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Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities

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World Journal of Gastroenterology 2021年第39期27卷 6527-6550页

作者： aditi Jain Vikas Bhardwaj The Jefferson Pancreas Biliary and Related Cancer CenterDepartment of SurgerySidney Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphiaPA 19107United States Department of Pharmaceutical Sciences Jefferson College of PharmacyThomas Jefferson UniversityPhiladelphiaPA 19107United States

Pancreatic ductal adenocarcinoma(PDAC)is the third leading cause of cancerrelated deaths in the United *** chemotherapeutic regimens such as gemcitabine+nab-paclitaxel and FOLFIRINOX(FOLinic acid,5-Fluroruracil,IRINotecan,and Oxaliplatin)significantly improve patient survival,the prevalence of therapy resistance remains a major roadblock in the success of these *** review discusses the molecular mechanisms that play a crucial role in PDAC therapy resistance and how a better understanding of these mechanisms has shaped clinical trials for pancreatic cancer ***,we have discussed the metabolic alterations and DNA repair mechanisms observed in PDAC and current approaches in targeting these *** discussion also includes the lessons learned following the failure of immunotherapy in PDAC and current approaches underway to improve tumor’s immunological response.

关键词： Pancreatic cancer Metabolism DNA repair Therapy-resistance Immunotherapy

Modeling and Analysis of PV Configurations to Extract Maximum Power Under Partial Shading Conditions

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CSEE Journal of Power and Energy Systems 2022年第6期8卷 1670-1683页

作者： aditi Atul Desai Suresh Mikkili Department of EEE National Institute of Technology GoaGoa 403401India

Photovoltaics(PV)are widely used as renewable energy sources for standalone and grid connected PV *** these PV systems face major reduction in output power and efficiency due to Partial Shading Conditions(PSCs).This research paper focuses on the different choices of optimum PV Configuration under a given shading pattern to extract maximum power by mitigating mismatching *** PV configurations,such as Series(S),Series Parallel(SP),Total Cross Tied(TCT),Bridge Linked(BL),Honey Comb(HC)and Alternate Total Cross Tied–Bridge Linked(A-TCT-BL)are modeled and analyzed under *** shading patterns,such as center,diagonal,corner,L-shaped,short and narrow,short and wide,long and narrow,long and wide and random,are considered to study the behavior of a 6×6 array form of a PV *** performances are compared based on open circuit voltage,short circuit current,global maximum power point(GMPP),maximum voltage,maximum current,shading loss,fill factor,mismatching loss and efficiency.A novel Hybrid Configuration called A-TCT-BL PV Configuration is proposed to generate maximum power under PSCs and to minimize the number of cross ties and wiring *** Configuration is an integration of TCT and BL PV Configuration and the simulation results prove the capability of this proposed PV Configuration to generate maximum power,fill factor,efficiency and minimum mismatching loss compared to S,SP,BL and HC PV Configurations under a majority of the PSCs investigated.A Canadian Solar CS5P-200M PV module is considered for simulation and is simulated using Matlab/Simulink software.

关键词： Alternate Total Cross Tied-Bridge Linked(A-TCT-BL)PV configuration mismatching loss partial shading conditions(PSCs) PV configurations

Multi-criteria land evaluation for suitability analysis of wheat:a case study of a watershed in eastern plateau region,India

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Geo-Spatial Information Science 2014年第2期17卷 119-128页

作者： aditi SARKAR Amit GHOSH Pabitra BANIK Agricultural and Ecological Research Unit Indian Statistical Institute203B.T.RoadKolkata 700108India

Improper land use results in land degradation as well as decline in agricultural *** obtain optimum benefit from the land,proper utilization of its resources is *** suitability analysis is the evaluation and grouping of specific areas of land in terms of their suitability for a defined use,which is a precondition for sustainable land use *** study investigated the applicability of Geographical Information System(GIS)techniques in combination with multi-criteria land evaluation for analysing land *** study used the weighted overlay technique for multi-criteria evaluation with GIS for the assessment of suitability of wheat cultivation in Beko watershed(Purulia,India).The watershed area is moderately suitable for wheat crop production,with constraints like imperfect drainage and poor soil depth.

