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Impact of Low Back Pain on Quality of Life: Assessment by Patient Functionality Questionnaire and Treatment Results Using a Combination of Diclofenac plus B Vitamins or Diclofenac Monotherapy

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International Journal of Clinical Medicine 2016年第2期7卷 113-119页

作者： Mauro Geller Marco Antonio Mibielli Carlos Pereira Nunes adenilson de souza da fonseca Stephanie Wrobel Goldberg Lisa Oliveira Teresópolis Medical School UNIFESO Rio de Janeiro Brazil Washington University School of Medicine St. Louis MO USA

Objective: To analyze the Patient Functionality Questionnaire (PFQ) scores of the patients treated with either Diclofenac + B vitamins (Group DB) or Diclofenac monotherapy (Group D) in order to better understand the impact of the combination of diclofenac with vitamins B1, B6, and B12 on quality of life. Research Design/Methods: We performed a post-hoc analysis of tabulated data generated during the DOLOR study (Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study), using the software GraphPad Prism 5 for Windows, v5.04. The absolute number or percentage of “True”/“False” respondents for each questionnaire item at each study visit, together with the absolute number and percentage of subjects with no change, improvement, or worsening of each PFQ item at each study visit, within and between treatment groups were arranged on contingency tables and analyzed with the Chi-squared or Fisher’s Exact test. Results: At pretreatment there were no statistically significant differences between treatment groups (p > 0.05 for all items). At Visit 2 in both treatment groups, there were statistically significant improvements in individual question responses in each of the 12 items of the questionnaire (p < 0.05 for all items). At Visit 2, comparing the distribution of patients in each treatment group with “improvement”, “no change”, or “worsening”, there was a statistically significant superiority among subjects of group DB in response to items 1, 6, 8, and 10. At Visit 3, both groups had statistically significant (p < 0.001) improvements in each individual item of the PFQ in relation to pretreatment values. The distribution of subjects in each treatment group presenting with “improvement”, “no change”, or “worsening” at Visit 3 varied significantly in favor of group DB in the responses to item 4. At Visit 4, the subjects remaining in treatment in both groups showed statistically significant improvement in PFQ response

关键词： Low Back Pain Quality Of Life Diclofenac Thiamine Pyridoxine Cyanocobalamin

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Alginate Matrix of Mda-MB-231 Breast Cancer Cell 3D Culturing Alters CD44 and CD24 mRNA Levels and Induces ALDH1 Expression

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Journal of Life Sciences 2017年第5期11卷 219-227页

作者： Layane Duarte e souza Elisa Raquel Anastacio Ferraz Isis Soares Salviano adenilson souza da fonseca Israel Felzenzswalb Andre Luiz Mencalha Laboratory of Cancer Biology (LABICAN) Roberto Alcantara Biology Institute University of Rio de Janeiro State Rio de Janeiro RJ20331-050 Brazil Department of Pharmacy and Pharmaceutical Administration Pharmacy College Fluminense Federal University Niteroi RJ 20331-050 Brazil Laboratory of Mutagenesis (LABMUT) Roberto Alcantara Biology Institute University of Rio de Janeiro State Rio de Janeiro RJ20331-050 Brazil

CSCs （Cancer stem cells） have been involved in tumor resistance, metastasis and recurrence. In breast cancer, tumor cells are characterized by CD44＋, CD24-/low and ALDH 1 expression represents a subpopulation of BCSC （breast cancer stem cell）. Several three-dimensional （3D） in vitro culturing cancer cells have been used to stimulate BCSC phenotype. The present study aimed to evaluate 3D cell culture in alginate matrix and the CD44, CD24 and ALDH1 mRNA levels of BCSC markers. The 3D culture was performed using Mda-MB-231 breast cancer cell line on alginate matrix 1.2% in RPMI medium. Expression of BCSC markers was evaluated by Real Time PCR （Polymerase Chain Reaction） comparing 3D to 2D culture. The 3D cultures increase of CD44 and CD24 mRNA levels and induce ALDH1 expression comparing to 2D culture. The data suggest that 3D alginate matrix alters the mRNA levels of genes involved in the phenotypic characteristics of BCSC.

关键词： 3D alginate culture CD44 CD24 ALDH1 breast cancer.

