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Management of 220 adolescents and adults with complications of hypospadias repair during childhood

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Asian Journal of Urology 2017年第1期4卷 14-17页

作者： adam S.howe Moneer K.Hanna Division of Pediatric Urology Cohen Children’s Medical Center of New YorkHofstra Northwell School of MedicineLong IslandNYUSA Department of Urology Weill Cornell Medical CenterNew YorkNYUSA

Objective:The goal of hypospadias repair is to achieve normal voiding and good penile cosmesis with minimal *** urethroplasties deteriorate from childhood to adolescence and late stage failures have been *** report our experience with adult patients who have had a previous repair during childhood and present with a late ***:We reviewed the records of 220 patients aged 15e39 years old with a history of hypospadias repair who presented to our ***-five patients with chordee,39 with urethral strictures,11 urethral fistulae,five with hairy urethras,three with urethral diverticula,and 117 patients with an abnormal glans or subterminal meatus were ***:Median follow-up was 14 *** patients had persistent *** skin flap urethroplasty afforded one patient with a urethral fistula and another with a recurrent urethral stricture,while the buccal mucosa group had one fistula which healed spontaneously and two recurrent *** the patients undergoing glanular repairs,seven had dehiscence or breakdown of the *** other operations were ***:Complications of childhood hypospadias repair may present later in life as some urethroplasties deteriorate with *** now recommend to parents of children with repaired proximal hypospadias to come for follow-up as their child transitions to adolescence.

关键词： Hypospadias Adult Adolescent Failure Complication

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy Chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan C.adam Dyker Department of Chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong Fu Dian Yu Jane howe Kaiwen Chen Ning Yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

New approaches to vibrational spectroscopy of zeolite catalysts: a perspective

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FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 2024年第11期18卷 123-123页

作者： howe, Russell F. Univ Aberdeen Chem Dept Aberdeen 999020 Scotland

This perspective discusses three alternative techniques which complement conventional infrared spectroscopy for obtaining vibrational information about zeolite catalysts and adsorbed molecules: inelastic neutron scattering, infrared micro-spectroscopy, and two-dimensional infrared spectroscopy. The techniques are illustrated briefly and future prospects for their use discussed.

关键词： FTIR zeolites INS micro-spectroscopy 2D FTIR

Solid rocket propulsion technology for de-orbiting spacecraft

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Chinese Journal of Aeronautics 2022年第3期35卷 128-154页

作者： adam OKNINSKI Center of Space Technologies Lukasiewicz Research Network-Institute of AviationWarsaw 02-256Poland

This paper presents the topic of using solid rocket propulsion for de-orbiting spacecraft,in order to fulfil space debris mitigation *** benefits and disadvantages of using such means are discussed.A dedicated system can be implemented in the satellite design phase and shall be a key subsystem of platforms inserted into ***,semi-controlled and controlled de-orbit can be completed using solid rocket *** impact on the space debris environment is *** requirements for dedicated propellants and systems are *** the majority of presently developed rocket systems worldwide require high burn rates,several applications,including de-orbiting,benefit from solid propellants with decreased regression *** allows limiting spacecraft accelerations and loads during de-orbit ***,the requirement of minimising solid particle generation is *** technology from the Mercury and Gemini human spaceflight programmes,where de-orbit motors were used,is *** Soviet,American and Chinese film-return-capsule solid propellant retrorockets,enabling deorbit,are also presented.A detailed survey of current work worldwide on end-of-life disposal using solid propulsion is *** of developing dedicated systems are ***,an outlook on solid rocket motor utilisation for space debris mitigation is provided.

关键词： De-orbit De-orbiting technology End-of-life disposal Satellite propulsion system development Solid propellant Solid rocket motor Space debris mitigation Space traffic management

Proactive interburden fracturing using UIS drilling with validation monitoring

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International Journal of Mining Science and Technology 2021年第1期31卷 3-7页

作者： adam Lines Anglo American Grosvenor MineMoranbah 4744Australia

A series of gas inrush events occurred during development at Grosvenor Mine resulting in exposure to elevated levels of methane at the production face.A total of 22 gas inrush events occurred,with between 15 and 130 m3 of methane released during each *** presence of an undrained seam in the immediate floor,geotechnical characteristics of the floor,and the stress environment all contributed to these dynamic floor events,while the geological characteristics of the seam below,such as the seam thickness and ash content of 75%,prevented effective ***,events only occurred in headings mined parallel to the principal horizontal stress *** cut-throughs(C/T)perpendicular to the principal stress direction no events occurred,and higher methane levels were observed at the production *** solution to preventing the gas inrush events involved creating a conduit in the interburden between the mined seam and the seam in the immediate floor to allow the gas to be drained during the development of the headings,as occurred in the cut-throughs(cut-through and cross-cut are regional terms that are analogous).A series of underground inseam(UIS)holes were drilled using the directional drill rig with the aim of fracturing this interburden ahead of the face and promote floor failure to allow the gas to release *** floor fracturing was conducted using water pressure generated from a longwall salvage pump,with the current UIS drilling equipment retrofitted with a series of subs,packers and a fracturing *** packers and the fracturing tool were shifted to desired locations along the drilled UIS borehole to achieve the required *** fractures were monitored using a proving hole and with a HYDAC data logger attached to the salvage pack,with the results analysed on the surface to ensure connectivity to the working seam.

关键词： Gas drainage Floor fracking UIS drilling

Evolutionary Origin of JAZ Proteins and Jasm onate Signaling

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Molecular Plant 2019年第2期12卷 153-155页

作者： Gregg A. howe Yuki Yoshida DOE Plant Research Laboratory Michigan State University East Lansing Ml 48824 USA Department of Biochemistry and Molecular Biology Michigan State University East Lansing Ml 48824 USA Plant Resilience Institute Michigan State University East Lansing Ml 48824 USA Graduate School of Science and Technology Kumamoto University Kumamoto 860-8555 Japan

The many roles of jasmonate in plant growth, reproduction, and defense raise interesting questions about how this lipid-derived hormone emerged during evolution. Recent studies indicate that a uhigher plant*5 pathway involving jasmonoyl-L-isoleucine (JA-lle) as the receptor-active ligand is conserved in vascular plants (Bowman et al., 2017;howe et al., 2018). Within this core sign aling pathway, J AZ protei ns link JA-lle perception to changes in the activity of MYC transcription factors (TFs)(Figure 1) and have emerged as a conserved hub for crosstalk in hormone response pathways.

关键词： Evolutionary Origin JAZ Proteins Jasm onate Signaling