关键词： spatial analysis GIS remote sensing multi-criteria decision analysis spatial decision support system

Graphene： from synthesis to engineering to biosensor applications

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Frontiers of Materials Science 2018年第1期12卷 1-20页

作者： Jagpreet SINGH aditi RATHI Mohit RAWAT Manoj GUPTA Department of Nanotechnology Sri Guru Granth Sahib World University Fatehgarh Sahib-140406 Punjab India Intelligent Material Pvt. Ltd. (Nanoshel LLC) Derabassi-140507 Punjab India Department of Mechanical Engineering National University of Singapore Singapore 117576 Singapore

Graphene is a fascinating material of recent origin whose first isolation was being made possible through micromechanical cleavage of a graphite crystal. Owing to its fascinating properties, graphene has garnered significant attention in the research community for multiple applications. A number of methods have been employed for the synthesis of single-layer and multi-layer graphene. The extraordinary properties of graphene such as its Hall effect at room temperature, high surface area, tunable bandgap, high charge mobility and excellent electrical, conducting and thermal properties allow for the development of sensors of various types and also opened the doors for its use in nanoelectronics, supercapacitors and batteries. Biological aspects of graphene have also been investigated with particular emphasis on its toxicity and drug delivery. In this review, many of the salient aspects of graphene, such as from synthesis to its applications, primarily focusing on sensor applications which are of current interest, are covered.

关键词： graphene nanoelectronics Hall effect tunable bandgap supercapacitors sensors catalysis

Revisiting novel symmetries in coupled N=2 supersymmetric quantum systems:examples and supervariable approach

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Communications in Theoretical Physics 2020年第10期72卷 103-112页

作者： aditi Pradeep Anjali S Binu M Nair Saurabh Gupta Department of Physics and Astronomy University of British ColumbiaVancouver Campus325-6224 Agricultural RoadVancouverBC V6T 1Z1Canada Department of Physics National Institute of Technology Calicut

We revisit the novel symmetries in N=2 supersymmetric quantum mechanical models by considering specific examples of coupled ***,we extend our analysis to a general case and list out all the novel *** each case,we show the existence of two sets of discrete symmetries that correspond to the Hodge duality operator of differential ***,we are able to provide a proof of the conjecture which points out the existence of more than one set of discrete symmetry transformations corresponding to the Hodge duality ***,we derive on-shell nilpotent symmetries for a generalized superpotential within the framework of supervariable approach.

关键词： N=2 SUSY quantum mechanical system continuous and discrete symmetries de Rham cohomological operators (anti-)chiral supervariable approach SUSY invariant restrictions

Salt Tolerance Mechanisms and Approaches:Future Scope of Halotolerant Genes and Rice Landraces

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Rice science 2020年第5期27卷 368-383页

作者： Tarun Bhatt aditi Sharma Sanjeev Puri Anu Priya Minhas Department of Biotechnology University Institute of Engineering and TechnologySector-25Panjab UniversityChandigarh 160014India

All rice plant developmental stages are severely affected by soil salinity. Salinity-induced ionic and osmotic stresses affect stomata closure and gaseous exchange, and reduce transpiration and the rate of carbon assimilation, and hence decrease plant yield. Understanding the response of rice plants toward salinity stress at the genetic level and developing salt-tolerant varieties are the vital mandates for its effective management. This review described the present status of salt-tolerance achieved in rice by various mechanisms including the ion homeostasis(Na^+/H^+, OsNHX antiporters), compatible organic solutes(glycine betaine and proline), antioxidative genes(OsECS, OsVTE1, OsAPX and OsMSRA4.1), salt responsive regulatory elements(transcription factors, cis-acting elements and miRNAs) and genes ecoding protein kinases(MAPKs, SAPKs and STRKs). Further, the future perspective of developing salt-tolerant varieties lies in exploring halotolerant gene homologs from rice varieties, especially the landraces. Genetic diversity among rice landraces can serve as a valuable resource for future studies toward variety improvement through breeding and genome editing. Further, identification, multiplication, preservation and utilization of biodiversity among landraces are the urgent buffers to be saved as a heritage for future generations to come.

