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工业水处理 2006年第7期26卷 88-88页

作者： irvin J．Cotton 纪永亮

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成为我自己

作者： (美)欧文·D. 亚隆(irvin D. Yalom)

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尼日利亚拉各斯州的“联合健康行动”

中国健康教育 2004年第1期20卷 86-87页

作者： Andrea irvin 劳云飞刘笑元王启林

“联合健康行动”（Action Health Incorporated，简称AHI）是尼日利亚最大和最有成效的由非政府组织开展的生育健康、性健康及生育权利的项目。该项目于1989年由项目主席Nike Esiet和她的丈夫、医学博士Uwem创立。以尼日利亚拉各斯为... 详细信息

“联合健康行动”（Action Health Incorporated，简称AHI）是尼日利亚最大和最有成效的由非政府组织开展的生育健康、性健康及生育权利的项目。该项目于1989年由项目主席Nike Esiet和她的丈夫、医学博士Uwem创立。以尼日利亚拉各斯为基地，AHI在“青年中心”（Youth Center）和诊所为青少年提供生育健康与性健康的教育和卫生服务；并通过33所学校的青少年同伴教育者和“健康与生命计划”俱乐部，对中学生提供性教育；并率先制定了全国青少年生育健康与性知识的教学与交流指南。1990年，AHI从“国际妇女健康联盟”（Inteinational Women's Health Coalition，IWHC）得到第一笔资助。

关键词：尼日利亚拉各斯州联合健康行动生育健康青少年性问题

Robotic pendant drop:containerless liquid for μs-resolved,AI-executable XPCS

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Light(Science & Applications) 2023年第9期12卷 1857-1866页

作者： Doga Yamac Ozgulbas Don Jensen Jr. Rory Butler Rafael Vescovi Ian T.Foster Michael irvin Yasukazu Nakaye Miaoqi Chu Eric M.Dufresne Soenke Seifert Gyorgy Babnigg Arvind Ramanathan Qingteng Zhang Data Science and Learning Division Argonne National LaboratoryLemontIL 60439USA X-ray Science Division Argonne National LaboratoryLemontIL 60439USA Departement of Computer Science University of Chicago5801 S Ellis AveChicagoIL 60637USA XRD Design and Engineering Department Rigaku Corporation 3-9-12 Matsubara-choAkishima-shiTokyo 196-8666Japan Bioscience Division Argonne National LaboratoryLemontIL 60439USA

The dynamics and structure of mixed phases in a complex fluid can significantly impact its material properties,such as ***-angle X-ray Photon Correlation Spectroscopy(SA-XPCS)can probe the spontaneous spatial fluctuations of the mixed phases under various in situ environments over wide spatiotemporal ranges(10−6–103 s/10−10–10−6 m).Tailored material design,however,requires searching through a massive number of sample compositions and experimental parameters,which is beyond the bandwidth of the current coherent X-ray *** 3.7-μs-resolved XPCS synchronized with the clock frequency at the Advanced Photon Source,we demonstrated the consistency between the Brownian dynamics of~100 nm diameter colloidal silica nanoparticles measured from an enclosed pendant drop and a sealed *** electronic pipette can also be mounted on a robotic arm to access different stock solutions and create complex fluids with highly-repeatable and precisely controlled composition *** closed-loop,AI-executable protocol is applicable to light scattering techniques regardless of the light wavelength and optical coherence,and is a first step towards high-throughput,autonomous material discovery.

关键词： resolved sealed mounted

HPV DNA检测在细胞学AGC处理中的有效性

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 16-17页

作者： irvin W. Evans S.R. Andersen W. 朱晓明 Division of Gynecologic Oncology Box 800712 University of Virginia Health System Charlottesville VA 22908 United States Dr.