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Assessment of Acute Episodes in Chronic Stable Angina: A Clinical-Laboratory Approach to the Use of the Coronary Vasodilator Propatyl Nitrate

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World Journal of Cardiovascular Diseases 2016年第7期6卷 246-252页

作者： Gerson Goldwasser Renato Kaufman Carlos Pereira Nunes Alexandre Hid Stephanie Wrobel Goldberg Alessandra Santos Lisa Oliveira adenilson de souza da fonseca Mauro Geller souza Marques Medical School Rio de Janeiro Brazil Universidade Estadual do Rio de Janeiro Rio de Janeiro Brazil UNIFESO Medical School Teresópolis Brazil Washington University School of Medicine St. Louis MO USA

Background/Objectives: Propatyl nitrate is a coronary vasodilator with immediate and prolonged action, indicated in the treatment and prevention of acute angina pectoris episodes. Methods: This was an open, self-paired comparative study performed at UNIFESO Medical School evaluating the clinical and laboratory results of treatment with propatyl nitrate in patients with chronic stable angina pectoris. Subjects received 10 mg of propatyl nitrate, at the dose of three sublingual tablets per day, to be taken at 8:00 A.M., 2:00 P.M., and 8:00 P.M. Subjects returned to the study center after 15 days of treatment for Visit 2 assessments, and at the end of the 30-day treatment period (Visit 3). Results: A total of 200 subjects were included in the study. There was a statistically significant reduction in blood pressure (p day treatment period. Treatment with propatyl nitrate increased angina stability and reduced angina frequency while increasing treatment satisfaction and quality of life in the patient population evaluated.

关键词： Propatyl Nitrate Stable Chronic Angina Pectoris Seattle Angina Questionnaire

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Simulated rainfall in Brazil:An alternative for assesment of soil surface processes and an opportunity for technological development

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International Soil and Water Conservation Research 2024年第1期12卷 29-42页

作者： Camila Calazans da Silva Luz Wilk Sampaio de Almeida Adilson Pacheco de souza Nivaldo Schultz Jamil Alexandre Ayach Anache daniel fonseca de Carvalho Postgraduate Program in Agronomy-Soil Sciences Federal Rural University of Rio de JaneiroSeropédicaRJBrazil Agronomy Department Federal Institute of EducationScience and Technology of RondôniaAriquemesROBrazil Federal University of Mato Grosso SinopMTBrazil Federal Rural University of Rio de Janeiro SeropédicaRJBrazil Federal University of Mato Grosso do Sul Campo GrandeMSBrazil

Rainfall simulators(RS)have been used,above all,to evaluate hydrological processes related to soil water infiltration,surface runoff and soil *** allow repeatability of rain application with different precipitation intensities in field and/or laboratory conditions and should produce events with physical characteristics similar to natural *** this manuscript,we carried out a bibliometric and scientometric analysis of studies with simulated rainfall in Brazil to assess the temporal evolution of publications,the main topics addressed and the degree of technological development of the *** searched for the terms“rainfall simulator”OR“simulated rainfall”AND“Brazil”in the Scopus,Web of Science,SciELO and Google Scholar *** found 143 articles published in the last 37 years(1985-2022).Our findings indicate that the main research areas covered in papers are soil erosion(57.34%),soil water infiltration(24.47%),nutrient losses(9.8%)and RS development and calibration/assessment(8.39%).In recent years,the number of published papers in international high-impact factor journals has *** of the papers(49.65%)refer to studies carried out by institutions located in the south and southeast regions of ***,there is a large gap of studies on simulated rainfall in other regions of Brazil,where important biomes such as the Cerrado,Amazon,Caatinga,and their transitions are *** study informs research priorities on soil erosion under simulated rainfall and provides a bibliographic database that can assist in more detailed future analyses.

关键词： Rainfall simulator Soil and water losses Soil water infiltration Bibliometrics Scientific review

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Clinical Assessment of Treatment Outcomes Following Borago officinalis Extract Therapy in Patients Presenting with Cyclical Mastalgia

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International Journal of Clinical Medicine 2015年第6期6卷 363-371页

