检索结果-南通市图书馆

Update on Colorectal Carcinomatosis—from Molecular Biology to Diagnosis and Management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical Science 2013年第5期4卷 251-254页

作者： Sandra f. Martins adhemar longatto f.lho Life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho Braga Portugal

After liver metastases, Peritoneal Carcinomatosis (PC) is the second most frequent cause of death in patients with Colorectal Cancer (CRC), although the precise incidence of Colorectal Cancer Peritoneal Carcinomatosis is not known, as the majority of the diagnostic studies cannot detect the disease in its initial stages, nowadays, the diagnosis of peritoneal carcinomatosis remains a challenge. The molecular biology of PC is only just beginning to be understood, future knowledge will permit not only identify novel strategies for PC prevention, but also contribute to therapeutic advances, through the development of molecular targeted therapies. The authors performed a literature revision about the Molecular Biology, Diagnosis and Management of Colorectal Cancer Peritoneal carcinomatosis.

关键词： Peritoneal Carcinomatosis Colorectal Cancer Molecular Biology Diagnosis Management

Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy:revising an option for peritoneal carcinomatosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2018年第1期4卷 104-109页

作者： filipa Macedo Katia Ladeira adhemar longatto-f.lho Sandra f.Martins Portuguese Oncology Institute-Coimbra Coimbra 3000-075Portugal Portuguese Oncology Institute-Lisbon Lisbon 1099-023Portugal Life and Health Science Research Institute School of Health SciencesUniversity of MinhoBraga 4710-057Portugal ICVS/3B's-PT Government Associate Laboratory Braga/GuimaraesBraga 4710-057Portugal Molecular Oncology Research Center Barretos Cancer HospitalBarretosSao Paulo 14784-400Brazil Laboratory of Medical Investigation 14 Faculty of MedicineUniversity of Sao PauloSao Paulo 01246-903Brazil Surgery Department Coloproctology UnitBraga HospitalBraga 4710-243Portugal

Aim:Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to dista nt orga n *** systemic chemotherapy has a mini mal effect in peritoneal metastasis so new types of treatment have *** authors revised the main studies done in pressurized in traperit on eal aerosol chemotherapy(PIPAC)and prese nted the main con clusi ***:A PubMed search was con ducted focus ing on PIPAC in gastric can *** MeSH database was searched with the terms:"Gastric can cer[MeSH]and in traperit on eal aerosol chemotherapy".Results:Seve n studies were an *** the studies performed the tech nique with aerosol of doxorubic in and cisplat *** cases were well tolerated,with minor adverse *** presented resolution of their abdominal symptoms and regression of macroscopic *** surgery or hypertermic intraperitoneal chemotherapy could be performed in some patients with good response to *** peritonitis caused by the chemotherapy was well ***:PIPAC can induce remission in end-stage and resistant disease with acceptable side effects,good safety levels for patients and health professionals,and quality of life improvement.

关键词： Pressurized intraperitoneal aerosol chemotherapy gastric cancer peritoneal carcinomatosis

Role of endoglin and VEGf family expression in colorectal cancer prognosis and anti-angiogenic therapies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2011年第6期2卷 272-280页

作者： Sandra f Martins Rui M Reis Antonio Mesquita Rodrigues fátima Baltazar adhemar longatto f.lho Life and Health Sciences Research Institute School of Health SciencesUniversity of MinhoPortugalCampos of Gualtar4710-057 BragaPortugal Coloproctology Unit Hospital BragaPortugal Molecular Oncology Research Center Barretos Cancer HospitalCEP 14784-400BarretosS.PauloBrazil Laboratory of Medical Investigation(LIM)14 Faculty of MedicineUniversity of Sao PauloBrazil

Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well ***,successful preventive measures are currently used in medical ***,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death ***,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical *** plays an important role in the growth and progression of cancer but its role as a prognostic factor is still *** the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic *** goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies.

关键词： Angiogenesis Colorectal cancer Colorectal cancer treatment Endoglin Prognosis Vascular endothelial growth factor

Simultaneous surface modification method for 0.4Li2MnO3-0.6LiNi1/3Co1/3Mn1/3O2 cathode material for lithium ion batteries： Acid treatment and LiCoPO4 coating

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2017年第12期10卷 4210-4220页

作者： Min-Joon Lee Eunsol lho Pilgun Oh Yoonkook Son Jaephil Cho Department of Energy Engineering School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST) Ulsan 44919 Republic of Korea

