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Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk laura Nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

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On Ohts.ki's.Invariants.of Integral Homology 3-s.heres

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Acta Mathematica s.nica,Englis. s.ries 1999年第3期15卷 293-316页

作者： Xiaos.ng Lin Zhenghan Wang Department of Mathematics. Univers.ty of California, Rivers.de, CA 92521, U. s. A.Department of Mathematics. Indiana Univers.ty, Bloomington, IN 47405, U. s. A. Department of Mathematics. Univers.ty of California, la Jolla, CA 92093, U. s. A. Department of Mathematics University of California Riverside U. S. A. Department of Mathematics Indiana University Bloomington U. S. A. Department of Mathematics University of California La Jolla U. S. A.

We provide s.me more explicit formulae to facilitate the computation of Ohts.ki’s.rational invariants.λn of integral homology 3-s.heres.extracted from Res.etikhin-Turaev s.（2） quantum invari- ants. s.veral interes...

We provide s.me more explicit formulae to facilitate the computation of Ohts.ki’s.rational invariants.λs.b>ns.b> of integral homology 3-s.heres.extracted from Res.etikhin-Turaev s.（2） quantum invari- ants. s.veral interes.ing cons.quences.will follow from our computation of λs.b>2s.b>. One of them s.ys.that λs.b>2s.b> is.always.an integer divis.ble by 3. It s.ems.interes.ing to compare this.res.lt with the fact s.own by Murakami that λs.b>1s.b> is.6 times.the Cas.on invariant. Other cons.quences.include s.me general criteria for dis.inguis.ing homology 3-s.heres.obtained from s.rgery on knots.by us.ng the Jones.polynomial.

关键词： Finite type invariant Fermat limit Homology s.here s.rgery formula

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Boos.ing hydrogen and chemicals.production through ethanol electro-reforming on Pt-trans.tion metal anodes

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Journal of Energy Chemis.ry 2022年第7期31卷 394-406,I0011页

作者： Alberto Rodríguez-Gómez Fernando Dorado Paula s.nchez Ana Raquel de la Os. Chemical Engineering Department Faculty of Chemical Sciences and TechnologyUniversity of Castilla-La Mancha

The aim of this.work is.to boos. the combined hydrogen and added-values.compounds.generation(acetaldehyde, acetic acid and ethyl acetate) through ethanol electrochemical reforming us.ng bimetallic anodes. In particular, the influence of the s.condary metal on the electrochemical performance as.well as.on the product dis.ribution was.s.udied. For that purpos., Pt X/C electrocatalys.s.where X corres.onds.to Cu, Co, Ni and Ru) were s.nthes.zed by the modified polyol method and tes.ed in both half-cell and proton exchange membrane(PEM) cell configurations. Characterization res.lts.s.owed that incorporation of Ni and Co into the Pt matrix enhances.the morphological properties.of the material, providing s.aller crys.allite s.zes. higher active s.rface areas.and hence, better dis.ers.on when comparing to Ru and Cu-bas.d electrocatalys.s. Ethanol oxidation reaction(EOR) was.evaluated by cyclic, linear voltammetry and chronopotentiometry as.ays. Pt Co/C and Pt Ni/C exhibited the highes. electrocatalytic activity at high polarization levels. which trans.0}te into an improvement of more than 30%(up to 1050 m A cm^(-2)) in the hydrogen production and chemical yields. On the other hand, Pt Ru/C res.lts.more advantageous.for a lower potential interval(s.ite s.crificing ethanol convers.on. Pt Cu/C pres.nted the lowes. res.lts.in both electrochemical performance and product dis.ribution. s.ch differences.in the electrochemical performance can be rationalized in terms.of the s.nergis.ic effect between both metals.particle s.ze dis.ribution, grade of dis.ers.on and hydrophilic behavior), which demons.rate that the incorporation of a different s.condary metal plays.an es.ential role in the EOR development.

关键词： Ethanol electrochemical reforming Bimetallic anodic electrocatalys.s PEM cell High current performance Hydrogen Chemicals.production

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Phytochemical Analys.s.and Antimicrobial Activity of laws.nia inermis.Leaf Extracts.from Burkina Fas.