关键词： rice soil salinity ion homeostasis halotolerant landrace

Chemically modified silica gel with 1-{4-[(2-hydroxy-benzylidene)amino]phenyl}ethanone:Synthesis, characterization and application as an efficient and reusable solid phase extractant for selective removal of Zn(Ⅱ) from mycorrhizal treated fly-ash samples

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Journal of Environmental Sciences 2013年第6期25卷 1252-1261页

作者： R.K.Sharma aditi Puri Anil Kumar Alok Adholeya 2 Green Chemistry Network Centre Department of ChemistryUniversity of Delhi Biotechnology and Management of Bioresources Division The Energy and Resource Institute

1-{4-[（2-hydroxy-benzylidene）amino]phenyl}ethanone functionalized silica gel was synthesized and used as a highly efficient, selective and reusable solid phase extractant for separation and preconcentration of trace amount of Zn（II） from environmental matrices. The adsorbent was characterized by fourier transform infrared spectroscopy （FT-IR）, elemental analysis,~3C CPMAS NMR spectroscopy, scanning electron microscopy （SEM）, thermogravimetric analysis （TGA） and BET surface area analysis. The dependence of zinc extraction on various analytical parameters such as pH, type and amount of eluent, sample flow rate and interfering ions were investigated in detail. The material exhibited superior adsorption efficiency for Zn（II） with high metal loading capacity of 1.0 mmol/g under optimum conditions. After adsorption, the recovery （〉 98%） of metal ions was accomplished using 1.0 mol/L HNO3 as an eluent. The sorbent was also regenerated by microwave treatment in milder acidic environment （0.1 mol/L HNO3）. The lower detection limit and preconcentration factor of the present method were found out to be 0.04 ~tg/L and 312.5 respectively. The modified silica surface possessed excellent selectivity for the target analytes and the adsorption/desorption process remained effective for at least ten consecutive cycles. The optimized procedure was successfully implemented for the extraction of Zn（II） from mycorrhizal treated fly ash and pharmaceutical samples with reproducible results.

关键词： solid phase extraction silica gel preconcentration fly-ash zinc

Association of retreating monsoon and extreme air pollution in a megacity

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Journal of Environmental Sciences 2021年第8期33卷 97-104页

作者： Gufran Beig aditi Rathod Suvarna Tikle Sujit Maji S.B.Sobhana Indian Institute of Tropical Meteorology Ministry of Earth SciencesPune 411008India

The world’s top ranked mega city Delhi is known for deteriorated air ***,the analysis of air pollution data of 5 years(2014–2018)reveals that years 2016 and 2017,which were marked by an unusual delayed withdrawal of monsoon,witnessed an unprecedented extreme levels of toxic PM2.5 particles(≤2.5μm in diameter)touching a peak level of~760μg/m3(24 hr average),immediately after the monsoon retreat,surpassing WHO standards by~30 time and Indian national standards by~12 times,jeopardising lives of its ***,the normal monsoon withdrawal years do not show such extreme levels of *** high resolution WRF-Chem model along with meteorological data are used in this work to understand that how the delayed monsoon withdrawal and associated vagarious anticyclonic circulation resulted in trapping externally generated pollutants ceaselessly under colder conditions,leading to historic air quality crisis in landlocked mega city in these selected *** sensitivity analysis confirmed that when WRF-chem model forced the climatology of normal monsoon year(2015)to simulate the pollution scenario of 2016 and 2017 for the above time period,the crisis *** findings suggest that such unusual monsoon patterns are on the hook to spur extreme pollution events in recent time.

关键词： Monsoon Air pollution Climatology WRF-Chem Extreme events PM2.5

One checkpoint may hide another: inhibiting the TGFβ signaling pathway enhances immune checkpoint blockade

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 289-294页

作者： aditi Gupta Sadna Budhu Taha Merghoub Swim Across America and Ludwig Collaborative Laboratory Immunology ProgramParker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA

Tumors employ several mechanisms to evade recognition by the immune *** these are epigenetic changes such as loss of the antigen presenting machinery(e.g.,HLA-A,B,C)that cause tumors to become invisible to the immune ... 详细信息

关键词： inhibiting immune TGFβ