作者： Carlos Romualdo Barboza Gama Ricardo Lasmar Gustavo Falcao Gama Lisa Oliveira Erika Cesar de Oliveira Naliato Marcia Goncalves Ribeiro Flavia de Paoli adenilson de souza da fonseca Camila Sirieiro Abreu Mauro Geller Alessandra Santos Teresopolis Medical School—UNIFESO Rio de JaneiroBrazil Universidade Federal Fluminense—UFF Rio de JaneiroBrazil Universidade Federal de Juiz de Fora—UFJF Juiz de ForaBrazil Universidade Federal do Rio de Janeiro—UFRJ Rio de JaneiroBrazil Instituto de Pós-Graduacao Medica Carlos Chagas Rio de JaneiroBrazil

In order to evaluate the safety and efficacy of Borago officinalis (900 mg borage oil capsules) in the treatment of patients presenting with cyclic mastalgia, 91 subjects were included in the study. Efficacy assessments were performed based on data obtained prior to the start of treatment (Pretreatment), and after each menstrual cycle (Assessment 2—following 45 days of treatment;and Assessment 3—at the end of the 90-day treatment period). Primary efficacy measures considered the results of the Mastalgia Questionnaire, including a 100 mm visual analog pain scale assessing mean, most intense mastalgia severity, and impact on work, sleep, and sexual activity. Safety and tolerability measures included any changes in vital signs and physical exam in relation to pretreatment, any changes in clinical laboratory exams in relation to pretreatment, and the occurrence of adverse events after the first dose of study medication. The VAS scores of the mean mastalgia and most severe mastalgia both showed statistically significant

关键词： Cyclic Mastalgia Borago officinalis Borage Oil

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Resection of Intracranial Giant Cavernous Malformation: Case Report and Literature Review

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Surgical Science 2024年第2期15卷 28-35页

作者： Vinicios Rivelli da fonseca Cleverson Martins Kill Mariana Alcantara Hugo Fialho Leonnan De Sa Oliveira Lucidio souza Filho Department of Neurosurgery Hospital Santa Rita Belo Horizonte Brazil

Cerebral cavernous malformations are a rare and congenital vascular malformation that can present as a challenge in neurosurgical management. The term “giant cerebral cavernous malformations” still does not have a clear definition in the literature, with a wide variety of results. It is known, however, that there is an association between the size of the cavernoma and postoperative sequelae, especially in those with a size greater than 3 cm in its largest diameter. We present a case report of resection of a giant brain cavernoma measuring approximately 8 cm in its largest diameter, emphasizing on clinical presentation, diagnoses and postoperative evolution. Additionally, we performed a comprehensive review of the existing literature on the subject, addressing the epidemiology, pathophysiology, diagnostic methods, treatment options, and prognosis associated with this condition.

关键词： Cavernous Malformation Cerebral Cavernous Malformation Giant Cavernous Malformation Cavernous Hemangioma Cavernous Angioma Cavernoma Giant Cavernoma

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Ecophysiological acclimatization to cyclic water stress in Eucalyptus

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Journal of Forestry Research 2020年第3期31卷 797-806页

作者： Rogerio de souza Noia Junior Genilda Canuto Amaral Jose Eduardo Macedo Pezzopane Mariana Duarte Silva fonseca Ana Paula Camara da Silva Talita Miranda Teixeira Xavier Department of Biosystems Engineering ESALQ University of Sao PauloPiracicabaSao PauloBrazil Department of Forestry Sciences NEDTEC Federal University of Espirito SantoJero nimo MonteiroEspirito SantoBrazil

Drought is considered the main environmental factor limiting productivity in eucalyptus plantations in Brazil. However, recent studies have reported that exposure to water deficit conditions enables plants to respond to subsequent stresses. Thus, this study investigates the ecophysiological acclimatization of eucalyptus clones submitted to recurrent water deficit cycles. Eucalyptus seedlings were submitted to three recurrent water deficit cycles and anatomical, morphological and physiological changes were analyzed. The results were:(1) Eucalyptus seedlings responded to water deficits by directing carbohydrates to root and stem growth;(2) Size and number of stomata were reduced;(3) Stomatal conductance decreased which allowed the plants to reduce water losses through transpiration,increasing instantaneous water use efficiency;(4) The relationship between gas exchanges and available water contents allowed the seedlings to uptake the retained soil water athigher tensions;and,(5) Physiological recovery from subsequent water deficits became faster. As a result of these changes, the eucalyptus seedlings recovered from the same degree of water stress more rapidly.

