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Efficacy of fexuprazan compared with rebamipide in Korean patients with gastritis:A matching-adjusted indirect comparison

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World Journal of Clinical Cases 2024年第19期12卷 3890-3897页

作者： Gwang Ha Kim Hang lak Lee Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea

BACKGROUND Gastritis is one of the most frequently diagnosed diseases requiring medical treatment in South ***,a novel potassium-competitive acid blocker,has been approved for treating gastritis and erosive ***,rebamipide is the most commonly used mucoprotective agent for acute and chronic gastritis in real-world settings in South ***,there have been no studies comparing the efficacy of these two drugs *** To compare the efficacy of fexuprazan with that of rebamipide for acute and chronic *** This was a matching-adjusted indirect *** patient data from a phase III study of fexuprazan(10 mg BID)were compared with cumulative data from two matching studies of rebamipide(100 mg TID).Erosion improvement and healing rates were compared between two weeks of fexurapan,two weeks of rebamipide,and four weeks of *** two main outcome variables were presented as percentages,and the risk differences(RD)and 95%confidence intervals(CI)were calculated for the relative treatment *** In the primary analysis,the erosion improvement and healing rates after a twoweek treatment with fexuprazan were 64.5%and 53.2%,respectively,while a twoweek treatment with rebamipide resulted in erosion improvement and healing rates of 43.6%(RD:21.0%;95%CI:9.6-32.3;P<0.01)and 35.6%(RD:17.6%;95%CI:6.1-29.2;P=0.003),*** the additional analysis,the erosion improvement and healing rates for the two-week fexuprazan treatment(64.2%and 51.2%,respectively)were similar to those obtained during a four-week treatment with rebamipide(60.6%;RD:3.6%;95%CI:-9.8,17.0;P=0.600 and 53.5%;RD:-2.3%;95%CI:-16.1,11.5;P=0.744,respectively).CONCLUSION The two-week fexuprazan treatment was superior to the two-week rebamipide treatment and similar to the fourweek rebamipide treatment for patients with gastritis.

关键词： Gastritis Erosive gastritis Fexuprazan Rebamipide Matching-adjusted indirect comparison Indirect treatment comparison

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Application of computational fluid dynamics in design of viscous dampers-CFD modeling and full-scale dynamic testing

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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 1065-1080页

作者： Hassan lak Seyed Mehdi Zahrai Seyed Mohammad Mirhosseini Ehsanollah Zeighami Department of Civil Engineering Collage of EngineeringArak BranchIslamic Azad UniversityArak ***Iran School of Civil Engineering College of EngineeringUniversity of TehranTehran ***Iran

Computational fluid dynamics(CFD)provides a powerful tool for investigating complicated fluid *** paper aims to study the applicability of CFD in the preliminary design of linear and nonlinear fluid viscous *** fluid viscous dampers were designed based on CFD *** first device was a linear viscous damper with straight *** second was a nonlinear viscous damper containing a one-way pressure-responsive valve inside its *** dampers were detailed based on CFD simulations,and their internal fluid flows were ***-scale specimens of both dampers were manufactured and tested under dynamic *** to the tests results,both dampers demonstrate stable cyclic behaviors,and as expected,the nonlinear damper generally tends to dissipate more energy compared to its linear *** compatibility was achieved between the experimentally measured damper force-velocity curves and those estimated from CFD *** a thermography camera,a rise in temperature of the dampers was measured during the *** was found that output force of the manufactured devices was virtually independent of temperature even during long duration ***,temperature dependence can be ignored in CFD models,because a reliable temperature compensator mechanism was used(or intended to be used)by the damper manufacturer.

关键词： fluid viscous damper passive control dynamic testing energy dissipation device computational fluid dynamic thermography

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Effect of seismic waves on the hydro-mechanical properties of fractured rock masses

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Earthquake Engineering and Engineering Vibration 2017年第3期16卷 525-536页

作者： Meysam lak Alireza Baghbanan Hamid Hashemolhoseini Department of Mining Engineering Isfahan University of Technology (IUT) Isfahan Iran Department of Civil Engineering Isfahan University of Technology (IUT) Isfahan Iran

