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Interaction between tumor stage and age on survival outcomes of patients with anaplastic thyroid cancer

World Journal of Experimental Medicine 2024年第3期14卷 90-100页

作者： Ayrton I Bangolo Auda Auda John Bukasa-Kakamba Nayan Bhakta Shraboni Dey Anupriya lilhori Gowry Reddy Budoor Alqinai Aman Sidiqui Imranjot Sekhon Barbare Khatiashvili Iqra Abbas Sandra Kunnel Amer Jarri Emelyn Martinez Deborah Daoud Ishita Gupta Harshini Gompa Silvanna Pender Dana Aljaberi Hamed Aljanaahi Sandra S Kunnel Yingxia Xiao Yoontae Jung Sneha Nagpaul Afshan Naz Tejaswee Mallela Phyo Maung Maung Ibtihal Y Khalaf Soobee Kim Roua Alrestom aditya gajera Hiba Alkealy Deepti Kansal Sonam Dhall Sanya Satheesha Simcha Weissman Pierre Fwelo Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Endocrine and Metabolic Disorders University of KinshasaKinshasa KinshasaCongo Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States

BACKGROUND Anaplastic thyroid cancer(ATC)is an aggressive,rare malignancy associated with rapid growth and metastasis,and a very poor *** investigated the clinical characteristics,survival outcomes and independent prognostic factors associated with anaplastic thyroid *** To assess to what extent the interaction between age and tumor stage affects *** A total of 622 patients diagnosed with anaplastic thyroid cancer,between 2010 and 2017 were enrolled in our study by retrieving data from the Surveillance,Epidemiology and End Results(SEER)*** analyzed demographics,clinical characteristics,overall mortality(OM)and cancer specific mortality(CSM)of *** with a P value<0.1 were incorporated into the multivariate cox model to determine the independent prognostic ***,we analyzed the interaction between age and tumor stage on *** In the multivariate analyses,the divorced/separated population had a lower OM[hazard ratio(HR)=0.63,95%CI:0.42-0.94,P<0.05]and CSM(HR=0.61,95%CI:0.40-0.92,P<0.05).OM was higher in tumors with direct extension only(HR=6.26,95%CI:1.29-30.42,P<0.05)and tumors with distant spread(HR=5.73,95%CI:1.34-24.51,P<0.05).CSM was also higher in tumors with direct extension(HR=5.05,95%CI:1.05-24.19,P<0.05)and tumors with distant spread(HR=4.57,95%CI:1.08-19.29,P<0.05).Mortality was not adversely affected by lymph node *** was lower in patients who received radiation(HR=0.66,95%CI:0.53-0.83,P<0.01),chemotherapy(HR=0.63,95%CI:0.50-0.79,P<0.01)or surgery(HR=0.53,95%CI:0.43-0.66,P<0.01).CSM was also lower in patient who received radiation(HR=0.64,95%CI:0.51-0.81,P<0.01),chemotherapy(HR=0.62,95%CI:0.50-0.78,P<0.01)or surgery(HR=0.51,95%CI:0.41-0.63,P<0.01).There was no significant interaction between age and tumor stage that affected *** In this large US SEER database retrospective study,we found the mortality to be higher in advanced stage tumors with direct extensi

关键词： Undifferentiated thyroid cancer Survival outcome Prognosis Metastasis Clinical trials Interaction

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Phoenix phylogeny, and analysis of genetic variation in a diverse collection of date palm(Phoenix dactylifera) and related species

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Plant Diversity 2019年第5期41卷 330-339页

作者： Srinivasa R.Chaluvadi Porter Young Kentrez Thompson Bochra Amina Bahri Bhavesh gajera Subhash Narayanan Robert Krueger Jeffrey L.Bennetzen Department of Genetics University of GeorgiaAthensGAUSA Institute of Plant Breeding Genetics and Genomics(Department of Crop and Soil Sciences)and Department of Plant BiologyUniversity of GeorgiaAthensGA 30602USA Laboratory of Bioaggressors and Integrated Protection in Agriculture The National Agronomic Institute of TunisiaUniversity of Carthage43 Avenue Charles-NicolleTunis 1082Tunisia Anand Agricultural University AnandIndia USDA-ARS National Clonal Germplasm Repository for Citrus and Dates RiversideCAUSA

Date palm(Phoenix dactylifera),one of the most ancient crops,is grown commercially in>30 *** whole plastome assemblies,phylogenetic analyses revealed that cultivated date palm accessions share the same clade with Phoenix sylvestris,Phoenix pusilla and Phoenix acaulis,which are native to the Indian subcontinent,and Phoenix caespitosa that is native to the Arabian Peninsula and the deserts of *** of genetic diversity and genetic relationships among date palm accessions from 13 producing countries involved 195 date palm accessions that were genotyped at 19 microsatellite *** genetic diversity was observed,with many accessions heterozygous for most markers in this clonally propagated *** average number of alleles per locus(42.1),expected heterozygosity(0.8),observed heterozygosity(0.47)and fixation indices(FST=0.42)demonstrated substantial genetic diversity and population *** accessions were found to have the richest allelic diversity,and the most private *** model-based Bayesian method indicated that these accessions could be broadly divided into two structure groups,one group with predominantly African accessions and another predominantly *** germplasm,especially from Tunisia and Iraq,deviated from this *** accessions in the STRUCTURE-derived groups were found to be genetic admixtures,with gene flow between Asian and African *** and Pakistani date palms were found to be most closely related to North African germplasm.

关键词： Date palm improvement Germplasm dissemination Plastome Simple sequence repeats

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Rethinking an Algorithm: The Utility of the Techinicium 99 m Labeled Red Cell (RBC) Scanning for Lower Gastrointestinal Bleeding (LGIB)

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International Journal of Clinical Medicine 2012年第2期3卷 110-114页

作者： Shaffer R. S. Mok Chijioke Ojiako Ankur Kalra Mithil gajera Sri Sujanthy Rajaram Division of Critical Care Medicine Department of Internal Medicine Cooper University Hospital Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey Camden USA Division of Internal Medicine Department of Internal Medicine Cooper University Hospital Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey Camden USA Mulica Hill Medical Associates Mullica Hill USA

Purpose: Technetium 99 m (99 m Tc) labeled scan is often done to localize bleeding to facilitate treatment. No level 1 or 2 data supports this approach. The aim of this study was to determine the correlation between site of bleeding by nuclear scan and findings at surgery, angiogram or colonoscopy. Methods: Records of patients admitted to Cooper University Hospital from January 2001-December 2005 with LGIB who had 99mTc scan were analyzed. Results: 164 of 170 patients were eligible to be evaluated. There were 45 positive (27.5%) and 119 negative scans (72.5%). 21 of 45 patients with positive scans had angiography. 7 patients (33.3%) had positive and 14 (66.6%) negative angiograms. In 6 patients (85.7%) with (+) angiograms, there was correlation on the area of bleed as seen on the 99 m Tc scan (p = 0.125). 20 patients, in the positive scan group, required surgery. In 15 (75%) the findings at surgery correlated with the scan result (p = 0.04). 31 patients (68.8%) with positive scan had colonoscopy. There was correlation in 27 patients (87.0%) (p < 0.001). The patients with (+) scan received a total of 372 (8.2 per patient) transfusions of packed red blood cells (PRBC) compared to 333 (2.7 per patients) transfusions in patients with (–) scans. Surgeons documented in 7 patients that the result of scan influenced surgery. Patients with (+) and (–) scans had similar rates of colonoscopy (73.35% vs 76.4%), hospital length of stay (14.3 vs 12.10 days), while mortality rate was (8.8% vs 6.72%) respectively, Conclusion: 99 m Tc scan has low yield in the evaluation of LGIB. However when positive, they tend to correlate with findings at angiogram, surgery and colonoscopy.

关键词： Technicium 99 m Lower Gastrointestinal Bleed LGIB Tc-99 m

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