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松质骨基质复合生物蛋白胶构建组织工程软骨的研究

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组织工程与重建外科杂志 2012年第3期8卷 126-129页

作者：王正辉常会敏吴宝俊杨壮群 Kamal mustafa 卢晓云西安交通大学第二附属医院耳鼻喉-头颈外科陕西省西安市710004 西安交通大学第一附属医院整形烧伤科陕西省西安市710061 挪威卑尔根大学牙科学院西安交通大学生命科学与技术学院陕西省西安市710049

目的尝试采用松质骨基质与生物蛋白胶复合材料构建组织工程软骨。方法体外培养大鼠软骨细胞,接种于松质骨基质/生物蛋白胶材料上行体外培养。采用HE、甲苯胺蓝染色免疫学检测、扫描电镜观察等方法观察所构建的组织工程软骨的特性。结果... 详细信息

目的尝试采用松质骨基质与生物蛋白胶复合材料构建组织工程软骨。方法体外培养大鼠软骨细胞,接种于松质骨基质/生物蛋白胶材料上行体外培养。采用HE、甲苯胺蓝染色免疫学检测、扫描电镜观察等方法观察所构建的组织工程软骨的特性。结果松质骨基质/生物蛋白胶组的组织学结构更接近于软骨样组织,其Ⅱ型胶原、蛋白多糖基因表达量及蛋白多糖含量明显高于松质骨基质组。结论松质骨基质/生物蛋白胶复合材料可用于构建组织工程软骨,是一种较理想的支架材料。

关键词：软骨细胞组织工程生物蛋白胶支架材料

Resistance of Hard Tick （Ixodidae） with some Acaricide in Cattle （Naturally Infestation） in Sulaimani Governorate Fields-Kurdistan Regional/Iraq

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Journal of Agricultural Science and Technology(A) 2013年第11期3卷 927-934页

作者： Bahzad Hama Salih mustafa Soran Hama Faraj Department of Animal Production Faculty of Agricultural Sciences Sulaimani University Sulaimani Governorate KurdistanRegion lraq Sulaimani Veterinary Office Sulaimani Governorate Kurdistan Region Iraq

A study carried out for assessment of acaricide for control and how to show resistance of hard tick (Ixodidae) with some types of acaricide which available in Sulaimani marked from February to April 2012, isolated 80 cattle (local breed) naturally infested with hard tick. Six hundred and fifteen ticks min7 tick/cattle including three genera species were collected and identified, the highest Boophilus spp. followed by Hyalomma spp., and Rhipicephalus spp. were less frequent species collected. Experimental cattle divided into four groups each group content 20 cattle, treatment with four types acaricide and their average of infestation in cattle with Boophilus spp. 33 (41.25%) as the commonest, followed by Hyalomma spp. 31 (75.38%), Rhipicephalus spp. 11 (13.75%) and 5 (6.25%) found mixed infested with Boophilus spp. and Hyalomma spp. 65 (81.3%) of cattle samples had emaciation and skin lesions. According to site of infestation, it showed that inguinal region was the most common predilection site for the ticks. Observed the genera Boophilus spp., there were highly significant differences (12.52%) between different tick species when calculated by general test (LSD). The objective of this study was to estimate and compare these acaricide to control hard tick, and there was highly significant relation between different species of hard ticks when treated by these acaricide, according to the chi-square tests. The activities of the acaricide through the time of application were different on the tick genera species. Diazinon (60%) and carbamate (saven 85%) has been a greater degree than other acaricide resistance, while shows the activity of both acaricide injectable ivermactin and cypromethrein through the early time on all species. The results of the study otherwise provide encouraging possibilities for the potential use recommended dose with both acaricide ivermactin-1% and cypromethrine-10%.

关键词：杀螨剂硬蜱小牛伊拉克省域侵扰混合侵染本地品种

A missense point mutation in COL10A1 identified with whole-genome deep sequencing in a 7-generation Pakistan dwarf family

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A missense point mutation in COL10A1 identified with whole-g...

The Impact of Geometrical Structure of Domes on the Acoustic Performance within Mosques

2017中国长三角遗传学大会

作者： Chao Zhang Jiaojiao Liu Furhan Iqbal Yan Lu Saima mustafa Firdous Bukhari Haiyi Lou Ruiqing Fu Zhendong Wu Xiong Yang Ihtisham Bukhari Muhammad Aslam Shuhua Xu Chinese Academy of Sciences(CAS) Key Laboratory of Computational Biology Max Planck Independent Research Group on Population GenomicsCAS-MPG Partner Institute for Computational Biology(PICB)Shanghai Institutes for Biological SciencesCAS University of Chinese Academy of Sciences School of Life Science and Technology ShanghaiTech University Department of Zoology Institute of Pure and Applied BiologyBahauddin Zakariya University MultanPakistan Department of Biochemistry Biomarkers Research Program Prince Mutaib Chair for Biomarkers of OsteoporosisKing Saud University Collaborative Innovation Center of Genetics and Development