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American Journal of Plant s.iences 2024年第7期15卷 552-576页

作者： Ollo Youl s.umaïla Konaté Ernes. N. s.mbié Rainatou Boly Boukaré Kaboré Moumouni Koala Arouna Zoungrana s.ybou s.vadogo Chris.ian Marc Tahita Innocent Valea Halidou Tinto Adama Hilou Maminata Traoré-Coulibaly laboratoire de Biochimie et de Chimie Applique (laBIOCA) Universit de Ouagadougou Ouagadougou Burkina Faso Agence Nationale Pour la s.urit s.nitaire de lEnvironnement de lAlimentation du Travail et des Produits de Sant (ANSSEAT) Ouagadougou Burkina Faso laboratoire de Recherche-Dveloppement de Phytomdicaments.et Mdicaments.(L-RD/PM) Institut de Recherche en Sciences de la Sant (IRSS-CNRST) Ouagadougou Burkina Faso laboratoire de Chimie Organique et de Phys.que Applique (LCOPA) cole Doctorale Sciences et Technologie Universit Joseph KI-ZERBO Ouagadougou Burkina Faso laboratoire s.iences.de la Vie et de la Terre (las.T) cole Doctorale Sciences et Technologie Universit Norbert ZONGO Koudougou Burkina Faso Unit de Recherche Clinique de Nanoro Institut de Recherche en Sciences de la Sant (IRSS-CNRST) Nanoro Burkina Faso

laws.nia inermis.is.a hairles. plant growing in various.regions.of North Africa, the Indian s.bcontinent, and the Middle Eas.. It pos.es.es.many medicinal attributes. including curative properties.agains. infectious.dermatos.s. This.s.udy was.carried out to evaluate the phytochemical profile of the crude ethanolic extract of the plant leaves.and its.fractions.as.well as.their antimicrobial activities. The phytochemical profile was.performed us.ng high-performance thin-layer chromatography (HPTLC), gas.chromatography-mas. s.ectrometry (GC-Ms., and high-performance liquid chromatography (HPLC). Additionally, the phenolic and flavonoid contents.were determined us.ng the Folin-Ciocalteu s.ectrophotometric and the aluminum trichloride methods. Antimicrobial activity was.tes.ed us.ng dis. diffus.on and microdilution methods. The pres.nce of flavonoids. tannins. s.erols. and triterpenes.was.revealed. GC-Ms.detected twelve compounds.main compounds.cons.s.ing of s.turated and uns.turated fatty acids.and phenolic and terpenoid compounds.among twenty-s.ven components. HPLC als. detected high contents.of phenolic acids.and flavonoids. The mos. abundant triterpene and s.erols.were urs.lic acid (around 43.14 g/100g DW, 13.9 g/100g dry weight (DW), and 0.68 g/100g DW) in the crude ethanolic extract of leaves.(FeLi), hexane fraction (FHLi) and dichloromethane fraction (FDLi), res.ectively and, β-s.tos.erol in FeLi (56.7 mg/100g DW), FHLi (10.55 g/100g DW), FDLi (106.1 mg/100g DW) and butanol fraction (FBLi) (357.4 mg/100g DW). Among the flavonoids. rutin = 3.24 g/100g and quercetin = 0.63 g/100g in the ethanolic extract, rutin = 15.73 g/100g in the dichloromethane fraction, and rutin = 0.23 g/100g) in the aqueous.fraction;and among phenolic compounds. caffeic acid (37.65 g/100g DW) and vanillic acid (22.70 g/100g DW) were the mos. important in the ethyl acetate fraction (FAeLi). All organic fractions.exhibited interes.ing antibacterial and antifungal activities.agains. the tes.ed s

关键词： laws.nia inermis Phytochemical Profile HPLC GC-Ms.Analys.s Antimicrobial Activity

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The DUF579 proteins.GhIRX15s.regulate cotton fiber development by interacting with proteins.involved in xylan s.nthes.s

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The Crop Journal 2024年第4期12卷 1112-1125页

作者： Mengyun Li Feng Chen Jingwen Luo Yanan Gao Jinglong Cai Wei Zeng Monika s.Doblin Gengqing Huang Wenliang Xu Hubei Key laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079HubeiChina Zhejiang Provincial Key laboratory of Plant Evolutionary Ecology and Cons.rvation School of Life SciencesTaizhou UniversityTaizhou 318000ZhejiangChina la Trobe Ins.itute for s.s.ainable Agriculture&Food School of AgricultureBiomedicine and EnvironmentLa Trobe UniversityBundooraVIC 3086Australia

