A comparison of the effect of Vitamin D and Vitamin E supplementations,alone,and in combination,on reducing the intensity and duration of dysmenorrhea in women:A randomized controlled trial

作     者：Tahereh BEHROUZI LAK Nader AGHAKHANI Davoud VAHABZADEH Samereh EGHTEDAR Rozita CHERAGHI Nazafarin GHASEMZADEH Vahid ALINEJAD Maryam MESGARZADEH 

作者机构：Reproductive Health Research CenterUrmia University of Medical SciencesUrmiaIran Food and Beverages Safety Research CenterUrmia University of Medical SciencesUrmiaIran Department of Nutrition and BiochemistryFaculty of MedicineIlam University of Medical SciencesIlamIran Department of Medical Surgical NursingSchool of Nursing and MidwiferyUrmia University of Medical SciencesUrmiaIran Department of Medical EthicsFaculty of MedicineUrmia University of Medical SciencesUrmiaIran Department of BiostaticsFaculty of MedicineUrmia University of Medical SciencesUrmiaIran Department of MidwiferySchool of Nursing and MidwiferyUrmia University of Medical SciencesUrmiaIran 

出 版 物：《Journal of Integrative Nursing》 (中西医结合护理杂志（英文）)

年 卷 期：2023年第5卷第1期

页      面：21-26页

学科分类：1011[医学-护理学（可授医学、理学学位）] 10[医学] 

基　　金：Shahid Motahari Hospital in Urmia University of Medical Sciences Urmia University of Medical Sciences, UMSU 

主　　题：Duration dysmenorrhea intensity randomized controlled trial Vitamin D Vitamin E women 

摘      要：Objective:The aim of this study is to compare the effect of Vitamin D and Vitamin E supplementations,alone,and in combination,on reducing the intensity and duration of dysmenorrhea in women who were referred to the Kowsar gynecological clinics of Shahid Motahari Hospital of Urmia University of Medical Sciences.Materials and Methods:A double-blinded clinical trial was conducted on 112 women with dysmenorrhea who were randomly allocated into the four study groups.Finally,100 women complete the study and received capsules containing a placebo(n=25),1000 IU of Vitamin D(n=25),400 mg of Vitamin E(n=25),and 1000 IU of Vitamin D+400 mg of Vitamin E(n=25)every 24 h for 2 consecutive months at the beginning of the menstrual period.The pain intensity and duration among groups were compared before and after the intervention.Results:The mean menstrual pain duration in all three experimental groups(Vitamin E,Vitamin D,and the combination of them)was lower than the placebo group(all P0.05),and the mean pain intensity scores in all three experimental groups were significantly lower than the placebo group(all P0.05).The results(means)for all of the drugs administered at the end of the 2nd month were better than the 1st month(all P0.01).Conclusions:Vitamin E and Vitamin D,as well as their combination,are recommended as an effective and safe treatment for the management of the complications of dysmenorrhea.