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A simple,azulene-based colorimetric probe for the detection of nitrite in water

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Frontiers of chemical Science and Engineering 2020年第1期14卷 90-96,F0004页

作者： Lloyd c.Murfin carlos M.Lopez-Alled adam c.sedgwick Jannis Wenk Tony D.James Simon E.Lewis Department of chemistry University of BathBath BA27AYUK centre for Sustainable chemical Technologies University of BathBath BA27AYUK Department of chemical Engineering and Water Innovation and Research centre(WIRc@Bath) University of BathBath BA27AYUK

We describe the synthesis and evaluation of an azulene-based chemodosimeter for *** probe was found to undergo two distinct color changes upon introduction of aqueous nitrite ion.A near-instant formation of a grey color provides a qualitative indication of the presence of nitrite,followed by the formation of a deep-yellow/orange color,the endpoint from which quantitative data can be *** azulene probe exhibits 1:1 stoichiometry of reaction with nitrite in water,and is selective for nitrite over other *** azulene probe was applied to determine nitrite content in cured meat,and compared with the British Standard testing procedure(Griess test).The value obtained from the azulene-based probe agreed closely with the standard *** procedure only requires the preparation of one standard solution,instead of the three required for the standard Griess test.

关键词： azulene nitrite diazoquinone

Dual enzyme activated fluorescein based fluorescent probe

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Frontiers of chemical Science and Engineering 2020年第1期14卷 117-121页

作者： Maria L.Odyniec Jordan E.Gardiner adam c.sedgwick Xiao-Peng He Steven D.Bull Tony D.James Department of chemistry University of BathBathBA27AYUK Department of chemistry University of Texas at AustinAustinTX 78712-1224USA Key Laboratory for Advanced Materials&Feringa Nobel Prize Scientist Joint Research center East China University of Science and TechnologyShanghai 200237China

A simple dual analyte fluorescein-based probe(PF3-Glc)was synthesised containingβ-glucosidase(β-glc)and hydrogen peroxide(H2O2)trigger *** presence ofβ-glc,resulted in fragmentation of the parent molecule releasing glucose and the slightly fluorescent mono-boronate fluorescein(PF3).Subsequently,in the presence of glucose oxidase(GOx),the released glucose was catalytically converted to D-glucono-δ-lactone,which produced H2O2 as a *** GOx-produced H2O2,resulted in classic H2O2-mediated boronate oxidation and the release of the highly emissive fluorophore,*** unique cascade reaction lead to an 80-fold increase in fluorescence intensity.

关键词： chemosensors dual-activation GOx fluorescence β-glucosidase molecular logic

A boronic acid-based fluorescent hydrogel for monosaccharide detection

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Frontiers of chemical Science and Engineering 2020年第1期14卷 112-116页

作者： Suying Xu adam c.sedgwick Souad A.Elfeky Wenbo chen Ashley S.Jones George T.Williams A.Toby A.Jenkins Steven D.Bull John S.Fossey Tony D.James Department of Biochemistry Faculty of ScienceBeijing University of Chemical TechnologyBeijing 100029China Department of chemistry University of BathBath BA27AYUK Department of chemistry University of Texas at AustinTX 78712-1224USA School of chemistry University of BirminghamBirmingham B152TTUK National Institute of Laser Enhanced Sciences Cairo UniversityGiza 12613Egypt Higher Institute for Optics Technology SheratonCairo 17361Egypt Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power Shanghai University of Electric PowerShanghai 200090China

A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide *** solution,the fluorescent probe displayed a strong fluorescence turn-on response upon exposure to fructose,and an expected trend in apparent binding constants,as judged by a fluorescence response where D-fructose>D-galactose>D-mannose>*** hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of D-fructose resulting in a 10-fold enhancement(≤0.25 mol/L).

关键词： boron hydrogel monomer

Fluorescent probes for the detection of disease-associated biomarkers

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Science Bulletin 2022年第8期67卷 853-878,M0004页

作者： Wei-Tao Dou Hai-Hao Han adam c.sedgwick Guo-Biao Zhu Yi Zang Xin-Rong Yang Juyoung Yoon Tony D.James Jia Li Xiao-Peng He Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China National center for Drug Screening State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Liver Surgery&Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityKey Laboratory of Carcinogenesis and Cancer InvasionMinistry of EducationShanghai 200032China Department of chemistry University of BathBath BA27AYUK Department of chemistry and Nanoscience Ewha Womans UniversitySeoul 03760Republic of Korea Department of chemistry The University of Texas at AustinAustinTX 78712-1224USA School of chemistry and chemical Engineering Henan Normal UniversityXinxiang 453007China