The transmission of seismic waves in a particular region may influence the hydraulic properties of a rock mass, including permeability, which is one of the most important. To determine the effect of a seismic wave on the hydraulic behavior of a fractured rock mass, systematic numerical modeling was conducted. A number of discrete fracture network（DFN） models with a size of 20 m × 20 m were used as geometrical bases, and a discrete element method（DEM） was employed as a numerical simulation tool. Three different boundary conditions without（Type Ⅰ） and with static（Type Ⅱ） and dynamic（Type Ⅲ） loading were performed on the models, and then their permeability was calculated. The results showed that permeability in Type Ⅲ models was respectively 62.7% and 44.2% higher than in Type I and Type Ⅱ models. This study indicates that seismic waves can affect deep earth, and, according to the results, seismic waves increase the permeability and change the flow rate patterns in a fractured rock mass.

关键词： wave transmission earthquake dynamic analysis discrete fracture network permeability UDEC

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Dynamic earth pressure on rigid retaining walls induced by a neighboring machine foundation,by the meshless local Petrov-Galerkin method

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Earthquake Engineering and Engineering Vibration 2015年第4期14卷 647-661页

作者： Mehdi Veiskarami Arash Bahar Erfan Zandi lak Geotechnical Engineering Division Department of Civil EngineeringUniversity of Guilan Department of Civil and Environmental Engineering School of Engineering No.1Shiraz University Structural Engineering Division Department of Civil EngineeringUniversity of Guilan

Dynamic earth pressure induced by machine foundations on a neighboring retaining wall is analyzed with emphasis on factors which control the intensity and location of the design forces. The meshless local Petrov-Galerkin (MLPG) method is used to analyze the problem for a variety of retaining wall and machine foundation geometries. The soil medium is assumed to be homogeneous and visco-elastic. The machine foundation is idealized as a harmonic sinusoidal dynamic force often encountered in practice. A number of analyses have been made to reveal the effect of the loading frequency, the location and size of the foundation and the soil shear wave velocity on the distribution and magnitude of the dynamic earth pressure. Results indicate that there is a critical frequency and a critical location for which the passive pressure takes the maxima in the entire duration of the dynamic load.

关键词： MLPG retaining wall dynamic loading visco-elastic soil machine foundation

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A comparison of the effect of Vitamin D and Vitamin E supplementations,alone,and in combination,on reducing the intensity and duration of dysmenorrhea in women:A randomized controlled trial

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Journal of Integrative Nursing 2023年第1期5卷 21-26页

作者： Tahereh BEHROUZI lak Nader AGHAKHANI Davoud VAHABZADEH Samereh EGHTEDAR Rozita CHERAGHI Nazafarin GHASEMZADEH Vahid ALINEJAD Maryam MESGARZADEH Reproductive Health Research Center Urmia University of Medical SciencesUrmiaIran Food and Beverages Safety Research Center Urmia University of Medical SciencesUrmiaIran Department of Nutrition and Biochemistry Faculty of MedicineIlam University of Medical SciencesIlamIran Department of Medical Surgical Nursing School of Nursing and MidwiferyUrmia University of Medical SciencesUrmiaIran Department of Medical Ethics Faculty of MedicineUrmia University of Medical SciencesUrmiaIran Department of Biostatics Faculty of MedicineUrmia University of Medical SciencesUrmiaIran Department of Midwifery School of Nursing and MidwiferyUrmia University of Medical SciencesUrmiaIran

Objective:The aim of this study is to compare the effect of Vitamin D and Vitamin E supplementations,alone,and in combination,on reducing the intensity and duration of dysmenorrhea in women who were referred to the Kowsar gynecological clinics of Shahid Motahari Hospital of Urmia University of Medical *** and Methods:A double-blinded clinical trial was conducted on 112 women with dysmenorrhea who were randomly allocated into the four study ***,100 women complete the study and received capsules containing a placebo(n=25),1000 IU of Vitamin D(n=25),400 mg of Vitamin E(n=25),and 1000 IU of Vitamin D+400 mg of Vitamin E(n=25)every 24 h for 2 consecutive months at the beginning of the menstrual *** pain intensity and duration among groups were compared before and after the ***:The mean menstrual pain duration in all three experimental groups(Vitamin E,Vitamin D,and the combination of them)was lower than the placebo group(all P<0.05),and the mean pain intensity scores in all three experimental groups were significantly lower than the placebo group(all P<0.05).The results(means)for all of the drugs administered at the end of the 2nd month were better than the 1st month(all P<0.01).Conclusions:Vitamin E and Vitamin D,as well as their combination,are recommended as an effective and safe treatment for the management of the complications of dysmenorrhea.

