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A Novel Technique for Early Detection of COVID-19

Computers, Materials & Continua 2021年第8期68卷 2283-2298页

作者： Mohammad Yamin adnan ahmed abi sen Zenah Mahmoud AlKubaisy Rahaf Almarzouki Department of Management Information Systems Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddah21589Saudi Arabia Faculty of Computer and Information Systems Islamic University of MadinahAl MedinaSaudi Arabia

COVID-19 is a global pandemic disease,which results from a dangerous coronavirus attack,and spreads aggressively through close contacts with infected people and *** far,there is not any prescribed line of treatment for COVID-19 *** to control the disease are very limited,partly due to the lack of knowledge about technologies which could be effectively used for early detection and control the *** detection of positive cases is critical in preventing further spread,achieving the herd immunity,and saving ***,so far we do not have effective toolkits to diagnose very early detection of the *** research findings have suggested that radiology images,such as X-rays,contain significant information to detect the presence of COVID-19 virus in early ***,to detect the presence of the disease in in very early stages from the X-ray images by the naked eye is not *** Intelligence(AI)techniques,machine learning in particular,are known to be very helpful in accurately diagnosing many diseases from radiology *** paper proposes an automatic technique to classify COVID-19 patients from their computerized tomography(CT)scan *** technique is known as Advanced Inception based Recurrent Residual Convolution Neural Network(AIRRCNN),which uses machine learning techniques for classifying *** focus on the Advanced Inception based Recurrent Residual Convolution Neural Network,because we do not find it being used in the ***,we conduct principal component analysis,which is used for dimensional *** results of our method have demonstrated an accuracy of about 99%,which is regarded to be very efficient.

关键词： COVID-19 classification feature selection dimensionality reduction chest CT deep learning deep convolutional neural network AIRRCNN

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Achieving simultaneous removal of carbon and nitrogen by an integrated process of anaerobic membrane bioreactor and flow-through biofilm reactor

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Engineering Microbiology 2024年第1期4卷 18-27页

作者： Xueshen Wu Chao Wang Depeng Wang ahmed Tawfik Ronghua Xu Zhong Yu Fangang Meng School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Guangzhou 510006China National Research Centre Water Pollution Research Department12622DokkiCairoEgypt College of Life Sciences Environmental Sciences DepartmentKuwait UniversityP.O.5969Safat 13060Kuwait

In this study,a combined system consisting of an anaerobic membrane bioreactor(AnMBR)and flow-through biofilm reactor/CANON(FTBR/CANON)was developed to simultaneously remove carbon and nitrogen from synthetic livestock *** average removal efficiencies of total nitrogen(TN)were 64.2 and 76.4%with influent ammonium(NH4+-N)concentrations of approximately 200 and 500 mg/L,*** COD removal efficiencies were higher than 98.0%during the entire *** balance analysis showed that COD and TN were mainly removed by the AnMBR and FTBR/CANON,*** anammox process was the main nitrogen removal pathway in the combined system,with a contribution of over 80%.High functional bacterial activity was observed in the combined ***,an increase in the NH4+-N concentration considerably improved the anammox activity of the biofilm in the FTBR/CANON.16S rRNA high-throughput sequencing revealed that Methanosaeta,Candidatus Methanofastidiosum,and Methanobacterium were the dominant methanogens in the AnMBR granular *** the CANON biofilm,Nitrosomonas and Candidatus Kuenenia were identified as aerobic and anaerobic ammonium-oxidizing bacteria,*** summary,this study proposes a combined AnMBR and FTBR/CANON process targeting COD and nitrogen removal,and provides a potential alternative for treating high-strength wastewater.