Li-rich layered cathode materials have been considered the most promising candidates for large-scale Li-ion batteries due to their low cost and high reversible capacity. However, these materials have many drawbacks that hinder commercialization, such as low initial efficiency and cyclability at elevated temperatures. To overcome these barriers, we propose an efficient and effective surface modification method, in which chemical activation （acid treatment） and LiCoPO4 coating were carried out simultaneously. During the synthesis, the lithium ions were extracted from the lattice, leading to improved Columbic efficiency, and these ions were used for the formation of LiCoPO4. The Ni and Co doped spinel phase was formed at the surface of the host material, which gives rise to the facile pathway for lithium ions. The LiCoPO4 and highly doped spinel on the surface acted as double protection layers that effectively prevented side reactions on the surface at 60℃. Moreover, the transition metal migration of the modified cathode was weakened, due to the presence of the spinel structure at the surface. Consequently, the newly developed Li-rich cathode material exhibited a high 1st efficiency of 94%, improved capacity retention of 82% during 100 cycles at 60℃, and superior rate capability of 62% at 12C （1C = 200 mA/g） rate at 24℃. In addition, the thermal stability of the modified cathode was significantly improved as compared to that of a bare counterpart at 4.6 V, showing a 60% decrease in the total heat generation.

关键词： lithium ion battery cathode material Li-rich material electrochemistry surface modification

Merging bound states in the continuum in an open acoustic resonator

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas f.Sadreev Yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Urothelial bladder cancer progression: lessons learned from the bench

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2015年第1期1卷 57-66页

作者： Julieta P.Afonso Rui freitas francisco Lobo António Morais Jorge Oliveira Teresina Amaro Rui M.Reis fátima M.Baltazar adhemar longatto-f.lho Lúcio L.Santos Life and Health Sciences Research Institute(ICVS) School of Health SciencesUniversity of MinhoCampus de Gualtar4710-057 BragaPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal Department of Urology Portuguese Institute of OncologyRua Dr.António Bernardino de Almeida4200-072 PortoPortugal Experimental Pathology and Therapeutics Research Center Portuguese Institute of OncologyRua Dr.António Bernardino de Almeida4200-072 PortoPortugal Molecular Oncology Research Center Barretos Cancer HospitalCEP 14784-400 BarretosSão PauloBrazil Laboratory of Medical Investigation(LIM 14) Faculty of MedicineSão Paulo State UniversityCEP 01246-000São PauloBrazil Department of Surgical Oncology Portuguese Institute of OncologyRua Dr.António Bernardino de Almeida4200-072 PortoPortugal faculty of Health Sciences University Fernando PessoaRua Carlos da Maia4200-150 PortoPortugal.

Urothelial bladder carcinoma(UBC)is an intricate malignancy with a variable natural history and clinical *** developments in diagnosis/prognosis refi nement and treatment modalities,the recurrence rate is high,and progression from non-muscle to muscle invasive UBC commonly leads to ***,patients with muscle-invasive or extra-vesical disease often fail the standard chemotherapy treatment,and overall survival rates are ***,UBC remains a challenge in the oncology fi eld,representing an ideal candidate for research on biomarkers that could identify patients at increased risk of recurrence,progression,and ***,progress toward personalized medicine has been hampered by the unique genetic complexity of *** genome-wide expression and sequencing studies have brought new insights into its molecular features,pathogenesis and clinical diversity,revealing a landscape where classical pathology is intersected by the novel and heterogeneous molecular ***,it seems plausible to postulate that only an integrated signature of prognostic/predictive biomarkers inherent in different cancer hallmarks will reach clinical *** this review,we have summarized ours and others’research into novel putative biomarkers of progression and chemoresistance that encompass several hallmarks of cancer:tumor neovascularization,invasion and metastasis,and energy metabolism reprogramming of the tumor microenvironment.

关键词： CD147 lymphovascular invasion mammalian target of rapamycin monocarboxylate transporters progression Raf kinase inhibitor protein scoring system urothelial bladder cancer

Holomorphic Anomaly Equations for the formal Quintic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Peking Mathematical Journal 2019年第1期2卷 1-40页

作者： Hyenho lho Rahul Pandharipande Department of Mathematics ETH ZürichZurichSwitzerland

We define a formal Gromov-Witten theory of the quintic threefold via localization onℙ*** main result is a direct geometric proof of holomorphic anomaly equa-tions for the formal quintic in precisely the same form as predicted by B-model physics for the true Gromov-Witten theory of the quintic *** results sug-gest that the formal quintic and the true quintic theories should be related by trans-formations which respect the holomorphic anomaly *** a relationship has been recently found by ***,***,***,and *** via the geometry of new moduli spaces.

关键词： Gromov-Witten invariants Holomorphic anomaly equations Quintic threefold

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang f U Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy