检索结果-南通市图书馆

Trace analysis of off-flavor/odor compounds in water using liquid-liquid microextraction coupled with gas chromatography--positive chemical ionization-tandem mass spectrometry

北京周报(英文版) 2024年第20期 26页

作者： G.P.wilson

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Frontiers of Environmental science & Engineering 2016年第3期10卷 477-481页

作者： Jian LU Paul s. WILLs P. CHRIs wilson Indian River Research and Education Center University of Florida/IFAS 2199 South Rock Road Fort Pierce FL 34945-3138 USA Harbor Branch Oceanographic Institute at Florida Atlantic University 5600 U.S. 1 North Fort Pierce FL 34946 USA

A rapid, inexpensive and laboratory friendly method was developed for analysis of off-flavor/odor compounds in fresh and salt water using gas chromatography with chemical ionization-tandem mass spectrometry. Off-flavor/odor compounds, included geosmin, 2- methylisobomeol （MIB）, 2-isobutyl-3-methyoxypyrazine （IBMP）, and 2-isopropyl-3-methoxypyrazine （IPMP）. Using this method, a single sample can be extracted within minutes using only 1 mL of organic solvent. The ion transitions for IPMP, IBMP, MIB, and geosmin were 153 〉 121, 167 〉 125, 152 〉 95, and 165 〉 109, respectively. The linearity of this method for analyzing MIB ranged from 4 to 200ng·L^-1, and from 0.8 to 200ng·L^-1 for the other analytes. Method recoveries ranged from 97% to 111% and percent relative standard deviations ranged from 3% to 9%, indicating that the method is accurate, precise, and reliable.

关键词： off-flavor/odor compounds liquid-liquid microextraction gas chromatography-tandem mass spectrometry

speed of Thought and speed of Feet:Examining Perceptual-Cognitive Expertise and Physical Performance in an English Football Academy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of science in sport and Exercise 2021年第1期3卷 88-97页

作者： adam L.Kelly Mark R.wilson Daniel T.Jackson Jennifer Turnnidge Craig A.Williams Faculty of Health Education and Life SciencesBirmingham City UniversityBirminghamWest MidlandsUK Children’s Health and Exercise Research Centre and the College of Life and Environmental sciences University of ExeterSt Luke’s CampusHeavitree RoadExeter EX12LUDevonUK Exeter City Football Club ExeterDevonUK school of Kinesiology and Health studies Queen’s UniversityKingstonONCanada

The world's greatest professional football players are able to execute effective tactical decisions as well as fulfil various physical ***,the degree to which both are associated with greater potential in a football academy is ***,the aim of this study was to investigate decision-making skill and physical performance as contributing factors to coach potential rankings in an English football ***-eight outfield academy players(Foundation Development Phase[FDP]under-9 to under-11 n=40;Youth Development Phase[YDP]under-12 to under-16 n=58)participated in the *** engaged in 45 film-based simulations at two occlusion phases(e.g.,the visual display is cut-off at a precise time during an action),firstly"during"and secondly"post"execution,to examine decision-making *** also completed four fitness tests to examine physical performance.A classification of"higher-potentials"(top third)and"lower-potentials"(bottom third)were applied through coach *** t-tests compared the decision-making and physical performance ***-potentials made significantly more accurate decisions within the"post"phase within the FDP(Pse within the YDP(Ps were significantly faster for the 0-30 m sprint in both the FDP and YDP(Ps within the YDP also significantly faster in the 0-10 m sprint(Psignificantly higher in the countermovement jump(Pse findings indicated that greater football potential may be associated with superior perceptual-cognitive expertise and quicker sprint ability in both academy age phases,with a greater discriminatory function within the older cohort.

关键词： Decision-making sprint ability Fitness testing Academy football Talent identification Talent development

Current status and future directions of high-throughput ADME screening in drug discovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2020年第3期10卷 201-208页

作者： wilson Z.shou Bristol-Myers squibb PO Box 4000PrincetonNJ08540USA

During the last decade high-throughput in vitro absorption,distribution,metabolism and excretion(HTADME)screening has become an essential part of any drug discovery effort of synthetic *** conduct of HT-ADME screening has been"industrialized"due to the extensive development of software and automation tools in cell culture,assay incubation,sample analysis and data *** HT-ADME assay portfolio continues to expand in emerging areas such as drug-transporter interactions,early soft spot identification,and ADME screening of peptide drug ***,thanks to the very large and high-quality HT-ADME data sets available in many biopharma companies,in silico prediction of ADME properties using machine learning has also gained much momentum in recent *** this review,we discuss the current state-of-the-art practices in HT-ADME screening including assay portfolio,assay automation,sample analysis,data processing,and prediction model *** addition,we also offer perspectives in future development of this exciting field.

