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一项大样本社区研究中的鱼类摄取与年龄相关认知功能下降的关系

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 7-8页

作者： morris M.C. Evans d.A. Tangney C.C. 方伯言 Rush Institute for Healthy Aging Rush University Medical Center 1645 W Jackson Chicago IL 60612 United States Dr.

Background: dietary intake of fish and the ω-3 fatty acids have been associated with lower risk of Alzheimer disease and stroke. Objective: To examine whether intakes of fish and the ω-3 fatty acids protect against age-related cognitive decline. design: Prospective cohort study. Setting: Geographically defined Chicago, Ill, community. Participants: Residents, 65 years and older, who participated in the Chicago Health and Aging Project. Main Outcome Measure: Change in a global cognitive score estimated from mixed models. The global score was computed by summing scores of 4 standardized tests. Inhome cognitive assessments were performed 3 times over 6 years of follow-up. Results: Cognitive scores declined on average at a rate of 0.04 standardized units per year (SU/y). Fish intake was associated with a slower rate of cognitive decline in mixed models adjusted for age, sex, race, education, cognitive activity, physical activity, alcohol consumption, and total energy intake. Compared with a decline rate in score of -0.100 SU/y among persons who consumed fish less than weekly, the rate was 10%slower (-0.090 SU/y) among persons who consumed 1 fish meal per week and 13%slower (-0.088 SU/y) among persons who consumed 2 or more fish meals per week. The fish association was not accounted for by cardiovascular-related conditions or fruit and vegetable consumption but was modified after adjustment for intakes of saturated, polyunsaturated, and trans fats. There was little evidence that the ω-3 polyunsaturated fatty acids were associated with cognitive change. Conclusions: Fish consumption may be associated with slower cognitive decline with age. Further study is needed to determine whether fat composition is the relevant dietary constituent.

关键词：认知功能下降年龄相关性社区研究 ω-3多不饱和脂肪酸鱼类摄取大样本 ω-3脂肪酸功能评分饮食结构

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中文版《Ad8》信度与效度的初步研究

中华内科杂志 2012年第10期51卷 777-780页

作者：李涛王华丽杨渊韩 JamesE.Galvin John C. morris 于欣北京大学精神卫生研究所卫生部精神卫生学重点实验室 100191 中国台湾高雄医学大学神经科 New York University Langone School of Medicine Washington UniversitySchool of Medicine

目的检验《Ad8》中文译本在Alzheimer病（Ad）患者中应用的信度与效度；初步确定《Ad8》中文译本区分Ad患者与认知正常老人界限分值及敏感度和特异度。方法共入组240例受试者，正常对照75例，Ad患者165例。正常对照和Ad患者接受临床痴... 详细信息

目的检验《Ad8》中文译本在Alzheimer病（Ad）患者中应用的信度与效度；初步确定《Ad8》中文译本区分Ad患者与认知正常老人界限分值及敏感度和特异度。方法共入组240例受试者，正常对照75例，Ad患者165例。正常对照和Ad患者接受临床痴呆量表（CdR）、简易精神状态检查（MMSE）、画钟测验（CdT）评估。向所有正常对照及Ad患者知情者询问《Ad8》中文译本。其中158例Ad患者知情者在1个月内重测《Ad8》。结果（1）《Ad8》中文译本的克朗巴赫系数d=0．78，重测信度（ICC）=0．96（P〈0．01）。（2）各条目评分问相关系数为0．36—0．69（P〈0．01）；《Ad8》中文译本总分与CdR总体评分（r=0．82，P〈0．01）和各领域评分总和（r=0．80，P〈0．01）呈正相关，与MMSE（r=-0．75，P〈0．01）和CdT得分（r=-0．53，P〈0．01）呈负相关。（3）《Ad8》鉴别认知正常者与Ad患者的AUC=0．93，以I〉2为认知损害的界限分值，敏感度为93．9％，特异度为76．0％。结论《Ad8》中文译本具有良好的信度和效度，是识别早期痴呆的一项简单敏感的筛查工具。

关键词：阿尔茨海默病认知障碍 (AdS)

隐睾或去垂体大鼠血清中抑制素与FSH的关系

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男性学杂志 1992年第3期6卷 154-157页

作者：童建孙 R.Bandaso I.d.morris Y.T.Sun d.M.deKretser 江苏省计划生育研究所印度尼西亚Hasanuddin 大学英国Manchester 大学澳大利亚Monash 大学