Disease-associated variants in the human genome are continually being identified using DNA sequencing technologies that are especially effective for Mendelian *** sequenced whole genome to high coverage(> 30 ×) of 6 members of a 7-generation family with dwarfism from a consanguineous tribe in Pakistan to locate the causal variant(s).We identified a missense variant rs111033552(c.2011 T>C[***671 Pro]) located in COLlOAl,encoding the alpha chain of type Ⅹ collagen,which is the most likely contributor to the dwarfism in this Pakistan *** further confirmed the variant in 22 family members using Sanger *** affected individuals are heterozygous for the missense mutation *** individual homozygous for this variant was *** suggests that the disorder is dominantly ***,the mutation was absent in 69,985 individuals representing>150 global *** advantage of whole-genome sequencing data,we also examined other variant forms such as copy number variation and insertion/deletion but failed to identify any other variants enriched in the affected ***,this variant had priority for linkage with *** 50 discovered variants in COLlOAl were annotated,12 variants(including rs111033552) of which are absent from global populations and highly conserved in evolution indicating the functional importance of COLlOAl despite its allelic heterogeneity.

关键词： Short stature COLlOAl Metaphyseal chondrodysplasia Schmid type Next generation sequencing Consanguinity

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Journal of Civil Engineering and Architecture 2019年第4期13卷 244-250页

作者： Omar mustafa Alomari Firas Gandah Dema Khraisat Department of Architecture Faculty of Engineering CollegeAl-Balqa Applied UniversitySalt +9625Jordan

Mosques are considered as one of the most significant architectures for Muslim,where they have evolved to attain the Islamic *** worship activities are done within these public architectures and these activities required various acoustical *** geometry of mosques and their ceiling is largely impacted on the acoustical *** domes are the most shape that utilized to construct the mosque *** geometric architecture of the domes represents one of the key factors that impact on the performance of acoustics within the ***,this paper aims to determine the impact of geometric architecture of domes on the quality of acoustical characteristics within the *** mosque of King Abullah has been selected as a case study to address this ***,many mosques have been studied from the literature to determine the impact of the geometrical structure of the domes on the acoustic characteristics and speech *** parameters have been utilized to measure the acoustical performance like RT,clarity,dome volume,dome shape,dome height and the material utilized to cover the dome *** on the studies within the literature and the case study within this paper,the impact of the geometrical structure of the domes has been determined,also the impact of these parameters on the sound quality within the mosque has been determined at the end of this paper.

关键词： Mosque,geometry dome clarity RT acoustical performance and speech intelligibility

Mechanism of Haibat Sultan Mountain Land-slide in Koya, North Iraq

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Engineering（科研） 2016年第8期8卷 535-544页

作者： Sakar A. Sadiq Arezh S. Muhmed Hozan Govar K. Haris Dastan M. Hamma Mohanad M. Abdwllah Hozan H. Bibani Hamza K. Muhealddin Hawkar A. mustafa Varoujan Sissakian Nadhir Al-Ansari University of Kurdistan Hawler Iraq Pruvate Consultant Einkawa Erbil Iraq Lulea University of Technology Lulea Sweden

Haibat Sultan Mountain is a long range with elevation of about 860 m (a.s.l.);the PilaSpi Formation forms its carapace in Koya vicinity, with relief difference of about 300 m from Koisanjaq plain. The PilaSpi Formation consists of well thickly to massively bedded dolostone and dolomitic limestone with thickness of about 120 m in Koya vicinity. The main trend is NW - SE being a limb of Bustana anticline representing part of the southwestern limb, with dip amount that ranges from (15 - 30). On 11th of November 2015 a landslide had occurred after a heavy rainfall along Koya - Dukan main road. The type of the slide was plane sliding due to daylight slope, which was formed after the road cut. The length of the slide area: along the road is 90 m with height of 40 m forming almost a parallelogram shape;the thickness of the slid beds is about 2.5 m. The estimated volume of the slid mass is 9000 m3. The main cause of the landslide is the presence of daylight slope, high slope angle;more than the dip angle, presence of old crack surfaces which are filled by reddish brown clayey residual soil. After the he heavy rain fall, which lasted for 20 hours, the infiltrated rain water in the bedding planes in the well bedded, cracked, and jointed beds has increased the pore pressure and decreased the internal friction angle;therefore, the sliding has occurred. The root of the slid mass is below the base of the paved road;therefore, that part which is above the paved road has slid. The remaining part is highly cracked and partly accumulated in the base of the slid mass. Fortunately, the height of the slid mass is only 40 m and the relief difference between the crown area and the toe area is about 50 m;otherwise the slid mass would be larger than the present slid mass. From the field inspection, it is very clear that the involved area is very unstable and in critical equilibrium. The presence of daylight bedding above the crown area, clayey soil in the fractures and open joint