关键词： In vitro HT-ADME Automation Bioanalysis Mass spectrometry Acoustic ejection mass spectrometry

Pancreatic cancer and its stroma: A conspiracy theory

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第32期20卷 11216-11229页

作者： Zhihong Xu srinivasa P Pothula Jeremy s wilson Minoti V Apte Pancreatic Research Group South Western Sydney Clinical School Faculty of Medicine The University of New South Wales Sydney NSW 2170 Australia Ingham Institute for Applied Medical Research SydneyNSW 2170 Australia

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has received little attention until recent times. Given that treatments focusing on pancreatic cancer cells alone have failed to significantly improve patient outcome over many decades, research efforts have now moved to understanding the pathophysiology of the stromal reaction and its role in cancer progression. In this regard, our Group was the first to identify the cells(pancreatic stellate cells, PsCs) that produced the collagenous stroma of pancreatic cancer and to demonstrate that these cells interacted closely with cancer cells to facilitate local tumour growth and distant metastasis. Evidence is accumulating to indicate that stromal PsCs may also mediate angiogenesis, immune evasion and the well known resistance of pancreatic cancer to chemotherapy and radiotherapy. This review will summarise current knowledge regarding the critical role of pancreatic stellate cells and the stroma in pancreatic cancer biologyand the therapeutic approaches being developed to target the stroma in a bid to improve the outcome of this devastating disease.

关键词： Pancreatic cancer stromal reaction Tumour-stroma interactions Pancreatic stellate cells Metastasis

Post-harvest storage of lime fruits (Citrus aurantifolia) following high humidity and low temperature in a modified brick wall cooler

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Agricultural and Biological Engineering 2010年第3期3卷 80-86页

作者： Faiz MMT Marikar R s wilson Wijerathnam Ceylon Institute of scientific&Industrial Research 363Bauddaloka Mawathata011000 Colombo 7Sri Lanka

The use of a modified brick wall Evaporative Cooling Chamber(ECC)for extending the shelf life of limes(Citrus aurantifolia)was compared with ambient *** shelf life inside of the ECC was extended by five to twenty days relative to ambient *** inside temperatures were about 4-6℃less than the ambient temperatures,and humidity was about 10%-20%*** was conducted to check the weight loss and freshness of lime fruits,and data were observed *** loss in limes kept inside the chamber for ten days was 1.8%and in ambient conditions it was around 9.8%.The color of the fruit changed to yellowish inside the ECC and the control which was kept outside became *** storage did not adversely affect fruit firmness,or the percentage of soluble solids or titratable acidity of the *** modified ECC does not require mechanical or electrical energy input and can be constructed with locally available material by unskilled labour.

关键词： evaporative cooling systems lime temperature relative humidity Citrus aurantifolia weight loss firmness titratable acidity soluble solids

More evidence intratumoral DHT synthesis drives castration-resistant prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第1期16卷 99-100页

作者： Elizabeth M wilson Laboratories for Reproductive Biology Department of Pediatrics Lineberger Comprehensive Cancer Center Department of Biochemistry and Biophysics University of North Carolina

Again-of-function stabilizing somatic mutation in 3β-hydroxysteroiddehydrogenase type 1 （3βHsDI, HsD3B1） was reported in castration-resistant prostate cancer. The A-C nucleotide polymorphism replaced asparagine-367 with threonine （3βHsD1-N367T） as a homozygous somatic mutation in a subset of castration-resistant prostate cancers by loss of heterozygosity of the wild-type allele. Increased stability of 3[HsD I-N367T was associated with decreased ubiquitin-mediated degradation and higher levels of dihydrotestosterone （DHT）. The studies suggest that genetic instability in castration-resistant prostate cancer favors the more stable 313HsD I-N367T mutant that contributes to drug resistance. A somatic mutation in a steroid metabolic enzyme required for DHT synthesis provides further support for intratumoral androgen synthesis contributing to prostate cancer progression.