Objective: Given the demonstrated utility of human papilloma virus DNA triage in the management of atypical squamous cells of undetermined significance, this study sought to evaluate the potential role of human papilloma virus DNA testing in the evaluation and management of cytological atypical glandular cells. Study design: Following institutional review board approval, 28 women presenting with cytological atypical glandular cells underwent repeat thin-prep cytology, Hybrid Capture 2 human papilloma virus DNA testing, colposcopic evaluation, Fisher electrosurgical conization, and endometrial sampling. Human papilloma virus test results in each patient were then correlated with histologic lesions, if present. Results: Sixteen of the 28 study patients had pathologic lesions (11/28 high-grade squamous intraepithelial lesion, 3/28 low-grade squamous intraepithelial lesion, 1/28 adenocarcinoma in situ, 1/28 simple endometrial hyperplasia). Human papilloma virus DNA testing was available in 24 of 28 subjects (86% ). The sensitivity of human papilloma virus positivity to predict the presence of cervical intraepithelial neoplasia was 100% (confidence interval 77% to 100% ), specificity 64% (confidence interval 35% to 85% ), positive predictive value 76% , and negative predictive value 100% . Women who tested human papilloma virus positive were 12 times more likely to have cervical intraepithelial neoplasia than women who were human papilloma virus negative (Fisher P<.001). Human papilloma virus positivity was not predictive of endometrial pathology; women who were human papilloma virus positive were less likely to have endometrial pathology than were women who were human papilloma virus negative (risk ratio 1.6, 95% confidence interval 0.01- 1.7). Conclusion: Atypical glandular cells can represent a variety of lesions. The majority of the lesions will be squamous intraepithelial lesions of the cervix (50% ), with high-grade squamous intraepithelial lesion present in 40% of

关键词：细胞学诊断 HPV DNA检测 AGC DNA 鳞状上皮内病变宫颈锥切子宫内膜人乳头瘤病毒原位腺癌阴道镜检

Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”

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Bone Research 2019年第3期7卷 225-242页

作者： Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA Department of Biomedical Engineering University of Rochester Medical Center Rochester NY USA Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA Department of Orthopaedics University of Rochester Medical Center Rochester NY USA Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY USA Department of Orthopaedic Surgery Kyoto University Kyoto Japan Department of Orthopaedic Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, *** intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure.

关键词： disease caused by soft tissue necrotic tissuel

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大鼠胃的主细胞分离纯化培养及功能测定

南京医科大学学报（自然科学版） 2000年第5期20卷 339-341页

作者：缪锟孙亮 LauraHTang irvinMModlin 南京医科大学第一附属医院消化内科南京210029 美国耶鲁大学医学院外科系

目的　通过建立分离纯化大鼠胃的主细胞培养系统 ,为进一步深入研究主细胞的生理调节和病理变化提供新的方法。方法　采用链霉蛋白酶的消化、淘析法分离纯化大鼠胃的主细胞。主细胞的纯化率在光镜下根据细胞的大小、结构和颜色计算。用... 详细信息

目的　通过建立分离纯化大鼠胃的主细胞培养系统 ,为进一步深入研究主细胞的生理调节和病理变化提供新的方法。方法　采用链霉蛋白酶的消化、淘析法分离纯化大鼠胃的主细胞。主细胞的纯化率在光镜下根据细胞的大小、结构和颜色计算。用血红蛋白法测定胃蛋白酶。在主细胞的短期培养系统中 ,主细胞的最佳功能状态通过比较胆囊收缩素 (CCK 8)、卡巴可林和异丙肾上腺素在不同培养时间和刺激状态下 ,主细胞分泌胃蛋白酶原的量而定。结果　在泵速为 37ml/min收集分离的主细胞化率为 83%～ 92 %。细胞的存活率 >95 %。CCK 810 -5mol/L、卡巴可林 10 -4 mol/L和异丙肾上腺素 10 -5mol/L刺激 30min后 ,主细胞分泌胃蛋白原的量在培养 2 4h明显高于培养 6、12、36h(P <0 .0 5 )。在主细胞培养 2 4h后 ,CCK 810 -5mol/L、卡巴可林 10 -4 mol/L和异丙肾上腺素 10 -5mol/L刺激主细胞 45min时胃蛋白酶原的分泌量明显高于刺激 30、6 0、90min(P <0 0 5 )。卡巴可林EC50 为 2× 10 -7mol/L ,在浓度为 10 -5mol/L时最大分泌量是对照组的 1.82倍 (P <0 .0 5 )。CCK 8的EC50 为 10 -8mol/L ,在浓度为 10 -5mol/L时最大分泌量是对照组的 1.5 2倍 (P <0 .0 5 )。结论　具有良好功能的分离纯化大鼠胃的主细胞培养系统已被建立?

关键词：主细胞胃蛋白酶原分离培养功能测定

A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System

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A Bioinspired Platform for Effective Delivery of Protein The...