关键词： Carbon partition Drought Gas exchange Morpho-physiological changes Photosynthetic apparatus

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Bench for Vibration Study in an Unbalanced Motor Using Arduino

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Journal of Mechanics Engineering and Automation 2015年第2期5卷 82-87页

作者： Thayanne Barros Bandeira Andre souza da Cruz Wellington fonseca da Silva Faeuldade de Engenharia El~trica Universidade Federal do Para Campus Tucurui Tucurui 68464-000 Brazil Faculdade de Ciencia e Tecnologia Universidade Federal do Para Campus Ananindeua Ananindeua 67020-000 Brazil

Part of the difficulty in engineering education is to achieve aggregate theoretical knowledge to practice what therefore discourages the student. Trying to alleviate this difficulty, practical problems are created to encourage students to apply their knowledge in different ways; these problems can be computational order, resolved by programs through simulation, or physical, with the realization of models, prototypes, benches or interactive platforms with visual practical approach. From this, it was proposed to students of the Federal University of Pardi--Campus Tucurui through the Electric Power Systems and Mechanics Research Group, in order to apply knowledge arising from multidisciplinary fields of engineering in the construction of a prototype with reused materials and low cost enabling studies and analysis of vibrations in unbalanced motors. This system features an open source prototyping embedded platform Arduino to read values from the sensors used： accelerometers and potentiometers coupled to the engine, aiming to collect values and vary the supply voltage. The results are read by Arduino and computationally processed to be printed on an LCD display. Therefore, the aim of this is to provide an accessible way using simple techniques a prototype linking the theoretical and practical knowledge as the system of the bench that performs vibration analysis in an unbalanced motor interactively, and encourage research and development technologies in the Amazon region.

关键词： Arduino engineering engines vibrations.

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Role of lysophosphatidic acid and its receptors in health and disease:novel therapeutic strategies

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Signal Transduction and Targeted Therapy 2021年第3期6卷 630-647页

作者： Luiz Henrique Medeiros Geraldo Tania Cristina Leite de Sampaio Spohr Rackele Ferreira do Amaral Anna Carolina Carvalho da fonseca Celina Garcia Fabio de Almeida Mendes Catarina Freitas Marcos Fabio dosSantos Flavia Regina souza Lima Institute de Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Universite de Paris PARCCINSERMF-75015 ParisFrance Institute Estadual do Cerebro Paulo Niemeyer-Secretaria de Estado de Saude Rio de JaneiroBrazil Instituto de Saiide de Nova Friburgo Universidade Federal Fluminense28625-650 Nova FriburgoBrazil

Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we review the literature about the differential signaling of LPA through its specific receptors,which makes this lipid a versatile signaling *** differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis;and also,how it can act as a powerful mediator of pathological conditions,such as neuropathic pain,neurodegenerative diseases,and cancer ***,we review the preclinical and clinical uses of Autotaxin,LPA,and its receptors as therapeutic targets,approaching the most recent data of promising molecules modulating both LPA production and *** review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.

关键词： therapeutic clinical diseases

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Mapping of the Use of Waste as Raw Materials for Biogas Production

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Journal of Environmental Protection 2017年第2期8卷 120-130页

作者： Rafaela Lora Grando Fabiana Valeria da fonseca Adelaide Maria de souza Antunes Graduate Program in Chemical and Biochemical Processes School of Chemistry Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Nacional de Propriedade Industrial (INPI) Rio de Janeiro Brazil

Anthropic methane emissions can largely be prevented or minimized using technologies that are already available. One such technology is anaerobic digestion (AD), which is used commercially around the world, especially in Europe and the United States, where some challenging targets have been set to diversify the energy mix with more renewable energy. This foresight study was designed to identify which technological solutions out of the many options available for biogas production are attracting most interest, for which purpose patent documents and scientific publications were analyzed. The aim is to identify which raw materials are most attractive for AD and biogas production. It was found that the raw materials that have attracted most research and patenting activity are sludge, sewage, and wastewater, livestock waste, and agriculture waste, which together account for 62% of all the patents filed and 74% of all the scientific publications. The countries most engaged in producing biogas from AD plants are China, Germany, and the United States. We also identified a rising trend in the use of biogas around the world, and a steady increase in the number of patents filed on the subject, especially in Japan and South Korea. This growth is driven, amongst other things, by strategic governmental actions, global environmental pacts, and the realization on the part of industry that anaerobic digestion can be used as an efficient method for treating waste and effluents.

关键词： Anaerobic Digestion Biogas Production Investigative Overview Raw Material

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