关键词： 3-BETA-HYDROXYsTEROID DEHYDROGENAsE ANDROGEN RECEPTOR sTEROIDOGENEsIs DIHYDROTEsTOsTERONE ABIRATERONE

Ultrastructural analysis of the loss of desiccation tolerance in germinating Eremanthus erythropappus seeds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2019年第4期30卷 1331-1336页

作者： Rayana s.Martins Anderson C.José José Marcio R.Faria wilson V.s.Pereira Department of Forest sciences Federal University of Lavras(UFLA)

Eremanthus erythropappus(DC.)MacLeish is an important forest species native to the Brazilian savanna biome,an environment with well-defined rainy and dry *** seeds are desiccation tolerant,non-dormant and dispersed at the end of dry *** exposes them to the first sporadic rains that can trigger germination but the subsequent dry days can compromise survival of the newly germinated *** study evaluates if the damages caused by drying of germinating *** seeds,at the stage when they have lost desiccation tolerance,are *** percentage of normal seedlings was evaluated when seeds with different imbibition times were dried to their initial water content and then pre-humidified and *** tolerance was fully lost after 0.5 mm of hypocotyl-radicle protrusion(approximately 72 h)when the radicle had root hairs,a possible indicator of sensitivity to *** of cell contents and ultrastructural damage to the seeds subjected to drying were observed by electron scanning *** hairs disappeared after drying,reappearing after pre-humidification,possibly an attempt to increase the surface area of the radicle for water ***,the hypocotylradicle axis became darkened,probably by antioxidant system failure,causing seed death.

关键词： Candeia Drying Desiccation tolerant seeds Rehydration scanning electron microscopy

Correlation of in vivo tumor response and singlet oxygen luminescence detection in mTHPC-mediated photodynamic therapy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health sciences 2015年第1期8卷 106-112页

作者： Brian C.wilson Michael s.Patterson Buhong Li Mark T.Jarvi Department of Medical Biophysics University of Toronto/University Health Network Toronto Ontario M5G 1L7Canada Juravinski Cancer Centre and McMaster University Hamilton Ontario L8V 5C2Canada MOE Key Laboratory of OptoElectronic science and Technology for Medicine Fujian Provincial Key Laboratory for Photonics Technology Fujian Normal University FuzhouFujian 350007P.R.China

Excited-state singlet axygen(^(1)O_(2)),generated during photodynamic therapy(PDT),is believed to be the primary cytotoxic agent with a number of clinically approved *** relative concentration in cells or tissues can be measured directly through its near-infrared(NIR)luminescence emission,which has correlated well with in vitro cell and in triro normal skin treatment ***,its correlation with the response of tumor tiss1e in vito is examined,using the photosensitizer meso-tetralydroxyphenylchlorin(mTHPC)in an animal model comprising luciferase-and green fluorescent protein(GFP)-transduced gliosarcoma grown in a dorsal window *** change in the bioluminescence signal,imaged pre-treatment and at 2,5 and 9 d post treatment,was used as a quantitative measure of the tumor response,which was classified in individual tumors as"non","moderate"and"strong"in order to reduce the variance in the *** the bioluminescence-based response vs the^(1)O_(2)counts demonstrated clear correlation,indicating tha^(1)O_(2)luminescence provides a valid do-simetric technique for PDT in tumor tissue.

关键词： Photodynamice therapy singlet axygen lumninescence dosinetry bioluminescence

Can dietary flavonoids be useful in the personalized treatment of colorectal cancer?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第6期14卷 1115-1123页

作者： Cristina Pereira-wilson Department of Biology Centre of Biological EngineeringLABBELS Associate LaboratoryUniversity of MinhoBraga 4710-057Portugal

Activating mutations in the oncogenes KRAs,BRAF and PI3K define molecular colorectal cancer(CRC)subtypes because they play key roles in promoting CRC development and in determining the efficacy of chemotherapeutic agents such as 5-fluorouracil and anti-epidermal growth factor receptor monoclonal *** of patients with cancers displaying these molecular profiles is *** the limited efficacy of therapeutic strategies for CRC presenting mutational activations in mitogen-activated protein kinase and/or PI3K pathways,developing combination therapies with natural flavonoids or other phytochemicals with demonstrated effects on these pathways(and little or no toxic effects)may constitute a valuable path *** has been published on the anticancer effects of dietary ***,even an exhaustive characterization of potential beneficial effects produced by in vitro studies cannot be extrapolated to effects in *** far,the available data constitute a good starting *** results show quercetin and curcumin as possibly the best candidates to be further explored in the context of adjuvant CRC therapy either as part of dietary prescriptions or as purified compounds in combination regimens with the drugs currently used in CRC *** trial data is still largely missing and is urgently needed to verify relevant effects and for the development of more personalized treatment approaches.

关键词： Colorectal cancer Personalized treatment Quercetin Curcumin KRAs BRAF