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加拿大维多利亚华人谭公信俗与文化身份认同

文化遗产 2024年第1期 137-143,F0002,I0001,I0002页

作者：黄韧陈曦广州南方学院公共管理学院广东广州510970 武汉商学院通识教育研究中心湖北武汉430056

作为第一座加拿大华人庙宇,维市谭公庙经历了客家先民迁徙至此租木屋供谭公神像、买土地建谭公庙宇、遭遇排华火烧庙宇到搬驻人和会馆形成顶楼“人和庙”至今香火绵延的过程。一方面表现出加拿大客家人艰苦卓绝的异乡迁徙史和奋斗史,另... 详细信息

作为第一座加拿大华人庙宇,维市谭公庙经历了客家先民迁徙至此租木屋供谭公神像、买土地建谭公庙宇、遭遇排华火烧庙宇到搬驻人和会馆形成顶楼“人和庙”至今香火绵延的过程。一方面表现出加拿大客家人艰苦卓绝的异乡迁徙史和奋斗史,另一方面反映出客家人民间信俗特征及其海外移动的在地重构。谭公庙作为加拿大客家人营造的第一个神圣空间,它既是亲缘、地缘和神缘纽带,表现着加拿大客家人的族群身份认同;同时,又通过异国地方化的世代参与,共同打造出与家乡类似的神-人-物与地方的交叠互动场域。通感、仪式传承、文化记忆以及当下参与感又重构出“他乡犹吾境”的地方感,从中可窥见加拿大客家人历史性与当下性的生活图景和精神世界。

关键词：谭公信俗加拿大客家跨地方性地方感视觉体验

以图像漫步重组质性研究过程:从教育场景中的观察者到参与者

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北京大学教育评论 2024年第2期22卷 149-171,191,192页

作者：林小英黄安妮北京大学教育经济研究所/教育学院北京100871

教育研究现场与社会调查实地相比,更需要研究者的共情性理解,图像漫步方法作为质性研究中的一种情境方法论,具有构建共情的教育研究现场的潜能。研究者通过直接参与研究对象的图像创作分享其想象的世界,成为研究对象分享记忆和体验的参... 详细信息

教育研究现场与社会调查实地相比,更需要研究者的共情性理解,图像漫步方法作为质性研究中的一种情境方法论,具有构建共情的教育研究现场的潜能。研究者通过直接参与研究对象的图像创作分享其想象的世界,成为研究对象分享记忆和体验的参与者。场景因信息流动而重新被理解,基于此达成互动的个体轨迹是开放和变化的。柏格森提出的“绵延”概念与图像漫步视角有着内在的共通性,从“绵延”出发理解研究者在一项研究中作出的各种选择所构成的“局部视角”以及由研究者的“介入”所带来的现实的潜在分化,可以重组质性研究的过程,即教育研究的对象不完全是客观存在,需要研究者具备共情能力和必要时的扰动能力;通过共创图像可能比文本更接近“真实”,图像的情动能力有助于研究者了解和转译缄默知识。作为质性研究方法的图像漫步,有着捕捉个体差异性并通过集体对话将个体之间的点进行连线以构成网状图、从而实现从个体生成到群体生成的双重功能。研究者以全然接纳参与者的方式重组研究过程,通过与他人的眼睛一起看世界的共情方式,可以超越自我的边界、生成新的教育主题,创造更广阔视野的理念世界。

关键词：图像漫步质性研究教育场景绵延参与

Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus

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CCS Chemistry 2024年第2期6卷 487-496页

作者： Ke Sun Zhe Ding Xiaoying Jia Haonan Cheng Yingwen Li Yan Wu Zhuoyu Li Xiaohua Huang Fangxu Pu Entao Li Guiyou Wang Wei Wang Yun Ding Gary wong Sandra Chiu Jiaming Lan Aiguo Hu Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 CAS Key Laboratory of Molecular Virology&Immunology Chinese Academy of SciencesShanghai 200031 University of the Chinese Academy of Sciences Beijing 100049 State Key Laboratory of Virology Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071 Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230027 Department of Clinical Laboratory The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001

The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses ***,state-of-the-art treatments still lag behind the continual emergence of new *** to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural ***,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)*** core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the *** EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”

关键词： enediyne broad spectrum antiviral protein disintegration coronavirus polyanions

Celastrol promotes apoptosis of breast cancer MDA-MB-231 cells by targeting HSDL2

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Acupuncture and Herbal Medicine 2024年第1期4卷 92-101页

作者： Li Liu Yanqing Liu Shujie Zhang Junzhe Zhang Yuqing Meng Dandan Liu Liwei Gu Ying Zhang Liting Xu Ziyue Zhang Minghong Zhao Yinkwan wong Qixin Wang Yongping Zhu Jigang Wang College of Pharmacy Gannan Medical UniversityGanzhouChina State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijingChina Department of Pharmacological Sciences Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