Glucagon receptor gene mutations with hyperglucagonemia but without the glucagonoma syndrome

第十五届中国实验动物科学年会

作者： Di Wu Meng Qin Duo Xu Lan Wang Chaoyong Liu Jie Ren George Zhou Chen Chen Fengmei Yang Yanyan Li Yuan Zhao Ruyi Huang Sina Pourtaheri Chunsheng Kang Masakazu Kamata irvin S.Y.Chen Zhanlong He Jing Wen Wei Chen Yunfeng Lu Department of Chemical and Biomolecular Engineering University of California Los Angeles College of Life Science and Technology Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College

Central nervous system (CNS) diseases are the leading cause of morbidity and mortality;their treatment,however,remains constrained by the blood–brain barrier (BBB) that impedes the access of most therapeutics to the brain.A CNS delivery platform for protein therapeutics,which is achieved by encapsulating the proteins

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World Journal of Gastrointestinal Surgery 2015年第4期7卷 60-66页

作者： Helen C Miller Mark Kidd irvin M Modlin Patrizia Cohen Roberto Dina Panagiotis Drymousis Panagiotis Vlavianos Günter Klöppel Andrea Frilling Department of Surgery and Cancer Imperial College LondonLondon W12 0HSUnited Kingdom Department of Surgery Yale UniversityNew HavenCT 06510United States Emeritus Yale University School of MedicineNew HavenCT 06510United States Department of Histopathology Imperial College LondonLondon W12 0HSUnited Kingdom Department of Gastroenterology Imperial College LondonLondon W12 0HSUnited Kingdom Department of Pathology Technical University of Munich81675 MunichGermany

Pancreatic neoplasms producing exclusively glucagon associated with glucagon cell hyperplasia of the islets and not related to hereditary endocrine syndromes have been recently described. They represent a novel entity within the panel of non-syndromic disorders associated with hyperglucagonemia. This case report describes a 36-year-old female with a 10 years history of nonspecific abdominal pain. No underlying cause was evident despite extensive diagnostic work-up. More recently she was diagnosed with gall bladder stones. Abdominal ultrasound, computerised tomography and magnetic resonance imaging revealed no pathologic findings apart from cholelithiasis. Endoscopic ultrasound revealed a 5.5 mm pancreatic lesion. Fine needle aspiration showed cells focally expressing chromogranin, suggestive but not diagnostic of a low grade neuroendocrine tumor. Octreo Scan was negative. Serum glucagon was elevated to 66 pmol/L(normal: 0-50 pmol/L). Other gut hormones, chromogranin A and chromogranin B were normal. Cholecystectomy and enucleation of the pancreatic lesion were undertaken. Postoperatively, abdominal symptoms resolved and serum glucagon dropped to 7 pmol/L. Although H and E staining confirmed normal pancreatic tissue, immunohistochemistry was initially thought to be suggestive of alpha cell hyperplasia. A count of glucagon positive cells from 5 islets, compared to 5 islets from 5 normal pancreata indicated that islet size and glucagon cell ratios were increased, however still within the wide range of normal physiological findings. Glucagon receptor gene(GCGR) sequencing revealed a heterozygous deletion,K349_G359del and 4 missense mutations. This case may potentially represent a progenitor stage of glucagon cell adenomatosis with hyperglucagonemia in the absence of glucagonoma syndrome. The identification of novel GCGR mutations suggests that these may represent the underlying cause of this condition.

关键词： Hyperglucagonemia Glucagon receptorgene Mutation Adenomatosis Pancreas

前蛋白转化酶枯草溶菌素9变异、低密度脂蛋白胆固醇与神经认知功能损害的关系

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中华高血压杂志 2017年第12期25卷 1103-1103页

作者：黄洁叶鹏 Mefford MT Rosenson RS Cushman M Farkouh ME McClure LA Wadley VG irvin MR Bittner VA Safford MM Somaratne R Monda KL Muntner P Levitan EB

尽管之前的研究引发了对抑制前蛋白转化酶枯草溶菌素9（proprotein convertase subtilisin／kexintype9，PCSK9）造成神经认知功能损害事件的关注，但近期一个第3期随机试验并没有发现药物性PCSK9抑制与神经认知损害有关。

关键词：神经认知功能低密度脂蛋白胆固醇认知功能损害溶菌素转化酶前蛋白变异损害事件