关键词： Duration dysmenorrhea intensity randomized controlled trial Vitamin D Vitamin E women

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Do we have enough evidence for expanding the indications of ESD for EGC?

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World Journal of Gastroenterology 2011年第21期17卷 2597-2601页

作者： Hang lak Lee Chang Hwan Choi Dae Young Cheung Department of Internal Medicine Hanyang University College of Medicine Department of Internal Medicine ChungAng University College of Medicine Division of Gastroenterology Department of Internal MedicineYeouido St.Mary's Hospitalthe Catholic University of Korea College of Medicine

Endoscopic submucosal dissection(ESD) is the most advanced and representative technique in the field of therapeutic endoscopy and has been used for the treatment of gastrointestinal neoplasms,including early gastric *** major difference and advantage of ESD compared to existing endoscopic resection techniques,such as endoscopic mucosal resection(EMR) and polypectomy,are the width and depth of the *** developed cutting devices,distal attachable endoscopic accessories,and an advanced electrosurgical unit have helped to overcome the limitations of therapeutic endoscopy in terms of lesion size,location,presence of fibrotic scarring,and accompanying *** a result,the indications for ESD have been expanded from the classical indication for EMR and polypectomy,and there is now support for a further expansion of ESD *** present,the most critical factor to consider in the decision of whether to perform ESD is the probability of unexpected lymph node *** guidelines for ESD are continually being updated and *** this review,we discuss the strengths and weaknesses of the expanded guidelines,based on evidence found in the literature.

关键词：公共服务电子化胃癌早期证据可持续发展教育胃肠道肿瘤切割设备

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In-depth analysis of the influence of bio-silica filler(Didymosphenia geminata frustules)on the properties of Mg matrix composites

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Journal of Magnesium and Alloys 2023年第8期11卷 2853-2871页

作者： Izabela B.Zgłobicka Anna Dobkowska Aleksandra Zielińska Ewa Borucinska Mirosław J.Kruszewski RafałZybała Tomasz Płociński Joanna Idaszek Jakub Jaroszewicz Krystian Paradowski Bogusława Adamczyk-Cieślak Kostiantyn Nikiforow Bartosz Bucholc WojciechŚwięszkowski Krzysztof J.Kurzydłowski Faculty of Mechanical Engineering Bialystok University of TechnologyWiejska 45C15-351 BialystokPoland Faculty of Materials Science and Engineering Warsaw University of TechnologyWoloska 14102-507 WarsawPoland Lukasiewicz Research Network–Institute of Microelectronics and Photonics Al.Lotnikow 32/4602-668 WarsawPoland Institute of Physical Chemistry Polish Academy of Sciences Kasprzaka 44/5201-224 WarsawPoland Institute of Fundamental Technological Research Polish Academy of Sciences Pawinskiego 5B02-106WarsawPoland

A novel metal matrix composites(MMC)with Mg matrix reinforced with natural filler in the form of Didymosphenia geminata frustules(algae with distinctive siliceous shells)are presented in this *** plasma sintering(PPS)was used to manufacture Mg-based composites with 1,5 and 10 vol.%ceramic *** a reference,pure Mg was *** results show that the addition of 1 vol.%Didymosphenia geminata frustules to the Mg matrix increases its corrosion resistance by supporting passivation reactions,and do not affect the morphology of L929 *** of 5 vol.%the filler does not cause cytotoxic effects,but it supports microgalvanic reactions leading to the greater corrosion *** content than 5 vol.%the filler causes significant microgalvanic corrosion,as well as increases cytotoxicity due to the greater micro-galvanic effect of the composites containing 10 and 15 vol.%*** results of contact angle measurements show the hydrophilic character of the investigated materials,with slightly increase in numerical values with addition of amount of ceramic *** addition of Didymosphenia geminata frustules causes changes in a thermo-elastic properties such as mean apparent value of coefficient of thermal expansion(CTE)and thermal conductivity(λ).The addition of siliceous reinforcement resulted in a linear decrease of CTE and reduction in thermal conductivity over the entire temperature *** the increasing addition of Didymosphenia geminata frustules,an increase in strength with a decrease in compressive strain is *** all composites an increase in microhardness was *** results clearly indicate that filler in the form of Didymosphenia geminata frustules may significantly change the most important properties of pure Mg,indicating its wide potential in the application of Mg-based composites with a special focus on biomedical use.