Objective:Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicinal herb,Tripterygium *** study aims to provide a scientific basis for the rational development and use of celastrol in breast ***:A quantitative chemical biology approach was used to investigate the protein targets and molecular mechanisms of celastrol in breast cancer ***:Low-concentration celastrol exerted an anti-tumor effect by directly binding to hydroxysteroid dehydrogenase-like 2(HSDL2)and inhibiting its ***,the expression of the pro-apoptotic protein,Bcl-2-associated X(BaX),increased,the level of the anti-apoptotic protein,B-cell lymphoma-2(Bcl-2),decreased,and the rate of apoptosis *** the transfection of cells with si-HSDL2,the apoptosis rate was similar to that observed after the administration of ***,apoptosis was reversed by the overexpression of ***,our mass spectrometry(MS)data indicated a relationship between HSDL2 and the mitogen-activated protein kinase(MAPK)signaling *** also found that the expression of HSDL2 was directly related to the degree of extracellular signal-regulated kinase(ERK)***:Celastrol may promote apoptosis by suppressing the HSDL2/MAPK/ERK signaling pathway.

关键词： Activity-based protein profiling Apoptosis Celastrol HSDL2

Development of biomedical hydrogels for rheumatoid arthritis treatment

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 35-48页

作者： Mirza Muhammad Faran Ashraf Baig Lee Kiwong Abdul Wasy Zia Hongkai Wu Department of Chemistry Hong Kong University of Science and TechnologyHong Kong 999077China Institute of Mechanical Process and Energy Engineering(IMPEE)School of Engineering and Physical SciencesHeriot-Watt UniversityEdinburghUnited Kingdom

Rheumatoid Arthritis(RA)is an autoimmune disorder that hinders the normal functioning of bones and joints and reduces the quality of human *** year,millions of people are diagnosed with RA worldwide,particularly among elderly individuals and ***,there is a global need to develop new biomaterials,medicines and therapeutic methods for treating *** will improve the Healthcare Access and Quality Index and also relieve administrative and financial burdens on healthcare service providers at a global *** are soft and cross-linked polymeric materials that can store a chunk of fluids,drugs and biomolecules for hydration and therapeutic *** are biocompatible and exhibit excellent mechanical properties,such as providing elastic cushions to articulating joints by mimicking the natural synovial ***,hydrogels create a natural biological environment within the synovial cavity to reduce autoimmune reactions and *** also lubricate the articulating joint surfaces to prevent degradation of synovial surfaces of bones and cartilage,thus exhibiting high potential for treating *** work reviews the progress in injectable and implantable hydrogels,synthesis methods,types of drugs,advantages and ***,it discusses the role of hydrogels in targeted drug delivery,mechanistic behaviour and tribological performance for RA treatment.

关键词： Rheumatoid arthritis Orthopeadic joints Hydrogel Therapeutics Mechanical properties Medicine

Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?

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Asian Journal of Urology 2024年第3期11卷 443-449页

作者： Ho Yee Tiong Wei Zheng So Jeremy Yuen-Chun Teoh Shuji Isotani Gang Zhu Teng Aik Ong Eddie Shu-Yin Chan Peggy Sau-Kwan Chu Kittinut Kijvikai Ming Liu Bannakji Lojanapiwat Michael wong Anthony Chi-Fai Ng Yong Loo Lin School of Medicine Department of SurgeryNational University of SingaporeSingapore S.H.Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong KongChina Department of Urology Juntendo University Graduate School of MedicineTokyoJapan Department of Urology National University HospitalSingapore Department of Urology Beijing United Family HospitalBeijingChina Department of Surgery University of Malaya Specialist CentreKuala LumpurMalaysia Division of Urology Department of SurgeryTuen Mun HospitalHong Kong Department of Urology Ramathibodi HospitalMahidol UniversitySalayaThailand Department of Urology Beijing HospitalBeijingChina Department of Urology Chiangmai Ram HospitalChiang MaiThailand International Urology Fertility&Gynaecology CentreSingapore

Objective:To correlate the utility of the Fundamentals of Laparoscopic Surgery(FLS)manual skills program with the Objective Structured Assessment of Technical Skills(OSATS)global rating scale in evaluating operative ***:The Asian Urological Surgery Training and Educational Group(AUSTEG)Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical ***’basic laparoscopic skills were assessed using three different training models(peg transfer,precision cutting,and intra-corporeal suturing).They also performed live porcine laparoscopic surgery at the same *** surgery skills were assessed by blinded faculty using the OSATS rating ***:From March 2016 to March 2019,a total of 81 certified urologists participated in the course,with a median of 5 years of post-residency *** differences in task time did not reach statistical significance,those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS ***,they took longer to complete the precision cutting task than participants with less *** OSATS scores correlated weakly with all three FLS tasks(peg transfer time:r=0.331,r^(2)=0.110;precision cutting time:r=0.240,r^(2)=0.058;suturing with intracorporeal knot time:r=0.451,r^(2)=0.203).Conclusion:FLS task parameters did not correlate strongly with OSATS globing rating scale *** FLS task models demonstrated strong validity,it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence,as evaluated by FLS and OSATS,respectively.