关键词： Anaerobic membrane bioreactors Anammox Bacterial community Livestock wastewater Methanogens Nitrogen removal

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Elucidating the molecular basis of ATP-induced cell death in breast cancer: Construction of a robust prognostic model

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World Journal of Clinical Oncology 2024年第2期15卷 208-242页

作者： Hao-Ling Zhang Sandai Doblin Zhong-Wen Zhang Zhi-Jing Song Babu Dinesh Yasser Tabana DahhamSabbar Saad Mowaffaq Adam ahmed Adam Yong Wang Wei Wang Hao-Long Zhang sen Wu Rui Zhao Barakat Khaled Department of Biomedical Sciences Advanced Medical and Dental InstituteUniversiti Sains MalaysiaPenang 13200Malaysia School of Public Health Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Clinical College of Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmonton AB T6G 2E1Canada Department of Science University of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA 92182United States Department of Pathology Center Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina College of Acupuncture-moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Universiti Sains Malaysia Advanced Medical and Dental InstitutePenang 13200Malaysia Department of Biomedical Science Universiti Sains MalaysiaPenang 13200Malaysia

BACKGROUND Breast cancer is a multifaceted and formidable disease with profound public health *** demise mechanisms play a pivotal role in breast cancer pathogenesis,with ATP-triggered cell death attracting mounting interest for its unique specificity and potential therapeutic *** To investigate the impact of ATP-induced cell death(AICD)on breast cancer,enhancing our understanding of its *** The foundational genes orchestrating AICD mechanisms were extracted from the literature,underpinning the establishment of a prognostic ***,a microRNA(miRNA)prognostic model was constructed that mirrored the gene-based prognostic *** between high-and low-risk cohorts within mRNA and miRNA characteristic models were scrutinized,with the aim of delineating common influence mechanisms,substantiated through enrichment analysis and immune infiltration *** The mRNA prognostic model in this study encompassed four specific mRNAs:P2X purinoceptor 4,pannexin 1,caspase 7,and cyclin *** miRNA prognostic model integrated four pivotal miRNAs:hsa-miR-615-3p,hsa-miR-519b-3p,hsa-miR-342-3p,and hsa-miR-324-3p.B cells,CD4+T cells,CD8+T cells,endothelial cells,and macrophages exhibited inverse correlations with risk scores across all breast cancer ***,Kyoto Encyclopedia of Genes and Genomes analysis revealed that genes differentially expressed in response to mRNA risk scores significantly enriched 25 signaling pathways,while miRNA risk scores significantly enriched 29 signaling pathways,with 16 pathways being jointly *** Of paramount significance,distinct mRNA and miRNA signature models were devised tailored to AICD,both potentially autonomous prognostic *** study's elucidation of the molecular underpinnings of AICD in breast cancer enhances the arsenal of potential therapeutic tools,offering an unparalleled window for innovative ***,this paper revea

关键词： ATP-induced cell death mRNA miRNA Prognostic model Breast cancer

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Scaling up impact of malaria control programmes: a tale of events in Sub-Saharan Africa and People’s Republic of China

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Infectious Diseases of Poverty 2012年第1期1卷 61-75页

作者： Ernest Tambo ahmed Adebowale Adedeji Fang Huang Jun-Hu Chen Shui-sen Zhou Ling-Hua Tang National Institute of Parasitic Disease Chinese Center for Disease Control and PreventionWHO Collaborating Centre on MalariaSchisostomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of Health207 Rui Jin Er RdShanghai 200025People’s Republic of China School of Medicine&Pharmacy Houdegbe North American University PK10Route de Porto-Novo06 BP 2080CotonouRépublique du Bénin Department of Pharmacology and Toxicology Kampala International University Western CampusP.O.Box 71IshakaBushenyiUganda

This review aims at providing synthetic information with scientific evidence on the trends in the malaria events from 1960 to 2011,with the hope that it will help policy makers to take informed decisions on public health issues and intervention designs on malaria control towards elimination in both Sub-Sahara Africa and in the People’s Republic of China by highlighting the achievements,progress and challenges in research on moving malaria from epidemic status towards *** findings showed that since 1960,malaria control programmes in most countries have been disjointed and not ***,during the last decade,the causal factors of the unprecedented and substantial decline in malaria morbidity and mortality rates in most vulnerable groups in these endemic areas are multifaceted,including not only the spread of malaria and its related effects but also political and financial willingness,commitment and funding by governments and international *** benefits of scaling up the impact of malaria coverage interventions,improvement of health system approaches and sustained commitment of stakeholders are highlighted,although considerable efforts are still necessary in Sub-Sahara ***,novel integrated control strategies aiming at moving malaria from epidemic status to control towards elimination,require solid research priorities both for sustainability of the most efficient existing tools and intervention coverage,and in gaining more insights in the understanding of the epidemiology,pathogenesis,vector dynamics,and socioeconomic aspects of the *** conclusion,political commitment and financial investment of stakeholders in sustaining the scaling up impact of malaria control interventions,networking between African and Chinese scientists,and their Western partners are urgently needed in upholding the recent gains,and in translating lessons learnt from the Chinese malaria control achievements and successes into practical interve

