonata).We exposed adult females to treatments with different sex-ratio and density(balanced and male-biased)to modify the male harassment *** analyzed female fecundity,fertility,and number of faecal deposits as an indirect measure of resources *** studied female flight performance after repeated exposures to *** analyzed survivorship,development,exploration,thigmotaxis,and feeding latency of larvae produced by the experimental *** both generations,we analyzed four metrics of behavior:mean value,interindividual differences in plasticity,intra-individual unpredictability,and *** duration increased in male-biased treatment,whereas female resources acquisition and fertility *** that mated longer showed higher fecundity when they were exposed to balanced treatment,but not if they were exposed to male-biased *** from the male-biased treatment showed interindividual differences in plasticity and no repeatability in flight *** showed balanced sex-ratio and similar survivorship,development,and feeding latency independently of the parental treatment;however,females exposed to male-biased treatment produced offspring with higher differences in exploration plasticity and daughters less explorative and with higher unpredictable *** propose prolonged copulation as courtship at balanced sex-ratio but a cost to females under male-biased ***-generational effects in behavioral variability may be a mechanism to cope with predicted future environments.

关键词： activity environmental perception Ischnura graellsii male harassment sex allocation

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Behavioural observation on Platycnemis latipes revealing novel function of males'patrol

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Zoological Systematics 2023年第2期48卷 140-146页

作者： Xin Yu adolfo Cordero-Rivera College of Life Sciences Chongqing Normal UniversityChongqing 401331P.R.China Universidade de Vigo ECOEVO LabEscola de Enxeñaría ForestalCampus UniversitarioPontevedra 36005Spain

Males of Platycnemis latipes (Platycnemididae, Odonata) have enlarged tibiae (fans) and patrol using a special longitudinal zig-zag flight. By means of focal observations and experimental manipulations of the colour of abdomen and fans of mature males, we suggest that the zig-zag flight is used to avoid unnecessary harassment from other males and has not the function to attract females. The fans of P. latipes are mainly used as a tool to threaten rivals, but their effectiveness seems limited. Both abdomen and fans of a mature male can reflect UV light strongly.

关键词： Damselfly enlarged tibiae zig-zag flight avoiding harassment UV reflecting

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汇率波动同美国分部门进口贸易流量之间关系研究

汇率波动同美国分部门进口贸易流量之间关系研究

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作者： garcia CORTES adolfo 复旦大学

学位级别：硕士

本文研究汇率水平及汇率波动对美国分部门进口贸易流量的影响。本文选取2002年1月至2012年12月之间美国同加拿大、中国、德国、日本及墨西哥等国的相关数据来进行上述研究。本文主要采用协整方法及误差纠正模型来研究美国分部门进口贸... 详细信息

本文研究汇率水平及汇率波动对美国分部门进口贸易流量的影响。本文选取2002年1月至2012年12月之间美国同加拿大、中国、德国、日本及墨西哥等国的相关数据来进行上述研究。本文主要采用协整方法及误差纠正模型来研究美国分部门进口贸易流量与其影响因素之间的关系。在研究过程中所使用的汇率波动为动态标准偏差,且实证过程中所用汇率为实际汇率。本文研究结果表明,汇率波动仅对美国对中国的分部门进口贸易流量产生显著正向影响。

关键词：汇率波动美国协整方法

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