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Monochromatic green light stimulation during incubation shortened the hatching time via pineal function in White Leghorn eggs

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1226-1235页

作者： Panlin Wang Yanyan Sun Yunlei Li Jing Fan Yunhe Zong adamu mani isa Lei Shi Yuanmei Wang Aixin Ni Pingzhuang Ge Linlin Jiang Shixiong Bian Hui Ma Zhengdong Yuan Xiaolin Liu Jilan Chen Institute of Animal Sciences Chinese Academy of Agricultural SciencesKey Laboratory of Animal(Poultry)Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsBeijing 100193China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Beijing DQY Agricultural Science and Technology Co. Ltd.Beijing 100094China

Background:Effect of monochromatic green light illumination on embryo development has been reported in *** avian pineal gland is an important photo-endocrine organ formed by a mediodorsal protrusion during embryonic ***,the involvement of pineal gland in the light transduction process remains to be *** the present study,we investigated the influence of monochromatic green light on hatching time and explored the possible mechanism via pineal ***:A total of 600 eggs of White Leghorn(Shaver strain)were incubated under photoperiods of either 12 h of light and 12 h of darkness using monochromatic green light(12L:12D group)or 24 h of darkness(0L:24D group)for 18 *** to 0L:24D group,the green light stimulation shortened the hatching time without extending the hatch window or impairing *** liver of embryos incubated in the 12L:12D light condition was heavier than those of the 0L:24D group on d 21 post incubation which may be linked to the observed increase in the serum concentration of insulin-like growth factor 1(IGF-1);primary secretion of the *** structure analysis of pineal gland demonstrated that the light stimulation increased follicle area,wall thickness and lumen area on d 10 and d 12 post *** function analysis demonstrated that three clock related genes(brain and muscle ARNT-like-1,BMAL1;circadian locomotor output cycles kaput,CLOCK;and cryptochrome-1,CRY1)and a melatonin rate-limiting enzyme related gene(arylalkylamine N-acetyltransferase,AANAT)were rhythmically expressed in the pineal gland of the 12L:12D group,but not in the 0L:24D ***,the light stimulation also increased the concentration of melatonin(MT),which was linked to hepatocyte proliferation and IGF-1 secretion in previous ***:The 12L:12D monochromatic green light stimulation during incubation shortened hatching time without impairing hatching *** gland’s ear

关键词： Circadian rhythm Hatching time Insulin-like growth factor 1 Melatonin Monochromatic green light Pineal gland

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Controlling Tendons to Modulate Stiffness of a Planar-to-Spatial Tendon-Driven Continuum manipulator Under External Uncertain Forces

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Journal of Bionic Engineering 2024年第2期21卷 821-841页

作者： Vipin Pachouri Pushparaj mani Pathak Indian Institute of Technology Roorkee Roorkee247667India

Continuum manipulators(CM)are soft and flexible manipulators with large numbers of degrees of freedom and can perform complex tasks in an unstructured ***,their deformability and compliance can deviate distal tip under uncertain external *** address this challenge,a novel tension-based control scheme has been proposed to modulate the stiffness of a tendon-driven CM,reducing the tip position errors caused by uncertain external *** minimize the tip position error,a virtual spring is positioned between the deviated and the desired tip *** proposed algorithm corrects the manipulator deviated tip position,improving tension distribution and stiffness profile,resulting in higher stiffness and better *** corresponding task space stiffness and condition numbers are also computed under different cases,indicating the effectiveness of the tension control scheme in modulating the manipulator's *** validation conducted on an in-house developed prototype confirms the practical feasibility of the proposed approach.