关键词： malaria funding scaling up interventions health system Sub-Sahara Africa People’s Republic of China

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Design of a Porous Cored Hexagonal Photonic Crystal Fiber Based Optical sensor With High Relative sensitivity for Lower Operating Wavelength

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Photonic sensors 2017年第1期7卷 55-65页

作者： Shuvo sen Sawrab CHOWDHURY Kawsar ahmed Sayed ASADUZZAMAN Department of Information and Communication Technology Mawlana Bhashani Science and Technology UniversitySantosh Tangail-1902 Bangladesh Group of Biophotomatix Bangladesh

In this article, highly sensitive and low confinement loss enriching micro structured photonic crystal fiber （PCF） has been suggested as an optical sensor. The proposed PCF is porous cored hexagonal （P-HPCF） where cladding contains five layers with circular air holes and core vicinity is formed by two layered elliptical air holes. Two fundamental propagation characteristics such as the relative sensitivity and confinement loss of the proposed P-HPCF have been numerically scrutinized by the full vectorial finite element method （FEM） simulation procedure. The optimized values are modified with different geometrical parameters like diameters of circular or elliptical air holes, pitches of the core, and cladding region over a spacious assortment of wavelength from 0.8 ktm to 1.8 -m. All pretending results exhibit that the relative sensitivity is enlarged according to decrement of wavelength of the transmission band （O＋E＋S＋C＋L＋U）. In addition, all useable liquids reveal the maximum sensitivity of 57.00%, 57.18%, and 57.27% for n=1.33, 1.354, and 1.366 respectively by lower band. Moreover, effective area, nonlinear coefficient, frequency, propagation constant, total electric energy, total magnetic energy, and wave number in free space of the proposed P-HPCF have been reported recently.

关键词： Optical sensor relative sensitivity porous core PCF confinement loss transmission band effective area

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Design and Optimization of Photonic Crystal Fiber Based sensor for Gas Condensate and Air Pollution Monitoring

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Photonic sensors 2017年第3期7卷 234-245页

作者： Md. Ibadul ISLAM Kawsar ahmed Shuvo sen Sawrab CHOWDHURY Bikash Kumar PAUL Md. Shadidul ISLAM Mohammad Badrul Alam MIAH Sayed ASADUZZAMAN Department of Information and Communication Technology (ICT) Mawlana Bhashani Science and Technology University Santosh Tangail 1902 Bangladesh Group of Bio-photomatix Tangail 1902 Bangladesh Department of Software Engineering (SWE) Daffodil International University Sukrabad Dhaka 1207 Bangladesh

In this paper, a hexagonal shape photonic crystal fiber （H-PCF） has been proposed as a gas sensor of which both micro-structured core and cladding are organized by circular air cavities. The reported H-PCF has a single layer circular core which is surrounded by a five-layer hexagonal cladding. The overall pretending process of the H-PCF is completed by using a full vectorial finite element method （FEM） with perfectly matched layer （PML） boundary condition. All geometrical parameters like diameters and pitches of both core and cladding regions have fluctuated with an optimized structure. After completing the numerical analysis, it is clearly visualized that the proposed H-PCF exhibits high sensitivity with low confinement loss. The investigated results reveal the relative sensitivity of 56.65% and confinement loss of 2.31×10^-5 dB/m at the 1.33%tm wavelength. Moreover, effective area, nonlinearity, and V-parameter of the suggested PCF are also briefly described.

