One checkpoint may hide another: inhibiting the TGFβ signaling pathway enhances immune checkpoint blockade

作     者：Aditi Gupta Sadna Budhu Taha Merghoub 

作者机构：Swim Across America and Ludwig Collaborative LaboratoryImmunology ProgramParker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2019年第8卷第3期

页      面：289-294页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by NIH grants R01CA056821 P01CA33049 and P01CA59350 and MSKCC Cancer Center Core Grant P30CA008748.This study was supported by funding from Ludwig Institute for Cancer Research Swim Across America Parker Institute for Cancer Immunotherapy Howard Hughes Medical Institute and the Breast Cancer Research Foundation 

主　　题：inhibiting immune TGFβ 

摘      要：Tumors employ several mechanisms to evade recognition by the immune *** these are epigenetic changes such as loss of the antigen presenting machinery(e.g.,HLA-A,B,C)that cause tumors to become invisible to the immune system.