关键词： Landslide Plane Slide Shear Plane Daylight Slopes Iraq

Management of hypertension: Current state of the art and challenges

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World Journal of Hypertension 2016年第1期6卷 53-59页

作者： Faruk Turgut mustafa Yaprak Emaad Abdel-Rahman Department of Nephrology School of Medicine Mustafa Kemal University Division of Nephrology Department of Medicine University of Virginia Health System

Hypertension is a major modifiable cardiovascular risk factor. Hypertension is also recognized as the mostimportant risk factor for global disease burden. It is well established that a sustained reduction in blood pressure by drugs reduces the incidence of cardiovascular morbidity and mortality. In recent years, studies and new guidelines published for the management of hypertension. Awareness, treatment and control of hypertension are very poor, despite the new guidelines. We highlighted the management of hypertension in the light of current literature.

关键词： Hypertension Therapy Blood pressure Cardiovascular risk factor

Aggrecanase-2表达沉默对体外培养的软骨细胞基质代谢的影响

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组织工程与重建外科杂志 2012年第5期8卷 245-248页

作者：王正辉杨壮群吴宝俊常会敏 Kamal mustafa 卢晓云西安交通大学第二附属医院耳鼻喉-头颈外科陕西省西安市710004 西安交通大学第一附属医院整形烧伤科陕西省西安市710061 挪威卑尔根大学牙科学院西安交通大学生命科学与技术学院陕西省西安市710049

目的探讨RNA干扰蛋白聚糖酶-2(Aggrecanase-2)对大鼠肋软骨细胞基质代谢的影响。方法体外分离培养大鼠肋软骨细胞,采用脂质体转染试剂将针对Aggrecanase-2的载体质粒转染软骨细胞,观察转染后细胞生长曲线、细胞形态的变化;RT-PCR检测Agg... 详细信息

目的探讨RNA干扰蛋白聚糖酶-2(Aggrecanase-2)对大鼠肋软骨细胞基质代谢的影响。方法体外分离培养大鼠肋软骨细胞,采用脂质体转染试剂将针对Aggrecanase-2的载体质粒转染软骨细胞,观察转染后细胞生长曲线、细胞形态的变化;RT-PCR检测Aggrecanase-2 mRNA水平的变化;Western Blot检测蛋白多糖(Aggrecan)的变化。结果RNA干扰Aggreanase-2对细胞生长速度及形态无明显影响,可明显降低Aggrecanase-2的mRNA表达水平(P<0.05),增加Aggrecan的含量(P<0.05)。结论抑制Aggrecanase-2可减少蛋白多糖的降解,RNAi是一种有效的研究软骨细胞基质代谢的工具。

关键词：软骨细胞蛋白聚糖酶-2 RNA干扰

Size Effects of Recovered Ti-6Al-4V Alloy Scrap by Conventional P/M Techniques

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材料科学与工程（中英文B版） 2018年第3期8卷 120-125页

作者： mustafa Ustundag Mehmet Fahri Sarac Remzi Varol Department of Mechanical Engineering Suleyman Demirel University Isparta 32260 Turkey

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牛支原体体外药物敏感性分析

中国奶牛 2015年第16期 32-35页

作者：贺晨飞 Riaz mustafa 陈颖钰晁金陈焕春郭爱珍华中农业大学农业微生物国家重点实验室武汉430070 华中农业大学动物医学院武汉430070 华中农业大学动物科技学院武汉430070

为了解牛支原体的体外药物敏感性,指导临床合理使用抗生素,对2008年以来收集的34株牛支原体临床分离株进行了药物敏感性测定,选取11类22种可能敏感的药物,采用微量稀释法测定药物的最低抑菌浓度(MIC)。结果显示,牛支原体分离株只对5种... 详细信息

为了解牛支原体的体外药物敏感性,指导临床合理使用抗生素,对2008年以来收集的34株牛支原体临床分离株进行了药物敏感性测定,选取11类22种可能敏感的药物,采用微量稀释法测定药物的最低抑菌浓度(MIC)。结果显示,牛支原体分离株只对5种药物呈现不同程度的敏感性,其中:94.12%(32/34)的菌株对达氟沙星敏感;70.59%(24/34)的菌株对林可霉素敏感;50.00%(17/34)的菌株对阿奇霉素敏感;20%左右的菌株对多西环素和甲砜霉素敏感;所有分离株对其他7种药物全部耐药。因此,建议目前临床上进行牛支原病治疗首选药物为达氟沙星、林可霉素和阿奇霉素。

关键词：牛支原体药物敏感性最低抑菌溶度耐药性