本研究观察了实验性隐睾与去垂体大鼠的血清、睾丸与间质液中抑制素水平与血清中FSH的水平。发现隐睾大鼠术后1～2周末,血清中抑制素水平下降到对照组的20～40％左右,FSH水平可增加到对照组水平的200％,二者之间有一个明显的负相关(r=-0... 详细信息

本研究观察了实验性隐睾与去垂体大鼠的血清、睾丸与间质液中抑制素水平与血清中FSH的水平。发现隐睾大鼠术后1～2周末,血清中抑制素水平下降到对照组的20～40％左右,FSH水平可增加到对照组水平的200％,二者之间有一个明显的负相关(r=-0.38,P=0.013)。去垂体大鼠的FSH水平下降到不能探测水平时,抑制素水平也明显下降。本实验认为抑制素调节着FSH的分泌,而FSH也部分地控制了抑制素的产生。

关键词：隐睾去垂体促滤泡激素

Estimating tropical cyclone surface winds: Current status, emerging technologies, historical evolution, and a look to the future

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Tropical Cyclone Research and Review 2021年第3期10卷 125-150页

作者： John A.Knaff Charles R.Sampson Matthew E.Kucas Christopher J.Slocum Michael J.Brennan Thomas Meissner Lucrezia Ricciardulli Alexis Mouche Nicolas Reul Mary morris Galina Chirokova Philippe Caroff NOAA/Center for Satellite Applications and Research Fort CollinsCOUSA Naval Research Laboratory MontereyCAUSA Joint Typhoon Warning Center Pearl HarborHawaiiUSA NOAA/NWS/NCEP National Hurricane Center MiamiFLUSA Remote Sensing Systems Santa RosaCAUSA Ifremer Univ.BrestCNRSIRDLaboratoire d’Océanographie Physique et SpatialeIUEM29280 BrestFrance NASA/Jet Propulsion Laboratory PasadenaCAUSA Cooperative Institute for Research in the Atmosphere Fort CollinsCOUSA Tropical Cyclone/Regional Specialized Meteorological Center Météo FranceRéunionFrance

This article provides a review of tropical cyclone(TC)surface wind estimation from an operational forecasting ***,we provide a summary of operational forecast center practices and historical ***,we discuss current and emerging objective estimates of TC surface winds,including algorithms,archive datasets,and individual algorithm strengths and weaknesses as applied to operational TC surface wind forecast *** review leads to recommendations about required surface coverage—an area covering at least 1100 km from center of TC at a 2-km resolution in the inner-core,and at a frequency of at least once every 6 *** is enough coverage to support a complete analysis of the TC surface wind field from center to the extent of the 34-kt(17 m s^(-1))winds at 6-h *** also suggest future designs of TC surface wind capabilities include funding to ensure near real-time data delivery to operators so that operational evaluation and use are feasible within proposed ***,we suggest that users of archived operational wind radii datasets contact operational organizations to ensure these datasets are appropriate for their needs as the datasets vary in quality through time and space,even from a single organisation.

关键词： Tropical cyclone Surface wind Satellite Best track Operations

Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 296-305页

作者： Khadga Raj Aran G.d.Gupta Shamsher Singh Neuroscience division Department of PharmacologyISF College of Pharmacy(An Autonomous College)MogaPunjabIndia-142001 I.K.Gujral Punjab Technical University JalandharIndia department of Pharmaceutics ISF College of PharmacyMogaPunjabIndia-142001

Objective:To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in ***:Rats were administered with cladribine(1 mg/kg,p.o.)and cryptotanshinone(10 and 20 mg/kg,i.p.)for four *** tests such as morris water maze and elevated plus maze were conducted to check memory impairment caused by *** day 29,all rats were sacrificed,and the brains were separated for estimation of neuroinflammatory factors,biochemical parameters,neurotransmitters,Aβ(1-42),blood-brain barrier permeability,nuclear factor erythroid 2-related factor 2(Nrf2),and brain-derived neurotrophic factor(BdNF).Results:Treatment with cryptotanshinone dose-dependently enhanced spatial memory,improved the levels of neurotransmitter and antioxidant enzymes,and suppressed proinflammatory cytokine *** also decreased Aβ(1-42)accumulation and increased the levels of Nrf2 and BdNF in the ***,the histopathological results showed that cryptotanshinone reduced cladribine-induced neuronal death in the ***:Cryptotanshinone exhibits a promising neuroprotective effect against cladribine-induced cognitive impairment in preclinical studies,and may be a potential phytochemical for the treatment and management of cognitive impairment.

