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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel adam.Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Heterogeneity of mature oligodendrocytes in the central nervous system

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作者： Claire adam.

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng adam.M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

A preliminary evaluation of throughfall sampling techniques in a mature coniferous forest

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Journal of Forestry Research 2014年第2期25卷 407-413页

作者： Darryl. E. Carlyle-Moses Chad. E. Lishman adam. J. McKee Department of Geography & Environmental Studies Thompson Rivers University Graduate Program in Environmental Science Thompson Rivers University

Rainfall, throughfall and stemflow were measured and canopy interception loss was derived for 14 rainfall events from June 22 to August 30, 2008 within a mature declining hybrid white spruce （Picea glauca （Moench） Voss x p engelmannii Parry ex Engelm.） - subalpine fir （Abies lasiocarpa （Hook.） Nutt.） - lodgepole pine （Pinus contorta vat. latifolia Dougl. ex Loud.） stand in south-central British Columbia, Can- ada. Stemflow was negligible during the study period, while, respectively throughfall and canopy interception loss accounted for approximately 59.4% and 40.6% of the 50.1 mm of cumulative rainfall. Throughfall variability was assessed with three approaches involving roving and stationary wedge-type gauges, and stationary trough gauges. Throughfall exhibited large spatial variability with the coefficient of variability of study period throughfall sampled using 16 stationary trough gauges being 30.3%, while it was 38.0% and 28.7% for 32 stationary and 32 roving wedge gauges, respectively. Our analysis suggests that a roving gauge method is better than a stationary approach since the errors associated with event mean throughfalls are summed quadratically and a greater portion of the canopy area is sampled. Trough gauges were more efficient than wedge gauges; however, this efficiency was less than expected given their much larger sampling areas, suggesting that spatial autocorrelation lengths of throughfall may be longer than the trough systems. The spatial distribution of throughfall showed a high degree of temporal persistence throughout the study suggesting the existence of stable ＂wet＂ and ＂dry＂ inputs to the floors of these coniferous forests.

关键词： throughfall canopy interception loss stemflow spatial variability temporal persistence

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Cracking the LSAT

连续油管快速柱创造下井20500ft的新记录

1999年

作者： Robinson adam.

来源：畅想之星图书光盘版（南... 评论

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油气田开发工程译丛 1993年第3期 30-32页

作者： adam.,LS 杜志彬

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一种新型免疫抑制剂对多种免疫细胞的影响

肝脏病杂志 1994年第1期2卷 16-18页

作者：刘杞 adam.,D 重庆医科大学病毒性肝炎研究所

我们研究了新型免疫抑制剂ＦＫ５０６在体外对人中性粒细胞，单核吞噬细胞和淋巴细胞亚群趋化反应的影响。在浓度为０．５ｎｇ／ｍｌ时，它对旦氨酸－亮氨酸－脯氨酸多肽（ＦＭＬＰ）引起的中性粒细胞、单核吞噬细胞趋化反应的抑制率分... 详细信息

我们研究了新型免疫抑制剂ＦＫ５０６在体外对人中性粒细胞，单核吞噬细胞和淋巴细胞亚群趋化反应的影响。在浓度为０．５ｎｇ／ｍｌ时，它对旦氨酸－亮氨酸－脯氨酸多肽（ＦＭＬＰ）引起的中性粒细胞、单核吞噬细胞趋化反应的抑制率分别达４２．９％和４４．２％。在浓度为５ｎｇ／ｍｌ时，对酵母多糖激活血清（ＺＳ）和趋化性胆汁（ＣＢ）引起的中性粒细胞的抑制率分别为４６％和２３．２％；引起单核吞噬细胞的抑制率分别为４９．８％和４７．８％。在ＦＭＩＰ－ＭＥ引起的淋巴细胞趋化反应中，它（０．５ｎｇ／ｍｌ）对和Ｔ细胞的抑制分别为５６．６％和２２．９％，对Ｂ细胞（ＣＤ＿（２２））和ＮＫ细胞（ＣＤ＿（５７））无明显影响。

关键词：免疫抑制剂 T淋巴细胞亚群趋化新药免疫细胞

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典型草原两种菊科植物生长对道路建设的响应

生态学报 2025年

作者：王星奇赵欣周 GULRAIZ Ahmad 张育文李佳欣 BHARELDIN adam.MERGA Daba Tuli 侯扶江草种创新与草地农业生态系统全国重点实验室兰州大学草地农业科技学院国家林业草原局西北退化草原生态修复与利用工程技术研究中心农业农村部草牧业创新重点实验室

近几十年来，由于道路网络的扩张和城市化的蓬勃发展，道路建设对典型草原的影响引起了广泛的关注。然而，道路类型和距离对植物种群生长的综合影响仍然知之甚少。因此，本研究以陇东黄土高原微温微干典型草原为研究对象，探讨了道路建... 详细信息

近几十年来，由于道路网络的扩张和城市化的蓬勃发展，道路建设对典型草原的影响引起了广泛的关注。然而，道路类型和距离对植物种群生长的综合影响仍然知之甚少。因此，本研究以陇东黄土高原微温微干典型草原为研究对象，探讨了道路建设（道路类型、距离）对菊科优势种茵陈蒿（Artemisia capillaris）和伴生种阿尔泰狗娃花（Aster altaicus）生长繁殖影响的驱动因素及其作用机制。结果表明，道路建设促进茵陈蒿的横向生长和无性繁殖，促进阿尔泰狗娃花的垂直生长和有性繁殖。阿尔泰狗娃花具有更强的更新潜力。普通公路茵陈蒿和阿尔泰狗娃花的地上生物量分别比其它两种道路平均高49%和27%，因此其对普通公路建设的响应更加敏感。此外，道路建设主要通过影响土壤进一步影响两个种群的地上生物量在群落中的占比。阿尔泰狗娃花的地上生物量及其在群落中的占比在距离20—35 m的范围存在明显阈值。因此需要注意将此范围内的植被保护和恢复措施与道路管理动态结合，影响植物生长繁殖，调控群落构建过程，以应对道路建设对种群和群落关系扰动的巨大挑战。

关键词：道路建设道路生态地上生物量生长权衡繁殖策略种间关系

Solid rocket propulsion technology for de-orbiting spacecraft

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Chinese Journal of Aeronautics 2022年第3期35卷 128-154页

作者： adam.OKNINSKI Center of Space Technologies Lukasiewicz Research Network-Institute of AviationWarsaw 02-256Poland

This paper presents the topic of using solid rocket propulsion for de-orbiting spacecraft,in order to fulfil space debris mitigation *** benefits and disadvantages of using such means are discussed.A dedicated system can be implemented in the satellite design phase and shall be a key subsystem of platforms inserted into ***,semi-controlled and controlled de-orbit can be completed using solid rocket *** impact on the space debris environment is *** requirements for dedicated propellants and systems are *** the majority of presently developed rocket systems worldwide require high burn rates,several applications,including de-orbiting,benefit from solid propellants with decreased regression *** allows limiting spacecraft accelerations and loads during de-orbit ***,the requirement of minimising solid particle generation is *** technology from the Mercury and Gemini human spaceflight programmes,where de-orbit motors were used,is *** Soviet,American and Chinese film-return-capsule solid propellant retrorockets,enabling deorbit,are also presented.A detailed survey of current work worldwide on end-of-life disposal using solid propulsion is *** of developing dedicated systems are ***,an outlook on solid rocket motor utilisation for space debris mitigation is provided.

关键词： De-orbit De-orbiting technology End-of-life disposal Satellite propulsion system development Solid propellant Solid rocket motor Space debris mitigation Space traffic management