关键词： Relative sensitivity confinement loss gas sensor effective area nonlinearity and photonic crystal fiber

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Discovery of a highly specific ^(18)F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1963-1975页

作者： Zhiwei Xiao Huiyi Wei Yi Xu ahmed Haider Junjie Wei Shiyu Yuan Jian Rong Chunyu Zhao Guocong Li Weibin Zhang Huangcan Chen Yuefeng Li Lingling Zhang Jiyun Sun Shaojuan Zhang Hai-Bin Luo sen Yan Qijun Cai Lu Hou Chao Che Steven H.Liang Lu Wang Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI Centerthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital&Department of RadiologyHarvard Medical SchoolBostonMA 02114USA Department of Cardiology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Guangdong Landau Biotechnology Co.Ltd. Guangzhou 510555China Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570228China Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhou 510632China

As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium spiny neurons of the striatum,it has been implicated in a variety of neurological ***,inhibition of PDE10A has proven to be of potential use for the treatment of central nervous system(CNS)pathologies caused by dysfunction of the basal ganglia–of which the striatum constitutes the largest component.A PDE10A-targeted positron emission tomography(PET)radioligand would enable a better assessment of the pathophysiologic role of PDE10A,as well as confirm the relationship between target occupancy and administrated dose of a given drug candidate,thus accelerating the development of effective PDE10A *** this study,we designed and synthesized a novel ^(18)F-aryl PDE10A PET radioligand,codenamed[^(18)F]P10A-1910([^(18)F]9),in high radiochemical yield and molar activity via spirocyclic iodonium ylide-mediated radiofluorination.[^(18)F]9 possessed good in vitro binding affinity(IC_(50)=2.1 nmol/L)and selectivity towards ***,[^(18)F]9 exhibited reasonable lipophilicity(logD=3.50)and brain permeability(P_(app)>10×10^(−6) cm/s in MDCK-MDR1 cells).PET imaging studies of[^(18)F]9 revealed high striatal uptake and excellent in vivo specificity with reversible tracer *** studies in rodents revealed an improved plasma and brain stability of[^(18)F]9 when compared to the current reference standard for PDE10A-targeted PET,[^(18)F]***,dose–response experiments with a series of escalating doses of PDE10A inhibitor 1 in rhesus monkey brains confirmed the utility of[^(18)F]9 for evaluating target occupancy in vivo in higher *** conclusion,our results indicated that[^(18)F]9 is a promising PDE10A PET radioligand for clinical translation.

关键词： Phosphodiesterase 10A PET radioligand 18F Spirocyclic iodonium ylide Nonhuman primate Target occupancy

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Color-selective three-dimensional polarization structures

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Light(Science & Applications) 2022年第11期11卷 2706-2715页

作者： Yuttana Intaravanne Ruoxing Wang Hammad ahmed Yang Ming Yaqin Zheng Zhang-Kai Zhou Zhancheng Li Shuqi Chen Shuang Zhang Xianzhong Chen Institute of Photonics and Quantum Sciences School of Engineering and Physical SciencesHeriot-Watt UniversityEdinburgh EH144ASUK Department of Mathematics and Physics North China Electric Power UniversityBaoding 071003China School of Physics and Electronic Engineering Changshu Institute of TechnologySuzhou 215000China State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China School of Physics and TEDA Applied Physics Institute Nankai University94 Weijin RoadTianjin 300071China Department of Physics University of Hong KongHong KongChina Department of Electronic&Electrical Engineering University of Hong KongHong KongChina

Polarization as an important degree of freedom for light plays a key role in *** beams with controlled polarization profles have diverse applications,such as information encoding,display,medical and biological imaging,and manipulation of ***,conventional polarization optics can only realize two-dimensional polarization structures in a transverse *** emergent ultrathin optical devices consisting of planar nanostructures,so-called metasurfaces,have shown much promise for polarization *** we propose and experimentally demonstrate color-selective three-dimensional(3D)polarization structures with a single *** geometric metasurfaces are designed based on color and phase multiplexing and polarization rotation,creating various 3D polarization ***,different 3D polarization knots in the same observation region can be achieved by controlling the incident wavelengths,providing unprecedented polarization control with color information in 3D *** research findings may be of interest to many practical applications such as vector beam generation,virtual reality,volumetric displays,security,and anti-counterfeiting.