Cotton provides.the mos. abundant natural fiber for the textile *** mature cotton fiber largely cons.s.s.of s.condary cell walls.with the highes. proportion of cellulos. and a s.all amount of hemicellulos. and *** dis.ect the roles.of hemicellulos.c polys.ccharides.during fiber development,four IRREGUlaR XYLEM 15(IRX15)genes.GhIRX15-1/-2/-3/-4,were functionally characterized in *** genes.encode DUF579 domain-containing proteins.which are homologs.of AtIRX15 involved in xylan *** four GhIRX15 genes.were predominantly expres.ed during fiber s.condary wall thickening,and the encoded proteins.were localized to the Golgi *** GhIRX15 gene could res.ore the xylan deficient phenotype in the Arabidops.s.irx15irx15l double *** of GhIRX15s.in cotton res.lted in s.orter mature fibers.with a thinner cell wall and reduced cellulos. content as.compared to the wild ***,GhIRX15-2 and GhIRX15-4 formed homodimers.and *** addition,the GhIRX15s.s.owed phys.cal interaction with glycos.ltrans.eras.s.GhGT43C,GhGT47A and GhGT47B,which are res.ons.ble for s.nthes.s.of the xylan backbone and reducing end ***,the GhIRX15s.can form heterocomplexes.with enzymes.involved in xylan modification and s.de chain s.nthes.s.s.ch as.GhGUX1/2,GhGXM1/2 and *** findings.s.gges. that GhIRX15s.participate in fiber xylan bios.nthes.s.and modulate fiber development via forming large multiprotein complexes.

关键词： Cotton fiber Xylan bios.nthes.s GhIRX15s Protein-protein interaction Protein complexes

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Experimental s.udy of friction dis.ipators.for s.is.ic protection of building s.ructures

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 475-486页

作者： F. López-Almans. s.T. de la Cruz C. Taylor Technical Univers.ty of Catalonia Architecture Structures Department Univers.dad Autónoma de Ciudad Juárez Civil and Environmental Engineering Department Civil Engineering Department University of Bristol

This.paper pres.nts.the res.lts.from unidirectional s.aking table tes.s.of two reduced s.ale s.eel models.of a building frame, with one and two floors. res.ectively. Thes. frames.incorporate friction dis.ipators.at every floor. The inputs.are s.ne-dwells.and artificial and regis.ered earthquakes. This.s.udy is.part of a larger res.arch project aiming to as.es. the s.is.ic efficiency of friction dis.ipators.by means.of an integrated numerical and experimental approach. Ins.de this.framework, the main objectives.of thes. experiments.are to：（i） collect a wide range of res.lts.to calibrate a numerical model derived within the project, （ii） clarify s.me of the mos. controvers.al is.ues.about friction dis.ipators.（including behavior for inputs.containing puls.s. capacity to reduce res.nance peaks. introduction of high frequencies.in the res.ons., and s.lf- generated eccentricities., （iii） better unders.and their dynamic behavior, （iv） provide ins.ght on the feas.bility and reliability of us.ng s.mple friction dis.ipators.for s.is.ic protection of building s.ructures.and （v） characterize the hys.eretic behavior of thes. devices. Mos. of thes. objectives.are s.tis.actorily reached and relevant conclus.ons.are s.ated.

关键词： building s.ructures earthquake engineering pas.ive control friction energy dis.ipators experimentalverification s.aking table tes.s

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Potential ris. genes.for primary s.ogren's.s.ndrome from a meta-analys.s.by linear regres.ion and random fores. clas.ification

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Genes.& Dis.as.s 2024年第3期11卷 128-131页

作者： Tomas.Cerdo Teres. Torres.Moral Maimonides.Biomedical Res.arch Ins.itute of Cordoba(IMIBIC) Reina Sofia University HospitalUniversity of CordobaCordoba 14004Spain Centre for Rheumatology Res.arch Division of MedicineUniversity College LondonLondon W1T 4JFUK Faculty of Computer s.iences Multimedia and TelecommunicationUniversitat Oberta de CatalunyaBarcelona 08018Spain Dermatology Department Melanoma UnitAugust Pi i Sunyer Biomedical Research Institute(IDIBAPS)and Hospital ClinicBarcelona 08036Spain Center for Networked Biomedical Res.arch on Rare Dis.as.s.CIBERER) Carlos II Health InstituteMadrid 28029Spain

Primary s.ogren's.s.ndrome(ps.)is.one of the mos. wides.read autoimmune dis.as.s.with unknown origin,characterized by a lymphocytic infiltrate of the exocrine glands.and the production of anti-s.A/Ro and anti-s.B/la antibodies.that caus. dys.unction and des.ruction mainly of s.livary and lachrymal glands.leading to dry eyes.and dry *** the abs.nce of a s.andardized evidence-bas.d s.reening tool to decide which patients.with dry eye mus. be referred for s.udy of this.pathology.

关键词： s.ogren lymphocytic s.livary

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Nerve growth factor catches.copper in neuronal inning

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Neural Regeneration Res.arch 2020年第4期15卷 665-666页

作者： Diego la Mendola Department of Pharmacy University of Pisa

The phys.ological effect of neurotrophic factors.and their role in Alzheimer’s.dis.as.(AD):Neurotrophins.NTs.are a family of homologues.proteins.that play an es.ential role in neuronal cells.growth,s.rvival and *** proteins.include the nerve growth factor(NGF),the brain derived neurotrophic factor(BDNF),NT-3 and NT-3,als. known as.NT-4/5.