关键词： Alzheimer's disease Cladribine Cryptotanshinone Neurotransmitters Neuroprotective Proinflammatory cytokines Cognitive deficit

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Metsa副总裁谈全面研发与创新

生活用纸 2014年第10期14卷 16-17页

作者： Helen morris 邢婉娜

在极具挑战性的德国市场中，零售商品牌颇具优势，能源成本较高、民间组织影响力大和人口老龄化等因素并存。Metsa Tissue公司克服重重困难，在产品、服务、能源效率、设备、有机增长等方面全方位发展创新。《世界卫生纸》杂志主编Helen... 详细信息

在极具挑战性的德国市场中，零售商品牌颇具优势，能源成本较高、民间组织影响力大和人口老龄化等因素并存。Metsa Tissue公司克服重重困难，在产品、服务、能源效率、设备、有机增长等方面全方位发展创新。《世界卫生纸》杂志主编Helen morris日前采访了Metsa Tissue公司西欧地区生活用纸业务高级副总裁Christoph Zeiler。

关键词：创新总裁研发人口老龄化能源成本组织影响能源效率生活用纸

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堆石堤坝的安全系数和破坏机率

江西水利科技 1991年第1期17卷 73-82页

作者： M. R. BARBOSA d. V. morris S. K. SARMA 张德祥铁道部第四设计院科研所

本文采用极限平衡法来分析堆石堤坝的稳定性。应用零临界加速度系数等值线绘制了稳定性曲线图。这些曲线作为辅助设计足有价值的,其表述形式可以用于直接计算安全系数。该系数是稳定性分析中一个很常见的参数。而可靠性理论以二次矩的... 详细信息

本文采用极限平衡法来分析堆石堤坝的稳定性。应用零临界加速度系数等值线绘制了稳定性曲线图。这些曲线作为辅助设计足有价值的,其表述形式可以用于直接计算安全系数。该系数是稳定性分析中一个很常见的参数。而可靠性理论以二次矩的形式用来计算堆石堤坝的破坏机率。采用三种略为不同的密度函数表征度参数,旨在研究截头对系统破坏机率的影响。引进应用数理逻辑分布作为计算结构破坏机率的一种方法,而毋需使用图表,对计算安全系数及其可靠度两者所需的参数作出了评估,并根据常用的设计变量,用曲线图表示。研究涉及了大范围内的几何形状和强度参数的实用组合。

关键词：堆石堤坝安全系数破坏统计分析

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疾病的演化

国外畜牧学（猪与禽） 2002年第5期22卷 32-33页

作者：钟伟(译) 张海洪(校) R.S.morris R.R.davies d.E.Lawton 不详新西兰Massey大学兽医动物和生物医学学院 Massey大学流行病学研究中心

许多因素造成了疾病的演化 ,我们会面临什么样的未来呢 ?

关键词：猪传播机理生产体系疾病

The regenerative response of cardiac interstitial cells

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Journal of Molecular Cell Biology 2022年第10期14卷 19-36页

作者： Laura Rolland Alenca Harrington Adèle Faucherre Jourdano Mancilla Abaroa Girisaran Gangatharan Laurent Gamba dany Severac Marine Pratlong Thomas Moore-morris Chris Jopling Institute of Functional Genomics University of MontpellierCNRSINSERMLabEx ICSTMontpellier 34094France Montpellier GenomiX France GénomiqueMontpellier 34094France

Understanding how certain animals are capable of regenerating their hearts will provide much needed insights into how this process can be induced in humans in order to reverse the damage caused by myocardial ***,it is becoming increasingly evident that cardiac interstitial cells play crucial roles during cardiac *** understand how interstitial cells behave during this process,we performed single-cell RNA sequencing of regenerating zebrafish *** a combination of immunohistochemistry,chemical inhibition,and novel transgenic animals,we were able to investigate the role of cell type-specific mechanisms during cardiac *** approach allowed us to identify a number of important regenerative processes within the interstitial cell ***,we provide detailed insight into how interstitial cells behave during cardiac regeneration,which will serve to increase our understanding of how this process could eventually be induced in humans.

关键词： heart regeneration interstitial cells single-cell RNA-sequencing macrophage fibroblast endothelium inflammation