关键词： polarization optics dimensional

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Fatigue resistance of ProTaper gold exposed to high-concentration sodium hypochlorite in double curvature artificial canal

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Bioactive Materials 2019年第1期4卷 245-248页

作者： Fahda Algahtani Xiangya Huang Markus Haapasalo Zhejun Wang ahmed Hieawy Duo Zhang Jolanta Aleksejuniene Ya Shen Department of Oral Biological and Medical Sciences Faculty of DentistryThe University of British ColumbiaVancouverCanada College of Dentistry Princess Nourah Bint Abdulrahman UniversitySaudi Arabia Department of Conservative Dentistry and Endodontics Guanghua School of StomatologySun Yat-Sen UniversityGuangzhouChina

This study aimed to evaluate and compare the fatigue resistance of ProTaper Gold(PTG)and ProTaper Universal(PTU)in artificial single and double curvature canals in 5%sodium hypochlorite(NaOCl)at body temperature(37℃).PTG and PTU files(size F1)were subjected to fatigue tests in two different artificial ceramic *** single curvature model had a 60°curvature angle with a 5mm *** double curvature model had a 60°curvature angle with a 5mm radius and a second 30°curvature with a 2mm radius.A file segment was introduced into the artificial canal and immersed in water or 5%NaOCl at 37℃.The total number of cycles to fracture(NCF)was *** were analyzed using t-test and linear regression *** NCF of all files was significantly influenced by the type of NiTi metal alloy(P<.01),canal curvatures(P<.01),and the environmental conditions(P<.05).PTG had higher fatigue resistance than PTU files in both single and double curvature canals(P<.05).The NCF of PTU files in 5%NaOCl was shorter than that in water(P<.05).The mean length of broken PTG was significantly shorter than those of PTU files in both single and double curvature canals(P<.01).The fatigue performance of PTG is better than that of PTU in both single and double *** conditions may affect the fatigue behavior of PTU files with single curvature.

关键词： Body temperature Corrosion Double curvature Fatigue resistance ProTaper Gold

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Qingyi decoction protects against myocardial injuries induced by severe acute pancreatitis

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World Journal of Gastroenterology 2020年第12期26卷 1317-1328页

作者： Lei Li Yong-Qi Li Zhong-Wei Sun Cai-Ming Xu Jun Wu Ge-Liang Liu ahmed MH Bakheet Hai-Long Chen Department of Vascular Surgery The Second Affiliated Hospital of Dalian Medical UniversityDalian 116027Liaoning ProvinceChina Department of General Surgery The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Graduate School of Comprehensive Human Sciences University of TsukubaTsukuba 3058575Japan Department of Emergency Medicine The Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001Liaoning ProvinceChina Department of Traditional Chinese Medicine Dalian Obstetrics and Gynecology HospitalDalian 116021Liaoning ProvinceChina Department of Ultrasound The Second Affiliated Hospital of Dalian Medical UniversityDalian 116027Liaoning ProvinceChina Department of Urology Surgery The Second Affiliated Hospital of Dalian Medical UniversityDalian 116027Liaoning ProvinceChina Department of Pathology The Third Affiliated Hospital of San Yet-sen UniversityGuangzhou 510360Guangdong ProvinceChina

BACKGROUND We studied the protective effects of Qingyi decoction(QYD)(a Traditional Chinese Medicine)against severe acute pancreatitis(SAP)-induced myocardial infarction(MI).AIM To study the function and mechanism of QYD in the treatment of myocardial injuries induced by *** Ultrasonic cardiography,hematoxylin and eosin staining,immunohistochemistry,qRT-PCR,western blot,enzyme-linked immunosorbent assays,and apoptosis staining techniques were used to determine the effects of QYD following SAP-induced MI in Sprague-Dawley *** Our SAP model showed severe myocardial histological abnormalities and marked differences in the symptoms,mortality rate,and ultrasonic cardiography outputs among the different groups compared to the *** expression of serum cytokines[interleukin(IL)-1?,IL-6,IL-8,IL-12,amyloidβ,and tumor necrosis factor-α]were significantly higher in the SAP versus QYD treated group(P<0.05 for all).STIM1 and Orai1 expression in myocardial tissue extracts were significantly decreased post QYD gavage(P<0.001).There was no significant histological difference between the 2-aminoethyl diphenylborinate inhibitor and QYD *** SAP group had a significantly higher apoptosis index score compared to the QYD group(P<0.001).CONCLUSION QYD conferred cardio-protection against SAP-induced MI by regulating myocardial-associated protein expression(STIM1 and Orai1).

关键词： Severe acute pancreatitis Multiple organ dysfunction Myocardial injury Qingyi decoction STIM1/Orai1-SOCE

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