关键词： TheFundamentalsof Laparoscopic Surgery The Objective Structured Assessment of Technical Skills Laparoscopic training Surgical education Surgical training Urological laparoscopic surgery

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

Over 18.2%efficiency of layer–by–layer all–polymer solar cells enabled by homoleptic iridium(Ⅲ)carbene complex as solid additive

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Science Bulletin 2024年第18期69卷 2862-2869页

作者： Hang Zhou Yingjie Sun Miao Zhang Yuheng Ni Fenghua Zhang Sang Young Jeong Tianhuan Huang Xiong Li Han Young Woo Jian Zhang Wai-Yeung wong Xiaoling Ma Fujun Zhang Key Laboratory of Luminescence and Optical Information(Ministry of Education) Beijing Jiaotong UniversityBeijing 100044China Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Physics Beijing Technology and Business UniversityBeijing 100048China Organic Optoelectronic Materials Laboratory Department of ChemistryCollege of ScienceKorea UniversitySeoul 02841Republic of Korea School of Materials Science and Engineering Engineering Research Center of Electronic Information Materials and DevicesMinistry of EducationGuangxi Key Laboratory of Information MaterialsGuilin University of Electronic TechnologyGuilin 541004China Tangshan Research Institute of Beijing Jiaotong University Tangshan 063000China

The vertical phase distribution of active layers plays a vital role in balancing exciton dissociation and cha rge transport for achieving efficient polymer solar cells(PSCs).The layer-by-layer(LbL)PSCs are commonly prepared by using sequential spin-coating method from donor and acceptor solutions with distinct solvents and solvent *** enhanced exciton dissociation is expected in the LbL PSCs with efficient charge transport in the relatively neat donor or acceptor *** this work,a series of LbL all-polymer solar cells(APSCs)were fabricated with PM6 as donor and PY-DT as acceptor,and triplet material m-Ir(CPmPB)_(3)is deliberately incorporated into PY-DT layer to prolong exciton lifetimes of active *** power conversion efficiency(PCE)of LbL APSCs is improved to 18.24%from 17.32%by incorporating 0.3 wt%m-Ir(CPMPB)_(3)in PY-DT layer,benefiting from the simultaneously enhanced short-circuit current density(Isc)of 25.17 mA cm^(-2)and fill factor(FF)of 74.70%.The enhancement of PCE is attributed to the efficient energy transfer of m-Ir(CPmPB)_(3)to PM6 and PY-DT,resulting in the prolonged exciton lifetime in the active layer and the increased exciton diffusion *** efficient energy transfer from m-Ir(CPmPB)_(3)to PM6 and PY-DT layer can be confirmed by the increased photoluminescence(PL)intensity and the prolonged PL lifetime of PM6 and PY-DT in PM6+m-Ir(CPmPB)_(3)and PY-DT+m-Ir(CPmPB)_(3)*** study indicates that the triplet material as solid additive has great potential in fabricating efficient LbL APSCs by prolonging exciton lifetimes in active layers.

关键词： Layer-by-layer All-polymer solar cells Additive strategy Triplet material Energy transfer

Ethical frontiers in liver transplantation

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World Journal of Transplantation 2024年第4期14卷 50-60页

作者： Hoi Pong Nicholas wong Surya Varma Selvakumar Pei Yi Loh Jovan Yi Jun Liau Matthias Yi Quan Liau Vishalkumar Girishchandra Shelat Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore Surgical Science Training Centre Tan Tock Seng HospitalSingapore 308433Singapore

Liver transplantation represents a pivotal intervention in the management of end-stage liver disease,offering a lifeline to countless *** significant strides in surgical techniques and organ procurement,ethical dilemmas and de-bates continue to underscore this life-saving *** the ethical terrain surrounding this complex procedure is hence *** the nuances of ethical principles of justice,autonomy and beneficence that underpin transplant protocols worldwide,we explore the modern challenges that plaques the world of liver *** investigate the ethical dimensions of organ transplantation,focusing on allocation,emerging technologies,and decision-making ***,Scopus,Web of Science,Embase and Central were searched from database inception to February 29,2024 using the following key-words:“liver transplant”,“transplantation”,“liver donation”,“liver recipient”,“organ donation”and“ethics”.Information from relevant articles surrounding ethical discussions in the realm of liver transplantation,especially with regards to organ recipients and allocation,organ donation,transplant tourism,new age technologies and developments,were *** the definition of death to the long term follow up of organ recipients,liver transplantation has many ethical *** new transplant techniques,societal acceptance and perceptions also play a pivotal ***,religious and regional factors including but not limited to beliefs,wealth and accessibility are extremely influential in public at-titudes towards donation,xenotransplantation,stem cell research,and adopting artificial *** and addressing these perspectives whilst upholding bioethical principles is essential to ensure just distribution and fair allocation of *** regulatory oversight for ethical sourcing of organs,ensuring good patient selection and transplant techniques,and high-quality long-term surveillance to mitiga

关键词： “liver transplant” “transplan-tation” “liver donation” “liver recipient” “organ donation”and“ethics”