关键词： Continuum arm Hyper-redundant robots Variable stiffness manipulator Tension-based control Mechatronic systems

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鸽毛滴虫外泌体的分离鉴定及蛋白质谱分析

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畜牧兽医学报 2020年第7期51卷 1737-1747页

作者：倪爱心李云雷葛平壮王攀林 adamu mani isa 石雷范静孙研研孙鸿麻慧陈继兰中国农业科学院北京畜牧兽医研究所农业部动物遗传育种与繁殖(家禽)重点实验室北京100193 北京优帝鸽业有限公司北京101300

旨在研究鸽毛滴虫是否分泌外泌体及虫源外泌体的蛋白组成和功能,为探索外泌体在鸽毛滴虫寄生过程中的作用奠定基础。采集鸽毛滴虫感染个体口腔及咽部病灶处样本,进行分离培养及纯化,使用显微镜鉴定虫体形态,提取DNA并比对其序列,确定培... 详细信息

旨在研究鸽毛滴虫是否分泌外泌体及虫源外泌体的蛋白组成和功能,为探索外泌体在鸽毛滴虫寄生过程中的作用奠定基础。采集鸽毛滴虫感染个体口腔及咽部病灶处样本,进行分离培养及纯化,使用显微镜鉴定虫体形态,提取DNA并比对其序列,确定培养物是否为鸽毛滴虫虫株;通过对培养液上清进行超速离心,透射电子显微镜、Western blot技术和纳米颗粒追踪分析(nanoparticle tracking analysis,NTA)鉴定培养液上清中是否含有虫源外泌体;最后通过Label-free技术分析虫源外泌体的蛋白质谱表达。结果显示,虫体具有明显的毛滴虫形态及特征,与鸽毛滴虫ITS1/5.8S/ITS2基因比对率达98%。从虫体培养液中提取的囊泡经透射电子显微镜观察具有明显的茶托样结构;NTA结果显示,粒径集中于125.1 nm,峰值粒径为132.3 nm,占比99.3%;CD63和TSG101等外泌体标记蛋白的条带明显,表明提取物为外泌体。质谱结果显示,烯醇酶、3-磷酸甘油醛-脱氢酶、磷酸甘油酸变位酶和延伸因子为表达量较高的蛋白质。GO功能注释显示外泌体蛋白富集到细胞内和胞浆等细胞组分,发挥GTP连接和GTP酶活性功能,参与小GTPase介导的信号转导与糖酵解等过程。KEGG通路富集表明,虫源外泌体蛋白主要富集于代谢途径、糖酵解/糖异生、抗生素的生物合成和次级代谢产物的生物合成等通路。本研究发现鸽毛滴虫可以分泌外泌体,并对虫源外泌体进行蛋白质谱分析,提示虫源外泌体中的蛋白质在寄生虫的能量代谢、信号转导及生物合成等过程中发挥重要作用。

关键词：鸽毛滴虫外泌体 Label-free技术蛋白质谱分析

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Optimization Algorithms of PERT/CPM Network Diagrams in Linear Diophantine Fuzzy Environment

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1095-1118页

作者： mani Parimala Karthikeyan Prakash Ashraf Al-Quran Muhammad Riaz Saeid Jafari Department of Mathematics Bannari Amman Institute of TechnologySathyamangalamTamil Nadu638401India Basic Sciences Department Preparatory Year DeanshipKing Faisal UniversityAl-Ahsa31982Saudi Arabia Department of Mathematics University of the PunjabLahorePakistan College of Vestsjaelland South Herrestraede 11Slagelse4200Denmark

The idea of linear Diophantine fuzzy set(LDFS)theory with its control parameters is a strong model for machine learning and optimization under *** activity times in the critical path method(CPM)representation procedures approach are initially static,but in the Project Evaluation and Review Technique(PERT)approach,they are *** study proposes a novel way of project review and assessment methodology for a project network in a linear Diophantine fuzzy(LDF)*** LDF expected task time,LDF variance,LDF critical path,and LDF total expected time for determining the project network are all computed using LDF numbers as the time of each activity in the project *** primary premise of the LDF-PERT approach is to address ambiguities in project network activity timesmore simply than other approaches such as conventional PERT,Fuzzy PERT,and so *** LDF-PERT is an efficient approach to analyzing symmetries in fuzzy control systems to seek an optimal *** also present a new approach for locating LDF-CPM in a project network with uncertain and erroneous activity *** the available resources and activity times are imprecise and unpredictable,this strategy can help decision-makers make better judgments in a project.A comparison analysis of the proposed technique with the existing techniques has also been *** suggested techniques are demonstrated with two suitable numerical examples.