Fluorescent probes have emerged as indispensable chemical tools to the field of chemical biology and *** ability to detect intracellular species and monitor physiological processes has not only advanced our knowledge in biology but has provided new approaches towards disease *** this review,we detail the design criteria and strategies for some recently reported fluorescent probes that can detect a wide range of biologically important species in cells and in *** doing so,we highlight the importance of each biological species and their role in biological systems and for disease *** then discuss the current problems and challenges of existing technologies and provide our perspective on the future directions of the research ***,we hope this review will provide inspiration for researchers and prove as useful guide for the development of the next generation of fluorescent probes.

关键词： Fluorescent probes Fluorescence imaging Biomarker detection chemical biology

2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

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Bioactive Materials 2022年第8期7卷 76-85页

作者： Yunjie Xu Yingwei Wang Jusung An adam c.sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang Lijun Qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationShenzhen Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People’s HospitalThe First Affiliated HospitalCollege of Optoelectronic EngineeringShenzhen UniversityShenzhen518060China Department of chemistry Korea UniversitySeoul02841South Korea Department of Hepatobiliary and Pancreatic Surgery Shenzhen People’s HospitalSecond Clinical Medical College of Jinan UniversityShenzhen518020China Department of chemistry The University of Texas at AustinAustinTX78712-1224USA Hunan Key Laboratory of Nanophotonics and Devices School of Physics and ElectronicsCentral South University932 South Lushan RoadChangsha410083China Institute of Translation Medicine Shenzhen Second People’s Hospital First Affiliated Hospital of Shenzhen University Shenzhen518035China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia

An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and *** makes iron metabolism an attractive therapeutic ***,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target *** report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer *** prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)c_(2) MXene nanosheets produces a construct,Ti_(3)c_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)c_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in *** results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy.

关键词： 2D MXene Nanomedicine Prodrug Iron chelation Photothermal therapy

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

A simple umbelliferone based fluorescent probe for the detection of nitroreductase

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Frontiers of chemical Science and Engineering 2018年第2期12卷 311-314页

作者： adam c. sedgwick Alex Hayden Barry Hill Steven D. Bull Robert B. P. Elmes Tony D. James Department of chemistry University of Bath Bath BA2 7AY UK Department of chemistry Maynooth University Maynooth Co. Kildare Ireland

A simple nitrobenzyl-umbelliferone （NcOU1） was synthesised containing a nitroreductase （NTR） trigger moiety. The presence of NTR, resulted in the fragmentation of the parent molecule and release of the highly emissive fluorophore umbelliferone via an NTR-catalyzed reduction of the nitro group. In the presence of the NTR enzyme, NcOU1 gave rise to a 5-fold increase in fluorescence intensity at 455 nm and was selective for NTR over other reductive enzymes. These results indicate that NcOU1 can be used as a simple assay for the detection of NTR.

关键词： NITRO RADIcALS NTSR1 gene FLUOREScENT PROBES Skimmetin Nitroreductases noise-temperature ratio

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Interventions and targets aimed at improving quality in inflammatory bowel disease ambulatory care

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World Journal of Gastroenterology 2013年第38期19卷 6375-6382页

作者： adam V Weizman Geoffrey c Nguyen Division of Gastroenterology Women’s College HospitalUniversity of TorontoTorontoON M5S 1B2Canada Mount Sinai Hospital centre for Inflammatory Bowel Disease University of TorontoTorontoON M5G 1X5Canada Division of Gastroenterology and Hepatology Johns Hopkins School of MedicineBaltimoreMD 21205United States

Over the past decade,there has been increasing focus on improving the quality of healthcare delivered to patients with chronic diseases,including inflammatory bowel *** bowel disease is a complex,chronic condition with associated morbidity,health care costs,and reductions in quality of *** condition is managed primarily in the outpatient *** delivery of high quality of care is suboptimal in several ambulatory inflammatory bowel disease domains including objective assessments of disease activity,the use of steroid-sparing agents,screening prior to anti-tumor necrosis factor therapy,and monitoring thiopurine *** review outlines these gaps in performance and provides potential initiatives aimed at improvement including reimbursement programs,quality improvement frameworks,collaborative efforts in quality improvement,and the use of healthcare information technology.

关键词： Ambulatory care crohn’s disease Inflammatory bowel disease Quality improvement Ulcerative colitis