关键词： Metal-matrix composites(MMCs) Pulse plasma sintering(PPS) Ceramic filler Microstructure Properties

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Behaviorist Fundamentalism Turns Radical:ETIM/TIP’s Islamic Fundamentalist Representations and Narratives

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Asian Journal of Middle Eastern and Islamic Studies 2015年第4期9卷 85-99,I0005页

作者： Yee lak Elliot LEE Department of Cultural and Religious Studies Chinese University of Hong Kong

Many contemporary Islamic terrorist groups have been identified as forms of religious ***,the narratives and representations constructed by many of these groups contain traces of religious *** this article,ETIM/TIP’s narratives and representations are examined as a case *** group’s power discourses as they relate to religious fundamentalism are analyzed through examining the group’s rhetoric of its own origin,its current situation,and its reactions toward this *** power discourse of an unconventional“Orientalism”and the use of behaviorist logic are especially ***,the presence of behaviorism in religious fundamentalist narratives suggests the need for China to revise its official national counterterrorist *** of continuing the current behaviorist rhetoric in the legal framework,this article suggests a deconstruction-ultimately,a discouragement-of religious behaviorism to prevent the radicalization of Muslims in the country.

关键词： East Turkistan Islamic Movement(ETIM)/Turkistan Islamic Party(TIP) Religious Fundamentalism Terrorism Orientalism Behaviorism Radicalization Salafism Jihad

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Corrosion behavior of fine-grained Mg-7.5Li-3Al-1Zn fabricated by extrusion with a forward-backward rotating die(KoBo)

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Journal of Magnesium and Alloys 2022年第3期10卷 877-887页

作者： Anna Dobkowska Boguslawa Adamczyk-Cieslak Milena Koralnik Witold Chromiński Jiri Kubasek Jakub Ciftci Dariusz Kuc Jaroslaw Mizera Faculty of Materials Science and Engineering Warsaw University of Technology141 WoloskaStWarsaw 02-507Poland Department of Metals and Corrosion Engineering University of Chemistry and TechnologyTechnicka 5Prague 616628Czechia Institute of Materials Engineering Silesian University of TechnologyKrasiÂnskiego 8Katowice 40-019Poland

The microstructure-dependent corrosion resistance of dual structured fine-grained Mg-7.5 Li-3 Al-lZn has been *** alloys were extruded using extrusion with a forward-backward rotating die(KoBo,a newly developed SPD method)at two different extrusion *** fine-grained microstructures formed in the alloys were characterized,and the influence of grain refinement on corrosion resistance was *** fine-grained(α+β)Mg-Li alloys,a higher extrusion ratio led to more intensive grain refinement;however,this relationship did not improve their corrosion resistance in a chloride-containing *** corrosion resistance of the alloys was mainly controlled by the refinement ofα(Mg)andβ(Li),along with the distribution of second *** presence of MgLi_(2) Al at grain boundaries facilitated their dissolution.

关键词： Corrosion Grain refinement Grain size distribution Magnesium alloy.

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A Novel Ultra-Wideband Monopole Antenna with Band-Stop Characteristic

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Wireless Engineering and Technology 2011年第4期2卷 235-239页

作者： Hadi Jalali lak Changiz Ghobadi Javad Nourinia 不详

In this letter, a simple monopole antenna with variable band-notched characteristic for ultra wide band (UWB) function is proposed. Two L-shaped quarter-waveguide resonators coupled to the ground plane with two shorting tracks at the sides of the antenna are used to generate stop-band performance around 5.5 GHz (WLAN). The proposed antenna is fabricated on the substrate FR4 (relative permittivity of 4.7) and has a compact size of 16 × 28.5 × 1.6 mm. The designed antenna has a good impedance matching in 3.1 - 11.4 GHz frequency range with VSWR < 2, except the band 5 - 5.85 GHz.

关键词： Band-Notched Antennas Band Rejection Antennas Planar Antennas Ultra Wideband (UWB)

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