关键词： Linear Diophantine fuzzy graphs project management PERT CPM linear Diophantine fuzzy numbers score function accuracy function

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Bio-analysis of Saliva Using Paper Devices and Colorimetric Assays

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Journal of Analysis and Testing 2024年第1期8卷 114-132页

作者： Adhan Narasimhan Harshil Jain Kowshika Muniandy Raja Chinnappan Naresh Kumar mani Microfluidics Sensors and Diagnostics(μSenD)LaboratoryCentre for MicrofluidicsBiomarkersPhotoceutics&Sensors(μBioPS)Department of BiotechnologyManipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India College of Medicine Alfaisal UniversityRiyadh 11533SaudiArabia Tissue/Organ Bioengineering&BioMEMS Lab Organ Transplant Centre of ExcellenceTransplant Research&Innovation DepartmentKing Faisal Specialist Hospital and Research CentreRiyadhSaudi Arabia

In light of the evolving nature of various diseases,time becomes a crucial factor in diagnosis and identifying the underlying causes.A point-of-care device provides a rapid diagnosis of a disease without using complex and advanced instruments,which are costly and difficult to transport.A paper-based device is a relatively frugal solution wherein the paper is used as a substratum in which the reactions are carried *** methods are non-invasive,and the sample collection is relatively *** is one such body fluid in which various biomarkers are present for numerous *** of saliva has attracted more attention recently due to its non-invasiveness and *** the discovery of clinical biomarkers from salivary analysis has the potential to revolutionize the healthcare sector by providing crucial information to monitor the health status of individuals and disease progression which enables personalized *** review provides the limitation of the traditional methods in clinical applications and highlights the significance of saliva as a non-invasive biological fluid that is a source of multiple biomarkers associated with various *** also provides insights into the different paper-based colorimetric microfluidic devices developed against salivary biomarkers in the past *** major challenges in the point-of-care application and the future prospects have been discussed as ***,we also emphasize the importance of this approach in dental disease diagnosis which is least explored and holds potential applications.

关键词： Paper-based assay Salivary analysis Non-invasive Point-of-care Body fluids Biomarkers Qualitative detection

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鸡卵巢组织miRNA表达谱分析揭示连产性状杂种优势形成机制

鸡卵巢组织miRNA表达谱分析揭示连产性状杂种优势形成机制

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第九届全国畜牧兽医青年科技工作者学术研讨会

作者：孙研研 adamu mani isa 李云雷麻慧袁经纬王园美石雷王攀林陈继兰农业农村部动物(家禽)遗传育种与繁殖重点实验室中国农业科学院北京畜牧兽医研究所

引言杂种优势是一种复杂的生物现象,杂交产生的后代与亲本相比表现出优异的表型特征。家禽育种中广泛利用了杂种优势,但是主要通过配合力测定等常规性能测定手段进行评估,其潜在的分子机制仍不明确。由于在杂交过程中没有产生新的基因,... 详细信息

引言杂种优势是一种复杂的生物现象,杂交产生的后代与亲本相比表现出优异的表型特征。家禽育种中广泛利用了杂种优势,但是主要通过配合力测定等常规性能测定手段进行评估,其潜在的分子机制仍不明确。由于在杂交过程中没有产生新的基因,杂种优势可能是由基因表达的定性或定量修饰产生的差异引起的。miRNA在转录后水平的基因表达调控中起关键作用,特别是在表观遗传基因调控中。

关键词：杂种优势率 miRNA 卵巢组织

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贮精能力差异母鸡的贮精腺形态、激素水平及激素受体基因表达量的研究

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畜牧兽医学报 2020年第8期51卷 1845-1852页