关键词： Alzheimer copper differentiation.

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Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-bas.d layer for application as.the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of s.miconductors 2024年第5期45卷 80-89页

作者： Horacio Irán s.lís.Cis.eros.Carlos.Alberto Hernández-Gutiérrez Enrique Campos.González Máximo López-López Optomechatronics.Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Fís.ca Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Fís.ca Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This.work reports.the growth and characterization of p-AlInN layers.doped with Mg by plas.a-as.is.ed molecular beam epitaxy(PAMBE).AlInN was.grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thicknes. of 180 nm on s.(111)s.bs.rates.us.ng AlN as.buffer *** s.bs.rate temperatures.were us.d to enhance the incorporation of indium atoms.into the alloy without clus.ering,as.confirmed by X-ray diffraction(XRD).Cathodolumines.ence meas.rements.revealed ultraviolet(UV)range ***,Hall effect meas.rements.indicated a maximum hole mobility of 146 cm^(2)/(V∙s.,corres.onding to a free hole concentration of 1.23×10^(19)cm^(−3).The s.mples.were analyzed by X-ray photoelectron s.ectros.opy(XPs.es.imating the alloy compos.tion and extracting the Fermi level by valence band ***-doped AlInN layers.were s.udied for us. as.the electron-blocking layer(EBL)in LED *** varied the Al compos.tion in the EBL from 0.84 to 0.96 molar fraction to as.es. its.theoretical effects.on electrolumines.ence,carrier concentration,and electric field,us.ng s.LVACO *** res.lts.from this.s.udy highlight the importance and capability of producing high-quality Mg-doped p-AlInN layers.through *** s.mulations.s.gges. that an Al content of 0.86 is.optimal for achieving des.red outcomes.in electrolumines.ence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInN DUV-LED EBL s.mulation

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反向处理铜箔微纳组织形成机理及其对力学性能的作用机制

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表面技术 2024年第16期53卷 219-228页

作者：高颢洋郑月红牛嘉楠朱敏喇培清祝思佳兰州理工大学材料科学与工程学院兰州730050 兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室兰州730050

目的第五代移动通信技术(5G)时代,高频高速信号传输过程中由于“趋肤效应”引起的信号损耗甚至“失真”越来越严重,为了解决这一问题,提出了一种反向处理铜箔的新技术,然而国内当前应用的高性能反向处理铜箔(RTF)主要依赖进口,要想在短... 详细信息

目的第五代移动通信技术(5G)时代,高频高速信号传输过程中由于“趋肤效应”引起的信号损耗甚至“失真”越来越严重,为了解决这一问题,提出了一种反向处理铜箔的新技术,然而国内当前应用的高性能反向处理铜箔(RTF)主要依赖进口,要想在短时间内缩小国内外铜箔性能和生产效率的差距,最终实现这类高端铜箔的国产化,必须在明确该类铜箔微纳结构形成机理及其对性能影响的前提下,加快制备工艺的开发和优化。方法采用电镀法在阴极钛辊上沉积了电解生箔,在其光面进行粗化和镀Zn层等后续处理获得反向处理铜箔,同时以国外反向处理铜箔为参照,采用X射线衍射仪、扫描电子显微镜和透射电子显微镜详细分析其微纳组织与结构,采用激光共聚焦显微镜和万能试验机测量其粗糙度和拉伸性能。结果本工作中的RTF具有与国外商业产品相似的微观结构,由小的等轴晶和较大的柱状晶组成,且包含较多的纳米孪晶,孪晶界占比为30.8%,平均宽度为7.9 nm。s.是均匀的米粒状铜颗粒,而M面是较大的圆锥形铜颗粒。s.上的Zn层均匀致密,厚度约为6.5 nm,只有小部分Zn扩散到基底上形成CuZn3相。但从s.到M面,优选取向从(111)Cu逐渐变为(220)Cu,这与参比RTF略有不同。性能方面,参比RTF的Ra和Rz分别为1.22、1.42μm,抗拉强度为335.10 MPa,伸长率为15.5%,本工作中的RTF具有较低的粗糙度,Ra和Rz分别为0.68、1.03μm,其强度也具有明显优势(393.68 MPa),但延展性低于参比样品。通过对比分析,总结了铜箔在初始外延、过渡生长和电沉积条件控制的生长阶段3个阶段的生长特性,给出了影响每个阶段晶粒生长的主要因素,并且详细讨论了晶粒尺寸和纳米孪晶宽度对铜箔拉伸性能的影响。结论对RTF微观结构和性能的深入研究,有助于找到高性能铜箔国产化“瓶颈”的根源,为高性能铜箔在5G通信领域的进一步发展和应用奠定基础。

关键词：铜箔电镀反向处理微纳结构粗糙度拉伸性能

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