作者：马腾壑范静王攀林石雷李云雷 adamu mani isa 倪爱心葛平壮江琳琳宗云鹤麻慧孙研研陈继兰河北工程大学生命科学与食品工程学院邯郸056038 中国农业科学院北京畜牧兽医研究所农业部动物遗传育种与繁殖(家禽)重点实验室北京100193

旨在探究不同贮精能力母鸡的贮精腺形态、主要性激素水平以及激素受体基因表达量的差异,以期进一步揭示母鸡贮精能力差异产生的原因。本研究以27周龄158只的白来航母鸡和28只公鸡为试验材料,混精连续输精2 d,第3天开始按照个体收集种蛋... 详细信息

旨在探究不同贮精能力母鸡的贮精腺形态、主要性激素水平以及激素受体基因表达量的差异,以期进一步揭示母鸡贮精能力差异产生的原因。本研究以27周龄158只的白来航母鸡和28只公鸡为试验材料,混精连续输精2 d,第3天开始按照个体收集种蛋孵化,根据输精后21 d内每天的种蛋受精情况统计个体受精率作为母鸡贮精能力;挑选高、低贮精能力极端个体各4只,分别为高、低贮精能力组;采血测定血清孕酮、雌激素、睾酮和催乳素激素浓度;解剖获取富含贮精腺的子宫阴道连接部组织,并沿纵向分为两份,一份制作石蜡切片并HE染色,用于贮精腺形态观察,另一份采用荧光定量PCR检测相应激素受体基因的表达量。结果表明,高、低贮精能力组子宫阴道连接部的黏膜面积、贮精腺数量、贮精腺密度均差异不显著(P>0.05),但高贮精能力组母鸡的贮精腺平均横截面积显著高于低贮精能力组(P0.05);与低贮精能力组相比,高贮精能力组睾酮受体基因和催乳素受体基因表达上调,雌激素α、β受体基因和孕酮受体基因下调,但未达显著水平(P>0.05)。结果提示,母鸡的贮精能力可能与贮精腺横截面积有关,此外,孕酮激素可能对诱导贮精腺中精子的激活起重要作用,从而影响母鸡持续受精能力。

关键词：母鸡贮精能力贮精腺激素激素受体

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母鸡持续受精能力的群体变异分析

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畜牧兽医学报 2019年第10期50卷 2013-2021页

作者：范静马腾壑王攀林石雷李云雷 adamu maniisa 黄子妍倪爱心麻慧孙研研陈继兰中国农业科学院北京畜牧兽医研究所农业部动物遗传育种与繁殖(家禽)重点实验室北京100193 河北工程大学生命科学与食品工程学院邯郸056038

旨在探究母鸡持续受精能力在品种间的差异和群体内的变异程度及相关性状之间的相关性,为制定合理的输精间隔和开展母鸡持续受精能力的选育提供理论依据。本研究以27周龄的白来航、哥伦比亚洛克、芦花和洛岛红4个品种健康的母鸡各158只... 详细信息

旨在探究母鸡持续受精能力在品种间的差异和群体内的变异程度及相关性状之间的相关性,为制定合理的输精间隔和开展母鸡持续受精能力的选育提供理论依据。本研究以27周龄的白来航、哥伦比亚洛克、芦花和洛岛红4个品种健康的母鸡各158只为试验材料,连续输精2d,第3天开始按照母鸡个体收集种蛋孵化,统计输精后4周内的种蛋受精情况,比较各品种输精后产蛋数、日/周受精率、4周平均受精率、最长受精天数和最大连产受精蛋数等性状,并计算部分性状间的相关系数。结果显示,4个品种输精后日受精率随着天数的增加而降低,但程度不同,白来航、哥伦比亚洛克、芦花和洛岛红日受精率大于90%的输精后最大天数分别为10、9、8和11d。4个品种输精后前9d种蛋的日受精率除了第4天(P=0.01)外均无显著差异(P>0.05),第10~18天种蛋的日受精率除了第13(P=0.08)和16天(P=0.19)外均差异显著(P0.05);输精后品种间第1(P>0.05)和4周(P>0.05)的周受精率均无显著差异,第2(P=0.005)和3周(P=0.04)均差异显著;不同品种母鸡的产蛋数、4周受精蛋数、4周平均受精率、最长受精天数、最大连产受精蛋数、第1周受精蛋数、第2周受精蛋数、第3周受精蛋数和第2~3周受精蛋数均存在显著差异(P<0.05),其中洛岛红的各个指标均最高;品种内个体间上述性状也存在变异,其中洛岛红变异较小,哥伦比亚洛克和芦花变异较大;母鸡受精能力相关性状间均为正相关,其中第2周受精蛋数(r=0.86,P<0.0001)、第2~3周受精蛋数(r=0.92,P<0.0001)与4周受精蛋数相关系数较大。本研究结果表明,不同品种母鸡持续受精能力存在差异,可制定品种特异性输精间隔;品种内母鸡持续受精能力存在较大变异,具有进一步选育的基础;第2周受精蛋数可以在保证准确性的前提下减少性状测定的工作量,相较而言是评估和选育母鸡持续受精能力的理想性状。

关键词：母鸡持续受精能力受精率贮精腺

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Rare etiology of colonic intussusception involving an adult with emphysematous cystic enteropathy:A case report and review of literature

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World Journal of Clinical Cases 2024年第17期12卷 3161-3167页

作者： Eric Bergeron Maude Pichette Geneviève Boisvert Thibaut manière Étienne Désilets Department of Surgery Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada Department of Medical Imaging Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada Department of Gastroenterology Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada

BACKGROUND Pneumatosis cystoides intestinalis(PCI),characterized by a collection of gas-filled cysts in the intestinal wall,is an uncommon but well-known condition in *** pain is the most frequent symptom associated with *** represents a potential cause of recurrent abdominal pain or emergency ***,the occurrence of colonic intussusception secondary to PCI is very unusual in *** SUMMARY A 52-year-old male,known with idiopathic PCI,presented seventeen months after initial diagnosis with a new right upper quadrant pain.A computed tomographyscan demonstrated a colonic intussusception at the hepatic *** did not progress compared with initial *** patient underwent an emergency right *** Resection was recommended in this case because PCI proved to be persisting with no identified curable *** allowed to address the underlying pathology,the potential relapse of intussusception,and the likely cause of recurrent abdominal pain,either invagination or PCI itself.

关键词： Pneumatosis cystoides intestinalis Colonic intussusception Colonic obstruction Colonoscopy Case report

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Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension

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Cardiology Discovery 2024年第1期4卷 30-37页

作者： Niki S.Kakouril Costas G.Thomopoulos Eirini P.Siafi Angeliki E.Valatsoul Kyriakos S.Dimitriadis Iliana P.mani Sotirios P.Patsilinakos Dimitrios M.Tousoulis Konstantinos P.Tsioufis First Department of Cardiology Medical SchoolNational and Kapodistrian University of AthensHippokration HospitalAthens 11527Greece Department of Cardiology Elena Venizelou HospitalAthens 11521Greece Department of Cardiology General Hospital Agia OlgaAthens 14233Greece

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its prevalence is rising. NAFLD is closely associated with metabolic syndrome, with both conditions sharing common clinical characteristics such as obesity, insulin resistance, type 2 diabetes mellitus, hypertension, and hypertriglyceridemia. Several observational studies have evaluated the relationship between NAFLD and hypertension, with the overall evidence suggesting a bidirectional relationship. It is hypothesized that activation of the sympathetic nervous and renin-angiotensin systems, observed in NAFLD with or without insulin resistance promotes the development of hypertension. In patients with hypertension, activation of these systems can lead to hepatic fibrosis and progressive inflammation through increased oxidative stress and activation of hepatic stellate cells and Kupffer cells. The present review examines the pathophysiologic and clinical evidence supporting the bidirectional association between NAFLD and hypertension.

关键词： Hypertension Non-alcoholic fatty liver disease Insulin resistance Sympathetic nervous system Metabolic syndrome

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